Significant Component Research Articles

Food Contamination with Micro-plastics: Occurrences, Bioavailability, Human Vulnerability, and Prevention

Abstract: Microplastics (MPs) are emergent environmental contaminants that are designated as either primary or secondary dependent on their origins. Formulation, morphology, dimensions, and colour scheme, along with other features, are connected with their propensity to reach the food webs and their dangers. Whilst ecological adversities of MPs have drawn considerable interest, the hazards to individuals from dietary exposure have yet to be determined. The aim of this review is to gauge existing understanding concerning MPs in foodstuffs and to explore the problems and inadequacies for threat assessment. The prevalence of MPs in foodstuffs and sugary drinks has been detected all over the world, but most researchers judged the existing information to be not only inadequate but also of dubious value, owing to the notable lack of agreement on a regulated quantification methods and a consistent appellation. Most published papers have highlighted potable water and condiments such as sugars, salts, and nectar as significant food components of MPs for humans. The threat assessment reveals significant discrepancies in our understanding of MP toxicity for human consumption, which hinders the estimate of risk-based regulations regarding food safety. The lack of comparators for evaluating MPs food consumption prohibits dietary MPs risk description and risk mitigation. Researchers and Food Safety Administrators confer various obstacles along with possibilities linked to the appearance of MPs in foodstuffs. Further investigation on the MPs categorization and exposures is essential considering that any subsequent threat evaluation record can contain a comprehensive dietary viewpoint.

The multiple facets of the club cell in the pulmonary epithelium.

The non-ciliated bronchiolar cell, also referred to as "club cell", serves as a significant multifunctional component of the airway epithelium. While the club cell is a prominent epithelial type found in rodents, it is restricted to the bronchioles in humans. Despite these differences, the club cell's importance remains undisputed in both species due to its multifunctionality as a regulatory cell in lung inflammation and a stem cell in lung epithelial regeneration. The objective of this review is to examine different aspects of club cell morphology and physiology in the lung epithelium, under both normal and pathological conditions, to provide a comprehensive understanding of its importance in the respiratory system.

Disparity in temporal and spatial relationships between resting-state electrophysiological and fMRI signals.

Resting-state brain networks (RSNs) have been widely applied in health and disease, but the interpretation of RSNs in terms of the underlying neural activity is unclear. To address this fundamental question, we conducted simultaneous recordings of whole-brain resting-state functional magnetic resonance imaging (rsfMRI) and electrophysiology signals in two separate brain regions of rats. Our data reveal that for both recording sites, spatial maps derived from band-specific local field potential (LFP) power can account for up to 90% of the spatial variability in RSNs derived from rsfMRI signals. Surprisingly, the time series of LFP band power can only explain to a maximum of 35% of the temporal variance of the local rsfMRI time course from the same site. In addition, regressing out time series of LFP power from rsfMRI signals has minimal impact on the spatial patterns of rsfMRI-based RSNs. This disparity in the spatial and temporal relationships between resting-state electrophysiology and rsfMRI signals suggests that electrophysiological activity alone does not fully explain the effects observed in the rsfMRI signal, implying the existence of an rsfMRI component contributed by "electrophysiology-invisible" signals. These findings offer a novel perspective on our understanding of RSN interpretation.

Iranian Traditional Medicine (ITM) and Natural Remedies for Treatment of the Common Cold and Flu.

Traditional Iranian medicine is usually used for both prevention and relief of cold and flu symptoms in China, Iran, and many other Asian countries all over the world. There are 4 kinds of influenza viruses. Unlike type B, which may cause seasonal epidemics, type A viruses can cause pandemics, and influenza C may lead to mild human infection with little public health effects. A literature review was done by using multiple databases such as ISI Web of knowledge, PubMed, Science Direct and Google Scholar. The most notable antiviral medicinal plants for flu and cold are honeysuckle flowers, thyme leaf, green chiretta, andrographis, peppermint oil and leaf and calendula. The most important expectorant medicinal plants for cold and flu are snake root, tulsi, licorice root, slippery elm, clove, and sage leaf. Recommended immunostimulant medicinal plants for cold and flu are eucalyptus, Echinacea root, ginseng, garlic, slippery elm, marshmallow, Usnea lichen, Isatis root, ginger root, and myrrh resin. Iranian traditional medicine, which is one of the oldest schools of traditional medicine, is one of the main concepts of disease and health, and it can be considered as an important complementary and alternative medicine, as in some cases, modern medicine has many side effects, low efficiency, and high costs. Medicinal plants and herbs, which are included in many traditional systems, have significant and promising bioactive components in organic life.

