Simple Diet Research Articles

Feasibility of using simple diet self-assessment tool (SDSAT) to establish trajectory of dietary intake for patients undergoing chemotherapy.

e13805 Background: Chemotherapy is often accompanied by impaired dietary intake, which is associated with poor clinical outcomes without effective intervention. Predicting dietary changes during chemotherapy enables early nutritional support, but the dynamic pattern and interindividual variability in dietary intake during chemotherapy remain unclear. Our aim was thus to assess the feasibility of using the Simple Diet Self-Assessment Tool (SDSAT) to establish dietary intake trajectories in patients receiving chemotherapy. Methods: This study used data from an ongoing, prospective cohort study (Patient-Reported Outcome Management Including Surveillance and Intervention in Nutritional Group) of patients receiving chemotherapy in 2021 and 2022. Diet was assessed using the SDSAT once before the treatment and at least three times during one chemotherapy cycle. We applied a group-based trajectory model to identify trajectories of dietary intake. The 24-hour dietary recall (24HR) was used to verify the validity of energy and protein intake estimated by SDSAT; compliance with SDSAT was also assessed. Results: Five trajectory groups were identified for food intake based on 217 entries by 56 patients. The compliance rate accounted for 81.11% for ≥4 cumulative responses per cycle. The agreement between the SDSAT score and the dietary energy and protein intake estimated from 24HR was high (κ: 0.888–1.0, P<0.001). Groups 1 and 2 had significantly lower dietary energy/protein intake than Groups 4 and 5 (P<0.001) but with distinct dietary patterns. Group 4 was the most common dietary trajectory (35.10%). Furthermore, Groups 1, 2, and 3 had significantly weaker handgrip strength (OR: 1.12, 95% CI: 1.02–1.22, P=0.016) compared with Groups 4 and 5. Conclusions: SDSAT was feasible to establish dietary trajectories during one chemotherapy cycle. Longitudinal analysis highlights the interindividual differences in dietary intake patterns among patients receiving chemotherapy and may help to inform proactive and individually tailored nutritional interventions.

'Dust you shall eat': The complex nutritional and functional considerations underlying a simple diet.

Animals assimilate macronutrients and mineral nutrients in specific quantities and ratios to maximise fitness. To achieve this, animals must ingest different foods that contain the needed nutrients or facilitate the digestion of those nutrients. We explored how these multidimensional considerations affect the desert isopods (Hemilepistus reaumuri) curious food selection, using field and laboratory experiments. Wild isopods consumed three-fold more macronutrient-poor biological soil crust (BSC) than plant litter. Isopods tightly regulated macronutrient and calcium intake, but not phosphorus when eating the two natural foods and when artificial calcium and phosphorus sources substituted the BSC. Despite the equivalent calcium ingestion, isopods performed better when eating BSC compared to artificial foods. Isopods that consumed BSC sterilised by gamma-radiation ate more but grew slower than isopods that ate live BSC, implying that ingested microorganisms facilitate litter digestion. Our work highlights the need to reveal the multifaceted considerations that affect food-selection when exploring trophic-interactions.

Effect of Prebiotic, Probiotic Bacteria and Symbiotic Diets Containing Bacillus Coagulans and Gum Arabic on Lipid Profile in Hypercholesterolemic Rats

