Senior Research Scientist Research Articles

Bioluminescent AMP Detection

Genetic Engineering & Biotechnology NewsVol. 33, No. 15 TutorialBioluminescent AMP DetectionHomogeneous, Sensitive Assay to Monitor AMP in Diverse Biochemical ReactionsSaid A. Goueli, Kevin Hsiao, and Hicham ZegzoutiSaid A. GoueliSaid A. Goueli, Ph.D. (E-mail Address: said.goueli@promega.com), is research fellow, Kevin Hsiao is senior research scientist, and Hicham Zegzouti, Ph.D., is senior research scientist at Promega. Website: www.promega.com.Search for more papers by this author, Kevin HsiaoSearch for more papers by this author, and Hicham ZegzoutiSaid A. Goueli, Ph.D. (E-mail Address: said.goueli@promega.com), is research fellow, Kevin Hsiao is senior research scientist, and Hicham Zegzouti, Ph.D., is senior research scientist at Promega. Website: www.promega.com.Search for more papers by this authorPublished Online:3 Sep 2013https://doi.org/10.1089/gen.33.15.10AboutSectionsView articleView Full TextPDF/EPUB Permissions & CitationsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail View articleFiguresReferencesRelatedDetails Volume 33Issue 15Sep 2013 Information© 2013 by GEN PublishingTo cite this article:Said A. Goueli, Kevin Hsiao, and Hicham Zegzouti.Bioluminescent AMP Detection.Genetic Engineering & Biotechnology News.Sep 2013.24-24.http://doi.org/10.1089/gen.33.15.10Published in Volume: 33 Issue 15: September 3, 2013PDF download

An interview with Aljosa Smolic

Dr. Aljosa Smolic joined Disney Research Zürich, Switzerland in 2009, as Senior Research Scientist and Head of the "Advanced Video Technology" group. Before he was Scientific Project Manager at the Fraunhofer Institute for Telecommunications, Heinrich- Hertz-Institut (HHI), Berlin, also heading a research group. He has been involved in several national and international research projects, where he conducted research in various fields of video processing, video coding, computer vision and computer graphics and published more than 100 refereed papers in these fields. In current projects he is responsible for research in 2D video, 3D video and free viewpoint video processing and coding.

Advances in Electrospun Functional Nanofibers

Advances in Electrospun Functional Nanofibers

Why the Internet is More Attractive than the Library

Lynn Silipigni Connaway, Ph.D., Senior Research Scientist at OCLC Research, discussed results of her research of library user information-seeking behavior and user attitudes toward the library. She discovered that while students and researchers are confident in their own ability to find and use information, information literacy has not kept pace with digital literacy and there is a need for education and support. These findings have implications for librarians and the development of library services to make libraries more relevant today.

Satellite instrument provides nighttime sensing capability

“This is not your father's low‐light sensor,” Steve Miller, senior research scientist and deputy director of the Cooperative Institute for Research in the Atmosphere at Colorado State University, Fort Collins, said at a 5 December news briefing at the AGU Fall Meeting. He and others at the briefing were showing off the nighttime sensing capability of the day/night band of the Visible Infrared Imaging Radiometer Suite (VIIRS) of instruments onboard the Suomi National Polar‐orbiting Partnership (NPP) Earth‐observing research satellite, a joint NASA and National Oceanic and Atmospheric Administration (NOAA) satellite that was launched on 28 October 2011. Noting that low‐light satellite technology has been available for about 40 years, Miller said that the VIIRS day/night band “is truly a paradigm shift in the technology and capability.”

