Diagonal lattice systems are extensively structured systems of tubular and frame structures and can drastically reduce the weight of the structure and significantly improve the behavior of high-rise buildings by significantly reducing shear lameness. In this paper, the number of partitions, the angle and the optimal structure of single and double layer diagonal grid systems in tall buildings are determined. For this purpose, a computer program and meta-innovative solutions based on genetic algorithm and Caramba have been used as the engine of structural analysis. In these analyzes, the relationship between input factors including distance between two layers, angle and number of elements and number of vertical and horizontal divisions with output factors obtained from structural analysis using Caramba engine, including maximum deformations, weight and Pi delta effect were obtained. Based on the results obtained from genetic algorithms and meta-heuristic solutions, the weights obtained for diagonal lattice systems are more than one layer compared to two-layer systems. In addition, due to lower weight, simpler geometric structure, higher execution speed, no need for highly skilled technical force, lower energy consumption, less architectural space, creating more open spaces and better exposure in single-layer systems than two-layer, These systems are recommended for use in high-rise buildings.