Purpose: Hypercholesterolemia poses a significant challenge for numerous communities and healthcare professionals because of the association between cardiovascular conditions and dyslipidemia. The objective of this research was to assess the impact of prebiotics, probiotics, as well as a diet incorporating Bacillus coagulants and gum Arabic on blood lipid levels in hypercholesterolemic rats.
 Methodology: In order to create an antiseptic solution, acquire the organic substance known as gum Arabic. Thirty-five male Albino rats (170 ± 5 g) were feeding a prepared diet includes supplemented cholesterol to raise the levels of cholesterol. Mice were divided to 5 groups (n = 7). Group 1: simple diet (negative control), the other 4 groups were assigned for a hypercholesterolemia diet comprising 25% lard and 2% cholesterol for 6 weeks in order to increase fat cholesterol in rats. Group 2: (positive control), Group 3: fed with a supplement including 5% gum Arabic (prebiotic), Group 4: fed with a dietary supplement comprising coagulase spores, Group 5: assigned for a simple meal. It was supplemented with 5% daily gum Arabic and Bacillus coagulants spores (symbiotic).
 Results: Triglyceride levels and total cholesterol (mg/dL) were improved (P<0.05). In (advantageous manipulate) fed a simple diet (B.D.), compared with (poor manipulate).
 Unique Contribution to theory, Practice and Policy: The Anti-Inflammatory Theory and the concept of prebiotics usage to decrease cholesterol and minimize its absorption. This shows that the concept used has been validated. The satisfactory results which confirmed the extreme spread variations with the poor manipulate organization had been done within side the hypercholesterolemia organizations include with Gum Arabic (GA5%), where the best indicated a fee recorded (28.54 ± 3. seventy one mg/dL), which transferred into the poor manipulate (36.33 ± 5.00 mg/dL). As for the organizations that took B. coagulants and GA 5% + B. coagulants, a lower in LDL-c, (VLDL-c), levels of AST and AST, and the satisfactory outcome documented and directed within side of the organization GA 5% + B.Coagulants. Histological checkups furthermore confirmed that the liver sections inside the 5th organization established a regular structure, also the liver cells mild degeneration. CONCLUSION: The satisfactory final outcome indicated within side the organization of GA 5%+ B. coagulants remedy organization compared with the opposite organizations.

Tanino condensado de acácia-negra (Acacia mearnsii) como aditivo nutricional em dietas de leitões desmamados

ABSTRACT: This study evaluated the effect of black wattle (Acacia mearnsii) condensed tannin extract in simple and complex diets for weaned piglets on performance, faecal consistency and serum haptoglobin concentrations. Eighty-eight female and castrated male piglets were used, weaned at 28 ± 3 days old, with an initial body weight of 8.02 ± 1.21 kg, housed in same-sex pairs and distributed in four treatments in a 2 x 2 factorial experiment in a randomised complete block design. The experimental treatments were simple diet (SD), simple diet + tannin (SD+T), complex diet (CD) and complex diet + tannin (CD+T). The simple diets contained lower concentrations of dairy ingredients, inclusion of barley and no addition of zinc oxide, palatant, acidifier and yeast. The diets with tannin were supplemented with 1,850 mg kg-1 of black wattle condensed tannin extract. The feed programme consisted of three diets: Pre-starter I (0-7 days), Pre-starter II (8-21 days) and Starter (22-28 days). Feed and water were available ad libitum. Body weight and feed intake were measured weekly to calculate the average daily feed intake, daily weight gain and feed conversion ratio. The faecal consistency score was measured daily to calculate the diarrhoea occurrence percentage. Blood samples for serum haptoglobin concentration were collected at 7 and 14 days after weaning. The addition of condensed tannin had no effect (P > 0.05) on evaluated performance variables for weaned piglets. The diet type also did not affect the piglets’ performance (P > 0.05). The inclusion of black wattle (Acacia mearnsii) condensed tannin does not affect piglet performance, reduces the incidence of diarrhoea in the first week after weaning and decreases the haptoglobin inflammatory response.

Combination of β-mannanase plus multi-carbohydrase complex in simple or complex post-weaned pig diets on nutrient metabolism and gut health.