Temperature Jump Phenomenon During Plasmatron Testing of ZrB2-SiC Ultrahigh-Temperature Ceramics

U LTRAHIGH temperature ceramic (UHTC) materials containing hafnium diboride (HfB2) and zirconium diboride (ZrB2) with a silica former, most commonly silicon carbide (SiC), have been studied extensively over the last decade as materials for leading-edge and control surface components on hypersonic vehicles [1–3]. Such components experience extreme aerothermal heating in chemically aggressive, partially dissociated air environments. Promising aspects of diboride-based UHTC materials include the very high melting points of HfB2 and ZrB2 and their refractory oxides hafnia (HfO2) and zirconia (ZrO2), as well as the high thermal conductivities of HfB2 and ZrB2, which enables efficient heat conduction away from stagnation point regions [4]. Zirconium diboride has some advantages over hafnium diboride as an aerospace material, because it is lighter and less expensive. The oxidation of ZrB2 produces both zirconia and boron oxide (B2O3). Significant oxidation of ZrB2 in atmospheric air begins at about 1050 K. The softening temperature for amorphous B2O3 is in the range of 830–900 K [5]; below about 1500 K, the oxide scale consists of a porousZrO2 network filled with liquidB2O3 that acts as an effective oxygen diffusion barrier [6,7]. However, the vapor pressure of B2O3 increases rapidly with temperature [8], resulting in rapid loss of B2O3 above 1500 K. The residual porous zirconia scale provides little resistance to inward oxygen transport and further oxidation [9,10], making the oxidation resistance of pure ZrB2 insufficient for high-temperature hypersonic vehicle applications. The addition of a silica former to ZrB2 improves its oxidation resistance [11–14]. Compositions containing from 10 to 30% (by volume) SiC have generally been found to be optimal in this regard. The virgin ZrB2-SiC surfaces oxidize through parallel reactions that generate ZrO2,B2O3, and SiO2. LiquidB2O3 mixes with amorphous SiO2 to form a borosilicate glass that seals the ZrO2 scale [15]. With increasing temperature, boron oxide evaporates preferentially from Received 10 August 2011; revision received 13 February 2012; accepted for publication 19 February 2012. Copyright © 2012 by the American Institute of Aeronautics and Astronautics, Inc. The U.S. Government has a royalty-free license to exercise all rights under the copyright claimed herein for Governmental purposes. All other rights are reserved by the copyright owner. Copies of this paper may be made for personal or internal use, on condition that the copier pay the $10.00 per-copy fee to the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923; include the code 0887-8722/12 and $10.00 in correspondence with the CCC. ∗Senior Research Scientist, Molecular Physics Laboratory, 333 Ravenswood Avenue; jochen.marschall@sri.com. Senior Member AIAA (Corresponding Author). Research Physicist, Molecular Physics Laboratory, 333 Ravenswood Avenue. Member AIAA. Professor, Department ofMaterials Science andEngineering, 223McNutt Hall; billf@mst.edu. Professor, Department ofMaterials Science andEngineering, 223McNutt Hall; ghilmas@mst.edu. Ph.D. Candidate, Aeronautics and Aerospace Department. Chaussee De Waterloo 72; panerai@vki.ac.be. ∗∗Associate Professor, Aeronautics and Aerospace Department, Chaussee De Waterloo 72; olivier.chazot@vki.ac.be. JOURNAL OF THERMOPHYSICS AND HEAT TRANSFER Vol. 26, No. 4, October–December 2012

Arctic Sea ice at a new low

On 26 August, Arctic sea ice cover dipped to 4.1 million square kilometers, 70,000 square kilometers below the 2007 mark, which was previously the lowest extent of ice cover in the satellite record, according to an analysis of satellite data by scientists with NASA and the National Snow and Ice Data Center (NSIDC) of the University of Colorado, Boulder. “By itself it's just a number, and occasionally records are going to get set. But in the context of what's happened in the last several years and throughout the satellite record, it's an indication that the Arctic sea ice cover is fundamentally changing,” said NSIDC scientist Walt Meier. “The persistent loss of perennial ice cover—ice that survives the melt season—led to this year's record summertime retreat. Unlike 2007, temperatures were not unusually warm in the Arctic this summer,” said Joey Comiso, senior research scientist at NASA's Goddard Space Flight Center, in Greenbelt, Md. The six lowest ice extents in the satellite record have occurred in the last 6 years, according to NSIDC.

