Simulated Conditions Research Articles

Impact Analysis of Welding Sequence to Reduce Weld Deformation in Aluminum Hulls

Aluminum hulls, which are preferred in the marine industry due to their durability, corrosion resistance, and lightweight properties, face serious challenges due to thermal deformation during welding. This study aims to predict and minimize transverse deformations due to welding sequences for a transverse model in the lower part of an aluminum hull. To predict deformations, heat source dimensions obtained from actual weld beads were used as simulation conditions, and various welding sequence conditions were simulated through the developed finite element method (FEM). The simulation results were compared with actual deformation measurements to verify their reliability, and the optimal welding sequence which minimized deformation was derived. The simulation results show that by changing the welding sequence conditions, the maximum displacement can be reduced from a maximum of 52.1% to a minimum of 39.1%, and the effective plastic strain can be reduced from a maximum of 19.6% to a minimum of 4.8%. These results show that adjusting the welding sequence conditions can significantly improve structural integrity by minimizing deformation. The results of this study suggest that the control of the welding sequence can be used to reduce the deformation of aluminum hulls and promote a more sustainable marine industry with improved quality.

Million Microfiber Releases: Comparing Washable and Disposable Face Masks.

The extensive use of single-use or disposable face masks has raised environmental concerns related to microfiber contamination. In contrast, research on the potential release and ecological impact of microfibers from washable masks (WMs), suggested as an eco-friendly alternative, is currently lacking. Here, we comprehensively investigated the release of microfibers from disposable and WMs of different types in simulated aquatic environments and real-life scenarios, including shaking, disinfection, hand washing, and machine washing. Using a combination of wide-field fluorescence microscopy, He-ion microscopy, and confocal μ-Raman spectroscopy, we revealed that disposable masks (DMs) released microfibers ranging from 18 to 3042 microfiber/piece, whereas WMs released 6.1 × 104-6.7 × 106 microfibers/piece depending on the simulated conditions above. Another noteworthy finding was the observed negative correlation between microfiber release and the proportion of reinforcement (embossing) on the DM surfaces. Microfibers from tested DMs primarily comprised polypropylene (PP), while WMs predominantly released poly(ethylene terephthalate) (PET) and cellulose microfibers. Furthermore, acute toxicological analyses unveiled that PP microfibers (0.01-50 mg/L) from DMs impacted zebrafish larval swimming behavior, while PET microfibers from WMs delayed early-stage zebrafish hatching. This study offers new insights into the source of microfiber contamination and raises concerns about the environmental implications linked to the use of washable face masks.

Inulin extracted from burdock root (Arctiumlappa L.) incorporated alginate/chitosan hydrogel beads for probiotics encapsulation

Burdock root is a reliable source of inulin, a prebiotic with potential benefits for probiotic encapsulation. This study aimed to extract inulin from burdock roots and assess its physicochemical properties and functional groups in comparison to standard inulin. The focus was on evaluating the effectiveness of inulin combined with alginate and coated with chitosan as an encapsulating material for probiotics. The extracted inulin was found to be a light brown powder with a high inulin content of 78.54 %. FTIR analysis confirmed the successful extraction of inulin and highlighted its prebiotic potential. When combined with alginate, the inulin formed dense bead structures that significantly enhanced encapsulation efficiency (∼88 %) and improved probiotic viability (>6 log CFU/g) during simulated gastrointestinal transit, outperforming pristine alginate beads. The beads demonstrated a gradual probiotic release within 3 h under simulated intestinal conditions, following the Korsmeyer–Peppas release mechanism. Storage experiments showed that the beads containing extracted inulin maintained probiotic levels above 7.6 log CFU/g after 28 days. Incorporating inulin extracted from burdock root into alginate-based encapsulation systems could significantly improve probiotic survival and provide a potential method for targeted probiotic delivery to the intestine. This approach offers a promising strategy for enhancing the effectiveness of probiotics through improved protection and controlled release.