This study was conducted to evaluate whether adding β-mannanase alone or in combination with a multi-carbohydrase complex to simple and complex diets could improve diet digestibility, nutrient and energy metabolism, and gut health in weaned pigs. Thirty pigs (7.9 kg ± 0.851 kg) weaned at 28 days were randomly split into a 2 × 3 factorial arrangement, considering a simple (corn and soybean meal-based diet) or complex diet (13% point reduction in inclusion of soybean meal, 5% of whey power, and 2.5% of spray-dried plasma compared to the simple diet) and diet without any addition (control) or the addition of β-mannanase (BM; 0.300 g/kg of the diet) or β-mannanase plus a multi-carbohydrase complex blend such as xylanase, β-glucanase, and arabinofuranosidases (BM + MCC; 0.300 + 0.050 g/kg of the diet) for 17 days post-weaned. Total fecal and urine samples were collected on days 11-17. Fecal samples were collected from all pigs to identify fecal biomarkers using commercial ELISA tests. Blood samples were collected from all pigs at the end of the experimental period to assess serum concentrations of acute-phase proteins. All pigs were euthanized on day 18 for intestinal tissue collection. The simple diet had greater (p < 0.05) protein digestibility and metabolizability coefficients than the complex diet. Greater (p < 0.05) energy digestibility and energy metabolizability coefficients were observed in the BM and BM+ MCC compared to the control diet. On average, BM improved by 64 kcal/kg and BM + MCC improved by 100 kcal/kg of metabolizable energy. Furthermore, the addition of BM and BM + MCC to the diets led to lower fecal moisture and fecal output. Moreover, the BM and BM + MCC diets also reduced fecal calprotectin concentrations by 29 and 46%, respectively, compared to control pigs (p < 0.001). We conclude that simple diets are a suitable alternative to complex diets, without compromising the nutrient digestibility and gut health of post-weaned pigs. The addition of exogenous enzymes improves nutrient and energy utilization, as well as the absorption area, and decreases calprotectin concentrations.

Metabolomic assessment of African snail (Achatina fulica) meal on growth performance of giant river prawn (Macrobrachium rosenbergii)

This study aimed to investigate the effects of replacing fishmeal (FM) with African giant snail (Achatina fulica) meal (SM) on the growth performance of giant river prawn (Macrobrachium rosenbergii), as well as to analyze the associated metabolomic changes. Six diets were formulated, replacing FM with SM at different inclusion levels ranging from 0 % to 100 %. Growth performance and feed conversion ratio of prawns fed diets with FM replaced by SM up to 80 % were not significantly different from control. In contrast, significantly decreased growth performance and higher feed conversion ratio (FCR) occurred with diets containing 100 % SM. To gain insights into the metabolic regulation of prawns fed different diets, a 1H NMR metabolomics approach was used to assess the metabolic changes in prawns fed diets containing 0 % and 80 % SM. The results revealed up-regulated metabolites significantly involved in several metabolic pathways, including alanine, aspartate, and glutamate metabolism; citrate cycle (TCA cycle); aminoacyl-tRNA biosynthesis; and valine, leucine, and isoleucine biosynthesis. These findings imply that including SM in the diet might modulate the regulation of muscle amino acids and tRNA synthesis, suggesting a potential impact on protein biosynthesis mechanisms. Additionally, alterations in the TCA cycle may reflect changes in carbon utilization, potentially contributing to the growth performance of giant river prawns when fishmeal is replaced with SM without adversely affecting their growth. In conclusion, this study demonstrated that SM could be a promising alternative protein source in aquafeed. The metabolomic approach provides valuable insights into the metabolic changes in prawns fed different diets, aiding in the development of more effective aquafeeds in the future. The study's limitations, such as the simplified diet formulation and the limited scope of the metabolomic analysis, were acknowledged and discussed, highlighting the need for further research to build upon these findings.

The global nutrition can be greatly improved with diet optimization

Malnutrition and nutritional imbalances resulting from a poor diet are common worldwide. Here, we present a diet structure optimization model aimed at improving the nutritional levels, while keeping the optimized diet affordable and acceptable. We optimized the current diet of 181 countries by incorporating ten major food groups. A simple diet adjustment could increase the nutritional levels by up to 11.9 % and significantly address the existing nutrient imbalances. The optimized diet is environmentally friendly, reducing the total land use and greenhouse gas emissions by 11.8 % and 8.3 %, respectively. Furthermore, compromising on some nutritional improvements could yield greater environmental benefits, which could result in 17.1 %, and 12.7 % reductions in total land use and greenhouse gas emissions, respectively. Moreover, a 28.4 % diet cost increase can lead to a maximum of 9.7 % greater nutritional improvement than the optimal increase of constant cost. We provide a global diet optimization strategy that improves both human nutrition and sustainability.

