SERS/ratio-colorimetric/smartphone triple-mode sensing LFIA based on mesoporous silica nanospheres for precise on-site detection of chlorothalonil.

Single-microsphere biosensors based on UiO-66 confinement-enhanced fluorescence emission for sensitive detection of antibiotics and pathogenic bacteria.

Highly sensitive closed-tube detection of alkaline phosphatase based on phosphate-mediated CRISPR/Cas12a regulation.

An ACRCA-microchip integrated with immune-reaction and RCA for trace norovirus antigen detection.

FFA4 inhibits bleomycin-induced pulmonary fibrosis in mice by suppressing IL-33.

Mechanistic insights into persulfate-driven electrochemiluminescence amplification enabled by a Ru@Cu-MOGs/Zr-CeO2-Ag hybrid system.

Cascade catalysis-based signal amplification for colorimetric detection of β-galactosidase activity and its application.

A simple method for enhanced detection of biological analytes is presented. It does not involve temperature cycling or temperatures above 37°C, can easily be integrated into existing protocols and requires only standard equipment. The procedure adds an extra amplification step to classical immunoassays. Oligonucleotide primers attached to antibodies are used for signal amplification and analyte detection. The oligonucleotides serve as primers in a reverse transcriptase (RT) reaction using a soluble complementary template and labeled nucleotides. The DNA strand synthesized is detected using the incorporated labels. Factors such as primer length, amount of labeled ligand, amount of RT activity, type of polymerase used, polymerase reaction time and temperature are explored and optimized to maximize the level of signal amplification. The capacity of the method is exemplified by a comparison between a standard capture ELISA for SARS-CoV-2 spike protein, and a polymerase amplified version of the same test. The increase in detection sensitivity achieved was approximately 70 times.

Loop-recognition dual-hairpin competitive probes enabling a dual-ratiometric electrochemical platform for specific SNP discrimination and logic gate construction.

Rapid self-assembly and signal amplification based on photoactive Z907 for detecting colorectal cancer biomarker vascular endothelial growth factor.

Starfish-like gold nanotags aggregation induced high density hot-spots to boost surface-enhanced Raman scattering signals for ultrasensitive detection of foodborne pathogens.

Biofilm surface proximity-induced branched hybridization chain reaction strategy based on microchip electrophoresis for distinguishing exosomes from different cancer cells.

Potential adoption of electrochemical biosensors for cancer DNA biomarker detection in liquid biopsies: A systematic review.

Luminescent transition metal complexes for functional food quality and safety: Analysis of bioactive constituents and contaminants

A Eu-MOF based ECL biosensor for kanamycin with a ternary heterojunction ZnS-ZnIn₂S₄-In₂S₃ as a co-reaction accelerator and a DNA walker as a signal amplifier

Leptin-driven microglial activation in fibromyalgia: mechanistic insights and therapeutic implications.

The cGAS/STING pathway enables cells to sense cytosolic DNA and mount rapid innate immune responses to infection, cellular stress, and tissue damage. While essential for host defense and immune surveillance, inappropriate or sustained activation of this pathway can drive chronic inflammation, autoimmunity, and disease-associated immune dysfunction, which can promote cancer growth. Effective immunity therefore depends on precise regulatory control that restrains cGAS/STING activity under homeostatic conditions while preserving the capacity for swift and robust responses to diverse danger signals. In this Review, we synthesize emerging principles that regulate cGAS/STING signaling across cellular contexts to control signal initiation, amplification, and termination. We discuss how disruption, persistence, or pathological rewiring of these regulatory processes contributes to immune imbalance across health and disease, promoting chronic inflammation, immunosuppression, and tissue pathology, with particular relevance to tumor progression and therapeutic resistance. Finally, we consider how restoring appropriate cGAS/STING regulation, rather than simply enhancing or inhibiting pathway activity, may reestablish immune homeostasis and improve therapeutic outcomes in cancer and other inflammatory diseases, framing the pathway as a dynamic regulatory circuit rather than a simple linear signaling cascade.

Hepassocin drives EGFR-dependent endothelial atherogenic activation via NOX1/ROS amplification and p38 signaling.

Molecular dissection of pancreatic cancer signaling: Toward targeted therapies for KRAS, MDM2-TP53, EGFR, and PI3K/AKT/mTOR.

PEGDA hydrogel-based biosensor for continuous salivary cortisol monitoring without pre-treatment.