Brain Tumor Segmentation Research Articles

Dual vision Transformer-DSUNET with feature fusion for brain tumor segmentation

Brain tumors are one of the leading causes of cancer death; screening early is the best strategy to diagnose and treat brain tumors. Magnetic Resonance Imaging (MRI) is extensively utilized for brain tumor diagnosis; nevertheless, achieving improved accuracy and performance, a critical challenge in most of the previously reported automated medical diagnostics, is a complex problem. The study introduces the Dual Vision Transformer-DSUNET model, which incorporates feature fusion techniques to provide precise and efficient differentiation between brain tumors and other brain regions by leveraging multi-modal MRI data. The impetus for this study arises from the necessity of automating the segmentation process of brain tumors in medical imaging, a critical component in the realms of diagnosis and therapy strategy. The BRATS 2020 dataset is employed to tackle this issue, an extensively utilized dataset for segmenting brain tumors. This dataset encompasses multi-modal MRI images, including T1-weighted, T2-weighted, T1Gd (contrast-enhanced), and FLAIR modalities. The proposed model incorporates the dual vision idea to comprehensively capture the heterogeneous properties of brain tumors across several imaging modalities. Moreover, feature fusion techniques are implemented to augment the amalgamation of data originating from several modalities, enhancing the accuracy and dependability of tumor segmentation. The Dual Vision Transformer-DSUNET model's performance is evaluated using the Dice Coefficient as a prevalent metric for quantifying segmentation accuracy. The results obtained from the experiment exhibit remarkable performance, with Dice Coefficient values of 91.47 % for enhanced tumors, 92.38 % for core tumors, and 90.88 % for edema. The cumulative Dice score for the entirety of the classes is 91.29 %. In addition, the model has a high level of accuracy, roughly 99.93 %, which underscores its durability and efficacy in segmenting brain tumors. Experimental findings demonstrate the integrity of the suggested architecture, which has quickly improved the detection accuracy of many brain diseases.

FPL+: Filtered Pseudo Label-Based Unsupervised Cross-Modality Adaptation for 3D Medical Image Segmentation.

Adapting a medical image segmentation model to a new domain is important for improving its cross-domain transferability, and due to the expensive annotation process, Unsupervised Domain Adaptation (UDA) is appealing where only unlabeled images are needed for the adaptation. Existing UDA methods are mainly based on image or feature alignment with adversarial training for regularization, and they are limited by insufficient supervision in the target domain. In this paper, we propose an enhanced Filtered Pseudo Label (FPL+)-based UDA method for 3D medical image segmentation. It first uses cross-domain data augmentation to translate labeled images in the source domain to a dual-domain training set consisting of a pseudo source-domain set and a pseudo target-domain set. To leverage the dual-domain augmented images to train a pseudo label generator, domain-specific batch normalization layers are used to deal with the domain shift while learning the domain-invariant structure features, generating high-quality pseudo labels for target-domain images. We then combine labeled source-domain images and target-domain images with pseudo labels to train a final segmentor, where image-level weighting based on uncertainty estimation and pixel-level weighting based on dual-domain consensus are proposed to mitigate the adverse effect of noisy pseudo labels. Experiments on three public multi-modal datasets for Vestibular Schwannoma, brain tumor and whole heart segmentation show that our method surpassed ten state-of-the-art UDA methods, and it even achieved better results than fully supervised learning in the target domain in some cases.

Enhanced TumorNet: Leveraging YOLOv8s and U-net for superior brain tumor detection and segmentation utilizing MRI scans

Brain tumors, characterized by abnormal cell growth, pose a significant challenge in clinical imaging due to their complex and diverse structures. Early and accurate identification, classification, localization, and segmentation of these tumors are critical to reducing mortality. However, the extensive data generated by MRI scans makes manual segmentation time-consuming and impractical for clinical use. To address these challenges, we propose, a hybrid deep learning model that precisely segmented tumor regions with U-Net to enable YOLOv8s to efficiently detect, classify and localize tumors. The model was trained and validated using The Cancer Imaging Archive (TCIA) dataset, which includes MRI images of brain tumors, and the Cancer Genome Atlas (CGA) low-grade glioma dataset, which includes data from 110 patients with FLAIR aberrant segmentation masks. The proposed hybrid model was evaluated using several performance metrics, including F1 score, specificity, recall, precision, accuracy, and ROC-AUC score. Hybrid proposed performed highly, achieving a precision of 97.8 %, accuracy of 98.6 %, recall of 95.2 %, F-1 score of 96.3 %, specificity of 89.1 %, and ROC-AUC score of 98.5 %. The integration of YOLOv8s and U-Net in Enhanced TumorNet offers a powerful solution for the automated analysis of brain tumors in MRI scans, significantly improving detection and segmentation accuracy. This hybrid approach holds great potential for clinical applications, enhancing the efficiency and effectiveness of brain tumor diagnosis.