510TiP - Dendritic Cell Therapy for Patients with Refractory Solid Tumours

ABSTRACT Background Dendritic Cell (DC) therapy initiates immune response against tumor. Study ongoing in 7 sites in India has objective to assess toxicity and efficacy in refractory solid tumours. Materials DC therapy is prepared using Peripheral Blood Mononuclear Cells (PBMCs), cultured with cytokines (IL4 and GMCSF) and exposed to patient's antigen retrieved from their own tumor tissue. Mature DCs are harvested on Day 8 and checked for surface markers (CD 80 + (PE)CD 86+ (APC) and CD 83 + ( FITC) positive) and adequate counts (>1 million DCs) per dose. Patients with recurrent disease on symptomatic care were enrolled and 6 doses of DC were administered over 14 week's period. Response criteria used are RECIST-version 1.1 (Response Evaluation Criteria for Solid Tumours) and irRC (Immune Related Response Criteria). Per protocol, Objective Response (OR) covers Stable Disease (SD), Partial Response (PR) and Complete Response (CR). Results and observations 51 patients (ovary-9, colon and rectum- 7, head & neck -6, lung-5, Prostate- 5, sarcoma-4, breast-4, stomach-3, cervix-3, squamous cell carcinoma of heel-1, pancreas-1, melanoma-1, renal cell-1 and Cholangiocarcinoma-1) were enrolled and evaluated for safety. 220 infusions have been completed. All patients tolerated therapy well except one who had single episode of rigors during one infusion. Other adverse events reported were due to disease progression. Response assessment was done at Week 8 (before dose 4), Week 14 (before dose 6) and Week 26 from start of therapy. 33 patients' Week 8 assessment is 22/33 (67%) OR by irRC and 9/33 (27%) by RECIST. Among OR, 1 shows PR for 2 consecutive visits. 20 patients' Week 14 assessment is 9/20 (45%) continuing with OR by irRC and 6/20 (30%) are OR by RECIST. Trends suggest patients with chronic disease (average period of disease of 45 months), less metastatic sites, fewer prior chemotherapy failure and cancers like ovary, prostate and breast, have responded well. 19 patients are on trial, 6 are alive after withdrawal and are being followed up for survival and 26 died due to disease progression. Survival data is yet to mature. Conclusions DC therapy is safe and extremely well tolerated. The response data is encouraging. More survival data is needed to conclude survival benefit. Disclosure P.P. Bapsy: I am medical monitor for the study (consultant), involved with the study design, scientific inputs and safety monitoring aspects of the study. I am being paid a monthly professional fee for this activity. B. Sharan: I work for APAC Biotech (sponsor) as Research Director in the R & D Department and am being paid my monthly salary. C. Kumar: I work as Asst Director R & D for the sponsor APAC Biotech Pvt. Ltd. I get mothly salary for my job. A. Mahmood: I work as Senior Research Scientist in the R&D Department of APAC Biotech Pvt. Ltd and get my monthly salary. B. Rangarajan: I am Investigator for the trial and being compensated for my role as Clinical Research Investigator. S. Atilli: I am Investigator for the trial and being compensated for my role as Clinical Research Investigator. M. Jain: I am Investigator for the trial and being compensated for my role as Clinical Research Investigator. S. Subramanian: I am Investigator for the trial and being compensated for my role as Clinical Research Investigator. S. Rajappa: I am Investigator for the trial and being compensated for my role as Clinical Research Investigator. M. Srivastava: I am providing advisory consultancy to APAC Biotech Pvt. Ltd for study operations and being paid professional fees.

Foundation News

For five years now, the Jackson School of Geosciences at the University of Texas at Austin has provided a first-class, unique marine field camp experience. The field course was designed by lead instructor and research scientist Sean Gulick, who got the idea for the field course after Mead Allison, school associate director and senior research scientist, arrived at the Jackson school with equipment. Gulick, who was already working with the Jackson School's existing equipment, realized that the department now had enough equipment to start teaching students through hands-on experience. “The best way to teach is to get out in the field, process, and interpret,” Gulick said.

