1. 1. Sixteen cases with wounds of the ventricles are reported and are presented in two groups. 2. 2. Group one is composed of three patients who were admitted to the hospital with signs of impending death and had short survival periods. 3. 3. Group two is composed of thirteen operative cases with two fatalities. 4. 4. The operative mortality for penetrating wounds of the ventricles is two and one-half times that for penetrating wounds of the brain without ventricular involvement. 5. 5. Intracranial infection was not a factor in any of the deaths. 6. 6. Bilateral and bipolar ventricular wounds usually lead to an early fatal termination.