A Practical Guide to Manual and Semi-Automated Neurosurgical Brain Lesion Segmentation.

The medical images used were sourced from the Medical Image Computing and Computer Assisted Interventions Society (MICCAI) Multimodal Brain Tumour Segmentation Challenge (BRATS) image database and from the local Picture Archival and Communication System (PACS) record with consent. Image pre-processing was carried out using MRIcron software (v1.0.20190902). ITK-SNAP (v3.8.0) was used in this guideline due to its availability and powerful built-in segmentation tools, although others (Seg3D, Freesurfer and 3D Slicer) are available. Quality control was achieved by employing expert segmenters to review. A pipeline was developed to demonstrate the pre-processing and manual and semi-automated segmentation of patient images for each cranial lesion, accompanied by image guidance and video recordings. Three sample segmentations were generated to illustrate potential challenges. Advice and solutions were provided within both text and video. Semi-automated segmentation methods enhance efficiency, increase reproducibility, and are suitable to be incorporated into future clinical practise. However, manual segmentation remains a highly effective technique in specific circumstances and provides initial training sets for the development of more advanced semi- and fully automated segmentation algorithms.

Cross-domain additive learning of new knowledge rather than replacement.

In medical clinical scenarios for reasons such as patient privacy, information protection and data migration, when domain adaptation is needed for real scenarios, the source-domain data is often inaccessible and only the pre-trained source model on the source-domain is available. Existing solutions for this type of problem tend to forget the rich task experience previously learned on the source domain after adapting, which means that the model simply overfits the target-domain data when adapting and does not learn robust features that facilitate real task decisions. We address this problem by exploring the particular application of source-free domain adaptation in medical image segmentation and propose a two-stage additive source-free adaptation framework. We generalize the domain-invariant features by constraining the core pathological structure and semantic consistency between different perspectives. And we reduce the segmentation generated by locating and filtering elements that may have errors through Monte-Carlo uncertainty estimation. We conduct comparison experiments with some other methods on a cross-device polyp segmentation and a cross-modal brain tumor segmentation dataset, the results in both the target and source domains verify that the proposed method can effectively solve the domain offset problem and the model retains its dominance on the source domain after learning new knowledge of the target domain.This work provides valuable exploration for achieving additive learning on the target and source domains in the absence of source data and offers new ideas and methods for adaptation research in the field of medical image segmentation.

Enhancing brain tumor segmentation in MRI images: A hybrid approach using UNet, attention mechanisms, and transformers

Accurate brain tumor segmentation in MRI images is crucial for effective treatment planning and monitoring. Traditional methods often encounter challenges due to the complexity and variability of tumor shapes and textures. Consequently, there is a growing need for automated solutions to assist healthcare professionals in segmentation tasks, improving efficiency and reducing workload. This study introduces an innovative method for accurately segmenting brain tumors in MRI images by employing a refined 3D UNet model integrated with a Transformer. The goal is to leverage self-attention mechanisms to enhance segmentation capabilities. The proposed model combines Contextual Transformer (CoT) and Double Attention (DA) architectures. CoT is extended to a 3D format and integrated with the baseline model to exploit intricate contextual details in MRI images. DA blocks in skip connections aggregate and distribute long-range features, emphasizing inter-dependencies within an expanded spatial scope. Experimental results demonstrate superior segmentation performance compared to current state-of-the-art methods. With its ability to accurately segment and delineate tumors in 3D, our segmentation model promises to be a powerful tool for medical image processing and performance optimization, saving time for healthcare professionals and healthcare systems.

Assessment of brain tumor detection techniques and recommendation of neural network.