Enhancing concrete self-healing capabilities of Bacillus sphaericus spores through the encapsulation in biopolymeric microcapsules

This study examined the encapsulation of Bacillus sphaericus LMG 22257 spores in biopolymeric microcapsules (MCs) for use in cement mortar, with a focus on enhancing self-healing properties. Biopolymers, including alginate (ALG), chitosan (CTS), carboxymethyl cellulose (CMC), and ALG/CMC blends at various ratios, were employed to fabricate the MCs through ionotropic gelation and freeze–drying. The physicochemical properties of MCs, including size, morphology, and swelling behavior under simulated concrete conditions, were assessed. Among these, ALG/CMC-MCs exhibited superior characteristics and demonstrated the highest urea hydrolysis activity when incorporated into the mortar, indicating optimal spore protection. Despite an initial decrease in compressive strength, the ALG/CMC blend with an ALG:CMC mass ratio of 6:4 achieved a crack healing efficiency of 96.7% over 28 days under cyclic wet-dry conditions. These findings highlight the potential of biopolymer encapsulation for embedding functional microorganisms in construction materials, contributing to a more durable and sustainable infrastructure.

Superoxide radical derived metal-free spiro-OMeTAD for highly stable perovskite solar cells

Lithium salt-doped spiro-OMeTAD is widely used as a hole-transport layer (HTL) for high-efficiency n-i-p perovskite solar cells (PSCs), but unfortunately facing awkward instability for commercialization arising from the intrinsic Li+ migration and hygroscopicity. We herein demonstrate a superoxide radicals (•O2−) derived HTL of metal-free spiro-OMeTAD with remarkable capability of avoiding the conventional tedious oxidation treatment in air for highly stable PSCs. Present work explores the employing of variant-valence Eu(TFSI)2 salts that could generate •O2− for facile and adequate pre-oxidation of spiro-OMeTAD, resulting in the HTL with dramatically increased conductivity and work function. Comparing to devices adopting HTL with LiTFSI doping, the •O2−-derived spiro-OMeTAD increases the PSCs efficiency up to 25.45% and 20.76% for 0.05 cm2 active area and 6 × 6 cm2 module, respectively. State-of-art PSCs employing such metal-free HTLs are also demonstrated to show much-improved environmental stability even under harsh conditions, e.g., maintaining over 90% of their initial efficiency after 1000 h of operation at the maximum power point and after 80 light-thermal cycles under simulated low earth orbit conditions, respectively, indicating the potentials of developing metal-free spiro-OMeTAD for low-cost and shortened processing of perovskite photovoltaics.

Corrosion of Chromium Coating Fabricated on Zircaloy-4 Substrate

In the nuclear industry, coated cladding is a topical problem and it is chosen as the near-term and most promising ATF (Accident-Tolerant Fuel) cladding concept. The main objective of this concept is to enhance the accident tolerance of nuclear power plants and accordingly, the performance of cladding is expected to be improved. This work assesses the corrosion performance of a Zircalloy-4 alloy coated with a thin chromium coating by MS (magnetron sputtering), tested under a CANDU (CANada Deuterium Uranium) reactor primary circuit simulated condition (LiOH solution, 10 MPa, 310 °C, pH = 10.5). The anticorrosive performance is evaluated by a gravimetric analysis, a metallographic analysis, X-ray diffraction, electronic microscopy, and electrochemical methods. A four times less gain mass was noticed compared to uncoated Zircaloy-4, indicating a smaller corrosion rate. The SEM micrographs illustrate that the coatings are still adherent, and they are keeping the initial morphological characteristics during the autoclaving process. A SEM cross-section analysis shows values of the thickness of the coatings between 0.8 and 1.46 µm. By XRD, the presence of Cr2O3 oxide is identified. Electrochemical testing confirms good stability and good corrosion performance of Cr coating over time under autoclave conditions.