PSIV-19 Understanding Intestinal Health in Nursery Pigs Through Potential Non-Invasive Biomarkers

Abstract Mannans in feed ingredients can cause a feed-induced immune response (FIIR), resulting in intestinal inflammation. The addition of beta-mannanase can limit this anti-nutritional action, reducing the cost of activating the immune response. In the same way, non-invasive biomarkers are important tools that can provide early diagnosis of low-grade inflammation by mannans. The objective of this study was to assess potential non-invasive biomarkers in nursery pigs reared in different scenarios of low-grade inflammation. Female piglets (n = 396; 6.86 ± 0.9 kg; Large white × Landrace) weaned at 21 days of age were used for this trial. Treatments were organized in a factorial design with two diet types (simple or complex feed formulas containing 25 and 12% of soybean-meal, respectively) and two enzyme supplementation plans (control without supplementation or supplemented with beta-mannanase at 0.4 kg per feed of 1,000 kg Hemicell HT, Elanco Animal Health, São Paulo, Brazil). Fecal samples were collected from 10 pigs per treatment at the 21st experimental day. The fecal concentration of calprotectin, neopterin, free fatty acid, lactoferrin, and calcium binding proteins were determined using commercially available ELISA kits. Blood was sampled 6h after oral gavage of FITC-dextran at the 22nd experimental day to access intestinal permeability. The variables were subjected to the normality test (Shapiro-Wilk), analysis of variance (ANOVA), and Tukey's test. Differences among treatments were considered at 5 and 10% significance levels. Piglets receiving beta-mannanase had reduced fecal levels of calprotectin (-41%; P = 0.048), neopterin (-43%; P = 0.019), and free fatty acid (-34%; P = 0.050) in relation to the control group. A tendency was observed for the reduction of novel lactoferrin (-1%; P = 0.072) and calcium binding proteins (-35%; P = 0.095) when comparing control with supplemented animals. In addition, beta-mannanase supplementation decreased intestinal permeability (-10%; P = 0.053) compared with control treatment. However, there was no effects of diet type or diet by enzyme interactions (P &amp;gt; 0.10). The addition of beta-mannanase in the nursery phase reduced fecal biomarkers associated with gut health inflammation. However, there was no difference between diets indicating a simple diet may be used to reduce diet cost without compromising the intestinal health of the animals.

Snack quality and snack timing are associated with cardiometabolic blood markers: the ZOE PREDICT study

BackgroundSnacking is a common diet behaviour which accounts for a large proportion of daily energy intake, making it a key determinant of diet quality. However, the relationship between snacking frequency, quality and timing with cardiometabolic health remains unclear.DesignDemography, diet, health (fasting and postprandial cardiometabolic blood and anthropometrics markers) and stool metagenomics data were assessed in the UK PREDICT 1 cohort (N = 1002) (NCT03479866). Snacks (foods or drinks consumed between main meals) were self-reported (weighed records) across 2–4 days. Average snacking frequency and quality [snack diet index (SDI)] were determined (N = 854 after exclusions). Associations between snacking frequency, quality and timing with cardiometabolic blood and anthropometric markers were assessed using regression models (adjusted for age, sex, BMI, education, physical activity level and main meal quality).ResultsParticipants were aged (mean, SD) 46.1 ± 11.9 years, had a mean BMI of 25.6 ± 4.88 kg/m2 and were predominantly female (73%). 95% of participants were snackers (≥ 1 snack/day; n = 813); mean daily snack intake was 2.28 snacks/day (24 ± 16% of daily calories; 203 ± 170 kcal); and 44% of participants were discordant for meal and snack quality. In snackers, overall snacking frequency and quantity of snack energy were not associated with cardiometabolic risk markers. However, lower snack quality (SDI range 1–11) was associated with higher blood markers, including elevated fasting triglycerides (TG (mmol/L) β; – 0.02, P = 0.02), postprandial TGs (6hiAUC (mmol/L.s); β; – 400, P = 0.01), fasting insulin (mIU/L) (β; – 0.15, P = 0.04), insulin resistance (HOMA-IR; β; – 0.04, P = 0.04) and hunger (scale 0–100) (β; – 0.52, P = 0.02) (P values non-significant after multiple testing adjustments). Late-evening snacking (≥ 9 pm; 31%) was associated with lower blood markers (HbA1c; 5.54 ± 0.42% vs 5.46 ± 0.28%, glucose 2hiAUC; 8212 ± 5559 vs 7321 ± 4928 mmol/L.s, P = 0.01 and TG 6hiAUC; 11,638 ± 8166 vs 9781 ± 6997 mmol/L.s, P = 0.01) compared to all other snacking times (HbA1c remained significant after multiple testing).ConclusionSnack quality and timing of consumption are simple diet features which may be targeted to improve diet quality, with potential health benefits.Clinical trial registry number and websiteNCT03479866, https://clinicaltrials.gov/ct2/show/NCT03479866?term=NCT03479866&draw=2&rank=1