Brain tumor classification is amongst the most complex and challenging jobs in the computer domain. The latest advances in brain tumor detection systems (BTDS) are presented as they can inspire new researchers to deliver new architectures for effective and efficient tumor detection. Here, the data of the multi-modal brain tumor segmentation task is employed, which has been registered, skull stripped, and histogram matching is conducted with the ferrous volume of high contrast. This research further configures a capsule network (CapsNet) for brain tumor classification. Results of the latest deep neural network (NN) architectures for tumor detection are compared and presented. The VGG16 and CapsNet architectures yield the highest f1-score and precision values, followed by VGG19. Overall, ResNet152, MobileNet, and MobileNetV2 give us the lowest f1-score. The VGG16 and CapsNet have produced outstanding results. However, VGG16 and VGG19 are more profound architecture, resulting in slower computation speed. The research then recommends the latest suitable NN for effective brain tumor detection. Finally, the work concludes with future directions and potential new architectures for tumor detection.

A Novel Approach for Detection, Segmentation, and Classification of Brain Tumors in MRI Images Using Neural Network and Special C Means Fuzzy Clustering Techniques

Brain tumors present a significant health challenge globally, necessitating advanced techniques for accurate detection, segmentation, and classification. This paper presents a comprehensive study focused on the development and evaluation of innovative methodologies for brain tumor analysis using medical imaging data. The primary objective of this research is to enhance the accuracy and efficiency of brain tumor detection, segmentation, and classification processes. To achieve this goal, a multi-step approach is proposed, integrating various computational techniques and machine learning algorithms. First, the study explores novel methods for preprocessing medical imaging data to enhance image quality and reduce noise artifacts. This preprocessing step plays a crucial role in improving the subsequent analysis stages' accuracy and reliability. Next, a robust tumor detection algorithm is developed, leveraging advanced image processing techniques and deep learning models. The proposed algorithm effectively identifies tumor regions within brain images with high accuracy and minimal false positives. Following tumor detection, a segmentation framework is introduced to precisely delineate tumor boundaries from surrounding healthy tissues. The segmentation algorithm combines traditional image processing methods with state-of-the-art deep learning architectures to achieve accurate and efficient tumor delineation. In this paper, we proposed three novel methods for automatic detection, classification, and segmentation of brain tumors. Comprehensive experiments are conducted on the BRATS dataset and show that the proposed model obtains competitive results. The parameters under study are Accuracy rate, Specificity, and Sensitivity. First approach focuses on classifying cancerous and non-cancerous brain tumors in MRI scans. The system first reads the images and employs a novel fusion method to combine information from various modalities (Flair, T1, T1C, T2) for a more comprehensive picture. This enhances the accuracy of tumor characterization. Following this fusion, the images undergo preprocessing, feature extraction, and classification. The preprocessing stage involves grayscale conversion, binarization, wavelet analysis, and region-of-interest (ROI) calculation. Finally, a robust Neural Network (NN) classification method effectively differentiates cancerous and non-cancerous brain tissue. Performance is evaluated by metrics like accuracy, sensitivity, and specificity. Compared to existing methods, this research system demonstrates superior results, achieving a classification accuracy of 96.61%, sensitivity of 96.66%, and specificity of 96.55%. The Second approach combines Backpropagation Neural Networks (BPNN) with Spatial Fuzzy C-Means (SFCM) clustering for brain tumor analysis. The BPNN classifies brains into normal, benign (non-cancerous abnormality), or malignant (cancerous) categories. SFCM helps pinpoint the exact tumor location and size within the MRI scan through segmentation. A dual-tree complex wavelet transform is employed to extract image features efficiently. This method achieved exceptional results: 99.77% classification accuracy, 99.87% sensitivity (correctly identifying tumors), and 98.69% specificity (correctly identifying healthy tissue). Additionally, the over 90% precision demonstrates the effectiveness of this technique in feature extraction and classification. The experiments demonstrate that BPNN-SFCM successfully segment, and extracts brain tumors from MRI scans. The overall accuracy of BPNN-SFCM is better as compared to other proposed methods and existing methods.

