Cystadenoma of the salivary glands (CSG) is a rare benign, multicystic neoplasm, representing approximately 1%-4.7% of all benign salivary gland tumors. This study aimed to systematically review the clinicopathological data reported on case reports and case series of CSG. This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Comprehensive searches were performed across PubMed, Web of Science, Scopus, and Embase electronic databases. A total of 81 studies were included, encompassing 126 cases of CSG. A slight female predominance was observed (54.91%), with a mean patient age of 54.2 ± 21.5 years. The median lesion size was 1.4 ± 1.6 cm. The parotid gland was the most affected site (23.47%). Most cases were asymptomatic (86.58%), and nodular presentation was noted in 70.96%. Mucocele was the most suspected clinical diagnosis. Histopathologically, the papillary subtype was predominant (67.03%), with oncocytic cells prevailing, followed by columnar and cuboidal cell types. Of the 57 cases with available data on growth pattern, 38 were multicystic and 19 unicystic. Immunohistochemical analysis frequently involved the use of p63, MUC4, MUC1, and CK7. All cases were managed surgically, with a recurrence rate of 6.25%. The median follow-up period was 12.1 ± 23.2 months. CSG is a rare benign tumor that predominantly affects the parotid gland in female patients, typically presenting as a multicystic lesion. Surgical excision remains the treatment of choice, with a generally favorable prognosis.

Retinal vein occlusion (RVO) is a leading cause of vision loss, yet there are inconsistent risk estimates related to risk factors. Mendelian randomization (MR) uses genetic variants as proxies for lifelong exposure and can clarify causal pathways for RVO. We aimed to systematically review MR studies to identify causally supported systemic and ocular risk factors for RVO. Four databases (PubMed, Embase, Scopus, and Web of Science) were searched from inception to June 2025 for peer-reviewed MR studies evaluating modifiable systemic or ocular risk factors in relation to any form of RVO utilizing GWAS data. Narrative synthesis was undertaken as methodological heterogeneity precluded meta-analysis. All effect estimates (ORs) were extracted directly from individual studies and robustness of evidence for each exposure across studies was assessed as robust, probable, suggestive, insufficient, and non-evaluable based on significance and direction of evidence. Twelve two-sample MR studies, all conducted in European cohorts, met inclusion criteria. Ocular traits showed the most consistent signals: higher intraocular pressure (RVO (OR = 1.53, 95% CI: 1.0402.26) and glaucoma liability (OR = 1.31, 95% CI: 1.18-1.45) were robustly associated with greater risk of RVO. Among cardiovascular factors, elevated blood pressure/hypertension liability demonstrated probable evidence of increased RVO risk (OR = 1.58, 95% CI: 1.34-1.85), whereas lipid profiles yielded mixed signals, with some support for higher LDL (OR = 1.23, 95% CI: 1.05-1.44) and total cholesterol (OR = 1.44, 95% CI: 1.08-1.92) effects. For metabolic factors, glycemic traits showed probable to robust evidence with fasting glucose (OR = 5.01, 95% CI: 2.00-12.55) and two-hour glucose (OR = 3.17, 95% CI: 1.63-6.18) associated with higher RVO risk. Similarly, type 2 diabetes liability showed probable evidence (OR = 2.82, 95% CI: 2.07-3.85); anthropometric measures offered probable to robust support with body mass index (OR = 1.94, 95% CI: 1.23-3.08) and waist circumference (OR = 2.40, 95% CI: 1.36-4.24) associated with RVO. In other domains, selected coagulation and platelet traits showed probable-robust signals, vitamin D evidence was insufficient, and gut microbiota instruments provided preliminary robust evidence for Bacilli and Family XIII AD3011 association with RVO. Genetic evidence supports a multifactorial vascular-metabolic model for RVO in which elevated IOP, glaucoma, hypertension, adiposity, and acute hyperglycemia are genetically supported risk factors. These findings highlight blood-pressure control, weight management, and glycemic regulation as important prevention targets and underscore the need for ancestry-diverse MR studies with refined phenotyping.

This article aims to scan and classify Ottoman waqf studies by cluster analysis method, and fill the gap in the literature. In addition, this study is expected to be a guiding resource for those who want to do research on Ottoman waqfs.In the study, Scopus database was scanned using the keywords "Ottoman AND waqf" and the data obtained were analyzed by clustering method. The screening was conducted on May 9, 2024. As a result of the screening, a total of 137 studies were identified, including 106 journal articles, 2 books, 11 book chapters, 3 conference papers and 15 review articles. The date range of all studies is between 1979 and 2024. Then, the collected data was processed and analyzed with the R-Biblioshiny software program. This program is a free open source that provides tool support for bibliometric analysis research. The biggest feature of this software is that it creates bibliometric maps using the metadata of the collected articles. In addition to the R-Biblioshiny software program, the Scopus AI was also used to strengthen the analysis. Scopus AI is an AI-powered platform designed to navigate over the Scopus database. As a result of the cluster analysis, 3 main findings were reached. The first of these findings is the significance of the Egyptian region in the studies on Ottoman waqfs. The second finding is the richness of the cluster that touches on the function and importance of Ottoman waqfs throughout the centuries. The third important finding is the size of the cluster, which is generally categorized under the heading of "Ottoman waqfs". Ottoman waqf system included dynastic waqfs established by sultans and high-ranking state officials, with large budgets and providing various public services. Thus, these large waqfs had an economic impact known as the waqf economy.