Decarbonization of shipping: Hydrogen and fuel cells legislation in the maritime industry

The maritime industry is a significant component of the transportation sector. Ships are the major element of the maritime industry, and propulsion power comes from fossil fuels, such as heavy fuel oil or marine diesel oil. These fossil fuels are used in conventional marine diesel engines and result in high levels of harmful emissions. These emissions contribute to the greenhouse effect and global warming, which is why efforts have been made to regulate and limit them within specific boundaries through various rules and regulations. However, with current technology, it is not possible to stay within these regulations. Therefore, the maritime sector has embarked on the quest for alternative power sources, and as a result, alternative fuels and fuel cells have gained importance. Hydrogen, one of these alternative fuels, is a promising solution with a carbon-free structure for the maritime industry to move toward sustainability. However, ships are considered high-risk areas, which is why specific standards need to be established for the use of hydrogen and fuel cell technology in ships. Hydrogen bunkering, onboard storage, and power system design, limits, and operational aspects must be properly elaborated. Although there are several substantial international standards and regulations for gas, liquid, and dangerous cargo, there is a lack of specific and detailed regulations for the use of fuel cells and hydrogen fuel onboard ships. This paper reviews the relevant regulations and standards while showing the regulatory gap concerning hydrogen and fuel cells by discussing the main barriers and highlights the current and future agenda of the industry toward decarbonization vision.

An adaptive threshold based gait authentication by incorporating quality measures

In this paper, an adaptive threshold-based gait authentication model is proposed, which incorporates the quality measure in the distance domain and maps them into the gradient domain to realize the optimal threshold of each gait sample, in contrast to the fixed threshold, as most of the authentication model utilizes. For accessing the quality measure of each gait, a gait covariate invariant generative adversarial network (GCI-GAN) is proposed to generate normal gait (canonical condition) irrespective of covariates (carrying, and viewing conditions) while preserving the subject identity. In particular, GCI-GAN connects to gradient weighted class activation mapping (Grad-CAMs) to obtain an attention mask from the significant components of input features, employs blending operation to manipulate specific regions of the input, and finally, multiple losses are employed to constrain the quality of generated samples. We validate the approach on gait datasets of CASIA-B and OU-ISIR and show a substantial increase in authentication rate over other state-of-the-art techniques.

A critical review of soil algae as a crucial soil biological component of high ecological and economic significance.

Aero-terrestrial algae are ecologically and economically valuable bioresources contributing to carbon sequestration, sustenance of soil health, and fertility. Compared to aquatic algae, the literature on subaerial algae is minimal, including studies of distinctive habitats such as forest soils, agricultural fields, deserts, polar regions, specific subaerial zones, artificial structures, and tropical soils. The primary goal here was to identify the gaps and scope of research on such algae. Accordingly, the literature was analyzed per sub-themes, such as the "nature of current research data on terrestrial algae," "methodological approaches," "diversity," "environmental relationships," "ecological roles," and "economic significance." The review showed there is a high diversity of algae in soils, especially members belonging to the Cyanophyta (Cyanobacteria) and Chlorophyta. Algal distributions in terrestrial environments depend on the microhabitat conditions, and many species of soil algae are sensitive to specific soil conditions. The ecological significance of soil algae includes primary production, the release of biochemical stimulants and plant growth promoters into soils, nitrogen fixation, solubilization of minerals, and the enhancement and maintenance of soil fertility. Since aero-terrestrial habitats are generally stressed environments, algae of such environments can be rich in rare metabolites and natural products. For example, epilithic soil algae use wet adhesive molecules to fix them firmly on the substratum. Exploring the ecological roles and economic utility of soil and other subaerial algae could be helpful for the development of algae-based industries and for achieving sustainable soil management.

Fungal footprints in oral cancer: unveiling the oral mycobiome.