Reconstruct incomplete relation for incomplete modality brain tumor segmentation

Different brain tumor magnetic resonance imaging (MRI) modalities provide diverse tumor-specific information. Previous works have enhanced brain tumor segmentation performance by integrating multiple MRI modalities. However, multi-modal MRI data are often unavailable in clinical practice. An incomplete modality leads to missing tumor-specific information, which degrades the performance of existing models. Various strategies have been proposed to transfer knowledge from a full modality network (teacher) to an incomplete modality one (student) to address this issue. However, they neglect the fact that brain tumor segmentation is a structural prediction problem that requires voxel semantic relations. In this paper, we propose a Reconstruct Incomplete Relation Network (RIRN) that transfers voxel semantic relational knowledge from the teacher to the student. Specifically, we propose two types of voxel relations to incorporate structural knowledge: Class-relative relations (CRR) and Class-agnostic relations (CAR). The CRR groups voxels into different tumor regions and constructs a relation between them. The CAR builds a global relation between all voxel features, complementing the local inter-region relation. Moreover, we use adversarial learning to align the holistic structural prediction between the teacher and the student. Extensive experimentation on both the BraTS 2018 and BraTS 2020 datasets establishes that our method outperforms all state-of-the-art approaches.

Retraction Note: Automated brain tumor detection and segmentation using modified UNet and ResNet model

Retraction Note: Automated brain tumor detection and segmentation using modified UNet and ResNet model

Application of U-Net Network Utilizing Multiattention Gate for MRI Segmentation of Brain Tumors.

Studies have shown that the type of low-grade glioma is associated with its shape. The traditional diagnostic method involves extraction of the tumor shape from MRIs and diagnosing the type of glioma based on corresponding relationship between the glioma shape and type. This method is affected by the MRI background, tumor pixel size, and doctors' professional level, leading to misdiagnoses and missed diagnoses. With the help of deep learning algorithms, the shape of a glioma can be automatically segmented, thereby assisting doctors to focus more on the diagnosis of glioma and improving diagnostic efficiency. The segmentation of glioma MRIs using traditional deep learning algorithms exhibits limited accuracy, thereby impeding the effectiveness of assisting doctors in the diagnosis. The primary objective of our research is to facilitate the segmentation of low-grade glioma MRIs for medical practitioners through the utilization of deep learning algorithms. In this study, a UNet glioma segmentation network that incorporates multiattention gates was proposed to address this limitation. The UNet-based algorithm in the coding part integrated the attention gate into the hierarchical structure of the network to suppress the features of irrelevant regions and reduce the feature redundancy. In the decoding part, by adding attention gates in the fusion process of low- and high-level features, important feature information was highlighted, model parameters were reduced, and model sensitivity and accuracy were improved. The network model performed image segmentation on the glioma MRI dataset, and the accuracy and average intersection ratio (mIoU) of the algorithm segmentation reached 99.7%, 87.3%, 99.7%, and 87.6%. Compared with the UNet, PSPNet, and Attention UNet network models, this network model has obvious advantages in accuracy, mIoU, and loss convergence. It can serve as a standard for assisting doctors in diagnosis.

Deep evidential fusion with uncertainty quantification and reliability learning for multimodal medical image segmentation

Single-modality medical images generally do not contain enough information to reach an accurate and reliable diagnosis. For this reason, physicians commonly rely on multimodal medical images for comprehensive diagnostic assessments. This study introduces a deep evidential fusion framework designed for segmenting multimodal medical images, leveraging the Dempster–Shafer theory of evidence in conjunction with deep neural networks. In this framework, features are first extracted from each imaging modality using a deep neural network, and features are mapped to Dempster–Shafer mass functions that describe the evidence of each modality at each voxel. The mass functions are then corrected by the contextual discounting operation, using learned coefficients quantifying the reliability of each source of information relative to each class. The discounted evidence from each modality is then combined using Dempster’s rule of combination. Experiments were carried out on a PET-CT dataset for lymphoma segmentation and a multi-MRI dataset for brain tumor segmentation. The results demonstrate the ability of the proposed fusion scheme to quantify segmentation uncertainty and improve segmentation accuracy. Moreover, the learned reliability coefficients provide some insight into the contribution of each modality to the segmentation process.

