Similar Patterns Of Results Research Articles

Do production and verification tasks in arithmetic rely on the same cognitive mechanisms? A test using alphabet arithmetic.

In this study, 17 adult participants were trained to solve alphabet–arithmetic problems using a production task (e.g., C + 3 = ?). The evolution of their performance across 12 practice sessions was compared with the results obtained in past studies using verification tasks (e.g., is C + 3 = F correct?). We show that, irrespective of the experimental paradigm used, there is no evidence for a shift from counting to retrieval during training. However, and again regardless of the paradigm, problems with the largest addend constitute an exception to the general pattern of results obtained. Contrary to other problems, their answers seem to be deliberately memorised by participants relatively early during training. All in all, we conclude that verification and production tasks lead to similar patterns of results, which can therefore both confidently be used to discuss current theories of learning. Still, deliberate memorization of problems with the largest addend appears earlier and more often in a production than a verification task. This last result is discussed in light of retrieval models.

Replication of combined school readiness interventions for teachers and parents of head start pre-kindergarteners using remote delivery

This replication study examined remote delivery of 2 evidence-based prekindergarten (pre-k) interventions to evaluate whether the combination of interventions, one in Head Start classrooms (online The Early Education Model, eTEEM) and one in the home (online Play and Learning Strategies, ePALS) resulted in enhanced effects on at-risk 3- to 5-year-old children's school readiness skills when compared to either of these interventions alone. The aligned interventions trained adults – teachers and parents – to use responsiveness and guided learning approaches within routine activities with the aim of increasing children's social-behavioral and academic skills. Both the original in-person study (Landry et al., 2017) and the present remote study used a four-group factorial design. The present study first randomized classrooms to eTEEM (n = 36) or control (n = 33). Next, within classrooms, parent-child dyads were randomized to ePALS or No ePALS, resulting in four conditions: n = 186 eTEEM/ePALS; n = 151 eTEEM/No ePALS; n = 160 No eTEEM/ePALS; and n = 133 No eTEEM/No ePALS control. The original study found small to moderate effects on parent and teacher behaviors ( d = 0.18 to 0.55). In this remote study, there were generally larger parent and teacher effects for responsiveness (g = 0.63 to 0.70) and for guided learning ( g = 0.37 to 1.05), behaviors targeted by the interventions. Results of the original study showed few effects on children's academic outcomes and the strongest effect on children's social-behavioral skills for the parent intervention ( d = 0.15 to 0.19). The present study produced similar patterns of results for child outcomes with larger social-behavioral effects ( g = 0.19 to 0.27) than academic ( g = -0.23 to 0.30). We discuss the importance of these replication findings when delivering interventions remotely to improve scalability.

Do nuclear magnetic resonance (NMR)-based metabolomics improve the prediction of pregnancy-related disorders? Findings from a UK birth cohort with independent validation

