Two decades of the Mexican Proteomics Society: the history and evolution of proteomics and metabolomics in Mexico.

Beyond molecular structure: Comparing Australian and European regulatory approaches to nano-identification and classification.

Effects of transcranial direct current stimulation on foot sensorimotor function and postural control in healthy young adults: A systematic review and meta-analysis based on randomized controlled trials.

Chinese medicines as therapeutic options for treating prostate cancer: Therapeutic effects and underlying mechanisms.

A knowledge-data fusion framework accelerates deep reinforcement learning for real-time control of urban drainage systems.

Abstract: Adopting an interdisciplinary approach, this study demonstrates how the French epistemologist and philosopher of science Michel Serres and the Appalachian poet Robert Morgan recount the Great Story of life in a remarkably similar way. Informed and inspired by scientific knowledge of the universe and our small place in it, Serres and Morgan decenter dominant anthropocentric metanarratives by exploring the bittersweet laws that govern the existence of all species. Eviscerating mechanistic explanations of the biosphere through the metaphor of music and a reevaluation of “background noise,” they put the final proverbial nail in the coffin of the animal-machine hypothesis. Nonetheless, on an interconnected planet where all material beings are “Kudzu cousins,” Serres and Morgan’s reflections about the doctrine of universal predation caution us to not idealize indiscriminate, ecological forces. Despite the unavoidability of anguish and mortality in a given ontological shape, they also adamantly maintain that the elemental concert of which we are a tiny part can at times be beautiful. For the philosopher and the poet, we can tap into this cosmic grandeur by rehabilitating our numbed senses, thereby permitting us to catch a glimpse of the Divine in the process. Unfortunately, Serres and Morgan recognize that it is becoming harder with each passing day to envision a more viable path for preserving the musical refrains that sustain all life in the Anthropocene.

QUANTIFICATION OF COPPER IN TRADITIONAL SWEETS FROM PELOTAS: CONTRIBUTION OF SCIENTIFIC KNOWLEDGE TO THE DEBATE ON THE USE OF COPPER PANS IN THE MANUFACTURE OF ARTISANAL SWEETS. The sweets from Pelotas, recognized as Brazilian heritage, preserve ancestral knowledge maintained by female confectioners. The ban on copper pans in production has sparked debate, as these utensils are believed to release excess copper into food. This study quantifies copper in sweets to support discussion on restrictions and gaps between ANVISA (Brazilian Health Regulatory Agency) regulations and scientific evidence. Five traditional sweets from Pelotas were analyzed, and copper concentration ranged from < limits of detection (LOD) of 0.140 to 25.97 mg kg–1. Among them, three had copper levels in sweets below ANVISA limit (10 mg kg–1), while two exceeded it. Even so, the latter concentrations were lower than those limits recommended by ANVISA to other foods such as nuts and coffee. In this context, these results raise questions about the true source of copper in sweets that exceeded the limit, as samples prepared in the same copper pans sometimes showed concentrations below the LOD, while others surpassed legal thresholds. This suggests copper may come from ingredients rather than pans. Thus, copper pans – already legalized for sweet production in states like Minas Gerais – may not be the “villain”, supporting the preservation of traditional sweet-making with appropriate safety measures.

Introduction: Pregnancy was recognised as a stage of major physical, emotional and social changes, during which women faced risks that compromised their well-being and that of their babies. When perinatal death occurred, that moment of hope turned into deep sadness, affecting not only the mother but also her family. Globally and locally, as in Santander, the figures showed the magnitude of this public health problem.Development: Perinatal bereavement was a painful experience that was misunderstood and not adequately addressed by the health system. The mother experienced complex emotions such as guilt, frustration and anger. In this context, nursing played an essential role, providing empathetic support and comprehensive care. Trained professionals applied strategies to recognise emotional suffering and mitigate its consequences. Kristen Swanson's theory of care provided guidance based on close support, empathy and compassion. The Colombian legal framework established standards to protect pregnant women and ensure timely and humane interventions, recognising the right to dignified and respectful mourning.Conclusion: Perinatal death was a traumatic event that required a holistic response from nursing. It was necessary to integrate scientific knowledge, human sensitivity, and regulatory compliance to provide comfort and guidance to families. The intervention of nursing staff, based on theories such as Swanson's, made it possible to address this experience from an emotional, spiritual, and clinical perspective, strengthening the well-being of the mothers affected.

A data-driven and expert flood knowledge model based on the development of the Huber loss function for flood forecasting.

ABSTRACT The Covid-19 pandemic and looming prospect of climate change have brought a debate on the role of expertise and scientific knowledge in policymaking to the fore. This debate informs the work of many scholars working on the dangers and promises of technocracy. Technocracy, however, is neither the only nor the most important ideology that calls for policymaking based on science, research, scholarship, and expertise. In the wake of the ongoing crisis of democratic regimes, it is the ideology of expertocracy that is most significantly gaining in influence. This paper proposes a conceptualization of expertocracy, while at the same time taking its flexible, promiscuous-by-design character into account and framing it as a thin-centered ideology that needs to be distinguished from technocracy and scientific policy advice. These concepts are then used to analyze the writings of Luisa Neubauer, a leading figure of the German branch of Fridays for Future. This case also helps us to understand why the thin-centered ideology of expertocracy is better adapted than technocracy and scientific policy advice both to the current polarization of democratic political life and to the context of looming climate change.

