Skin Sensitivity Research Articles (Page 1)

Sensitive skin is a common condition with a complex pathogenesis involving both host-related factors and microbial interactions. Emerging evidence suggests a bidirectional relationship between skin microbiome dysbiosis and sensitive skin, although whether microbial shifts are causal or consequential remains unclear. Characterizing the microbiome in this population is particularly challenging due to low microbial biomass and heightened skin reactivity, both of which may compromise sampling and data quality. While swabbing remains the most common method for skin microbiome collection, it may fail to yield sufficient DNA, especially from delicate facial areas. In this pilot study of 10 patients with sensitive facial skin, we compared swabbing to gentle scraping using a sterile No. 10 surgical blade. Swabbing consistently failed to recover detectable microbial DNA. In contrast, scraping was well-tolerated and enabled one-time sampling that yielded sufficient DNA for both bacterial and fungal sequencing. DNA concentrations ranged from 0.065 to 13.2 ng/µL for bacteria and 0.104 to 30.0 ng/µL for fungi. Genus-level classification rates exceeded 99.7% for bacteria and 97% for fungi. Shannon diversity indices ranged from 0.03 to 2.85 for bacteria and 0.106 to 2.849 for fungi. PCoA revealed substantial inter-individual variation in community composition. Dominant taxa included Staphylococcus aureus group, Cutibacterium acnes group, Malassezia restricta, and Malassezia globosa. These findings indicate that skin scraping is a feasible and reproducible method for microbiome studies of sensitive skin, providing comprehensive taxonomic and ecological profiling in a single, non-invasive session.Supplementary InformationThe online version contains supplementary material available at 10.1038/s41598-025-22259-w.

Objective To prepare low-temperature extracted Portulaca oleracea L. (P. oleracea) and investigate the application of masks containing this extract in photorejuvenation for sensitive skin. Methods Eligible participants were randomly divided into two groups. Experimental group used the mask for 14 days prior to photorejuvenation. Both groups used the mask for 7 days post-treatment. Changes in physiological parameters and Dermatology Life Quality Index (DLQI) were observed. Results Immediately after photorejuvenation, control group showed a significant increase in skin red area and red blood cell concentration, while experimental group did not. At 7 days post-treatment, skin hydration and transepidermal water loss (TEWL) improved significantly in both groups, with greater improvement in the experimental group. Both groups’ DLQI decreased, with a significant reduction in the experimental group. Conclusion Facial masks containing low-temperature extracted P. oleracea show promising potential in protecting sensitive skin from photothermal stimulation and improving skin barrier function during photorejuvenation therapy.

Abstract Stretchable and recyclable organic electrochemical transistors (OECTs) have emerged as a promising platform for flexible and green electronics. However, stretchable OECTs and OECT‐based sensors usually show limited transconductance and sensitivity. Herein, stretchable, recyclable, high‐transconductance, and multifunctional OECTs based on nanoporous semiconducting polymer aerogels are developed. The flexible nanoporous structures (pore size ≈ 10–160 nm) effectively facilitate ion penetration/transport and doping of semiconductor, significantly enhancing transconductance of the stretchable OECTs and sensitivity of the OECT‐based sensors. The resulting OECT achieves a high transconductance of 27.4 mS and high stretching stability. Notably, both the semiconducting aerogel and substrate are recyclable, achieving the recyclability of the OECTs. It is demonstrated that the stretchable nanoporous aerogel OECTs can be used as platforms for various applications, including ultrasensitive stretchable biosensors for monitoring trace amount of biomarkers in biological fluids, stretchable tactile electronic skins with an ultralow detection limit (0.5 Pa), and artificial synapses for neuromorphic simulation. This work provides a versatile strategy toward stretchable nanoporous semiconducting polymers promising for sustainable, stretchable, and highly sensitive electronics.

