With the challenges of the energy crisis and related environmental issues, the development and utilization of renewable energy have become a mandatory requirement for the sustainable development of modern society. Recently, triboelectric nanogenerators (TENGs) have been widely utilized in renewable energy sources harvesting, such as solar power, wind power, hydropower and so on. Here, a wheel-disk-shaped TENG based on natural pollution-free cotton is reported for simultaneously harvesting wind and water energy. 8.9 µA of short-circuit current and 782 V of open-circuit voltage are obtained by cotton assemble triboelectric nanogenerator (C-TENG) under a rotation speed of 210 r/min. The maximum peak power can reach 1.89 mW at a matched load resistance of 330 MΩ. Moreover, C-TENG can be used as a self-powered system to power electronic devices and sensing wind speed. This work not only presents a feasible solution for sustainable and clean energy harvesting, but also provides a reliable self-powered sensor for environmental monitoring.