Contributors

Contributors

Dr. Denis O. Krause

Dr. Denis O. Krause passed away on October 16, 2011, at his home surrounded by his family. Denis was Professor of Gut Microbiology in the Department of Animal Science with a cross-appointment in the Department of Medical Microbiology at the University of Manitoba. Denis was born in Johannesburg, South Africa, on January 24, 1965. In 1988, he received his B.Sc. at the University of Stellenbosch in South Africa. Denis obtained his Master’s and Ph.D. degrees from theUniversity of Illinois in 1990 and 1994, respectively. Subsequently, he was a Postdoctoral Scientist in Microbiology at Cornell University. In 1996 he moved to Australia, where he was employed as a Research Scientist at CSIRO Livestock Industries until 2000, when he was promoted to Senior Research Scientist. In 2003 he obtained the position of Assistant Professor in the Department of Animal Science at the University of Manitoba. He was promoted to Associate Professor in 2006 and to Full Professor in 2010. Denis had a very active, well-funded and internationally recognized research program. His expertise in gut microbiology greatly improved the understanding of the movement of pathogens in the farm ecosystem, identified solutions to stressors in the animal’s intestinal tract, mitigated food safety issues, and contributed to several medical science networks focused on the etiology and prevention of inflammatory bowel disease in humans. He emphasized the need for stronger linkages between animal agriculture and medicine as a means of advancing food safety. He established successful research networks in swine gut microbiology and rumen microbiology that stretch across Canada and internationally. During the last six years alone, he supervised five post-doctoral fellows, eight Ph.D., eight M.Sc., and numerous undergraduate students as well as technical staff. He served on committees for 16 Ph.D. and M.Sc. students. Many of these individuals have been recognized through NSERC postgraduate and industry awards, and have gone on to discipline-related positions as academics, scientists and experts within government. He authored or co-authored over 85 peer-reviewed publications, as well as numerous book chapters and abstracts. He edited the book on ‘‘Zoonotic pathogens in the food chain’’ that was published in 2010. In 2011, he received the prestigious award for ‘‘Technical Innovation in Enhancing Production of Safe Affordable Food’’ from the Canadian Society of Animal Science. He was an active member of the Canadian Society of Animal Science, the Crohn’s and Colitis Foundation of Canada, and the American Society for Microbiology. Denis served on the scientific advisory boards of the Canadian Johne’s Disease Network and the International Committee for the Nutrition of Herbivores, and on the Committee for Genomes, Environment, and Microbes of the Crohn’s and Colitis Foundation of Canada. In addition, he was Section Editor for Microbiology for Inflammatory Bowel Diseases. Next to his work, Denis, had many interests, including sports, travel, history, and reading. No day was too cold for him to go running. He most enjoyed spending time with his three sons. Denis was diagnosed with a serious disease early in 2011. He fought this disease bravely, while continuing his research and teaching. He will be greatly missed by his family, friends, colleagues, and students, and leaves a great void. Denis is survived by his wife Alice, and his sons David, Jonathan and Joshua. In memory of Denis, donations may be made to the Krause Family Education Fund at any branch of the Steinbach Credit Union, in Manitoba. Dr. Denis O. Krause

New Award to Recognize Outstanding Research in Space Weather and Nonlinear Waves and Processes

