BackgroundEvidence for widespread comorbidity of executive dysfunctions with psychiatric disorders suggests common mechanisms underlying their pathophysiology. However, the shared genetic architectures between psychiatric disorders and executive functions remain poorly understood. MethodsLeveraging large GWAS datasets of European ancestry on bipolar disorder (BIP, N=353,899), major depressive disorder (MDD, N=674,452), schizophrenia (SCZ, N=130,644) from the Psychiatric Genomics Consortium (PGC) and the Integrative Psychiatric Research (iPSYCH), and a common factor of executive functions (N=427,037) from UK Biobank, we systematically investigated the shared genomic architectures between psychiatric disorders and executive function with a set of statistical genetic, functional genomic, and gene-level analyses. ResultsOur study demonstrated substantial genetic overlaps and significant genetic correlations between psychiatric disorders and executive function. Executive function has an estimated 95.9%, 98.1%, and 99.2% of phenotype-influencing variants, as well as 50, 23, and 130 genomic loci shared with BIP, MDD, and SCZ, respectively. SNP heritability enrichment suggests that genetic architecture of psychiatric disorders and executive function implicate in brain frontal cortex and prefrontal glutamergic neurons 1 (ExPFC1) and ExPFC2. Functional genomic analysis of shared variants identified 12 functional regulatory variants that regulate gene expression by affecting the binding affinities of five transcription factors. Additionally, functional characterization analyses of shared genes revealed potential common biological mechanisms related to synaptic processes and fetal brain development. ConclusionsOur findings provide evidence for extensive shared genetic architectures between psychiatric disorders and executive function and have valuable implications for future mechanistic investigations and drug development efforts.