BackgroundPrediction of pregnancy-related disorders is usually done based on established and easily measured risk factors. Recent advances in metabolomics may provide earlier and more accurate prediction of women at risk of pregnancy-related disorders.MethodsWe used data collected from women in the Born in Bradford (BiB; n = 8212) and UK Pregnancies Better Eating and Activity Trial (UPBEAT; n = 859) studies to create and validate prediction models for pregnancy-related disorders. These were gestational diabetes mellitus (GDM), hypertensive disorders of pregnancy (HDP), small for gestational age (SGA), large for gestational age (LGA) and preterm birth (PTB). We used ten-fold cross-validation and penalised regression to create prediction models. We compared the predictive performance of (1) risk factors (maternal age, pregnancy smoking, body mass index (BMI), ethnicity and parity) to (2) nuclear magnetic resonance-derived metabolites (N = 156 quantified metabolites, collected at 24–28 weeks gestation) and (3) combined risk factors and metabolites. The multi-ethnic BiB cohort was used for training and testing the models, with independent validation conducted in UPBEAT, a multi-ethnic study of obese pregnant women.ResultsMaternal age, pregnancy smoking, BMI, ethnicity and parity were retained in the combined risk factor and metabolite models for all outcomes apart from PTB, which did not include maternal age. In addition, 147, 33, 96, 51 and 14 of the 156 metabolite traits were retained in the combined risk factor and metabolite model for GDM, HDP, SGA, LGA and PTB, respectively. These include cholesterol and triglycerides in very low-density lipoproteins (VLDL) in the models predicting GDM, HDP, SGA and LGA, and monounsaturated fatty acids (MUFA), ratios of MUFA to omega 3 fatty acids and total fatty acids, and a ratio of apolipoprotein B to apolipoprotein A-1 (APOA:APOB1) were retained predictors for GDM and LGA. In BiB, discrimination for GDM, HDP, LGA and SGA was improved in the combined risk factors and metabolites models. Risk factor area under the curve (AUC 95% confidence interval (CI)): GDM (0.69 (0.64, 0.73)), HDP (0.74 (0.70, 0.78)) and LGA (0.71 (0.66, 0.75)), and SGA (0.59 (0.56, 0.63)). Combined risk factor and metabolite models AUC 95% (CI): GDM (0.78 (0.74, 0.81)), HDP (0.76 (0.73, 0.79)) and LGA (0.75 (0.70, 0.79)), and SGA (0.66 (0.63, 0.70)). For GDM, HDP and LGA, but not SGA, calibration was good for a combined risk factor and metabolite model. Prediction of PTB was poor for all models. Independent validation in UPBEAT at 24–28 weeks and 15–18 weeks gestation confirmed similar patterns of results, but AUCs were attenuated.ConclusionsOur results suggest a combined risk factor and metabolite model improves prediction of GDM, HDP and LGA, and SGA, when compared to risk factors alone. They also highlight the difficulty of predicting PTB, with all models performing poorly.

Intimate Partner Violence Predicts Posttraumatic Stress Disorder Severity Independent of Early Life and Deployment-Related Trauma in Deployed Men and Women Veterans

Intimate partner violence (IPV) refers to emotional, physical, and/or sexual abuse perpetrated by a current or former partner. IPV affects both genders, though little is known about its effects on men as victims. The aims of this study were to determine if IPV is a factor contributing to posttraumatic stress disorder (PTSD) severity independently of deployment-related trauma, and to determine if there are gender differences in these associations. Participants were 46 female and 471 male post-9/11 veterans. Four sequential regressions were employed to examine the independent contribution of IPV among multiple trauma types on PTSD severity in men and women at two epochs, post-deployment (participants were anchored to deployment-related PTSD symptoms) and current (within the past month). Models were significant for both epochs in men (ps < .001) but not in women (ps > .230). In men, IPV independently predicted PTSD severity in both epochs (β > .093). However, in women, early life trauma (β = .284), but not IPV was a significant and independent predictor for current PTSD. Thus, there are distinct gender differences in how trauma type contributes to PTSD symptom severity. Although the statistical models were not significant in women, we observed similar patterns of results as in men and, in some cases, the β was actually higher in women than in men, suggesting a lack of power in our analyses. More research is clearly needed to follow-up these results; however, our findings indicate that IPV is a contributing factor to PTSD severity in veterans.

Undersweep fixations during reading in adults and children

Return sweeps take a reader’s fixation from the end of one line to the start of the next. Return sweeps frequently undershoot their target and are followed by a corrective saccade toward the left margin. The pauses prior to corrective saccades are typically considered to be uninvolved in linguistic processing. However, recent findings indicate that these undersweep fixations influence skilled adult readers’ subsequent reading pass across the line and provide preview of line-initial words. The current research examined these effects in children. First, a children’s reading corpus analysis revealed that words receiving an undersweep fixation were more likely skipped and received shorter gaze durations during a subsequent pass. Second, a novel eye movement experiment that directly compared adults’ and children’s eye movements indicated that, during an undersweep fixation, readers very briefly allocate their attention to the fixated word—as indicated by inhibition of return effects during a subsequent pass—prior to deploying attention toward the line-initial word. We argue that prior to the redeployment of attention, readers extract information at the point of fixation that facilitates later encoding and saccade targeting. Given similar patterns of results for adults and children, we conclude that the mechanisms controlling for oculomotor coordination and attention necessary for reading across line boundaries are established from a very early point in reading development.