Acute ischemic stroke (AIS) is the most common neurological complication of infective endocarditis (IE), occurring in 20-40% of patients. In this context, while mechanical thrombectomy (MT) is the standard treatment for patients with AIS due to large-vessel occlusion (LVO), its efficacy and safety in patients with stroke secondary to IE remain unclear. Therefore, amore robust analysis of the efficacy and safety of MT in patients with AIS due to IE was conducted to address the gaps identified in previous studies. An extensive search of PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, and Scopus databases was conducted from inception to December 2024. The endpoints of interest were: (1)favorable functional outcomes at 90days, (2)successful recanalization, (3)symptomatic intracranial hemorrhage (sICH), (4)any intracranial hemorrhage (aICH), and (5)overall mortality. The pooled proportion rates were employed with arandom effects model with 95% Confidence Intervals (CI) and risk ratios (RR) for binary outcomes with 95% CI. I2 statistics and CochranQ test were performed to verify the heterogeneity. Eight studies published between 2017 and 2024 enrolled 2037 patients (mean age 57.9 years, 62.3% women), of whom 1401 (69%) received mechanical or endovascular thrombectomy for Infective Endocarditis-Related Large Vessel Occlusion (IE-LVO) stroke. Apooled proportion of 29.0% for favorable functional outcomes (mRS 0-2) was reported (95% CI 14.0-43.0%; I2 = 65.7%). Successful recanalization (mTICI2b-3) was observed in 76.0% of patients (95% CI 68.0-84.0%; I2 = 23.6%). sICH was reported in 19.0% (95% CI 0.0-38.0%; I2 = 49.2%) and aICH in 30.0% of the patients (95% CI 23.0-38.0%; I2 = 78.3%). Apooled proportion of 33.0% for all-cause mortality was evidenced (95% CI 21.0-45.0%; I2 = 90.4%). Asignificantly lower incidence of favorable functional outcomes (mRS 0-2) was observed in patients with IE-LVO who underwent MT compared to non-IE-LVO patients (RR 0.48; 95% CI 0.31-0.75; I2 = 0.0%), and no significant difference in the incidence of aICH was found between patients with IE-LVO and those with non-IE-LVO who underwent MT (RR 1.38; 95% CI 0.96-1.98; I2 = 62.4%). High successful recanalization rates were achieved in this population through MT, demonstrating its potential as an effective treatment for IE-LVO. However, the clinical outcomes of patients with IE-LVO were significantly unfavorable compared with those of patients without IE-LVO.

Gas-based therapies in chronic wounds: A scoping review of preclinical and clinical data.

This study presents a comprehensive bibliometric analysis of self-determination theory (SDT) research over 25 years of scholarly work (1998-2023) published in the Scopus database and comprising over 3706 publications. Using VOSviewer and Bibliometrix, this analysis identified the trends in SDT research covering core trending topics, authors, and institutional networks, as well as emerging themes, among others. The study highlights the theory's evolution from a focus on intrinsic motivation to its broader application today, covering both intrinsic and extrinsic motivation and extended organisational outcomes such as well-being and engagement. Key findings reveal that with the rise in the digital work environment, there has been a surge in publication post-2018, and attention has diversified in terms of adapting SDT to meet the evolving psychological needs of employees in the contemporary work environment. Additionally, SWOT analysis uncovers SDT's strengths in its foundational emphasis on three basic psychological needs (autonomy, competence, and relatedness) and its adaptability across diverse fields. The findings reveal the potential for cross-disciplinary integration between diverse areas in human resource management and organisational behaviour. Nonetheless, the study also reveals key limitations in operationalising SDT in high-pressure work environments and cross-cultural adaptability. As such, the study suggests future directions for research in exploring the theory's role in the digital work setting and its potential in supporting the psychological well-being of employees by addressing the evolving workplace, changing workplace dynamics, and addressing the evolving psychological needs of employees.

Micro-credentials are bite-sized collections of skills or knowledge, complementing formal, informal, or non-formal degrees or certificates. Clarifying the role of micro-credentials in open and distance learning, a comprehensive review of the existing literature is essential. This study presents the results of a systematic literature review employing the PRISMA method to analyze the integration of micro-credentialing systems, stakeholder perceptions of their value, the impact of emerging technologies on their recognition, and future trends. A total of 205 publications, encompassing as specified terms of micro-credentials in their title, were retrieved from the Web of Science and Scopus databases. The results were discussed in five principle impact areas including the strategies in higher education and lifelong learning, sector-specific upskilling and reskilling, the digital proof of competency, challenges in design and implementation, and critiques on micro-credentials. The study reveals the evolution of micro-credentials and provides a roadmap for their future advancement.