Comment on permeability conditions in finite element simulation of bone fracture healing

The most popular model of the bone healing considers the fracture callus as poroelastic medium. As such it requires an assumption of the callus’ external permeability. In this work a systematic study of the influence of the permeability of the callus boundary on the simulated bone healing progress is performed. The results show, that these conditions starts to play significant role with the decrease of the callus size. Typically enforced impermeability inhibits the progress of healing during simulation. A remedy for this effect is imposing drainage conditions at the callus’ boundary.

Critical assessment of furrow openers and operational parameters for optimum performance under conservation tillage

Conservation Agriculture (CA) is an innovative approach that promotes sustainable farming while enhancing soil health. However, residue management challenges often hinder its adoption, causing farmers to burn crop leftovers in fields. This study aimed to evaluate the effectiveness of various furrow openers under simulated soil bin conditions. Three types of furrow openers were examined: single disk (SD), Inverted T-type furrow opener with a plain rolling coulter (ITRC), and double disc (DD) furrow opener. Tests were conducted at different forward speeds (1.5, 2, and 2.5 km h−1) and with three straw densities (1, 2, and 3 t ha−1) at a consistent working depth of 5 cm. Draft measurements were obtained using load cells connected to an Arduino-based data-logging system. Results indicated that draft requirements increased with forward speed and straw density, while straw-cutting efficiency decreased with these factors. Average draft values for SD, ITRC, and DD were 290.3 N, 420 N, and 368.5 N, respectively, and straw-cutting efficiencies were 53.62%, 59.47%, and 74.89%, respectively. The DD furrow opener showed the highest straw-cutting efficiency (81.36%) at a working speed of 1.5 km h−1 and a straw density of 1 t ha−1, demonstrating optimal performance compared to other furrow openers.

Preserving Cultural Heritage: Enhancing Limestone Durability with Nano-TiO2 Coating

External and internal microclimatic conditions, biodeterioration, anthropogenic factors, etc, influence the natural stone support for artifacts and built heritage. Based on this fact, the present study explores the effectiveness of nano-TiO2 in preserving and enhancing the durability of natural stone used in the façades of heritage buildings, focusing on the Markovits-Mathéser House in Oradea Municipality, Romania. The investigation involved treating rock samples (fossiliferous limestone) with 2% and 5% nano-TiO2 solutions and subjecting them to simulated extreme climatic conditions for the analyzed area in a controlled climatic chamber for six months. The treated samples demonstrated a significantly higher compressive strength than untreated benchmarks. SEM analyses confirmed that nano-TiO2 formed a protective layer, filling micro-cracks and pores, thereby enhancing the stone’s resistance to environmental stressors. The study also found that the nanoparticle coating maintained its integrity under extreme temperature and humidity variations, with only a slight decrease in surface coverage. These findings suggest that nano-TiO2 coatings significantly improve heritage building materials’ mechanical properties and longevity. However, the study highlights the importance of careful application and long-term evaluation to ensure environmental and health safety. Overall, nano-TiO2 presents a promising solution for the conservation of cultural heritage, offering enhanced durability and protection against climatic and environmental challenges. Further research is recommended to optimize application workflow and formulations for broader and more effective use in heritage conservation.

Study on the novel green magnetoplumbite-type oxide BaZn6-xNixTi6O19: synthesis, structure and properties

Magnetoplumbite-type oxides display various properties and find applications in multiple fields. In this study, a novel magnetoplumbite-type solid solution BaZn6-xNixTi6O19 (0 ≤ x ≤ 4) with vivid green color was synthesized through a high-temperature solid-phase method for the first time. The as-synthesized BaZn6-xNixTi6O19 solid solution crystallizes in the space group of P63/mmc. The solid solution exhibits excellent green property, and its color is adjustable with increasing doping levels of Ni2+. The depth of color originates from the content and position of Ni2+ in the solid solution. BaZn6-xNixTi6O19 is suitable for PMMA (Polymethyl methacrylate) pigment and hydrophobic coating. Colored PMMA containing BaZn6-xNixTi6O19 exhibits vibrant colors with high saturation, showing excellent application potential. The hydrophobic coating compounded with BaZn6-xNixTi6O19 exhibits near-superhydrophobic properties and demonstrates excellent self-cleaning effects under simulated natural environmental conditions.