I think, therefore I forget - using experimental simulation of dementia to understand functional cognitive disorders.

Symptoms of functional neurological disorder have traditionally been thought to depend, in part, on patients' ideas about symptoms rather than on the rules of pathophysiology. The possibility that functional cognitive symptoms might similarly reflect ideas of dementia has not been explored. We aimed to assess beliefs, through performance, about symptoms of dementia in healthy non-medical adults with the intention of identifying potential markers of functional cognitive disorders. Healthy volunteers were asked to simulate symptoms of mild dementia during testing with the Montreal Cognitive Assessment (MoCA), coin-in-hand forced-choice test, short digit span trials, Luria 3-step test and interlocking finger test. Family history of dementia was recorded. In 50 participants aged 18-27, simulating dementia, mean MoCA score was 16 (SD 5.5, range 5-26). Delayed recall was the most frequently failed item (100%) and cube drawing least frequently failed (42%). Twenty-six percent failed forward three-digit span and 36% failed reverse two-digit span. On the coin-in-hand test, 32% scored at or below chance level. Inconsistent response patterns were common. Cognitively healthy young adults simulating mild dementia perform similarly to older adults with mild dementia, demonstrating beliefs that dementia is associated with significant global impairment, including attention, motor function, and letter vigilance, but preservation of cube drawing. Inconsistent response patterns were common. Contrary to expectation, family history of dementia did not influence performance. Two and three digit span showed particular promise as a bedside test for simulation. Further investigation will establish whether similar patterns of results are produced in individuals with functional cognitive symptoms.

Age-Related Decline of Low-Spatial-Frequency Bias in Context-Dependent Visual Size Perception.

Global precedence has been found to decline or even shift to local precedence with increasing age. Little is known about the consequence of this age-related decline of global precedence on other aspects of older adults’ vision. The global and local processing has been preferentially associated with the low-spatial-frequency (LSF) and high-spatial-frequency (HSF) channels, respectively. Here, we used low- and high-pass filtered faces together with the Ebbinghaus illusion whose magnitude is an index of context sensitivity. The results demonstrated that, relative to HSF faces, prior exposure to LSF faces increased the illusion magnitude for younger participants, but it reduced the illusion magnitude for older participants. Significant age group difference was observed only with prior exposure to LSF faces but not to HSF faces. Moreover, similar patterns of results were observed when the filtered faces were rendered invisible with backward masking, and the magnitude of age-related decline was comparable to the visible condition. Our study reveals that LSF-related enhancement of context sensitivity declines with advancing age, and this age-related decline was independent of the awareness of the spatial frequency information. Our findings support the right hemi-aging model and suggest that the magnocellular projections from subcortical to cortical regions might also be vulnerable to age-related changes.

Small area deprivation and stigmatising attitudes towards mental illness: a multilevel analysis of Health Survey for England (2014) data

PurposeThe aim of this study was to explore how small area deprivation is associated with attitudes towards mental illness in a large sample of individuals living in private households in England.MethodCross-sectional data from Health Survey for England (2014) were analysed using multilevel models. The exposure of interest was the deprivation level of the small area in which an individual resides as measured by Index of Multiple Deprivation (IMD) score. The primary outcome was an individual’s overall attitude towards mental illness, measured using a 12 item version of the Community Attitudes toward the Mentally Ill (CAMI) scale. Further outcomes were the two subscales of the CAMI, reflecting attitudes of (1) prejudice and exclusion and (2) tolerance and support. Individuals were nested within household and small geographical area.Results5820 participants were included. Results from unadjusted models found strong evidence that individuals residing in the most deprived areas of England have worse attitudes towards mental illness compared to individuals living in the least deprived areas (estimated difference = − 3.5 points; 95% CI − 4.8 to − 2.2; P < 0.001). After adjusting for age, sex, education level, ethnicity and weekly income there was no longer evidence for this association (adjusted difference = − 0.1 points, 95% CI − 1.3 to 1.2; P = 0.931). Similar patterns of results were found for the CAMI subscales.ConclusionsThe relationship between small area-level deprivation and attitudes towards mental illness is no longer observed when controlling for certain individual-level characteristics.