The Global Diet Quality Score is associated with nutrient adequacy and depression among Vietnamese youths.

The Global Diet Quality Score (GDQS) has been recommended as a simple diet quality metric that is reflective of both nutrient adequacy and noncommunicable disease outcomes. It has been validated among women of reproductive age (15-49 years) in diverse settings but not specifically among younger women. This paper examines the relationship between the GDQS and nutrient adequacy, anthropometric outcomes, and depressive symptoms among 1001 Vietnamese young women aged 16-22 years. In energy-adjusted models, the GDQS was significantly (p < 0.05) and positively correlated with intakes of protein (ρ = 0.23), total fat (ρ = 0.06), nine micronutrients (calcium, iron, zinc, vitamin C, riboflavin, niacin, vitamin B6, folate, and vitamin A) (ρ = 0.12-0.35), and the mean probability of adequacy of micronutrients (ρ = 0.28). Compared to young women with optimal GDQS, those with low and very low GDQS were two to five times more likely to have a mean probability of nutrient adequacy less than 50% and showed two to three times higher odds for depression. No association was observed for GDQS and anthropometric outcomes. In conclusion, the GDQS performed well in capturing nutrient adequacy and depressive symptoms among Vietnamese young women. Further research is warranted to explore the relationship between diet quality and depression in other settings.

Postnatal care with Diet in Ayurveda

All the living beings in the universe require Aahaar which sustains the life. That is why it is said to be Praaninam Praana, Mahabhaishajya or Brahma in Ayurveda. Obviously, Lawful dietary intake results in Pran- Anuvartan. There is no life without Aahaar. Aahaar and existence of Agni is responsible for Praana. It maintains the equilibrium of Dhatus and helps in prevention of disorders and promotion of health. Nowadays in developing countries, the incidence and prevalence of postnatal morbidity are poorly known. After proper expulsion of placenta, a woman is said to be Sootika in which Vata-Dosha is in Prakopavastha. Improper knowledge of Sootika Kala diet followed by women, mother as well as child may suffer serious complications. There is definite need to study the preventive aspects described in classics. So, the mentioned diet given for puerperium is a medicated diet not a simple diet. Hence, this study will suggest some guidelines for the care of Sootika with diet.

Insulin resistance improvement and serum metabolomics of Hibiscus esulentus L. in patients with impaired glucose tolerance