A parallel coupling framework for DEM-MBD: Model verification and application

Bulk material handling equipment can be numerically studied using the DEM-MBD method, where the particulate dynamics are solved by DEM (Discrete Element Method) and the motion characteristics of the mechanical components are modeled by MBD (Multi-Body Dynamics). In this work, a two-way coupling framework is proposed for the co-simulation of our self-developed DEM solver (DEMSLab) with the commercial MBD software (RecurDyn) using a parallel staggered coupling approach. To verify the proposed coupling method, the simulation result of a torsional spring damper system is compared with the corresponding analytical solution. After that, to assess the feasibility of this method in industrial-scale applications, a series of simulations involving a wheel loader is carried out. Different simulation conditions are adopted to reveal their impact on computational efficiency and simulation accuracy. These conditions include the mesh representation of the equipment geometry, the MBD time step size, and the coupling interval. An improved mesh simplification algorithm is proposed and used to reasonably simplify the surface mesh of the wheel loader, thus lowering the computational intensity of particle-wall interactions in DEM. The comparison results indicate that the computational time can be largely saved while the simulation accuracy remains considerably high. The MBD step size and coupling interval are crucial for numerical stability and should be selected carefully.

Integrated operation of sand dam and groundwater dam to increase water supply capacity in mountainous areas of Chuncheon, South Korea

Study regionA valley area in South Korea Study focusSand dams are cost-effective water-storage facilities for water-stressed areas in arid and semi-arid climates, with the advantages of reducing evaporation losses and filtering pollutants. Generally, sand dams are constructed by placing a horizontal barrier across the river bed, creating a naturally sand-filled structure upstream. Unlike this typical construction, a sand dam in Korea in the monsoon climate region was built near a mountainous valley, not in a stream, in Mulori, Chuncheon City, to ensure a sustainable water supply throughout the year, and especially to prevent freezing in the winter. Furthermore, a small-scale groundwater dam was additionally constructed downstream of the sand dam to increase the water supply capacity in preparation for severe droughts. In this study, the hydrological reservoir-routing simulations were performed to evaluate the effects of the combined use of the two dams on increasing water supply. New hydrological insights for the regionDaily discharge rates for the period from March 16, 2020 to July 6, 2022 were simulated for several hybrid operations that supplies water primarily through the sand dam under the normal conditions, but combines both water sources to manage severe droughts. The simulated results showed that, compared with operating the sand dam alone, the hybrid operations could satisfy the village’s water demand by increasing the minimum water supply rates by 24.6–50.0 m³/day for different simulation conditions. The combined use of sand and groundwater dams presented in this study will help provide sustainable water supply in water-stressed areas, especially mountainous uplands vulnerable to droughts and freezes.

Experimental and numerical study of cadmium fate and transport mechanisms during artificial recharge in agricultural regions