In early 2013, AGU will begin accepting nominations for a new award that recognizes excellence in research involving space weather as well as nonlinear waves and processes. The award, called the Space Weather and Nonlinear Waves and Processes Prize, will be given every 2 years and will alternate in focus. The first award, to be presented at AGU’s 2013 Fall Meeting, will recognize an outstanding contribution to space weather research made by an AGU member; the second award, to be presented in 2015, will recognize a significant contribution to the field of nonlinear waves and processes by an AGU member. AGU’s Space Physics and Aeronomy Section and the Nonlinear Geophysics Focus Group, will jointly administer the award. The prize carries a $10,000 cash award and is funded by Bruce Tsurutani and Olga Verkhoglyadova, both AGU members and scientists at the NASA/California Institute of Technology’s Jet Propulsion Laboratory (JPL). “The vital research being done in the areas of space weather and nonlinear waves and processes has all too often gone unrecognized and unrewarded by the scientific community,” Tsurutani said. “These are two emerging areas of science, and we would very much like to support their gaining prominence, both in public awareness and also in recognition. We felt an AGU award would do both of these things at the same time.” “Space Weather and nonlinear wave processes are currently at the forefront of space physics,” Verkhoglyadova added. “We hope that this award will help to support and promote research in these fields.” Tsurutani explained that hopefully the awards will help the recipients’ careers. and, in turn, “will spur them on to even greater discoveries. Perhaps it may even stimulate graduate students to go into these areas,” he added. Tsurutani and Verkhoglyadova were motivated to create the award as a way of giving back to the scientific community and to AGU. An AGU member for nearly 50 years, Tsurutani has been affiliated with JPL since 1972 and is currently a senior research scientist at the laboratory. He served as president of AGU’s Space Physics and Aeronomy section from 1990 to 1992 and in 2009 received AGU’s John Adam Fleming Medal, given for “original research and technical leadership in geomagnetism, atmospheric electricity, aeronomy, space physics, and related sciences.” Before coming to JPL in 2008, Verkhoglyadova worked for 5 years at the Institute for Geophysics and Planetary Physics at the University of California, Riverside. Before that, she was a professor in the Department of Astrophysics and Space Physics at Ukraine’s Kiev University, working on the Interball satellite project, a multinational collaboration to study magnetospheric physics, plasma waves and space weather. While the first award will be for space weather research, the next award in the prize cycle will highlight nonlinear waves and processes, which are not exclusive to space physics and aeronomy. “This goes to all areas of geophysics. For example, ocean waves become nonlinear as they approach shorelines. An earthquake also is a nonlinear process,” explained Tsurutani, who is also an editor of Nonlinear Processes in Geophysics, an open access journal jointly published by AGU and European Geosciences Union. Nonetheless, he and Verkhoglyadova expect space physics to be well represented in the award’s nonlinear geophysics focus. “Most plasma waves that we study are indeed nonlinear,” Tsurutani noted, listing phenomena such as magnetosheath lion roars, mirror mode structures, magnetospheric chorus and magnetosonic waves, plasma bubbles in the ionosphere, and interplanetary shocks and Alfven waves. This new award strongly supports AGU’s mission to promote discovery in the Earth and space sciences for the benefit of humanity, according to Carol Finn, AGU president-elect. “We are extremely grateful to Dr. Tsurutani and Dr. Verkhoglyadova,” she noted. “Through their dedication and generosity we are able to recognize the extraordinary contributions of our members and their impact on society.” More details on the award, including nomination criteria, can be found at http://www.agu.org/about/honors/ section_fg/joint_pr.shtml.

New Space Weather and Nonlinear Waves and Processes Prize announced for 2013

At the 2011 Fall Meeting in San Francisco, Calif., AGU announced the creation of a new award: the Space Weather and Nonlinear Waves and Processes Prize. The prize, which is being made possible by a generous contribution from longtime AGU members and NASA Jet Propulsion Laboratory (JPL), California Institute of Technology, scientists Bruce Tsurutani and Olga Verkhoglyadova, will recognize an AGU member scientist and will come with a $10,000 award. Tsurutani has served as a researcher with JPL since 1972 and is currently a senior research scientist. He was also the president of AGU's Space Physics and Aeronomy section from 1990 to 1992 and is a recipient of AGU's John Adam Fleming Medal, given “for original research and technical leadership in geomagnetism, atmospheric electricity, aeronomy, space physics, and related sciences.” Verkhoglyadova served as a professor of space physics in the Department of Astrophysics and Space Physics at Taras Shevchenko National University of Kyiv, in the Ukraine, prior to coming to the United States. Their leadership and dedication to AGU and to their field are apparent in their passion for this prize.

