Serum Oxaloacetate Transaminase Research Articles

The Performance of Cihateup Ducks Liver Given Natural Isotonic in Dry Maintenance Systems

This study aims to observe the condition of serum glutamate pyruvate transaminase and serum oxaloacetate transaminase as an illustration of the liver performance of Cihateup Ducks that were given natural isotonic through drinking water in a dry maintenance system. The animals used were Cihateup ducks, kept for 8 weeks with 48 animals and divided into four treatments, namely T0 (Control with drinking water without isotonic), T1 (7% sugar + 2% lime juice + 25 mg celery extract + 0.8 salt g), T2 (7% sugar + 3% lime juice + 50 mg celery extract + 0.9 g salt), T3 (7% sugar + 4% lime juice + 75 mg celery extract + 1 g salt). Each treatment was repeated 4 times, 3 ducks for one treatment plot. This study used a Completely Randomized Design (CRD). Data were tested using analysis of variance and continued with Duncan's further test at 5% level. The results showed that the treatment of T2 (7% Sugar + 3% Lime juice + celery extract 50 mg + 0.9 g salt) significantly produced the lowest SGPT levels and seen a tendency for SGOT to decrease but not significantly. The use of natural isotonic solutions can be given to Cihateup ducks on dry system maintenance. Keywords: Cihateup’s duck, Dry system, Natural isotonic, SGOT, SGPT

ROLE OF OCIMUM CANUM IN PREVENTION OF REPERFUSION-INDUCED RENAL ISCHEMIA IN WISTAR ALBINO RATS

Acute renal failure is defined as rapid loss of renal function and has been associated with a high mortality rate. Ischemia and reperfusion (I/R) injury of the kidney is the most prominent cause of intrinsic acute renal failure. Activation of reactive oxygen species is implicated in renal ischemia/reperfusion (I/R) injury. This study investigated the anti-ischemic effect of hydro-alcoholic leaf extract of Ocimum canum (OC) against renal I/R injury by its effect on reactive oxygen species. Wistar albino rats were administered different doses of hydro-alcoholic leaf extract of Ocimum canum (OC) before renal ischemia, followed by reperfusion for 24 hours. Serum creatinine, Serum Cystatin C, serum oxaloacetate transaminase (SGOT), serum pyruvate transaminase (SGPT), blood urea nitrogen (BUN) and Lactate dehydrogenase (LDH) were measured for renal dysfunction. Serum and tissue Malondialdehyde (MDA), reduced glutathione (GSH) levels, catalase (CAT), and superoxide dismutase (SOD) levels were measured. Renal sections were analyzed for histological grading of renal injury. Hydro-alcoholic leaf extract of Ocimum canum (OC) significantly reduced increased creatinine, Cystatin C, serum oxaloacetate transaminase (SGOT), serum pyruvate transaminase (SGPT), blood urea nitrogen (BUN) and Lactate dehydrogenase (LDH). Ocimum canum also increased kidney superoxide dismutase activity, catalase and reduced glutathione levels and reduced the malondialdehyde levels. Hydro-alcoholic leaf extract of Ocimum canum reduced histological renal damage. These results suggest that the hydro-alcoholic leaf extract of Ocimum canum reduces renal dysfunction and injury caused by renal I/R.

Protective effects of interleukin-6 in lipopolysaccharide (LPS)-induced experimental endotoxemia are linked to alteration in hepatic anti-oxidant enzymes and endogenous cytokines

Endogenous interleukin-6 has been considered as an important anti-inflammatory cytokine controlling both local and systemic acute inflammatory responses; the usefulness of IL-6 in endotoxemia aiming to block the production of reactive oxygen species and the release of inflammatory cytokines is under discussion The aim of the study was to evaluate the protective effects of IL-6 in experimentally induced endotoxemia in mice correlating the changes in tissue anti-oxidant enzymes and circulating cytokines. Liver injury in low-dose bacterial lipopolysaccharide (5 μg/mouse)-induced endotoxemic mice receiving IL-6 (300 ng/mouse) treatment either before or after LPS injection was detected by the estimation of serum oxaloacetate transaminase and serum glutamate pyruvate transaminase. This finding supports that liver injury during experimental endotoxemia could be lowered by IL-6. Current data also demonstrate the critical role of IL-6 in inducing SOD in liver, whereas IL-6 prior and after LPS challenge group showed reduced PMN infiltration in the liver as evident by decreased hepatic MPO content in those mice. IL-6 treatment also showed higher IL-10 production in serum than endotoxic group as IL-10 is a potent and pleiotropic anti-inflammatory cytokine that inhibits the synthesis of pro-inflammatory cytokines and also has a suppressive effect on pro-inflammatory cytokine like TNF-α, IFN-γ and IL-12. It is also directly involved in the modulation of other aspects of inflammation, particularly cytokine responses and inflammatory cell infiltration.

Serum oxaloacetic transaminase levels following renal infarction. Report of a case and experimental observations following ligation of the renal arteries.

Serial determinations of serum glutamic-oxaloacetic transaminase (SGO-T) were recorded during the entire course of a patient, a woman 51 years of age. who survived unilateral renal arterial infarction. SGO-T levels were also studied in 10 dogs with surgically induced renal infarctions. The values rose to a maximum on the first day after infarction and returned to normal by the third day. The maximum elevations ranged from 62 to 155 units per milliliter.

Serum oxaloacetic transaminase activity in acute rheumatic fever; values in cases with and without salicylate therapy.

Serum glutamic oxaloacetic transaminase activity is frequently elevated in the presence of acute tissue damage 5,6 and has been found to be elevated in acute rheumatic fever. 4 Determination of this enzyme might, therefore, be helpful in the diagnosis of acute rheumatic fever and in the evaluation of the presence and severity of rheumatic carditis. In order to define more clearly the value of such determinations, patients with rheumatic fever have been studied during their acute and convalescent periods by relating serum glutamic oxaloacetic transaminase (SGOT) activity to the results of certain other laboratory tests and to the clinical status of the patient. Elevation of serum glutamic oxaloacetic transaminase has also been found during the course of salicylate administration. 7 In this study, specific attention has been given to the relationship of salicylate and cortisone therapy to the serological studies and clinical status of the patient. Methods Eighteen patients selected