ABSTRACTBackgroundTyrosinase is the rate‐limiting enzyme in melanin biosynthesis, and its overactivity contributes to hyperpigmentation disorders. Existing tyrosinase inhibitors are often limited by poor potency against human tyrosinase (hTYR) or safety concerns.AimsTo evaluate the inhibitory potency, safety, and multifunctional activity of KT‐939, a newly synthesized human tyrosinase inhibitor, compared with established depigmenting agents.Patients/MethodsKT‐939 was synthesized and tested in vitro for tyrosinase inhibition, melanin suppression in human melanocytes, antioxidant activity (DPPH radical scavenging, NRF2 pathway activation), and anti‐inflammatory activity (cytokine expression in LPS‐stimulated macrophages). Safety was assessed in multiple skin‐related cell lines. A 28‐day, single‐center clinical study in healthy women with sensitive skin assessed the effects of 0.2% KT‐939 lotion on pigmentation and tolerability.ResultsKT‐939 strongly inhibited hTYR (IC₅₀ = 0.07 μM), demonstrating ~4‐fold greater potency than Thiamidol and far surpassing other comparators. In melanocytes, KT‐939 reduced melanin production (IC₅₀ = 0.36 μM) with reversible effects upon withdrawal. KT‐939 also displayed antioxidant activity, NRF2 activation, and suppression of pro‐inflammatory cytokines, without cytotoxicity up to 50 μM. Clinically, 28 days of KT‐939 lotion use improved skin spot lightening, tone uniformity, and overall brightness, with good tolerability in sensitive skin.ConclusionsKT‐939 is a potent and safe human tyrosinase inhibitor with additional antioxidant and anti‐inflammatory activity. These findings support its potential in cosmetic skin brightening and as a therapeutic candidate for hyperpigmentation disorders.

Skin compatibility is a common issue and can often be worsened by certain ingredients in cosmetics. This is why developing well-balanced and -tolerated formulas is now an essential challenge. In this work we developed a cream rich in antioxidant, soothing, and moisturizing agents complying with concentration limits for sensitive skin. An initial optimization was carried out, and the best-performing formula was fully characterized to test its rheological properties under static or dynamic conditions and product safety. The formulation proved to be highly stable even under thermal stress, as shown by Turbiscan Lab analyses, which reported backscattering values ±2. Rheological tests also indicated a solid-like behavior with reduced viscosity at skin temperature of 32 °C, confirming the good spreadability of the cream. Finally, in vivo tests on healthy volunteers showed excellent safety results and good overall appreciation of the product. No changes in transepidermal water loss (7.9 ± 3.5 vs. 5.5 ± 0.4, p > 0.05), skin hydration (44.2 ± 18.6 vs. 50.5 ± 14.1, p > 0.05), or color were detected within 6 h from application, compared with baseline values. Moreover, volunteers highlighted the cream’s suitability for dry skin and expressed satisfaction with spreadability, a nourishing and hydrating sensation after application, and the absence of residues, consistently rating them ≥4 in the skin feeling questionnaire. These results are promising and support the potential use of the product on sensitive skin.

Various high-performance wearable sensors have attracted increasing interest from researchers for the accurately monitoring of physiological signal. Wearable temperature sensors, as an important part of wearable sensors, allow accurate access to temperature information and are widely used in fields such as intelligent robotics and health monitoring. Improving key characteristics of wearable electronics is essential to expanding their application areas. In this study, we develop a wearable temperature sensor that leverages an ion capture and release dynamics mechanism, based on hydrogen bonding, to enhance the sensitivity of a wearable temperature sensor via a novel silica-in-ionogel composite. The developed sensor demonstrates ultra-high temperature sensitivity (0.008 °C) and excellent stability. Departing from conventional healthcare applications of physiological temperature monitoring, our work pioneers a novel paradigm to mirror our subjective thermal sensations, utilizing sensor data that exceeds the sensitivity of the human skin. As proof of concept, we demonstrate the sensor’s potential of apparent temperature monitoring for the purpose of establishing a smart dynamic temperature control system, with the aim of keeping the human in a thermally comfortable environment throughout. Our work opens up a potential application scenario for wearable temperature sensors in personalized temperature regulation.

This study systematically analyzed five common acne-fighting ingredients, investigating their mechanisms of action, onset times, and side effects. The subjects included salicylic acid, benzoyl peroxide, tea tree oil, sulfur, and retinol. Results were derived through literature review and data synthesis. Findings indicate these ingredients exhibit differences in anti-inflammatory, antibacterial, keratolytic, and sebum-regulating properties, with varying efficacy and onset times. Salicylic acid acts rapidly with low irritation, benzoyl peroxide demonstrates the strongest antibacterial activity, tea tree oil is suitable for sensitive skin, while sulfur and retinol show significant efficacy in deep sebum regulation. Limitations include the absence of long-term clinical data and insufficient consideration of individual skin type variations. Future research may explore ingredient combinations, personalized skin type studies, clinical trials, novel drug development, or systemic optimization of current acne treatment strategies. These findings not only guide acne ingredient selection and personalized care but also establish a scientific foundation for new formulation development.