Agricultural Managed Aquifer Recharge (AgMAR) uses agricultural lands and floodwater to enhance groundwater recharge, but its effectiveness can be hindered by heavy metals like cadmium (Cd), which pose risks to groundwater quality. Cd is particularly concerning due to its high mobility and persistence in the environment. This study investigates Cd's fate and transport in agricultural regions during MAR, focusing on sandy loam soils through batch and column experiments. Equilibrium and kinetic batch studies were conducted under varying Cd concentrations and exposure times to quantify the adsorption capacity and rate. HYDRUS-2D was used to simulate Cd's transport in soil under various ponding depths and Cd concentrations. Results showed a maximum Cd adsorption capacity of 439.58 mg/kg, with the Freundlich isotherm providing a better fit (R2 = 0.98) and indicating heterogeneous adsorption sites (n = 0.389). The kinetic experiment indicated chemisorption as the predominant mechanism, with an equilibrium adsorption capacity of 236.49 mg/kg. The pseudo-second-order kinetic model (rate constant 0.0016 h⁻1, R2 = 0.99) suggested that adsorption kinetics are influenced by Cd concentration and available adsorption sites. The column experimental findings supported by HYDRUS-2D modeling successfully explained the fate and transport of Cd within the soil columns. The model fitted parameter values for Freundlich adsorption isotherm coefficient (KF), linearity factor (Nu), and kinetic rate coefficient are (α) 47.37 L/kg, 0.00389 cm³/ppm and 0.0029 min⁻1, respectively. Modeling scenarios further elucidated the transport dynamics of Cd under simulated AgMAR conditions. Modeling scenarios indicated that with constant ponding of 5 cm over a year, Cd at 20 and 40 ppb concentrations in floodwater could potentially migrate below root zone systems. This study highlights the critical role of understanding Cd fate and transport in optimizing AgMAR systems and reducing Cd pollution risks, providing valuable insights for developing effective monitoring and management strategies.

Optimization and evaluation of a chitosan-coated PLGA nanocarrier for mucosal delivery of Porphyromonas gingivalis antigens

Recent advances in understanding Alzheimer's disease (AD) suggest the possibility of an infectious etiology, with Porphyromonas gingivalis emerging as a prime suspect in contributing to AD. P. gingivalis may invade systemic circulation via weakened oral/intestinal barriers and then cross the blood-brain barrier (BBB), reaching the brain and precipitating AD pathology. Based on the proposed links between P. gingivalis and AD, a prospective approach is the development of an oral nanovaccine containing P. gingivalis antigens for mucosal delivery. Targeting the gut-associated lymphoid tissue (GALT), the nanovaccine may elicit both mucosal and systemic immunity, thereby hampering P. gingivalis ability to breach the oral/intestinal barriers and the BBB, respectively.The present study describes the optimization, characterization, and in vitro evaluation of a candidate chitosan-coated poly(lactic-co-glycolic acid) (PLGA-CS) nanovaccine containing a P. gingivalis antigen extract. The nanocarrier was prepared using the double emulsion solvent evaporation method and optimized for selected experimental factors, e.g. PLGA amount, surfactant concentration, w1/o phase ratio, applying a d-optimal statistical design to target the desired physicochemical criteria for its intended application. After nanocarrier optimization, the nanovaccine was characterized in terms of particle size, polydispersity index (PdI), ζ-potential, encapsulation efficiency (EE), drug loading (DL), morphology, and in vitro release profile, as well as for mucoadhesivity, stability under simulated gastrointestinal conditions, antigen integrity, in vitro cytotoxicity and uptake using THP-1 macrophages.The candidate PLGA-CS nanovaccine demonstrated appropriate physicochemical, mucoadhesive, and antigen release properties for oral delivery, along with acceptable levels of EE (55.3 ± 3.5 %) and DL (1.84 ± 0.12 %). The integrity of the encapsulated antigens remained uncompromised throughout NPs production and simulated gastrointestinal exposure, as confirmed by SDS-PAGE and Western blotting analyses. Furthermore, the nanovaccine showed effective in vitro uptake, while exhibiting low cytotoxicity. Taken together, these findings underscore the potential of PLGA-CS NPs as carriers for adequate antigen mucosal delivery, paving the way for further investigations into their applicability as vaccine candidates against P. gingivalis.

The novel stereoscopic cooling plate designs and performance analysis for battery thermal management systems