Eating Disorder Finding May Be Prevention Road Map

Back to table of contents Previous article Next article Clinical & Research NewsFull AccessEating Disorder Finding May Be Prevention Road MapJoan Arehart-TreichelJoan Arehart-TreichelSearch for more papers by this authorPublished Online:4 Nov 2011https://doi.org/10.1176/pn.46.21.psychnews_46_21_18_1AbstractBody dissatisfaction appears to be the major factor propelling young people on the road to eating disorders, an eight-year prospective study of adolescent girls suggests. Credit: Suzanne Tucker/ShutterstockThe study was headed by Eric Stice, Ph.D., a senior research scientist at Oregon Research Institute. The results were published in the October Behavior Research and Therapy. The research by Stice and his team "provides a sort of roadmap for prevention interventions," Michael Devlin, M.D., clinical codirector of eating disorders research at the New York State Psychiatric Institute, commented to Psychiatric News. "Preventing the onset of eating disorders among those at risk is certainly preferable to intervening only after the disorders have become established."The cohort in Stice's study included more than 400 middle-school girls with an average age of 14 who were recruited from four public schools and four private schools in the Austin, Texas, area.They were evaluated at baseline with a number of instruments designed to measure putative eating disorder risk factors—perceived sociocultural pressure to be thin, thin-ideal internalization, body dissatisfaction, dieting practices, negative affectivity, and depressive symptoms. Semi-structured interviews were used to evaluate the subjects annually throughout the study for three DSM-IV eating disorders—anorexia nervosa, bulimia nervosa, and binge eating disorder—as well as for subthreshold versions of these disorders and for what the researchers dubbed "purging disorder" in which an individual had to have engaged in self-induced vomiting or diuretic/laxative use for weight control purposes at least eight times a month for three months. By the end of the study, three subjects had developed anorexia nervosa, three subthreshold anorexia nervosa, six bulimia nervosa, 26 subthreshold bulimia nervosa, five binge eating disorder, 21 subthreshold binge eating disorder, and 22 purging disorder. Body dissatisfaction emerged as the most potent predictor of development of an eating disorder. Subjects in the upper 24 percent of the body dissatisfaction measurement showed a fourfold increase in the incidence of an eating disorder relative to all those with lower dissatisfaction scores—24 percent versus 6 percent.Furthermore, among the subjects in the high body dissatisfaction category, those in the upper 32 percent of depressive symptoms showed a threefold increased incidence of eating disorder relative to all those with lower depression scores—43 percent versus 15 percent.And among the participants in the low body dissatisfaction category, those in the upper 12 percent of dieting showed a fourfold increased incidence of eating disorder relative to all those with lower dieting scores—18 percent versus 5 percent."This three-way interaction suggests a body dissatisfaction pathway to eating-disorder onset that is amplified by depressive symptoms, as well as a pathway characterized by self-reported dieting among young women who are more satisfied with their bodies," Stice and his colleagues concluded in their paper."These results are novel because no prospective study has investigated risk factors for onset of any eating disorder during the entire period of adolescence or tested for interactions among risk factors," they noted.The researchers hope the results will "allow clinicians to identify youth at greatest risk for eating pathology, which can be a challenge because of the low incidence of these conditions. . . . The findings suggest that a brief body-dissatisfaction scale is the most sensitive method of identifying adolescent females at risk for onset of any eating disorder." But one also needs to keep in mind that even low body dissatisfaction accompanied by dieting is a risk factor. And the results, they pointed out, might also assist in the design of eating disorder prevention programs that target key vulnerability factors. They have designed a brief eating disorder prevention program for young women who are determined to pursue thinness regardless of what the mental or physical costs might be. Participants engage in verbal, written, and behavioral exercises designed to produce cognitive dissonance—that is, conflict between thin-ideal messages and the participants' underlying values and beliefs—and this cognitive dissonance is hoped to change participants' minds about wanting to be thin. "The program is being implemented by various organizations in the United States and several foreign countries," Stice told Psychiatric News. "The largest is Tri Delta Sorority, which is disseminating a version of this program … for sorority members."The study was funded by the National Institutes of Health.An abstract of "Risk Factors for Onset of Eating Disorders: Evidence of Multiple Risk Pathways From an Eight-Year Prospective Study" is posted at <www.sciencedirect.com/science/article/pii/S0005796711001306>. ISSUES NewArchived

