Abstract Background: Patients with advanced cancers face a wide range of physical and psychosocial needs, often dissatisfied by available means of support. As the treatment of metastatic breast cancer (mBC) has evolved and life expectancy increases, it is crucial to identify patient needs throughout the disease trajectory, particularly contrasting the overwhelming experience of diagnosis with the chronicity of ongoing treatment. Methods: From April 2021 to May 2024, adult women with mBC enrolled in the EMBRACE: Ending Metastatic Breast Cancer for Everyone cohort study and treated at the Dana Farber Cancer Institute were invited to complete a survey that assessed quality of life (5-point Emoji Scale, PROMIS Global Health), coping strategies (Brief COPE and SHINE), anxiety (PRO-CTCAE), depression (PHQ-9), and supportive care needs (SCNS-SF34). Following baseline assessment, the survey was repeated after 6 and 12 months. Patients reporting needs related to pain, professional counseling, depressive symptoms or sexual relationships, triggered a question offering to share this information with their clinical team. We summarize baseline survey data with descriptive statistics. Results: Of 81 respondents to baseline surveys, mean age was 58.2 ±8.2 years, 96% were of non-Spanish/non-Hispanic ethnicity and 90% were of Caucasian race. Most patients were diagnosed with recurrent mBC (69.1%) and responded to the baseline survey within 1 year of their mBC diagnosis (44.4%). At the time of baseline survey, 29.6% were receiving treatment with an antibody-drug conjugate, 24.7% with a cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor combined with endocrine therapy, 14.8% with chemotherapy and 14.8% with anti-HER2 therapy; 22.2% were receiving their treatment through a clinical trial protocol. Using the 5-point emoji scale, most (74.1%) patients reported feeling happy (4-5) on the day they completed the survey. At least occasional anxiety (PRO-CTCAE) was reported by 65.8%, and at least mild depressive symptoms (PHQ9) by 50.7%. Prominent coping strategies included acceptance (mean 6.4 ±1.4), self-distraction (5.8 ±1.6), use of emotional support (5.7 ±1.7) and active coping (5.3 ±1.8) and only rarely substance use (2.3 ±0.8. Supportive care needs were expressed in multiple domains; most frequently related to psychological needs (40.8%-73.6% reporting at least some need on an individual domain-related item), and with the highest need reported for “Uncertainty about the future” (8.3% no need – not applicable, 18.1% no need-satisfied, 31.9% some need – low, 25% some need – moderate, 16.7% some need - high). Needs were also reported regarding physical and daily living (30.1-53.5%) and less frequently in relation to sexuality (33.3-19.7%,) health system and information (11.3-35.2%), and patient care and support (11.0-24.7%). Prompts offering to notify the clinical team of high needs were triggered by 55 participants, of which only 20% agreed to share this information. Conclusion: While needs related to information communication and patient cancer are generally met, many patients with mBC report symptoms of anxiety and depression and subsequent psychological needs. Future analyses will aim to identify distinct needs through the disease trajectory. Citation Format: Tal Sella, Shoshana M. Rosenberg, Alyssa R. Martin, Melissa E. Hughes, Elizabeth S. Frank, Simone Buck, Sara Hanna, Sara M. Tolaney, Nancy U. Lin. Longitudinal survey on supportive care needs and coping strategies in women with recurrent/metastatic breast cancer [abstract]. In: Proceedings of the San Antonio Breast Cancer Symposium 2024; 2024 Dec 10-13; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2025;31(12 Suppl):Abstract nr P5-10-07.
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