Breath analysis is a cutting-edge technique that collects significant medical information by analyzing the substances found in exhaled breath. Fluctuations in the levels of chemicals such as acetone can serve as indicators of medical ailments or contact with hazardous substances such as occupational exposure. In order to detect acetone in exhaled air, techniques such as needle trap coupled with gas chromatography have been devised. This procedure involves the use of a nanocomposite called Mil101(Fe)@Fe3O4@SiO2.The nanocomposite is synthesized using a chemical hydrothermal method. In order to examine the properties of the Mil101(Fe)@Fe3O4@SiO2 nanocomposite, researchers utilized a range of analytical techniques including scanning electron microscopy (SEM), thermal analysis (TGA), x-ray analysis (EDX), Brunauer-Emmett-Teller (BET) method, and Fourier Transform Infrared Spectroscopy (FT-IR). The efficiency of the NTD-GC-FID method depends on several parameters, such as temperature, desorption time, fracture passage volume, sampling time, sample temperature, and sampling flow rate. These parameters have been studied using the simplex method to optimize the process. The optimal conditions yielded a limit of detection (LODs) of 0.4 µg/L and a limit of quantification (LOQs) of 1.1 µg/L. The calibration curve for the NTD-GC-FID method ranged from 0.011 to 10 mgl−1 with an acceptable error range. Moreover, the method demonstrated good repeatability and reproducibility, with calculated values of 3.9 and 4.6 %, respectively. The proposed method was successfully employed in this study to identify and measure acetone in the exhaled air of individuals with diabetes, yielding satisfactory results. The needle trap tool was used over 100 times without any decline in its efficiency for adsorbing acetone. In summary, this research presents a new analytical approach, namely the NTD-GC-FID method, to detect and measure acetone in exhaled air. Compared to the other methods for analyzing acetone, the application of Mil101(Fe)@Fe3O4@SiO2 nanocomposite demonstrated promising results in detection of diabetes.
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