The stratum corneum is essential for maintaining the skin barrier and preventing transepidermal water loss. Damage to this layer increases skin sensitivity, potentially leading to inflammation and related complications. This study aimed to establish reproducible skin damage models and to develop a non-invasive classification method for assessing the severity of skin barrier damage. Two controlled models of injury, tape stripping (TS) and friction-induced injury, were used to simulate barrier impairment. Raman imaging was employed to analyze biomarkers, including stratum corneum thickness, lipid content, and keratin levels. These parameters were combined with the K-nearest neighbour (KNN) algorithm to categorize skin damage severity. The integrated KNN-based model successfully classified skin damage severity ranging from normal to severe. It also enabled the prediction of severity in unknown samples, providing a robust diagnostic framework. This non-invasive model demonstrates strong potential for diagnostics and monitoring in dermatology. KNN-based classification combined with Raman imaging offers a reliable method for evaluating skin barrier damage severity.

This paper presents an innovative protocol for fabric functionalization using Tormentillae rhizoma extract, the chemical composition of which was proved via LC/MS analysis. The extract demonstrated antioxidant activity > 99%, and antibacterial efficacy against E. coli and S. aureus > 99%. Cotton, wool, polyamide, and cellulose acetate were functionalized with the prepared extract, all showing > 90% antioxidant activity. Functionalized cotton, wool, and polyamide exhibited > 99% antibacterial activity against both bacteria. Based on these findings and the fabrics’ ability to release bioactive compounds, functionalized cotton and polyamide fabrics having excellent bioactivity but a lower ability to release bioactive compounds can serve as protective fabrics for people with sensitive skin prone to wounds, and various products for hospitals. Functionalized wool was identified as the most suitable wound dressing for in vivo preclinical investigation on Wistar albino rats. The obtained results showcased a wound-healing rate of 95.54%, and hydroxyproline content of 8.08 µg/mg dry tissue for rats treated with functionalized wool. Compared to negative, positive, and a group of rats treated with non-functionalized wool, those treated with functionalized wool demonstrated elevated values of tissue redox state parameters, superoxide dismutase (SOD) and catalase (CAT), and a notable reduction in thiobarbituric acid reactive substances (TBARS) value. Analysis of the blood samples of rats treated with functionalized wool indicated increased levels of antioxidant defense system parameters (SOD and CAT) and decreased pro-oxidative markers superoxide (O2−) and TBARS. Further clinical trials are needed to validate these findings.

BackgroundThoracolumbar disc disease is a common neurological condition in dogs, which incorporates different pain components. Multimodal analgesic treatments, especially postoperatively, are often based on opioids and require an intravenous catheter for drug application. This might impede early physiotherapy and mobilisation. Different composite pain scales and sensory testing devices exist to evaluate postoperative pain behaviour in dogs. At present, no data are available to clearly recommend one tool or technique after spinal surgery over others. Therefore, the primary aim of this study was to evaluate whether subcutaneously applied methadone or transdermal fentanyl can offer sufficient postoperative analgesia in dogs after thoracolumbar neurosurgery without the need to maintain intravenous access. A secondary aim was to evaluate which type of pain recognition tool would be suitable for dogs in this clinical setting. The hypothesis is that both subcutaneously applied methadone and transdermal fentanyl solution provide adequate pain relief in dogs after thoracolumbar spinal surgery.MethodsIn a prospective, randomised, blinded clinical study, fifty client-owned dogs were repeatedly evaluated for 96 h after undergoing spinal surgery. Treatment group M received 0.4 mg/kg methadone subcutaneously two hours before the start of surgery and every 6 h thereafter. Treatment group F received a topical application of 2.6 mg/kg transdermal fentanyl two hours before the start of surgery. Dogs were assessed via the Glasgow Composite Measure Pain Scale–Short Form (CMPS-SF), the Colorado State University Canine Acute Pain Scale (CPS), a Visual Analogue Scale (VAS) and von Frey Filaments. The treatment groups were compared via the Wilcoxon rank sum test. Correlations between the three pain scores were evaluated via Spearman’s rank correlation coefficient.ResultsOver the whole study course none of the pain evaluation methods could demonstrate a significant difference in analgesic requirements between groups M and F (p < 0.05). In both treatment groups, the pain scores on all three scales decreased over time. The results of the different pain scales correlated moderately to strongly. Skin sensitivity assessed using von Frey filaments showed considerable individual variation among dogs, with most responding only to thicker filaments.ConclusionSubcutaneous methadone or transdermal fentanyl can provide adequate postoperative analgesia in dogs after spinal surgery without an intravenous catheter. The CMPS-SF and the CPS could reliably be used in this category of animals.