Oral squamous cell carcinoma (OSCC) is the most common type of head and neck cancer, with a high mortality rate. There is growing evidence supporting a link between oral cancer and the microbiome. The microbiome can impact various aspects of cancer, such as pathogenesis, diagnosis, treatment, and prognosis. While there is existing information on bacteria and its connection to oral cancer, the fungi residing in the oral cavity represent a significant component of the microbiome that remains in its early stages of exploration and understanding. Fungi comprise a minuscule part of the human microbiome called the mycobiome. Mycobiome is ubiquitous in the human body but a weakened immune system offers a leeway space for fungi to showcase its virulence. The role of mycobiome as a colonizer, facilitator, or driver of carcinogenesis is still ambiguous. Reactivating the mycobiome that undergoes collateral damage associated with cancer treatment can be watershed event in cancer research. The coordinated, virulent, non-virulent behavior of the fungi once they reach a critical density must be hacked, considering its diagnostic, prognostic and therapeutic implications in cancer. This review highlights the diversity of the mycobiome and its potential role in oral cancer.

Rainfall as a driver for near-surface turbulence and air-water gas exchange in freshwater aquatic systems.

Gas fluxes from aquatic ecosystems are a significant component of the carbon cycle. Gas exchange across the air-water interface is regulated by near-surface turbulence and can be controlled by different atmospheric forcing conditions, with wind speed and surface buoyancy flux being the most recognized drivers in empirical studies and modeling approaches. The effect of rainfall on near-surface turbulence has rarely been studied and a consistent relationship between rain rate and near-surface turbulence has not yet been established. In this study, we addressed some limitations still present in the quantitative understanding of the effect of rain rate on near-surface turbulence and on the resulting gas transfer velocity in freshwater. We performed controlled laboratory experiments over a wide range of rain rates (7 to 90 mm h-1) and estimated gas transfer velocities from high-resolution measurements of O2 concentration, while rain-induced turbulence was characterized based on particle image velocimetry. We found that the rain-induced dissipation rates of turbulent kinetic energy declined with depth following a consistent power-law relationship. Both energy dissipation rates and gas transfer velocity increased systematically with the rain rate. The results confirm a causal relationship between rainfall, turbulence, and gas exchange. We propose a power-law relationship between near-surface turbulent dissipation rates and rain rate. In combination with surface renewal theory, we derived a direct relationship between gas transfer velocity and rain rate, which can be used to assess the importance of short-term drivers, such as rain events, on gas dynamics and biogeochemical cycling in aquatic ecosystems.

Notoginsenoside R1 alleviates cerebral ischemia/reperfusion injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway through microbiota-gut-brain axis

BackgroundIschemic stroke (IS) ranks as the second common cause of death worldwide. However, a narrow thrombolysis timeframe and ischemia-reperfusion (I/R) injury limits patient recovery. Moreover, anticoagulation and antithrombotic drugs do not meet the clinical requirements. Studies have demonstrated close communication between the brain and gut microbiota in IS. Notoginsenoside R1 (NG-R1), a significant component of the total saponins from Panax notoginseng, has been demonstrated to be effective against cerebral I/R injury. Total saponins have been used to treat IS in Chinese pharmacopoeia. Furthermore, previous research has indicated that the absorption of NG-R1 was controlled by gut microbiota. Study designThis study aimed to access the impact of NG-R1 treatment on neuroinflammation and investigate the microbiota-related mechanisms. ResultsNG-R1 significantly reduced neuronal death and neuroinflammation in middle cerebral artery occlusion/reperfusion (MCAO/R) models. 16S rRNA sequencing revealed that NG-R1 treatment displayed the reversal of microbiota related with MCAO/R models. Additionally, NG-R1 administration attenuated intestinal inflammation, gut barrier destruction, and systemic inflammation. Furthermore, microbiota transplantation from NG-R1 exhibited a similar effect in the MCAO/R models. ConclusionIn summary, NG-R1 treatment resulted in the restoration of the structure of the blood-brain barrier (BBB) and reduction in neuroinflammation via suppressing the stimulation of astrocytes and microglia in the cerebral ischemic area. Mechanistic research demonstrated that NG-R1 treatment suppressed the toll-like receptor 4/myeloid differentiation primary response 88/nuclear factor kappa B (TLR4/MyD88/NF-κB) signaling pathway in both the ischemic brain and colon. NG-R1 treatment enhanced microbiota dysbiosis by inhibiting the TLR4 signaling pathway to protect MCAO/R models. These findings elucidate the mechanisms by which NG-R1 improve stroke outcomes and provide some basis for Panax notoginseng saponins in clinical treatment.