Is There an Increased Risk of Criminal Behavior Among Children Who Were In Utero When Their Mothers Were Exposed to Increased Alcohol Availability? A Register-Based Study Using a Natural Experiment Setting

Increased alcohol availability influences drinking behavior; however, little is known about the effect of availability changes on subsequent generations. This study examined whether exposure to increased alcohol availability while pregnant is associated with criminal behavior in subsequent generations. A register-linked study was conducted using data from a natural experiment setting, including 363,207 children born between 1965 and 1971. During 1967/68, strong beer became temporarily available in grocery stores instead of state-owned monopoly stores only, for individuals less than 21 years of age, in two regions of Sweden. Children born in regions exposed to the policy change were compared with children born elsewhere in Sweden (excluding a border area), children born before 1967, and children conceived after 1968. Information on criminal outcomes was obtained from the National Register of Criminal Convictions. Follow-up was from age 15 to 42 years. Hazard ratios with 95% confidence intervals were estimated using Cox regression analysis. Compared with the unexposed cohorts, children conceived by young mothers before the policy change but exposed to the change in utero did not appear to be at an increased risk of being convicted of a violent crime, theft, or drunk driving later in life. Similar patterns of results were found among children conceived by older mothers. Using data from a natural experiment setting, no consistent evidence was found that being exposed to increased alcohol availability while pregnant increased the risk of having a child who would be convicted of a crime later in life.

A multicenter study of entecavir vs. tenofovir on prognosis of treatment-naïve chronic hepatitis B in South Korea

It is currently unclear which antiviral agent, entecavir (ETV) or tenofovir disoproxil fumarate (TDF), is superior for improving prognosis in patients with chronic hepatitis B (CHB). Here, we assessed the ability of these 2 antivirals to prevent liver-disease progression in treatment-naïve patients with CHB. From 2012 to 2014, treatment-naïve patients with CHB who received ETV or TDF as a first-line antiviral agent were recruited from 4 academic teaching hospitals. Patients with decompensated cirrhosis or hepatocellular carcinoma (HCC) at enrollment were excluded. Cumulative probabilities of HCC and death or orthotopic liver transplant (OLT) were assessed. In total, 2,897 patients (1,484 and 1,413 in the ETV and TDF groups, respectively) were recruited. The annual HCC incidence was not statistically different between the ETV and TDF groups (1.92 vs. 1.69 per 100 person-years [PY], respectively; adjusted hazard ratio [HR] 0.975 [p = 0.852] by multivariate analysis). Propensity score (PS)-matched and inverse probability of treatment weighting (ITPW) analyses yielded similar patterns of results (HR 1.021 [p = 0.884] and 0.998 [p = 0.988], respectively). The annual incidence of death or OLT was not statistically different between the ETV and TDF groups (0.52 vs. 0.53 per 100 PY, respectively; adjusted HR 1.202 [p = 0.451]). PS-matched and ITPW analyses yielded similar patterns of results (HR 1.248 [p = 0.385] and 1.239 [p = 0.360], respectively). These findings were consistently reproduced in patients with compensated cirrhosis (all p >0.05). The overall prognosis in terms of HCC and death or OLT was not statistically different between the ETV and TDF groups. Further studies are needed to validate our results. It is currently unclear which antiviral agent, entecavir or tenofovir disoproxil fumarate, is superior for improving prognosis in patients with chronic hepatitis B virus infection. In this analysis we found that there was no difference in terms of overall prognosis, including risk of hepatocellular carcinoma, death, or the need for a liver transplant, in patients receiving either antiviral.