This study explores the design and performance of liquid cooling plate-based battery thermal management system for lithium-ion battery packs through numerical simulation. We first assess traditional straight-channel cooling plates with three different placement strategies. The conventional design with bottom-mounted cooling plates demonstrates the most effective thermal management at the same total coolant mass flow rate. This suggests that the influence of reducing coolant flow velocity on the cooling performance outweighs the influence of increasing the heat exchange area under our simulated conditions. Advanced stereoscopic cooling plate structures, referred to as 3DCP-A and 3DCP-B, are then introduced, significantly enhancing battery thermal management performance. To achieve a maximum temperature difference ≤ 5.0 K for the most discharge process, the required mass flow rate of the 3DCP-B decreases by 30.0 g∙s−1 and 10.0 g∙s−1 compared to the conventional bottom-mounted cooling plate and 3DCP-A, respectively, and the pressure drop reduces by 75.9 % and 44.3 %, respectively. The power consumption for the 3DCP-B design is only 6.0 % of that for the traditional design. Finally, the effects of key operating temperatures on the cooling performance of the optimal 3DCP-B design are discussed. The insights obtained in this study provide valuable guidance for developing more efficient and effective pack-level liquid cooling plate-based battery thermal management system, essential for improving the reliability and performance of electric vehicles.

Zinc oxide nanoparticles mediated salinity stress mitigation in Pisum sativum: a physio-biochemical perspective

Salinity is the major abiotic stress among others that determines crop productivity. The primary goal is to examine the impact of Zinc Oxide Nanoparticles (ZnO NPs) on the growth, metabolism, and defense systems of pea plants in simulated stress conditions. The ZnO NPs were synthesized via a chemical process and characterized by UV, XRD, and SEM. The ZnO NPs application (50 and 100) ppm and salt (50 mM and 100 mM) concentrations were carried out individually and in combination. At 50 ppm ZnO NPs the results revealed both positive and negative effects, demonstrating an increase in the root length and other growth parameters, along with a decrease in Malondialdehyde (MDA) and hydrogen peroxide concentrations. However, different concentrations of salt (50 mM and 100 mM) had an overall negative impact on all assessed parameters. In exploring the combined effects of ZnO NPs and salt, various concentrations yielded different outcomes. Significantly, only 50 mM NaCl combined with 50 ppm ZnO NPs demonstrated positive effects on pea physiology, leading to a substantial increase in root length and improvement in other physiological parameters. Moreover, this treatment resulted in decreased levels of MAD, Glycine betaine, and hydrogen peroxide. Conversely, all other treatments exhibited negative effects on the assessed parameters, possibly due to the high concentrations of both stressors. The findings offered valuble reference data for research on the impact of salinity on growth parameters of future agriculture crop.

Interface stability of ultrasonic additively manufactured Zircaloy-4 during hydrothermal corrosion

Simulated pressurized water reactor conditions (330 °C, 15.6 MPa, ∼20 ppb oxygen) without irradiation were used to investigate the hydrothermal corrosion behavior of ultrasonic additively manufactured Zircaloy-4 up to 1000 h. X-ray computed tomography allowed for visualization of defects from processing and their progression after corrosion experiments. The specimens were found to have clear variability in the mass change data, compared to typical wrought Zircaloy-4 specimens. The variation in the mass change after exposure was attributed to weld defects connected to the specimen surface which allowed ingress of oxidant into the samples. Defects visualized by computed tomography were found via metallography and characterized. Ultrasonic additively manufactured Zircaloy-4 was found to have comparable corrosion behavior as wrought Zircaloy-4 for specimens which did not have clear surface defects along weld interfaces.

In Vitro evaluation of probiotic properties of lactic acid bacteria strains isolated from juçara fruit native to the Atlantic Forest