Bioenergy in Europe is unlikely to make a timely contribution to climate change targets

Increasing bioenergy production is a significant component of European efforts to mitigate climate change, but has contested potential for reducing emissions. We use an integrated land system model to explore the effects of large-scale bioenergy production within the European Union on carbon balances. We find that increased bioenergy crop production is likely to cause substantial deforestation and a commensurate loss of associated carbon stocks largely due to displacement of food production from other areas. Deforestation would occur either within the EU if European forests were not protected, or in other parts of the world arising from indirect land use change if European forests were protected. The net carbon benefit of bioenergy production is largely negative, or uncertain, even under the most optimistic levels of fossil fuel replacement, and will not offset initial carbon losses over the coming 50 yr. The growth of intensive agriculture required to satisfy the demand for bioenergy and food will have negative impacts on crucial ecosystem services. Overall, we identify substantial disadvantages to increasing bioenergy production relative to freeing land for natural succession. At best, large-scale bioenergy production is likely to be irrelevant to time-sensitive climate targets.

Metabolite signatures associated with microRNA miR-143-3p serve as drivers of poor lung function trajectories in childhood asthma

Lung function trajectories (LFTs) have been shown to be an important measure of long-term health in asthma. While there is a growing body of metabolomic studies on asthma status and other phenotypes, there are no prospective studies of the relationship between metabolomics and LFTs or their genomic determinants. We utilized ordinal logistic regression to identify plasma metabolite principal components associated with four previously-published LFTs in children from the Childhood Asthma Management Program (CAMP) (n=660). The top significant metabolite principal component (PCLF) was evaluated in an independent cross-sectional child cohort, the Genetic Epidemiology of Asthma in Costa Rica Study (GACRS) (n=1151) and evaluated for association with spirometric measures. Using meta-analysis of CAMP and GACRS, we identified associations between PCLF and microRNA, and SNPs in their target genes. Statistical significance was determined using an false discovery rate-adjusted Q-value. The top metabolite principal component, PCLF, was significantly associated with better LFTs after multiple-testing correction (Q-value=0.03). PCLF is composed of the urea cycle, caffeine, corticosteroid, carnitine, and potential microbial (secondary bile acid, tryptophan, linoleate, histidine metabolism) metabolites. Higher levels of PCLF were also associated with increases in lung function measures and decreased circulating neutrophil percentage in both CAMP and GACRS. PCLF was also significantly associated with microRNA miR-143-3p, and SNPs in three miR-143-3p target genes; CCZ1 (P-value=2.6×10-5), SLC8A1 (P-value=3.9×10-5); and TENM4 (P-value=4.9×10-5). This study reveals associations between metabolites, miR-143-3p and LFTs in children with asthma, offering insights into asthma physiology and possible interventions to enhance lung function and long-term health. Molecular data for CAMP and GACRS via the Trans-Omics in Precision Medicine (TOPMed) program was supported by the National Heart, Lung, and Blood Institute (NHLBI).

Optimization of Lipopeptide Biosurfactant Production with Anti-Inflammatory and Antimicrobial Activities

Background:: Biosurfactants are very important amphiphile compounds due to their interesting advantages such as low toxicity, biodegradability and also their many biological properties. Methods:: In the present study, antimicrobial and anti-imflammatory activities were evaluated to determine the biological proprieties of biosurfactant BLA 2906 produced by Alcaligenes aquatilis YGD 2906 using different assays. Screening and optimization component concentrations in the medium were investigated using PBD and SRM to increase surfactant yield in term emulsification activity value (E24%). Results:: The halos of antifungal activity presented a mean value of 12.33 mm to 17.67 mm. For antibacterial activity, the diameter varied from 10.33 to 12.67 mm with a very important antiinflammatory activity using a protein denaturation method that showed a maximum inhibition of 92.79%. Conclusion:: These results suggest that BLA 2906 may be used as a new therapeutic and antiinflammatory agent. The PBD selected 7 significant components out of the 14 screened. The RSM resulted in the production in terms of emulsification activity of 68.37% in the optimized medium.

Dynamic modeling and characteristics analysis of sliding vane in a high-speed rotary compressor considering groove distribution and multi-body coupling

As one significant component in high-speed rotary compressors, sliding vane undergoes complex motions within the vane slot. The requirements for high-performance compressors result in the applications of low-viscosity lubrication techniques and high working frequency, thus worsening the operation conditions of the vane. To investigate the service performance of the sliding vane, a new tribo-dynamic model considering groove distribution and multi-body coupling is established in this study. Based on the solution with the modified extended backward differentiation formulae (MEBDF), the tribo-dynamic behaviors of the vane-related friction pairs are revealed. After comparison, the optimal scheme of the vane width is determined as 3.188 mm, with which the maximum wear load of the vane slot on the suction side is reduced obviously and the wear volume changes little. With the conical structure scheme of Lcs=1.5mm and hcs=1μm, the maximum wear load of the vane slot can be greatly reduced, thus increasing the wear uniformity. To improve the operation performance of the vane-slot conjunction, the lower suction pressure is suggested. This work provides comprehensive information for manufacturers to understand the working state of the sliding vane and conduct the optimal design.