Risky financial choices in a gain and loss decision frame \u2013 the role of chronic and situationally induced time perspectives

The aim of the research was to explore the relationship between people’s Time Perspectives (TPs) (chronic and induced) and their propensity to take financial risks in gambling tasks with a gain and loss decision frame. The results of the study 1 (N1 = 1093) revealed that a higher chronic Present Hedonistic TP is related to a preference for unsure options in loss and gain frames, while a higher chronic Past Negative TP is related to a preference for sure options in a gain frame of financial choice, but for unsure options in a loss frame. Moreover, higher chronic Future TP is related to unsure option preference in a loss decision frame. The results of the study 2 (N2 = 563) showed that the induced Past Negative TP (in a gain frame) and Present Hedonistic TP (in both decision frames) lead to similar patterns of results to those observed for the chronic TPs.

The cortical structure of functional networks associated with age-related cognitive abilities in older adults.

Age and cortical structure are both associated with cognition, but characterizing this relationship remains a challenge. A popular approach is to use functional network organization of the cortex as an organizing principle for post-hoc interpretations of structural results. In the current study, we introduce two complimentary approaches to structural analyses that are guided by a-priori functional network maps. Specifically, we systematically investigated the relationship of cortical structure (thickness and surface area) of distinct functional networks to two cognitive domains sensitive to age-related decline thought to rely on both common and distinct processes (executive function and episodic memory) in older adults. We quantified the cortical structure of individual functional network’s predictive ability and spatial extent (i.e., number of significant regions) with cognition and its mediating role in the age-cognition relationship. We found that cortical thickness, rather than surface area, predicted cognition across the majority of functional networks. The default mode and somatomotor network emerged as particularly important as they appeared to be the only two networks to mediate the age-cognition relationship for both cognitive domains. In contrast, thickness of the salience network predicted executive function and mediated the age-cognition relationship for executive function. These relationships remained significant even after accounting for global cortical thickness. Quantifying the number of regions related to cognition and mediating the age-cognition relationship yielded similar patterns of results. This study provides a potential approach to organize and describe the apparent widespread regional cortical structural relationships with cognition and age in older adults.

Information and learning in processing adjective inflection

We investigated the processing of inflected Serbian adjective forms to bring together quantitative linguistic measures from two frameworks – information theory and discrimination learning. From each framework we derived several quantitative descriptions of an inflectional morphological system and fitted two separate regression models to the processing latencies that were elicited by inflected adjectival forms presented in a visual lexical decision task. The model, which was based on lexical distributional and information theory revealed a dynamic interplay of information. The information was sensitive to syntagmatic and paradigmatic dimensions of variation; the paradigmatic information (formalized as respective relative entropies) was also modulated by lemma frequency. The discrimination learning based model revealed an equally complex pattern, involving several learning-based variables. The two models revealed strikingly similar patterns of results, as confirmed by the very high proportion of shared variance in model predictions (85.83%). Our findings add to the body of research demonstrating that complex morphological phenomena can arise as a consequence of the basic principles of discrimination learning. Learning discriminatively about inflectional paradigms and classes, and about their contextual or syntagmatic embedding, sheds light on human language-processing efficiency and on the fascinating complexity of naturally emerged language systems.

Fractal dimension of EEG signals and heart dynamics in discrete emotional states

In this study, we explored the fractal dimension (FD; a measure of signal complexity) of 28 EEG channels with positive and negative emotional states. The EEG of participants and their ECG were registered while watching short video clips that induced fear, disgust, humour, or neutral emotions. In order to better understand the nature of these emotions, the Higuchi FD of EEG segments and the heart rate variability (HRV) of the ECG associated with each emotion were obtained. Our results exhibited similar patterns of results with both measures. Humour elicited the highest FD scores in most EEG channels and the highest HRV, while fear, among all emotions, produced the lowest scores in both measures. These results may contribute to the understanding of the relationship between cortical and heart dynamics and their role on emotion perception.