Background/Aim. Prediabetes (PD) refers to the condition in which the blood sugar level is higher than normal but has not reached the diagnostic criteria for diabetes mellitus (DM) yet. Impaired glucose tolerance (IGT) is a major prediabetic symptom since most patients with type 2 DM have progressed from the previous PD phase. The aim of the study was to observe the changes in serum metabolomics in patients with IGT treated with Hibiscus esculentus L. (H. esculentus) combined with the change of lifestyle. Methods. Sixty patients with IGT were divided into two groups. In one group, the subjects made a life-style change (LC group, simple diet control), and the other group of subjects made a lifestyle change combined with H. esculentus (LCH group) treatment with daily consumption of 20 g of dried H. esculentus fruit tea. The aim was to compare the blood glucose, homeostasis model assessment-estimated insulin resistance (HOMA-IR) index, and serum metabolomics after a 60-day clinical observation period. Results. There was no statistical significance in the glucose level between the two groups by the end of the observation period. The HOMA-IR index in the LCH group was lower than in the LC group (1.7 ? 1.1 vs. 2.4 ? 1.2, p = 0.030). Serum metabolomics revealed that the levels of d-galactose, d-glucose, turanose, and uric acid in the LCH group were significantly lower than those in the LC group (16.7 ? 3.9 mmol/L vs. 21.2 ?2.9 mmol/L, 101.5 ? 40.2 mmol/L vs. 132.9 ? 36.7 mmol/L, 1.8 ? 1.6 mmol/L vs. 3.76 ? 2.46 mmol/L, 44.56 ? 15.7 ?mol/L vs. 67.8 ? 23.5 ?mol /L, respectively). The levels of lactic acid and conjugated linoleic acid in the LCH group were significantly higher than those in the LC group (3.3 ? 0.5 mmol/L vs. 2.3 ? 0.8 mmol/L, 6.9 ? 6.1 mmol/L vs. 2.1 ? 1.2 mmol/L, respectively). Conclusion. H. esculentus, combined with a change of lifestyle, can reduce insulin resistance and the levels of multiple monosaccharides and blood uric acid in IGT patients. Regulation of the metabolism of lactic acid and conjugated linoleic acid may be the potential mechanism of how H. esculentus reduces insulin resistance.

Effect of intermittent fasting and complete fasting on biochemical and histological parameters in high fat high sugar induced rat model of obesity

The prevalence of obesity has been increasing globally as one of the major health issues due to the increased calorie intake and decreased physical activity. Dietary restriction has been proved to induce changes in various biological processes. The present study was aimed to observe the effect of complete and intermittent fasting in obesity induced model rats by analyzing biochemical, and histological parameters. Twenty four Wister rats of either sex aged about twelve weeks were used for study. They were divided control, obese, complete fasting(CF) and intermittent fasting (IF). Other than control group, the remaining three groups were given obesogenic diet for six weeks . The IF and CF groups were given 2 different fasting regimens for two weeks. After the experimentation procedures the blood samples were collected and liver and pancreatic tissues was dissected for biochemical and histological analysis . The Data was analyzed using SPSS-16, Kruskal-Wallis test. Results were expressed as median with interquartile range p&lt;0.05 was expressed as statistically significant. Obesity induced increase in the lipid peroxidation was observed in the pancreatic (p&lt;0.05 and liver tissue (p&lt;0.01) when compared to control group. Decreased level of anti-oxidants was observed in the pancreatic tissue (p&lt;0.01) in the obese group .In both the fasting groups, decreased malondialdehyde (MDA) level and increased glutathione (GSH) was observed in the liver and pancreas. Comparatively, CF group showed lower MDA(p&lt;0.01) in both liver and pancreas and higher(p&lt;0.01) antioxidant in liver as compared to IF. Complete fasting group also showed a better histological profile. Complete fasting produced a better oxidative profile in the liver and pancreas when compared to Intermittent fasting group .The present research proves that simple diet control regime could be helpful in decreasing the pathophysiology associated with the obesity.

The impact of low-salt bread as a simple diet on hypertensive patients with cardiovascular comorbidities.

During recent years, hypertension and related cardiovascular complications have become the leading health challenges of this century. Non-pharmacologic strategies, emphasizing mainly salt restriction and physical activity, are recommended for all patients with hypertension. Our objective was to assess the impact of low salt white bread intake, widely consumed in Western Algeria, on blood pressure values in hypertensive patients with and without comorbidities. 134 hypertensive patients (male = 78, female = 56) were included. The study population was divided into two groups according to their choice of following a low salt white bread diet or not. Their dietary salt intake and physical activity were surveyed along with their blood pressure measurements and associated comorbidities. Other clinical and anthropometric data were collected. Patients following low salt bread diet showed decreased systolic and diastolic blood pressure values (119.07/74.63 mmHg) compared to the second group (131.92/79.81) (p < 0.01). These results were observed specifically in patients with adjacent cardiovascular diseases who seem to be less compliant to the diet (41.1% of the whole population, p < 0.05) and show significant increased blood pressure (135.75/81.53 mmHg) compared to compliant patients (116.66/75.33 mmHg) (p < 0.01). The study highlights the impact of low salt bread diet on the treatment of hypertension with and without comorbidities.