Combining several assessment methods (functional independence, psycho-emotional and cognitive state, medical and social factors, cardiovascular risk, hereditary history) is critically important, since carotid atherosclerosis is a systemic disease with a multi-vector impact. The study aims to optimize the system for assessing medical, social, and sociodemographic characteristics in patients with carotid atherosclerosis using validated survey instruments. At the Neurological Pathology Diagnostic Center of the MNPE "Regional Clinical Hospital of the Ivano-Frankivsk Regional Council" for 2022-2024, 84 male individuals were examined. Of these, the study group consisted of 44 patients with clinical signs of carotid atherosclerosis. Forty patients with asymptomatic atherosclerotic lesions of the carotid arteries were selected for the comparison group. The age of men in both cohorts was 50-79 years. The Framingham risk scale for the development of cardiovascular events over the next 10 years was used to assess the medical and social factors of influence. Possible neurological deficit was evaluated according to the results of the National Institutes of Health (NIH) stroke scale for a group of symptomatic patients. Self-care ability was also evaluated according to the 10-point Barthel index. The patient health questionnaire (PHQ-9) was used to assess the psychoemotional state, and the Montreal Cognitive Test (MoCA) was used to analyze cognitive function. The most common comorbidities in both samples were: arterial hypertension – 87,0 %, diabetes mellitus type 2 – 32,1 %, ischemic heart disease – 59,5 %. Smoking was significantly more common in 35 (79,5 %) people from the study group, and a family history of cardiovascular diseases was present in 36 (81,8 %). When testing according to the NIH scale, almost all individuals in the group of symptomatic patients had zero points, with some exceptions, where a few men noted weakness in the legs or mild loss of sensitivity. Alarming complaints in symptomatic patients were short-term loss of consciousness, memory, and vision impairment, decreased skin sensitivity, and decreased vocabulary (according to their own observations), which was the argument for adding an NIH assessment for this category of individuals. According to the Barthel scale, an inverse relationship was observed in both samples between the age of the patients and the ability to perform basic daily activities. In the study group, 32 (72,7 %) and in the comparison group, 25 (62,5 %) individuals showed decreased cognitive functions at 21-25 points. Signs of depression were detected in 29 (65,9 %) men in the study group and 21 (52,5 %) patients in the comparison group. Conclusions. In symptomatic patients with carotid atherosclerosis, a significant influence of the smoking factor (p=0,035) and family history of cardiovascular diseases (p=0,005) was found. In patients of both groups, when assessing functional independence, a decrease in the Barthel index with increasing age was determined, and by using validated scales that allow increasing the reliability of data assessment, patients with decreased cognitive functions and manifestations of depression were identified.

Periorbital melanosis (POM), or dark circles, is characterized by hyperpigmentation around the eyes, mainly affecting females aged between 16 to 25 years. It results from genetic and environmental factors. Chemical peels with mandelic acid and lactic acid are commonly used for treatment, but their comparative effectiveness and safety are underexplored. This study compares the effectiveness and safety of 30% mandelic acid peel versus 30% lactic acid peel for treating POM. A prospective, comparative study was conducted at a tertiary healthcare institute over 18 months (September 2022 to February 2024) with 70 patients. They were randomly assigned to receive either mandelic acid (35 patients) or lactic acid peels (35 patients) across three sessions (weeks 0, 2, and 4), followed by an end of study visit at week 6. Efficacy was measured using the POM grading, visual analog scale (VAS), and patient satisfaction score, while safety was assessed via adverse events. Both treatment groups showed significant improvement in POM severity, with a shift from higher to lower grades of pigmentation. However, the lactic acid group exhibited a significantly greater reduction in pigmentation (50% of patients with more than 30% improvement in VAS, P = 0.001). Patient satisfaction was higher in the lactic acid group (100% satisfied vs. 83.9% in the mandelic acid group, P = 0.011). Side effects included mild erythema and swelling, with exfoliation more common in the lactic acid group and irritation more frequent in the mandelic acid group. This study is limited by its small sample size and short duration, which may impact the generalizability and long-term evaluation of the treatments. Both 30% mandelic and lactic acid peels effectively treated POM, with lactic acid showing better outcomes and patient satisfaction. Both treatments were safe, but lactic acid may be better for sensitive skin due to milder side effects. Larger studies with longer follow-up are needed.