Individual differences in time perspectives and risky financial choices

Preferences for risks have been a subject of interest to both economists and psychologists. This has given rise to many findings about the role of psychological factors in influencing risky choices. The presented studies focused on the role of Time Perspectives (TPs) in explaining people's risky financial choices. The main goal was to examine the relationship between people's TPs (chronic and induced) and their propensity to invest and undertake investment risks. Three studies on Polish national representative samples (N1=1093; N2=1081, N3=1563) and one on a sample of Polish adults (N4=246) were conducted. The results showed that chronic Future and Present Hedonistic TPs are the most important in the context of risky financial choices. Higher Future TP is related to a propensity to invest and make safe investment choices. Higher Present Hedonistic TP is related to a low propensity to invest and risky investment. Moreover, induced Future and Present Hedonistic TPs lead to similar patterns of results to those obtained in studies on chronic TPs.

Are intertemporal preferences contagious? Evidence from collaborative decision making.

Prior research has provided substantial insight into individuals' intertemporal preferences (i.e., preferences about delayed rewards). In the present study, we instead investigated the preferences of small groups of individuals asked to express collective intertemporal decisions. The paradigm consisted of three phases. During the precollaboration and postcollaboration phases, participants completed an intertemporal decision task individually. During the collaboration phase, participants completed a similar task in small groups, reaching mutually-agreed-upon decisions. The results suggest that group preferences were systematically related to the mean of the group members' precollaboration preferences. In addition, collaborative decision making altered the group members' intertemporal preferences. Specifically, individuals' postcollaboration preferences converged toward the preferences of their respective groups. Furthermore, we found that individuals' postcollaboration preferences were independently related to both their precollaboration preferences and the preferences of the other group members, suggesting that individuals' postcollaboration preferences represented a revision of their precollaboration preferences based on the preferences observed in other group members. In Experiment 2, we demonstrated that similar patterns of results were found whether participants were making matching judgments or binary choices.

'Mixed blessings': parental religiousness, parenting, and child adjustment in global perspective.

Most studies of the effects of parental religiousness on parenting and child development focus on a particular religion or cultural group, which limits generalizations that can be made about the effects of parental religiousness on family life. We assessed the associations among parental religiousness, parenting, and children's adjustment in a 3-year longitudinal investigation of 1,198 families from nine countries. We included four religions (Catholicism, Protestantism, Buddhism, and Islam) plus unaffiliated parents, two positive (efficacy and warmth) and two negative (control and rejection) parenting practices, and two positive (social competence and school performance) and two negative (internalizing and externalizing) child outcomes. Parents and children were informants. Greater parent religiousness had both positive and negative associations with parenting and child adjustment. Greater parent religiousness when children were age 8 was associated with higher parental efficacy at age 9 and, in turn, children's better social competence and school performance and fewer child internalizing and externalizing problems at age 10. However, greater parent religiousness at age 8 was also associated with more parental control at age 9, which in turn was associated with more child internalizing and externalizing problems at age 10. Parental warmth and rejection had inconsistent relations with parental religiousness and child outcomes depending on the informant. With a few exceptions, similar patterns of results held for all four religions and the unaffiliated, nine sites, mothers and fathers, girls and boys, and controlling for demographic covariates. Parents and children agree that parental religiousness is associated with more controlling parenting and, in turn, increased child problem behaviors. However, children see religiousness as related to parental rejection, whereas parents see religiousness as related to parental efficacy and warmth, which have different associations with child functioning. Studying both parent and child views of religiousness and parenting are important to understand the effects of parental religiousness on parents and children.

Does Variability Across Events Affect Verb Learning in English, Mandarin, and Korean?