A Hybrid Approach to Combining CART and Logistic Regression for Stock Ranking

1. Min Zhu 1. is a Ph.D. candidate in finance at the Business School of the University of Sydney in Sydney, NSW, Australia, and a researcher at CSIRO Mathematics, Informatics, and Statistics in North Ryde, NSW, Australia. (minz{at}econ.usyd.edu.au) 2. David Philpotts 1. is a fund manager in the QEP Global Equities Team within Schroder Investment Management based in Sydney, NSW, Australia. (dave.philpotts{at}schroders.com) 3. Ross Sparks 1. is a senior research scientist at CSIRO Mathematics, Informatics, and Statistics in North Ryde, NSW, Australia. (ross.sparks{at}csiro.au) 4. Maxwell J. Stevenson 1. is a senior lecturer at the Business School of the University of Sydney in Sydney, NSW, Australia. (m.stevenson{at}econ.usyd.edu.au) <!-- --> 1. To order reprints of this article, please contact Dewey Palmieri at dpalmieri{at}iijournals.com or 212-224-3675. The performance of a stock relative to a suitable peer group is often influenced by a multitude of factors and their interactions. Traditional parametric models, albeit very useful, are often inadequate in capturing complicated relationships. In contrast, the nonparametric decision tree technique, such as classification and regression trees (CART), is more capable of capturing any nonlinearities and high-order interactions among stock characteristics, with the additional convenience of graphically representing the model, but discontinuous and coarse-grained responses produced by CART are potentially undesirable. In contrast, traditional regression models such as logistic regression produce a smooth response surface, which is more tractable in practice. The authors use a hybrid approach that takes advantage of the strengths in both parametric (logistic regression) and nonparametric models (CART). An application of this sophisticated technique to North American defensive stocks demonstrates its usefulness. TOPICS: [Equity portfolio management][1], [security analysis and valuation][2], [quantitative methods][3] [1]: https://www.pm-research.com/topic/equity-portfolio-management [2]: https://www.pm-research.com/topic/security-analysis-and-valuation-0 [3]: https://www.pm-research.com/topic/quantitative-methods-0

Neurocognitive and Behavioral Characteristics of Children with ADHD and Autism: New Data and New Strategies

Free AccessNeurocognitive and Behavioral Characteristics of Children with ADHD and Autism: New Data and New StrategiesSam Goldstein and Jack A. NaglieriSam GoldsteinSearch for more papers by this author and Jack A. Naglieri1 Faculty at the University of Utah, on the Editorial Board of the ADHD Report, and Editor-in-Chief of the Journal of Attention Disorders, Dr. Goldstein can be reached at [email protected].2 Professor Emeritus of Psychology at George Mason University (2000–2010), Research Professor at the University of Virginia (2010–present), and Senior Research Scientist at the Devereux Center for Resilient Children (1991–present). He is Senior Editor of the Journal of Attention Disorders. Dr. Naglieri can be reached at [email protected].Search for more papers by this authorPublished Online:August 2011https://doi.org/10.1521/adhd.2011.19.4.10PDFPDF PLUS ShareShare onFacebookTwitterLinkedInRedditEmail ToolsAdd to favoritesDownload CitationsTrack Citations About Previous article Next article FiguresReferencesRelatedDetails Cited byCited by1. Cognitive Profiles Based on PASS Theory and Strategy Characteristics as Measured by the Das-Naglieri Cognitive Assessment System: University Students With ADHD and ASDOnline publication date: Go to citation Crossref Google Scholar2. Perceptions d’un outil considérant la famille dans la planification des services à l’enfantOnline publication date: 21 January 2020. Go to citation Crossref Google Scholar3. A Pilot Feasibility Study of Neurofeedback for Children with AutismOnline publication date: 16 April 2014. Go to citation Crossref Google Scholar Volume 19Issue 4Aug 2011 Information© 2011 The Guilford PressPDF download