The aim of this pedagogical practice is to develop pupils’ interest in natural sciences through participation in practical, creative, and socially significant activities. The project demonstrates how scientific knowledge in biology, chemistry and technology can be applied in the development of a real cosmetic product with high added value and safety. Delicate baby skin requires special care and products that minimize the risk of irritation and allergies. With increasing awareness of the harms of synthetic ingredients, interest in natural and edible formulas in baby cosmetics is growing. The study presents the formulation of an innovative cosmetic washing product – baby shampoo, created entirely from safe edible ingredients. Natural surfactants (soap nuts and Sucrose cocoate) glycerin, prebiotic thickeners and food preservatives (potassium sorbate and sodium benzoate) were used. Each component was selected for its natural origin, low allergenicity and proven benefits for sensitive skin. The final product demonstrates good washing properties and a suitable viscosity texture, while eliminating the risk associated with potentially harmful chemicals and synthetic ingredients.

Borage and baobab seed oils are active ingredients with great potential for caring for particularly sensitive and problematic skin. Thanks to these properties, they are increasingly used in products intended for people undergoing chemotherapy and radiotherapy. The study aimed to assess how the use of pure, unrefined cold-pressed oils from borage and baobab affects selected skin parameters. The research was conducted with a view to their potential use in cosmetics for the skin care of oncology patients. The results suggest that both oils can have a beneficial effect on skin hydration, oiliness, and tension, and effectively reduce the rate of transepidermal water loss. At the same time, an increase in the erythema index was observed, which may be caused by the direct application of oils to the skin without prior dilution. The conclusions provide a basis for further analysis of the use of these oils in preparations for oncology patients.

MXene triggers room-temperature 4D printing of advanced ionic hydrogels for sensitive electronic skin

Adult female acne presents challenges, including increased prevalence, distinct clinical manifestations, heightened skin sensitivity, treatment-related intolerance, and reduced treatment adherence. Integrating skincare into acne management is essential, particularly in Nordic European countries, where environmental factors influence skin physiology. The Nordic European Countries Acne Skincare Algorithm (NECASA) II algorithm serves as an evidence-based practical tool for clinicians in this region to select appropriate skincare based on individual patients' needs to optimize acne care for adult females. Dermatologists from six Nordic European countries met to develop the NECASA II algorithm, which builds on the NECASA I framework. The advisors conducted a structured literature review and, combined with their clinical experience, established best practice recommendations for integrating skincare into adult female acne treatment regimens. The NECASA II algorithm recommends integrating skincare into adult female acne management based on acne severity, subtype, and patient characteristics. The panel concluded that all acne regimens should incorporate a physiologic pH cleanser, an emollient with humectants and lipids, and SPF 50+ sunscreen. Skincare monotherapy is recommended for mild acne, adjunctive skincare for moderate-to-severe acne, and maintenance skincare to prevent relapse following treatment. Personalized skincare regimens, combined with prescription and nonprescription treatments, can mitigate adverse effects, improve treatment tolerance and adherence, and enhance overall outcomes.

Due to their skin-friendly qualities and little environmental effect, herbal soaps have grown in popularity as a natural alternative to synthetic soaps. The extracts from a variety of medicinal plants known for their traditional therapeutic benefits are used to make these soaps. Essential oils, plant extracts, and powders are examples of natural components that are high in bioactive molecules such flavonoids, alkaloids, tannins, and saponins, which give them their antimicrobial, antioxidant, anti-inflammatory, and hydrating qualities. The growing interest in herbal soaps, their manufacturing processes, and their medicinal value are all examined in this review. It draws attention to widely used herbs like Aloe vera, Neem, Tulsi, Turmeric, and Mimosa pudica, discussing their traditional uses and modern relevance in skincare. The texture, lather, and moisturizing capacity of the finished product are greatly influenced by the selection of base ingredients, which may include glycerin, coconut oil, or castor oil. The most popular ways to make herbal soap, such as the cold process, hot process, and melt-and-pour methods, are also covered. Herbal soaps are appropriate for all skin types, especially sensitive and acne-prone skin, because they not only cleanse the skin but also have calming, healing, and revitalizing effects. Herbal compositions are biodegradable and less likely to cause skin irritation, allergic reactions, or long-term skin damage than chemical-based soaps. Their increasing popularity is a result of the rising consumer demand for organic, environmentally friendly, and sustainable personal care goods. The review also highlights the significance of phytochemical screening of plant extracts, quality control, and standardization in the production of herbal goods. These items must undergo safety assessments and dermatological testing in order to demonstrate their effectiveness, safety, and market acceptability. In conclusion, using herbal soaps is a holistic and environmentally responsible way to take care of your skin. The combination of plant-based components, traditional knowledge, and cutting-edge formulation approaches holds great promise for herbal cosmetics. Continued research and development in this area might result in the creation of high-quality, safe, and effective herbal cleaning products that meet the increasing demand for natural skincare options.