A human-centred review on maritime autonomous surfaces ships: impacts, responses, and future directions

ABSTRACT Maritime autonomous surface ships (MASS) are transforming the future of maritime transport. They are expected to shoulder important roles in seaborne trade and maritime resilience. As the primary operator of traditional ships and a significant component of maritime transport, seafarers are inevitably directly and indirectly affected by levels of automation introduced into the shipping space. Therefore, in addition to increasing attention to automated system designs, a holistic understanding of human elements in MASS operations is necessary. The current research (1) reviews human-centred MASS research, (2) categorises MASS impacts on seafarers, and (3) summarises responses to prepare seafarers for this emerging technology. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, a total of 101 articles were collected from Scopus. The systematic review reveals that MASS impacts seafarers from the following dimensions: employment, task contents, requisite skills, and human risks. Moreover, regulations and education frameworks can be adapted to respond to changes in seafarer demand and supply. Future research directions are also proposed and can serve as recommendations for future human-centred research on MASS. The research findings enhance the understanding of seafarer elements in MASS operations and provide policy implications for future seafarer management.

Students’ satisfaction and learning experiences at higher agricultural education institutions in Saudi Arabia: an empirical inquest

AimThis study aims to explore various factors that affect students’ satisfaction regarding postgraduate agricultural programs and the likelihood of recommending such programs to others.MethodsData were collected using structured paper-based questionnaires from a random sample of 127 students who were undertaking master and doctoral programs in eight different disciplines within agricultural sciences at King Saud University.ResultsThe findings showed that majority of the students expressed high academic learning experiences and were satisfied with their program of study. Multiple regression analysis revealed that students’ academic learning experience, faculty support, and the rationale for attending the university had significant positive influence on their satisfaction with the enrolled programs. Moreover, the students’ satisfaction and faculty support also showed significant positive correlation with their likelihood to recommend agricultural programs to others.SuggestionsIn order to further enhance the impact of agricultural programs, we suggest improvements in the university curriculum as well as faculty services to make current agricultural programs up-to-date and relevant to meet the kingdom’s national agricultural and human resource development goals. There should be a particular focus on enhancing students’ research and written communication skills as postgraduate agricultural programs entail a significant component of these highly essential skills.

Study of positive value attitude of university students to patriotism

Introduction. In modern conditions, in connection with the active process of integration of states and the internationalization of education, the issues of patriotic education of youth are becoming increasingly important. Patriotism is the main aspect of the sociocultural sphere. It becomes a priority to deeply understand how patriotism is perceived by young people, and how these views can influence the formation of young people’s civic, national identity, their willingness to participate in world initiatives and overcome global challenges. The purpose of the study is to study aspects of the positive value attitude of university students to patriotism and to determine the main levels and criteria for the formation of patriotic values. Materials and methods. The study involved university students in Petrozavodsk (Russia) in the areas of training “Pedagogical education (with two profiles of training) Life Safety and Physical Culture” and “Musicology and Musical Applied Arts” (n=99). Research methods: literature analysis, questionnaires, analysis of student works (essays), methods of descriptive statistics using MS Excel. Results. Within the framework of this study, key aspects are identified that influence students’ positive value attitude towards patriotism, such as: education, family upbringing, socio-cultural environment of the university and regional characteristics. The prevalence of a high level of positive-value attitude towards patriotism with a pronounced socially significant component among students-musicians and a focus on personal significance in the realization of life goals among student teachers is shown. Analysis of the data, according to the general indicator, showed that 61.8% of respondents have a high level of positive value attitude towards patriotism; average – 27.7%; emotional passivity and a low level of attitude towards patriotism are characteristic of 10.5% of respondents. Discussion of results and conclusion. The positive value attitude of university students to patriotism is of great importance in the formation of civic activity, national consciousness and identity. The results of the study confirmed that this is manifested through a positive attitude towards one’s country and its values, promotes active participation in public life, political processes, volunteer events, as well as an understanding of one’s cultural and historical affiliation for the preservation and promotion of cultural heritage and traditions. The scientific novelty of the study lies in the development of diagnostic tools for assessing, forming and adjusting the positive value attitude of students to patriotism in the educational space of the university

Review of Phytosomes and Ethosomes: Groundbreaking Approaches for Delivering the Phytochemical Components of Plants.

