Abstract Introduction: There are multiple options available for closing surgical incisions. This study compared the cosmetic results between the use of 2-octylcyanoacrylate and nylon sutures in elective breast surgery. Objectives: To compare the efficacy and cosmetic outcome between the adhesive and conventional suturing with nylon on the cutaneous synthesis mammary surgeries. Methods: we performed a prospective, randomized, controlled trial with 79 patients, 37 in group 2-octylcyanoacrilate and 42 in the group with nylon suture. We evaluated the surgical aspect of the scar in 40 and 180 days, the occurrence of complications (such as dehiscence, hematoma, infection and allergic reactions), the size of the wound and breast lesions, surgical time and skin closure time, hemoglobin and preoperative WBC, age, height and weight of patients. Statistical analysis was performed by t test and chi-square. Results and discussion: the study was stopped before the end of the recruitment of patients for the presence of a greater number of dehiscence in the adhesive group (OR: 11.42, 95% CI 1.36 - 96.02, p=0.007). There were no significant differences between the groups regarding other complications, not in relation to surgical time and the aesthetic appearance of scars after 40 and 180 days. The average size of the wound was greater in the adhesive group than in the suture, being respectively 32.97 (+ 10.54) mm and 27.64 (+ 9.56) mm, no correlation of size with the largest number of dehiscence. Conclusion: The results showed that the cosmetic scar appearance of 2-octylcyanoacrilate is equivalent to those obtained with the intradermal nylon suture, but the risk of dehiscence is higher. Citation Format: Ruffo Freitas-Junior, Thiago S Becker, Rosemar MS Rahal, Regis R Paulinelli. Randomized clinical trial comparing 2-octylcyanoacrylate versus intradermic suture with nylon: Similar cosmetic results with different safety profile [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P2-13-20.