DUNET D UNET Dilated UNET for Brain Tumor Sub Region Segmentation using MRI Images

The precise diagnosis and treatment planning of brain tumors significantly rely on the accurate segmentation of sub-regions from Magnetic Resonance Imaging (MRI) data. In this research, we propose a framework, D-UNET (Dilated-UNET), which enhances the traditional UNET architecture by incorporating dilated convolutions. UNET is the deep CNN architecture widely adopted for biomedical image segmentation tasks. D-UNET is specifically designed for brain tumor sub-region segmentation from multi-modal (T1, T2, T1ce, Flair) MRI images in nifti file format, each comprising 155 slices. The framework comprises of four distinct steps viz. data collection, data preprocessing, model training, and outcome evaluation. D-UNET employs two key modules during training, the dilated encoding module and the dilated decoding module. These modules enable the model to efficiently capture multi-scale contextual information, facilitating better representation learning for complex and varied tumor sub[1]regions. We evaluated the performance of D-UNET using Intersection over Union and Dice Coefficient metrics. The experimental results demonstrate that D-UNET outperforms the traditional UNET and other benchmark models in terms of segmentation accuracy. Notably, D-UNET excels in capturing finer details and intricate shapes of tumor sub-regions, contributing to its superiority in brain tumor segmentation. The ability to precisely delineate tumor sub-regions from different modalities provides crucial insights for medical professionals in treatment planning and decision-making.

Multimodal Fusion for Enhanced Semantic Segmentation in Brain Tumor Imaging: Integrating Deep Learning and Guided Filtering Via Advanced 3D Semantic Segmentation Architectures

ABSTRACTBrain tumor segmentation is paramount in medical diagnostics. This study presents a multistage segmentation model consisting of two main steps. First, the fusion of magnetic resonance imaging (MRI) modalities creates new and more effective tumor imaging modalities. Second, the semantic segmentation of the original and fused modalities, utilizing various modified architectures of the U‐Net model. In the first step, a residual network with multi‐scale backbone architecture (Res2Net) and guided filter are employed for pixel‐by‐pixel image fusion tasks without requiring any training or learning process. This method captures both detailed and base elements from the multimodal images to produce better and more informative fused images that significantly enhance the segmentation process. Many fusion scenarios were performed and analyzed, revealing that the best fusion results are attained when combining T2‐weighted (T2) with fluid‐attenuated inversion recovery (FLAIR) and T1‐weighted contrast‐enhanced (T1CE) with FLAIR modalities. In the second step, several models, including the U‐Net and its many modifications (adding attention layers, residual connections, and depthwise separable connections), are trained using both the original and fused modalities. Further, a “Model Selection‐based” fusion of these individual models is also considered for more enhancement. In the preprocessing step, the images are resized by cropping them to decrease the pixel count and minimize background interference. Experiments utilizing the brain tumor segmentation (BraTS) 2020 dataset were performed to verify the efficiency and accuracy of the proposed methodology. The “Model Selection‐based” fusion model achieved an average Dice score of 88.4%, an individual score of 91.1% for the whole tumor (WT) class, an average sensitivity score of 86.26%, and a specificity score of 91.7%. These results prove the robustness and high performance of the proposed methodology compared to other state‐of‐the‐art methods.

Highly accurate brain tumor detection with high sensitivity using transform-based functions and machine learning algorithms.

Brain tumor is an extremely dangerous disease with a very high mortality rate worldwide. Detecting brain tumors accurately is crucial due to the varying appearance of tumor cells and the dimensional irregularities in their growth. This poses a significant challenge for detection algorithms. Currently, there are numerous algorithms utilized for this purpose, ranging from transform-based methods to those rooted in machine learning techniques. These algorithms aim to enhance the accuracy of detection despite the complexities involved in identifying brain tumor cells. The major limitation of these algorithms is the mapping of extracted features of a brain tumor in the classification algorithms. To employ a combination of transform methods to extract texture feature from brain tumor images. This paper employs a combination of transform methods based on sub band decomposition for texture feature extraction from MRI scans, hybrid feature optimization methods using firefly and glow-worm algorithms for selection of feature, employment of MKSVM algorithm and stacking ensemble classifier for classification and application of the feature of fusion of different feature extraction methods. The algorithm under consideration has been put into practice using MATLAB, utilizing datasets from BRATS (Brain Tumor Segmentation) for the years 2013, 2015, and 2018. These datasets serve as the foundation for testing and validating the algorithm's performance across different time periods, providing a comprehensive assessment of its effectiveness in detecting brain tumors. The proposed algorithm achieves maximum detection accuracy, detection sensitivity and specificity up to 98%, 99% and 99.5% respectively. The experimental outcomes showcase the efficiency of the algorithm in detection of brain tumor. The proposed work mainly contributes in brain tumor detection in the following aspects: a) use of combination of transform methods for texture feature extraction from MRI scans b) hybrid feature selection methods using firefly and glow-worm optimization algorithms for selection of feature c) employment of MKSVM algorithm and stacking ensemble classifier for classification and application of the feature of fusion of different feature extraction methods.

