Objective: We sought to determine whether leg adiposity was inversely associated with hypertension using the 2011-2016 National Health & Nutrition Examination Surveys. Methods: The study included 5,997 non-pregnant adults aged 20-59 who were not taking antihypertensives and did not have self-reported history of cardiovascular disease. Leg adiposity was defined as the percent of total fat mass present in bilateral lower extremities as per dual-energy x-ray absorptiometry (DXA) scans. Leg adiposity was then categorized into two sex-specific groups (low fat %: <34 for male, <39 for female; high fat %: ≥34 for male, ≥39 for female). The outcome was hypertension subtype. Hypertension was defined as BP >130/80, and subtypes included isolated diastolic hypertension (IDH), isolated systolic hypertension (ISH), and systo-diastolic hypertension (SDH). We estimated relative risk ratios (RRR) using multinomial logistic regression, adjusting for covariates (see Table 1 ) and accounting for the complex survey design. Results: Among the 5,997 participants, 2,945 (49%) were female, the average (SD) age was 37.4 (0.3) years, and 1,465 (24%) had hypertension. Those with higher leg fat had 53%, 39%, and 61% lower unadjusted relative odds of IDH, ISH, and SDH, respectively ( Table 1 ). After adjustment, those with higher leg fat had 31%, 24%, and 34% lower relative odds of IDH, ISH, and SDH, respectively. When treating leg adiposity as a continuous variable, higher leg adiposity reduced relative odds of SDH significantly more than ISH ( Table 1 ). Conclusion: A greater proportional distribution of fat around the legs is inversely, independently associated with all hypertension subtypes.