Evaluation of Simplified Diet Scores Related to C-Reactive Protein in Heavy Smokers Undergoing Lung Cancer Screening.

The aim of this study was to assess the relationship between adherence to a healthy diet, such as the Mediterranean diet (MedDiet), and C-reactive protein (CRP) in Italian heavy smokers undergoing an LDCT screening program (bioMILD trial), using scores calculated by simple questionnaires. Simple formats of food frequency questionnaires were administered to a sample of 2438 volunteers, and the adherence to a healthy diet was measured by the validated 14-point MEDAS and by two adaptations proposed by us: 17-item revised-MEDAS and 18-item revised-MEDAS. The OR of CRP ≥ 2 mg/L for 1-point increase in 14-point MEDAS score was 0.95 (95% CI 0.91–0.99), for 17-point score was 0.94 (95% CI 0.91–0.98), and for 18-point score was 0.92 (95% CI 0.88–0.97). These inverse associations remained statistically significant also after further adjustment for body mass index. These results showed the efficacy of simplified scores and their relationship with lower levels of CRP in a population of heavy smokers. This suggests that a targeted nutritional intervention might achieve a substantial reduction in CRP levels. The findings will be prospectively tested in a new randomized study on primary prevention during lung cancer screening.

161. THE EFFECTIVENESS OF TELEPHONE AND INTERNET-BASED SUPPORTIVE CARE FOR PATIENTS WITH ESOPHAGEAL CANCER ON ENHANCED RECOVERY AFTER SURGERY IN CHINA

Abstract Esophageal cancer patients face problems related to eating and surgery-related symptoms. The eating-related problems are characterized by dysphagia, appetite loss, and nausea/vomiting linked to anatomic changes and the reconfiguration of their upper GI tract. Of all the surgery-related problems, 30% of patients reported fatigue/pain symptom cluster (pain, fatigue, insomnia, dyspnea), and 27% of patients reported the reflux/cough cluster (dry mouth, taste changes, cough, reflux). Evidence shows that the supportive care needs of esophageal cancer patients are very high. The study was designed as an open-label, randomized controlled trial to value the efficacy of a nurse-led supportive care program in comparison with conventional care. The control group received conventional care. Patients from the intervention group received conventional care and one-on-one phone calls from nurses following their discharge assessments and education about nutrition and symptoms. Nurses also set up a WeChat group, which they invited patients to join in before discharge. Nutritional status, quality of life, the helpfulness of the follow-up service, and the patients’ satisfaction were compared 6 months after discharge to assess for differences between the two groups. 168 patients were included in the study, with 86 patients in the intervention group and 82 in the control group. Significant differences between the intervention and control groups were found in the Nutrition Risk Screening 2002 and simple diet self-assessment tool scores. The changes in blood albumin, prealbumin, and transferrin were also statistically significant. All QLQ-C30 results of the intervention group were better than those of the control group. The patients’ scores on the helpfulness of the follow-up service and their satisfaction with it were both significantly higher in the intervention group than in the control group. This study highlighted the important role of nurse-led supportive care based on telephone and Internet-based support for patients after ERAS. The supportive care improved patients’ nutritional status, elevated their quality of life, and improved their satisfaction with the care provided to them.

Use of the Simplified Diet Method to Improve Metabolic Control Among Teens and Adults with Phenylketonuria: A Mixed Methods Approach

Use of the Simplified Diet Method to Improve Metabolic Control Among Teens and Adults with Phenylketonuria: A Mixed Methods Approach

Midgut and Head Transcriptomic Analysis of Silkworms Reveals the Physiological Effects of Artificial Diets.