HighlightsA multifunctional amphibious ionogel skin is prepared with MXene and ionic liquids.Conductive ionogel has excellent underwater self-healing and wet adhesion.AIGS combined with Morse code achieves amphibious communication.In combination with machine learning, ionogel enables the identification of respiration types intelligently.

Objective — to analyze current scientific data on the pathogenesis of acne, especially the role of C. acnes, first-line topical therapies according to international guidelines for the management of dermatosis; to compare topical retinoids and their combinations, in particular adapalene and clindamycin, in terms of mechanism of action, efficacy, and safety. Materials and methods. Based on an in-depth analysis of data from special literature and taking into account the results of domestic research, the feasibility of a differentiated approach to the prescription of topical retinoids and their combinations was determined. Results and discussion. Modern approaches to local therapy of patients with acne are considered. The effectiveness and tolerability of topical retinoids (tretinoin, tazarotene, adapalene, trifarotene) are analyzed. The issue of antibiotic resistance in treatment with antibiotics is discussed, ways of solving it through a combination with retinoids or benzoyl peroxide (BPO). A comparative analysis of the combination of adapalene and clindamycin, adapalene and benzoyl peroxide is conducted. Special attention is paid to the gels Deriva, Deriva С, and Deriva С MS, which are used in domestic practice, ensuring a rapid clinical result with minimal side effects. An algorithm for their appointment is proposed depending on the form, severity, and skin type. Conclusions. An individual approach is important when choosing external therapy for patients with acne, taking into account clinical manifestations, skin type, drug tolerability, and patient preferences. Effectiveness and safety should be balanced, and the benefits of use should outweigh the risks. The presence of monoforms of retinoids and combined preparations (retinoid and antibiotic) suggests a differentiated approach to the choice of therapy. Adapalene gel (Deriva gel) is effective mainly in non-inflammatory acne of mild to moderate severity, and has the best tolerability among retinoids. The combination of clindamycin and adapalene in the form of Deriva C gel is effective in inflammatory acne, mainly pustular, of mild to moderate severity. It can be considered the best option for starting therapy due to its rapid action and good tolerability. The combination of clindamycin and adapalene in microspheres (Deriva C MS gel) is effective in inflammatory acne, mainly pustular, of mild to moderate severity, with concomitant sensitive skin, atopic dermatitis, and seborrhea.

ABSTRACTObjectiveRegular massages can be an instrument to help the body recover and maintain health. The growing trend toward musculoskeletal personal health care is accompanied by the use of natural products. When deciding between topical products, their characteristics become crucial, especially in sensitive skin where treatments are applied routinely. This study evaluates for the first time the cosmetic and application properties of Physiorelax, a natural musculoskeletal health care product suitable for muscle and ligament massage, compared to Fisiocrem.MethodsThis is a sensory panel methodology, using a mixed descriptive approach (qualitative/quantitative). Twenty panelists trained in quantitative sensory analysis since 2018 evaluated the two products. Product presentation was randomized and blinded. Cosmetic results are presented as percent agreement among panelists and application aspects as quantitative scores.ResultsBoth products show a comparable sensory profile, in terms of application properties: shape integrity, firmness, moisture/grease balance, spreadability, low tack afterfeel, and residue. However, in terms of an overall preference for product, 90% of panelists liked Pshysiorelax, against 70% for Fisiocrem. An additional 10% of panelists disliked Fisiocrem over Pshysiorelax (chi‐square = 12.5, p = 0.002). The results should be interpreted considering the inherent limitations of the panel design itself. Future studies could assess the preference of use of the product by daily care professionals and the general population.ConclusionConsidering the panelists' general preference for Physiorelax, and the addition in this product of extra natural ingredients preserving skin care, Physiorelax seems a very good candidate for daily use for musculoskeletal health care and as a massage cream for muscles and ligaments in personal care.