Lactic acid bacteria (LAB) are the microorganisms most commonly used as probiotics. Since probiotic benefits are strain-dependent, there is a continuous need for research into new cultures with probiotic properties. Fruits such as juçara (Euterpe edulis Martius), a palm species from the Atlantic Forest threatened with extinction, are rich niches for microorganisms, including LAB. This study investigated the probiotic properties of Lactococcus lactis J7 and Leuconostoc pseudomesenteroides JF17 strains isolated from juçara fruits native to the Atlantic Forest. Probiotic characteristics, such as tolerance to simulated gastrointestinal fluids or juices, hydrophobicity, autoaggregation, coaggregation properties, inhibition of pathogenic microorganisms, and technological properties were evaluated. The survival rate of L. lactis J7 and L. pseudomesenteroides JF17 decreased after exposure to simulated gastrointestinal conditions; however, L. lactis J7 was more resistant, maintaining viability at the end of the enteric phase of 6.07 ± 0.16 log CFU mL-1. The J7 strain also exhibited the highest values in hydrophobicity (12.55 ± 0.52%), autoaggregation (25.63 ± 0.75%), and coaggregation capacity with E. coli ATCC 25922 (21.52 ± 0.98%) and S. Enteritidis ATCC 13076 (22.68 ± 1.01%). Both J7 and JF17 strains demonstrated antimicrobial activity, confirmed by the multilayer agar plate system. Additionally, the growth of the strains was temperature-dependent, and they were able to thrive in high concentrations of sodium chloride (6%). Thus, L. lactis J7 is a promising probiotic candidate for the development of functional products. Nevertheless, further studies using animal models are necessary to explore the properties of these probiotic bacteria. Novel strains isolated from fruits should be studied to broaden the application of probiotic microorganisms in the development of foods and medicines.

Симуляционное обучение: ключевой элемент профессиональной подготовки медицинских работников в контексте аккредитации.

The article shows the importance of simulation training in preparation for the procedure of primary specialized accreditation of medical specialists. Introduction. Simulation training is gaining popularity, and is gradually becoming one of the most important tools in medical education. It not only improves the quality of education, but also makes it more competitive. Due to the development of professional skills, including decision-making, according to pre-simulated scenarios, students and practicing medical professionals (doctors, paramedics, nurses) receive not only motivation, but also interest in mastering practical skills. In the future, they will be able to apply these skills in their professional activities. Training in simulated conditions also allows medical professionals to prepare for the accreditation procedure (primary, primary specialized). The purpose of this article is to describe the experience of using simulation training in the preparation of students of additional professional education (DPO) at the Department of Nursing Management of the branch of the Military Medical Academy in Moscow for the procedure of primary specialized accreditation (PSA). Materials and methods. We analyzed the results of the procedure of primary specialized accreditation in the specialty «medical care» and «nursing» of students who were trained at the department (nursing management) at the branch of the Military Medical Academy in Moscow in the period from September 2021 to December 2023 and practiced all practical skills in simulated conditions. Results. The analysis of the final tables with the results of the accreditation procedure for nurses and paramedics allows us to conclude that all students in the simulation center have successfully passed the accreditation procedure, training sessions provide students with a high level of training necessary for successful accreditation. Conclusions. Simulation training is an integral part of modern professional retraining and advanced training programs for medical professionals. It is a powerful tool that helps to prepare professional medical professionals for the realities of modern practice. Students and trainees who have completed such training demonstrate a higher level of knowledge, skills and abilities than those who receive traditional education.

Aerosol generation of sweeteners solutions during a drinking process

In this study, we hypothesize that flavor compounds, volatile as well as non-volatile, can be transferred from the oral cavity to the nasal cavity in the form of aerosol particles. To test the potential of aerosol as the carrier of flavor compounds during a drinking process, the aerosol particles of sweetener solutions (sucrose or rebaudioside A) have been quantified at both the in situ and simulated conditions, with or without saliva mixing. As observed by an optical particle counter, shaking or splashing of test samples can generate huge numbers (1000–10000) of aerosol particles with most of them smaller than 1 μm. It was further observed that addition of sucrose, rebaudioside A, saliva, thickener (konjac glucomannan) and defoamer (simethicone emulsion) can significantly alter the generated aerosol particles of water both in situ and in vitro. As estimated by the intensity of fluorescence, the amount of transferred mass within the in vitro prepared aerosol can be 4.9 μg/min. The shear viscosities, surface tension, extensional break time and relaxation time were found to correlate with the aerosol generation of test sample. These results suggest that aerosol particles have the potential in carrying substantial amount of flavor compounds during oral processing, and their generation can be sensitively affected by the presence of food components and saliva.