Simple SummaryAs oligophagous insects, silkworms have a very limited diet. Here, the transcriptomic characteristics of the head and midgut tissues of fifth instar male and female silkworms were studied to elucidate the effects of different food structures on silkworm innate immunity. Compared with mulberry leaves, artificial diets decreased the expression levels of immune-associated genes, thus decreasing silkworm immunity and susceptibility to pathogen infections.Silkworms, a model lepidopteran insect, have a very simple diet. Artificial diets as an alternative nutrient source for silkworms are gradually being developed. To understand the effects of various nutrients on the growth and development of silkworms, we studied the transcriptomic differences in the midgut and head tissues of male and female silkworms fed either fresh mulberry leaves or artificial diets. In the artificial diet group, compared with the control group (fed mulberry leaves), 923 and 619 differentially expressed genes (DEGs) were identified from the midgut, and 2969 and 3427 DEGs were identified from the head, in female and male silkworms. According to our analysis, the DEGs were mainly involved in the digestion and absorption of nutrients and silkworm innate immunity. These experimental results provide insights into the effects of different foods, such as artificial diets or fresh mulberry leaves, on silkworms.

The effectiveness of telephone and internet-based supportive care for patients with esophageal cancer on enhanced recovery after surgery in China: A randomized controlled trial

ObjectiveThe aim of this study was to establish a nurse-led supportive care program based on telephone and Internet support and evaluate its efficacy in comparison with conventional care on enhanced recovery after surgery. MethodsThe study was designed as an open-label, randomized controlled trial to value the efficacy of a nurse-led supportive care program in comparison with conventional care. A convenience sampling method was employed to recruit patients with esophageal cancer in a tertiary Grade A cancer center in Beijing from November 2018 to January 2019. Patients were assigned randomly (1:1) to one of the two groups (intervention group vs control group) via a web randomization system. The control group received conventional care. Patients from the intervention group received conventional care and one-on-one phone calls from nurses following their discharge assessments and education about nutrition and symptoms. Nurses also set up a WeChat group, which they invited patients to join in before discharge for better communication during follow-up. Statistical testing, including nutritional status, quality of life, the helpfulness of the follow-up service, and the patients’ satisfaction with their care, was conducted 6 months after discharge to assess for differences between the two groups. The independent sample t, chi-squared, and Mann–Whitney tests were used to compare between the experiences of the intervention and control groups. The Spearman correlation analysis was used for the analysis of correlation of the nutritional index and quality of life. ResultsFinally, 168 patients were included in the study, with 86 patients in the intervention group and 82 in the control group. Significant differences between the intervention and control groups were found in the nutrition risk screening 2002 and simple diet self-assessment tool scores. The changes in blood albumin, prealbumin, and transferrin were also statistically significant. All (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire) QLQ-C30 results of the intervention group were better than those of the control group. A significant positive correlation of the simple diet self-assessment tool (the higher, the better) and the scores for total health/quality of life were detected (r ​= ​0.214, P ​= ​0.005). A significant negative correlation of the nutrition risk screening 2002 (the lower, the better) and the scores of total health/quality of life was detected (r ​= ​−0.446, P ​= ​0.000). The patients’ scores on the helpfulness of the follow-up service and their satisfaction with it were both significantly higher in the intervention group than in the control group. ConclusionsThis study highlighted the important role of nurse-led supportive care based on telephone and Internet-based support for patients after enhanced recovery after surgery. The supportive care improved patients’ nutritional status, elevated their quality of life, and improved their satisfaction with the care provided to them.

The Philosopher’s Diet in Porphyry’s De Abstinentia: Characterizing a Historical Legacy of Minimalism in Food Consumption

Historical legacy, as an important constituent for the evaluation of the extent to which the past influences the present, sheds much light on some of the broader issues of the relation between the past and the present. One of the components of historical legacy is human food consumption habits. The domain of food consumption habits, in traditional Greek and Roman culture, contains a fairly noticeable diversity as it fluctuates between what seems to be two wide poles of dietary practices such as a simple diet, with the focus on minimalism and health and a luxury diet, with the focus on excess and extravagance. These poles, upon close analysis, have determined the dietary customs of antiquity while also formed a gastronomic identity. The impact of this historical legacy seems to have not only flavored Porphyry’s discussion of the nature of the philosopher’s diet in On Abstinence from Killing Animals but has also served in characterizing an advanced stage of minimalism in Greek and Roman food consumption habits.