G-Net: Implementing an enhanced brain tumor segmentation framework using semantic segmentation design.

A fundamental computer vision task called semantic segmentation has significant uses in the understanding of medical pictures, including the segmentation of tumors in the brain. The G-Shaped Net architecture appears in this context as an innovative and promising design that combines components from many models to attain improved accuracy and efficiency. In order to improve efficiency, the G-Shaped Net architecture synergistically incorporates four fundamental components: the Self-Attention, Squeeze Excitation, Fusion, and Spatial Pyramid Pooling block structures. These factors work together to improve the precision and effectiveness of brain tumor segmentation. Self-Attention, a crucial component of G-Shaped architecture, gives the model the ability to concentrate on the image's most informative areas, enabling accurate localization of tumor boundaries. By adjusting channel-wise feature maps, Squeeze Excitation completes this by improving the model's capacity to capture fine-grained information in the medical pictures. Since the G-Shaped model's Spatial Pyramid Pooling component provides multi-scale contextual information, the model is capable of handling tumors of various sizes and complexity levels. Additionally, the Fusion block architectures combine characteristics from many sources, enabling a thorough comprehension of the image and improving the segmentation outcomes. The G-Shaped Net architecture is an asset for medical imaging and diagnostics and represents a substantial development in semantic segmentation, which is needed more and more for accurate brain tumor segmentation.

Comparative Study of Denoising and Segmentation Techniques for Accurate Brain Tumor Detection in MRI

Background: Brain tumor incidence is on the rise each year, with more than 130 identified types. Precise segmentation models play a vital role in the diagnosis and treatment of brain tumors. This study specifically investigates the utilization of diffusion-based denoising techniques and thresholding methods for segmenting brain tumors from MRI images. Objective: The objective of this study is to examine and compare the efficacy of the Perona-malik and Weickert diffusion techniques in denoising brain MRI images. Additionally, the study aims to assess their performance in threshold-based segmentation of brain tumors. Moreover, it also aims to evaluate the compatibility, benefits, and limitations of the Perona-Malik and Weickert diffusion methods in the denoising of brain MRI images and the effect of denoising on segmentation. Methods: In this study, the Perona-Malik and Weickert diffusion methods are employed to denoise brain MRI images. The denoised images are then subjected to thresholding using both binary and fuzzy approaches, utilizing a triangular membership function. The performance of the diffusion techniques is evaluated using metrics, such as Mean Square Error and Peak Signal to Noise Ratio. Additionally, segmentation models are assessed using metrics such as Dice Similarity Coefficient, Jaccard Similarity Coefficient, and Structural Similarity Measurement Index. Results: The Perona-Malik and Weickert diffusion methods exhibit compatibility with various types of noise, each having its own set of advantages and limitations. The Weickert diffusion method excels in preserving image structure and texture during thresholding. Conclusion: The study provides evidence for the effectiveness of diffusion-based denoising techniques in segmenting brain tumors from MRI images. Specifically, the Weickert diffusion method outperforms in preserving essential image characteristics during thresholding. Additionally, fuzzy thresholding proves to be more successful in accurately segmenting brain tumors. These findings contribute to the advancement of precise models for brain tumor segmentation, ultimately enhancing the diagnosis and treatment of these tumors.

Neuro-XAI: Explainable deep learning framework based on deeplabV3+ and bayesian optimization for segmentation and classification of brain tumor in MRI scans

