Multifunctional bacterial consortium degrading phthalates, promoting plant growth and inhibiting soil-borne pathogenic fungi.

Methodological approaches for identifying rhizosphere bacteria and fungi: A systematic review of comparative insights and best practices

Exosomal lncRNA ENSSSCG00000049656 regulates porcine oocyte maturation via the ssc-miR-500-3p/EGLN2 axis.

Metabarcoding analysis of eukaryotic microalgae communities in the surface sediments of an integrated multi-trophic aquaculture zone.

Electric field as a priming trigger reshaping redox network for synergistic perfluorooctanoic acid degradation and humus synthesis during aerobic composting.

tRF-1432 orchestrates RBMS1-IMPDH2 regulatory control to drive purine-dependent chemoresistance in breast cancer.

ASIC1a promotes alveolar epithelial apoptosis and acute lung injury through repression of the LncRNA00178/miR-466b-3p/Gucy1b1 ceRNA network.

Inter-domain microbial collaboration drives sulfamethoxazole in situ biodegradation in lake sediments.

Over the past several decades, cure rates for paediatric hematologic malignancies have improved due to advances in cancer therapy. However, numerous obstacles limit the therapeutic efficacy of paediatric solid tumours, including the tumour's immunosuppressive microenvironment and the lack of specific tumour antigens for targeted therapy. Cancer vaccines, a form of immunotherapy, have been under development for more than half a century. Advances in immunology, materials science, sequencing technologies and bioinformatics have revolutionised cancer vaccine development, achieving substantial success in the prevention and treatment of solid tumours. Despite these achievements, the application of cancer vaccines developed for adults is not fully transferable to paediatric solid tumours because of differences in immune status and metabolic capacity. In clinical practice, most solid tumour vaccines designed for adults are applied directly to paediatric patients without modifications tailored to the unique features of the paediatric immune system. Limited attention has been given to designing cancer vaccines with improved efficacy and reduced toxicity for children and infants. This review discusses paediatric solid tumour vaccines from the immune system against tumour to different antigen types of cancer vaccines, illustrating the unique cancer-immunity cycle of young people and some potential strategies for vaccine modification. Additionally, it discusses the application of paediatric solid tumour vaccines through clinical trial data for conditions such as neuroblastoma, brain tumours and sarcomas. Challenges and potential solutions for enhancing vaccine efficacy, minimising side effects and broadening clinical applications are also addressed.

Diminazene attenuates astrocytic oxidative stress and neuronal ferroptosis via miR-10b-3p/NOX4 axis in Alzheimer's Disease Model.

Molecular and histopathological insights into renal neuroendocrine tumors (RenNETs): A comprehensive study.

Triazine-induced extracellular polymeric substance disruption drives metabolic reprogramming and enhanced volatile fatty acid production in anaerobic sludge fermentation.

Concentrated Angelica sinensis pills ameliorate ovarian insufficiency by promoting vascular remodeling via inhibiting CYP1B1/ACSL4-mediated ferroptosis.

Multiplex amplicon sequencing reveals polyclonality and low macrolide resistance in the French Mycoplasma pneumoniae outbreak, 2023-2024.

Solid waste dumping differentially impacts soil prokaryotic, fungal, and viral communities: Insights from metagenomics.

Metabolomics and transcriptomics uncover spatial regulation of flavonoids in Belamcanda chinensis (L.) Redouté rhizome endodermis.

Elucidation of the fungal community composition and quality of medium-high temperature Daqu: A study based on second-generation sequencing and electronic sensor technologies

Impact of readily biodegradable chemical oxygen demand on partial nitritation granules under high-salinity continuous-flow conditions.

Overexpression of the Cry1Ac in two poplar species can effectively inhibit Hyphantria cunea.

The immunomodulatory effects of intratumoral microbiota on tumor initiation, progression, and metastasis: From understanding to therapy.