Extending new verbs is important in becoming a productive speaker of a language. Prior results show children have difficulty extending verbs when they have seen events with varied agents. This study further examines the impact of variability on verb learning and asks whether variability interacts with event complexity or differs by language. Children (aged 2½ to 3 years) in the United States, China, Korea, and Singapore learned verbs linked to simple and complex events. Sets of events included one or three agents, and children were asked to extend the verb at test. Children learning verbs linked to simple movements performed similarly across conditions. However, children learning verbs linked to events with multiple objects were less successful if those events were enacted by multiple agents. A follow-up study rules out an influence of event order. Overall, similar patterns of results emerged across languages, suggesting common cognitive processes support children's verb learning.

Holding Back the Tears: Individual Differences in Adult Crying Proneness Reflect Attachment Orientation and Attitudes to Crying.

Despite being a universal human attachment behavior, little is known about individual differences in crying. To facilitate such examination we first recommend shortened versions of the attitudes and proneness sections of the Adult Crying Inventory using two independent samples. Importantly, we examine attachment orientation differences in crying proneness and test the mediating role of attitudes toward crying in this relationship. Participants (Sample 1 N = 623, Sample 2 N = 781), completed online measures of adult attachment dimensions (avoidance and anxiety), attitudes toward crying, and crying proneness. Exploratory factor analyses in Sample 1 revealed four factors for crying attitudes: crying helps one feel better; crying is healthy; hatred of crying; and crying is controllable; and three factors for crying proneness: threat to self; sadness; and joy. Confirmatory factor analyses in Sample 2 replicated these structures. Theoretically and statistically justified short forms of each scale were created. Multiple mediation analyses revealed similar patterns of results across the two samples, with the attitudes “crying is healthy” and “crying is controllable” consistently mediating the positive links between attachment anxiety and crying proneness, and the negative links between attachment avoidance and crying proneness. Results are discussed in relation to attachment and emotion regulation literature.

Long-Term Risk of Atherosclerotic Cardiovascular Disease in US Adults With the Familial Hypercholesterolemia Phenotype.

Heterozygous familial hypercholesterolemia (FH) affects up to 1 in 200 individuals in the United States, but atherosclerotic cardiovascular disease (ASCVD) outcomes of FH in the general US population have not been described. We therefore sought to evaluate long-term coronary heart disease (CHD) and total ASCVD risks in US adults with an FH phenotype. Using individual pooled data from 6 large US epidemiological cohorts, we stratified participants by low-density lipoprotein cholesterol level at index ages from 20 to 79 years. For the primary analysis, low-density lipoprotein cholesterol levels ≥190 and <130 mg/dL defined the FH phenotype and referent, respectively. Sensitivity analyses evaluated the effects of varying the FH phenotype definition. We used Cox regression models to assess covariate-adjusted associations of the FH phenotype with 30-year hazards for CHD (CHD death or nonfatal myocardial infarction) and total ASCVD (CHD or stroke). We included 68 565 baseline person-examinations; 3850 (5.6%) had the FH phenotype by the primary definition. Follow-up across index ages ranged from 78 985 to 308 378 person-years. After covariate adjustment, the FH phenotype was associated with substantially elevated 30-year CHD risk, with hazard ratios up to 5.0 (95% confidence interval, 1.1-21.7). Across index ages, CHD risk was accelerated in those with the FH phenotype by 10 to 20 years in men and 20 to 30 years in women. Similar patterns of results were found for total ASCVD risk, with hazard ratios up to 4.1 (95% confidence interval, 1.2-13.4). Alternative FH phenotype definitions incorporating family history, more stringent age-based low-density lipoprotein cholesterol thresholds, or alternative lipid fractions decreased the FH phenotype prevalence to as low as 0.2% to 0.4% without materially affecting CHD risk estimates (hazard ratios up to 8.0; 95% confidence interval, 1.0-61.6). In the general US population, the long-term ASCVD burden related to phenotypic FH, defined by low-density lipoprotein cholesterol ≥190 mg/dL, is likely substantial. Our finding of CHD risk acceleration may aid efforts in risk communication.