TB and HIV form a lethal combination, as each fuels the progress of the other in the infected patients. This study assessed the haematological parameters of pulmonary tuberculosis (PTB) patients with and without HIV infection attending the two secondary health facilities in Jigawa State, Nigeria. A total of 150 PTB patients visiting the two secondary health facilities were randomly selected for the study. 5ml of venous blood was drawn aseptically with the help of sterile syringe using vein puncture technique and transferred into EDTA bottle to avoid coagulation. 2ml of the EDTA blood was transferred in to plane test tube for the haematological analysis using automated Haematological Analyser (Abacus Junior 380) while the remaining 3ml of the blood was placed into a Western green tube up to the zero mark for Erythrocyte sedimentation rate (ESR) determination. The data was analysed using SPSS version 20, One-way ANOVA was used to check the significant difference among the new, follow-up and Multi drug resistant TB (MDR-TB) groups of patients. 136 (90.67%) patients were HIV negative and 14 (9.33%) were HIV positive, 95 (63.33%) were males and 55 (36.37%) were females. Among the studied population 56 (37.33%) and 94 (62.67%) were new and follow-up PTB patients respectively. In this study, there were significantly lower mean values at (P>0.05) of White blood cells, lymphocytes, neutrophils (MID), granulocytes, Red Blood Cells, packed cells volume, and Platelets counts among PTB-HIV co-infected patients when compared with PTB patients. Of the PTB patients, 27.94% were Leukopenic, 25.7% Lymphopenic, 26.47% neutropenic, 30.88% anaemic and 20.59% thrombocytopenic. On the other hand, of the PTB-HIV co-infected patients, 64.29% were leukopenic, 35.71% lymphopenic, 26.47% neutropenic, 21.43% anaemic, and 14.29% thrombocytopenic. This study demonstrated high prevalence of leucopenia, followed by neutropenia and anaemia, lymphopenia, and thrombocytopenia. There was also high ESR values among more than two-third of the 150 PTB patients. The study also revealed that, females were more co-infected with HIV 64.29% than the males with 35.71%. HIV co-infection worsens haematological abnormalities of PTB patients. Knowledge of these haematological parameters will enhance the overall management of the PTB patients with regard to monitoring the disease progression and response to antimicrobial chemotherapy as they will serve as useful indicators for treatment success or failure. It is recommended that all newly diagnosed and follow-up PTB and PTB-HIV co-infected patients should be exposed to haematological counts to monitor their immune status.