Knowledge mapping of SGLT2-inhibitors and cardiovascular outcomes: A bibliometric analysis.

Meta-Analysis Investigating the Association between the Degree of Chronic Kidney Disease and Outcomes of Carotid Endarterectomy in Symptomatic and Asymptomatic Carotid Artery Stenosis.

A comprehensive review of the types and management of stapling failures in colorectal surgery.

The rapid advancement of Industry 4.0 has positioned Cyber-Physical Systems (CPS) as key enablers of intelligent and autonomous manufacturing. While automation and autonomy are widely discussed, the concept of autonomicity—the system’s ability to self-manage, adapt, and make decisions independently—remains theoretically underdeveloped and lacks a structured framework for assessment. This study addresses this gap by defining the concept of autonomicity in CPS and proposing a five-level evaluation scale. A theory development approach was adopted, supported by a systematic literature review and a bibliometric analysis conducted using the Scopus database and VOSviewer software. The resulting scale classifies CPS autonomicity from total human dependence to full self-management, incorporating criteria such as AI capabilities, self-learning, fault tolerance, and autonomous decision-making. The findings contribute to both theory and practice by refining the conceptual understanding of CPS autonomicity and offering a structured tool for its assessment. This work provides a foundation for future empirical research and supports strategic planning in autonomous industrial environments.

Introduction: Physical Education plays a fundamental role in the development of socio-emotional competences, contributing to the improvement of school coexistence within the educational context. These skills are essential to ensure the overall well-being of pupils, fostering their interpersonal development and enhancing academic performance. Objective: To analyse, through a systematic review, how Physical Education promotes socio-emotional development and strengthens school coexistence. Methodology: An exhaustive search was conducted in the databases Scopus, WoS, SciELO, and Dialnet, considering studies published between 2012 and 2025 in Spanish and English. The inclusion criteria focused on the relationship with the subject, socio-emotional skills, and school coexistence. After applying methodological and thematic filters, 10 scientific studies were selected. Results: The findings reveal significant improvements in competences such as emotional self-regulation, empathy, cooperation, and problem-solving. Furthermore, Physical Education programmes are consolidated as an effective pedagogical resource for promoting an inclusive, cooperative, and respectful school climate. Conclusion: Physical Education constitutes a key pedagogical tool to enhance pupils’ socio-emotional development and optimise school coexistence.

Suboptimal dose of approved disease modifying therapies in management of patients with multiple sclerosis: A systematic review.

Antimicrobial resistance pattern of enterococcus species among clinical isolates in Iran: A systematic review and meta-analysis.

Natural language processing in medical text processing: A scoping literature review.

Contribution of sleep disturbances to cognitive changes in vascular cognitive impairment.

Management of neuropathic pain and paresthesia in patients with multiple sclerosis: A systematic review and network meta-analysis.

To systematically review the factors that predict changes in upper-extremity motor function in response to constraint-induced movement therapy (CIMT) or bimanual training in children with cerebral palsy (CP). The PubMed, Cochrane, Embase, Scopus, CINAHL, and PEDro databases were searched. Studies were included if predictor variables were measured at baseline and were linked to an upper-extremity motor function outcome after intervention. Studies investigating only neurophysiological biomarkers were excluded. Two independent reviewers conducted study selection, risk of bias assessment, data extraction, and synthesis. The electronic search yielded 4317 articles, of which 23 were included (14 of 23 were randomized controlled trials). The most frequently studied factors were baseline motor outcomes (19 studies), age (19 studies), behavior (six studies), sex (six studies), and affected side (six studies), with inconsistent evidence to support an association with changes in upper-extremity motor function after CIMT or bimanual training. Cognitive deficits, somatosensory deficits, and mixed effects of predictive factors were rarely studied. Based on current evidence, it is inconclusive whether children with CP benefit from CIMT or bimanual training, regardless of their baseline upper-extremity motor function, age, sex, affected side, or behavior.

Systematic review: The impact of virtual reality interventions on stress and anxiety in intensive care units.

This Literature Study aims to analyze various research results on biotechnology and bioengineering that focus on the potential of chicken egg biomaterials as medical solutions. This study uses descriptive qualitative research based on literature studies by reviewing scientific articles from 2020–2025 from the PubMed, Scopus, Sciencedirect, and Google Scholar databases. The results of the study show that chicken egg biomaterials have significant potential in tissue engineering, drug delivery, and degenerative disease therapy. Eggshells are rich in calcium carbonate and hydroxyapatite, which are relevant for hard tissue regeneration. The shell membrane contains collagen and glycosaminoglycans with anti-inflammatory and regenerative activities. Egg whites contain bioactive proteins such as ovalbumin and ovotransferrin, which play a role in wound healing and anticancer activity, while egg yolks are rich in lipids and immunoglobulin Y, which support drug delivery and immunological therapy. Overall, chicken egg biomaterials show high potential as a sustainable, biocompatible, and economical alternative to synthetic materials for the development of drug delivery systems and future biomedical therapies. Keywords: Biotechnology, Bioengineering, Biomaterial, Chicken Egg, Medical Drug.