The prevalence of brain tumor disorders is currently a global issue. In general, radiography, which includes a large number of images, is an efficient method for diagnosing these life-threatening disorders. The biggest issue in this area is that it takes a radiologist a long time and is physically strenuous to look at all the images. As a result, research into developing systems based on machine learning to assist radiologists in diagnosis continues to rise daily. Convolutional neural networks (CNNs), one type of deep learning approach, have been pivotal in achieving state-of-the-art results in several medical imaging applications, including the identification of brain tumors. CNN hyperparameters are typically set manually for segmentation and classification, which might take a while and increase the chance of using suboptimal hyperparameters for both tasks. Bayesian optimization is a useful method for updating the deep CNN's optimal hyperparameters. The CNN network, however, can be considered a "black box" model because of how difficult it is to comprehend the information it stores because of its complexity. Therefore, this problem can be solved by using Explainable Artificial Intelligence (XAI) tools, which provide doctors with a realistic explanation of CNN's assessments. Implementation of deep learning-based systems in real-time diagnosis is still rare. One of the causes could be that these methods don't quantify the Uncertainty in the predictions, which could undermine trust in the AI-based diagnosis of diseases. To be used in real-time medical diagnosis, CNN-based models must be realistic and appealing, and uncertainty needs to be evaluated. So, a novel three-phase strategy is proposed for segmenting and classifying brain tumors. Segmentation of brain tumors using the DeeplabV3+ model is first performed with tuning of hyperparameters using Bayesian optimization. For classification, features from state-of-the-art deep learning models Darknet53 and mobilenetv2 are extracted and fed to SVM for classification, and hyperparameters of SVM are also optimized using a Bayesian approach. The second step is to understand whatever portion of the images CNN uses for feature extraction using XAI algorithms. Using confusion entropy, the Uncertainty of the Bayesian optimized classifier is finally quantified. Based on a Bayesian-optimized deep learning framework, the experimental findings demonstrate that the proposed method outperforms earlier techniques, achieving a 97 % classification accuracy and a 0.98 global accuracy.

LightNet: A Novel Lightweight Convolutional Network for Brain Tumor Segmentation in Healthcare.

Diagnosis, treatment planning, surveillance, and the monitoring of clinical trials for brain diseases all benefit greatly from neuroimaging-based tumor segmentation. Recently, Convolutional Neural Networks (CNNs) have demonstrated promising results in enhancing the efficiency of image-based brain tumor segmentation. Most current work on CNNs, however, is devoted to creating increasingly complicated convolution modules to improve performance, which in turn raises the computing cost of the model. This work proposes a simple and effective feed-forward CNN, LightNet (Light Network). Based on multi-path and multi-level, it replaces traditional convolutional methods with light operations, which reduces network parameters and redundant feature maps. In the up-sampling stage, a light channel attention module is added to achieve richer multi-scale and spatial semantic feature information extraction of brain tumor. The performance of the network is evaluated in the Multimodal Brain Tumor Segmentation Challenge (BraTS 2015) dataset, and results are presented here alongside other high-performing CNNs. Results show comparable accuracy with other methods but with increased efficiency, segmentation performance, and reduced redundancy and computational complexity. The result is a high-performing network with a balance between efficiency and accuracy, allowing, for example, better energy performance on mobile devices.

AB093. Pixel-wise classification of glioma using deep learning for accurate tumour mapping on magnetic resonance imaging.

Central nervous system (CNS) tumours, especially glioma, are a complex disease and many challenges are encountered in their treatment. Artificial intelligence (AI) has made a colossal impact in many walks of life at a low cost. However, this avenue still needs to be explored in healthcare settings, demanding investment of resources towards growth in this area. We aim to develop machine learning (ML) algorithms to facilitate the accurate diagnosis and precise mapping of the brain tumour. We queried the data from 2019 to 2022 and brain magnetic resonance imaging (MRI) of glioma patients were extracted. Images that had both T1-contrast and T2-fluid-attenuated inversion recovery (T2-FLAIR) volume sequences available were included. MRI images were annotated by a team supervised by a neuroradiologist. The extracted MRIs thus obtained were then fed to the preprocessing pipeline to extract brains using SynthStrip. They were further fed to the deep learning-based semantic segmentation pipelines using UNet-based architecture with convolutional neural network (CNN) at its backbone. Subsequently, the algorithm was tested to assess the efficacy in the pixel-wise diagnosis of tumours. In total, 69 samples of low-grade glioma (LGG) were used out of which 62 were used for fine-tuning a pre-trained model trained on brain tumor segmentation (BraTS) 2020 and 7 were used for testing. For the evaluation of the model, the Dice coefficient was used as the metric. The average Dice coefficient on the 7 test samples was 0.94. With the advent of technology, AI continues to modify our lifestyles. It is critical to adapt this technology in healthcare with the aim of improving the provision of patient care. We present our preliminary data for the use of ML algorithms in the diagnosis and segmentation of glioma. The promising result with comparable accuracy highlights the importance of early adaptation of this nascent technology.