Phytoconstituents have been widely used since ancient times to form a complex with phospholipids due to their various therapeutic actions. Despite having strong pharmacodynamic efficiency, numerous phytoconstituents have shown lower in vivo bioavailability and few adverse effects. Phytochemicals soluble in water exhibit poor absorption, leading to a limited therapeutic impact. Phytosome nanotechnology overcomes this limitation by creating a bound of phytochemicals with phospholipids. This method exhibits improved absorption because phytosomes inhibit significant herbal extract components from being degraded by gastric juices and gut flora. This improves bioavailability, increases clinical benefit, and ensures delivery to tissues without compromising nutritional stability. This review also aims to highlight those vesicular systems that could be used in phytosome technology. Additionally, this review highlights the preparation, advantage, characterization, applications, and recent development of phytosome and ethosome with a list of recent patents and marketed formulations and their uses.

Petrography and Heavy Minerals as Tools for Provenance Identification of the Injana Sandstone (Upper Miocene), Al-Habbaniyah City, Anbar Governorate, Iraq

This study deals with the petrography and heavy mineral analysis of the Injana sandstone at Al-Habbaniyah City. Thirteen samples are collected from the Injana Formation. A petrographic study is achieved on ten samples while all samples are analyzed for heavy minerals. The petrographic analysis showed that the common components of the Injana sandstone are rock fragments, especially sedimentary fragments. Quartz grains (monocrystalline and polycrystalline) and feldspars (k-feldspar and plagioclase), bounded by matrix and carbonate cement. The suggested provenance for the Injana Formation is mainly sedimentary and igneous sources and the less dominant metamorphic source. These sandstones are considered to be mineralogically submature-immature and classified as litharenites. Heavy minerals analysis showed two sets of minerals including opaque and transparent minerals, the opaque minerals are significant components of the heavy mineral assemblages, then chlorite, epidotes, amphiboles, garnet, pyroxenes (ortho and clino), zircon, tourmaline, biotite, muscovite, rutile, and others. This assemblage implies that the dense minerals are typically found in basic igneous and metamorphic rocks, with less frequent occurrences in acidic igneous and reworked sediments. According to QLF and QmFLt classifications, the tectonic provenance of the Injana sandstone is described as recycled orogen. The MF-MT-GM classification showed that the sandstone of Injana is derived primarily from active continental margins. The result of maturity MI and ZTR revealed low values of maturity, the MI value ranges between 0.6 to 1.5 with an average of 0.9 and ZTR Maturity ranges between 0.7% and 9% with an average of 3.9%, these low values of maturity indicate sub-mature to immature sandstone.

Improving the methods to assess the investment attractiveness of fast-growing companies

Subject. The article addresses accounting and analytical support for assessing the investment attractiveness of fast-growing companies, having social and economic significance for countries of the world. Objectives. The aim is to improve the accuracy of investment valuation under discounted cash flow method by adding expert adjustments to financial models. Methods. The study employs logical and systems approaches, methods of comparative and investment analysis. A significant stage of the research was building a financial model based on the discounted cash flow method. The results of the study are presented in a tabular form. Results. I formulated my own definition of fast-growing companies, identified specific features of this group of companies that should be taken into account when assessing investment appeal. The paper reveals the main reasons for attractiveness of shares of fast-growing companies for potential investors and possible risks of investing in shares of such issuers, analyzes the dynamics of revenue as a significant component for building an estimation model under the discounted cash flow method, developed a predictive coefficient of revenue dynamics of fast-growing companies, which was used to assess the investment attractiveness of Detsky Mir company. Conclusions. The advantages of using the predictive coefficient of revenue dynamics in the context of assessing the investment attractiveness of fast-growing companies may be a more realistic revenue dynamics, and, therefore, a more conservative outcome of the investment assessment, consideration of the life cycle of fast-growing companies in general and the specifics of sectoral revenue dynamics. Disadvantages include the complexity of calculations to determine the coefficient and the need for statistical database for several subsequent periods.