About the Authors

About the Authors

Advances in the Krapcho Decarboxylation

Po. S. Poon, who received her Doctorate degree in 2007 from Venezuelan Institute of Scientific Research (IVIC), is working at IVIC as an Investigator in the Department of Chemistry. Her research encompases the synthesis of terpenoid and bioactive compounds. She was received the Paula Prize from IVIC for her high academic achievement. Manuel S. Laya obtained his MSc degree in 1997 from IVIC and is now working as Research Associate in the Department of Organic Chemistry, IVIC. He has published more than 30 papers, most of which are related to synthetic studies on terpenoid compounds. Ajoy K. Banerjee, who received his PhD in 1965 from the University of Kolkata (India), joined IVIC in 1968. Since 1982 he has been working as Senior Research Scientist. Most of his work is related to synthetic studies on terpenoid compounds (diterpenes and sesquitepenes). He teaches organic chemistry and supervises students who join IVIC for MSc or PhD degrees. Dr Banerjee is the author of two books on organic chemistry, written in Spanish, and several papers. 1. Modifications 2. General features 3. Mechanism 4. Synthetic applications 5. Conclusion 6. References This review provides a brief description of the Krapcho dealkoxycarbonylation and its recent applications in the synthesis of organic compounds and natural products. The general features of the Krapcho reaction, its mechanism and several modifications of the Krapcho reaction are discussed.

New Editors for Eos

Two new editors have been appointed to the Eos editorial board. José D. Fuentes of the Department of Meteorology at Pennsylvania State University is the new editor for atmospheric sciences. He succeeds Hassan Virji, who served as editor from mid‐2006 to early 2010. David Halpern, a senior research scientist at the Jet Propulsion Laboratory who is currently on assignment at NASA headquarters in Washington, D. C., is the new editor for ocean sciences.

Detection and biotechnological potential of the RNAi suppressors

The plant viruses have evolved to encode the factors, called RNAi suppressors to battle out the host RNAi factors and the infection/ symptom development or lack of it is the result of the balancing actions of these two groups of proteins. The suppressor proteins act in different pathways of RNAi activities and thus many different detection methods need to be devised to isolate and characterize these suppressors. We have developed six different assays to identify the viral RNAi-suppressor molecules and more than thirty suppressors were screened from viruses of various sources including the animal viruses. Some of these detection techniques will be presented. These molecules are generally pathogenic but could be tamed for biotechnological gains. First, we shall provide evidences to show that the ‘AC2’ suppressor from the Mungbean yellow mosaic india virus (MYMIV) could be used for molecular farming. Secondly, the catalytic activities ribozymes could be enhanced in presence of MYMIV-AC2. Thirdly, we will show that the VIGS vectors become robust silencing machines in the absence of suppressors. Fourthly and most importantly, the suppressors are attractive targets for antiviral strategies. The artificial microRNAs provided effective resistance against the Tomato leaf curl virus (ToLCV) when the ToLCVAC2 and -AC4 suppressors were targeted for silencing. Thus a host of interesting research activities is going on at various laboratories of the globe including ours, keeping the RNAi suppressors in the center stage. Biography Dr Mukherjee has completed his Ph.D. (Physics) from Calcutta University. He carried out his postdoctoral assignments at Johns Hopkins and Duke Universities in USA. Currently he is a senior research scientist at ICGEB, a premier biotechnological Institute. He has published more than fifty research papers in respected journals and is a fellow (FNA, FASc., FNASc.) of three important science academies of India. He serves as an expert member in the panel boards of many funding agencies.