The present text proposes a philosophical-theological reading of conversion based on Ignatian spirituality as reinterpreted by Karl Rahner (1904–1984), one of the most influential theologians of the twentieth century and a central figure in the anthropological turn of contemporary theology. His work marks the beginning of a new chapter in theological thought by integrating human experience as a hermeneutical locus of revelation and by fostering a fruitful dialogue with the philosophical and scientific knowledge of his time. Inspired by the wound of Pamplona and the itinerary of Ignatius of Loyola, this study understands conversion not merely as a religious event but as a cognitive and affective transformation of subjectivity — a process of transcendence involving reason, will, and sensibility. In dialogue with both classical and modern philosophers, it is argued that the experience of conversion can be understood as a movement of self-knowledge and of heeding meaning, in which the human being discovers himself as a discerning subject. Thus, conversion becomes a privileged hermeneutical categoryfor thinking the unity of pathos, logos, and praxis, revealing itself as an original form of theological knowledge and as a horizon for contemporary philosophical reflection.

In India, examinations play an important part in determining students' career choices, their ability to pursue the appropriate higher degrees, and the degree of knowledge they possess. Global competitive forces and a wave of industry upheavals have resulted in significant changes in skill development and in the decision-making process. India's long history of education has been documented throughout the ages. It elaborates on education systems referenced in various periods such as Upnishshadic, Bhudhist, Medieval, and Modern, as well as the systems used in ancient universities such as Taxila and Nalanda. It analyses education during the Mughal period. When much of the western world made fruitless attempts to go further into the educational area, India saw the growth of excellent, world-class universities. India was at the forefront of scientific knowledge and philosophical research during those eras of heavenly days. In this paper, manly explores the Vadic, Buddhist, and Islamic educational examination systems.

Objective: To provide a narrative overview of the scientific knowledge on Last Aid Courses and experiences from different countries. Background: The levels of death literacy, grief literacy, and knowledge about palliative care are low in many countries around the world. For many people, dying, death, and grief are still a taboo. Public Palliative Care Education (PPCE), the public knowledge approach, and the Last Aid Course (LAC) aim to increase death literacy, grief literacy, and public knowledge about palliative care. Methods: A literature search in the databases PubMed/Medline, CINAHL, and PsycInfo was undertaken. Other additional sources were found by hand searching, books, reference lists, and the internet. A narrative overview of the existing literature on LAC and Public Palliative Care Education (PPCE) is provided. Experiences with PPCE and LAC from different countries are presented. Based on the findings, a future agenda for research on PPCE and LAC is presented. Results and Discussion: PPCE and LAC have been introduced in 23 countries. A total of 17 articles and reviews on Last Aid were included. Research on the effects of LAC in different countries and cultural issues connected to LAC are ongoing. Conclusions: Since 2015, LACs have been introduced in 23 different countries. The LAC, the LAC-KT, and PPCE may enhance the public debate on dying, death, grief, and palliative care and may empower people to contribute to end-of-life care in the community. Future research on PPCE, the LAC, and the LAC-KT should focus on retention over time and the long-term effects of the courses.

Collaborative Learning (CL) is a longstanding teaching approach that is recognized to enhance academic success due to the promotion of learning activities among peers and through collaborative work. Despite its accepted international importance, very limited empirical studies on its impact at the primary school level are available in Islamabad. The aim of the study was to investigate how the collaborative learning strategies, namely: explicit group projects, peer tutoring, and collaborative problem-solving strategies, could improve the academic performance and knowledge retention of Grade V students in Federal Government Primary Schools. A true experimental design was used in which 62 students were randomly selected into control and experimental groups (31 students apiece). The experimental group was given instructions on the Science Explorations, collaborative method over an 8-week period, whereas the control group was instructed in a traditional way with lectures. An achievement test that was created by a researcher comprised 50 multiple-choice questions (MCQs), which served as a pre-test, post-test, and retention test. Independent sample t-tests were statistically analyzed with the effect sizes, and it was found that the students in the collaborative learning group significantly performed better than the students in the control group on the post-test scores and knowledge retention. Such results indicated that collaborative learning not only enhances short-term academic success but also aids in the long-term scientific knowledge. The research suggests that collaborative learning strategies should be incorporated in the classroom teaching at the primary level to ensure that students develop better insight and perpetual educational performance.

There is a known disconnect between scientific knowledge and its application in routine practice, known as the research-practice gap. A potential strategy to encourage research engagement among end-users is embedding researchers within an organization. This study set out to understand the views and experiences of senior managers, middle managers, and frontline staff in one department accessing and using research in a large organization with embedded researchers. We also investigated staff capacity to engage with research to identify opportunities to strengthen the use of research-based evidence in practice. We conducted 14 semi-structured in-depth interviews between November 2022 and April 2023 with senior managers, middle managers, and frontline staff working in the blood collection department at Australian Red Cross Lifeblood. Directed qualitative content analysis and the SPIRIT Action Framework were used to interpret the data. Capacity to engage with and use research varied greatly between participants and appeared to be affected by their role, training, and prior work experience. Participants valued research highly. However, only a few felt confident in their knowledge and skills to engage with research. Participants described a lack of visibility of research within the organization as well as systems and structures to access research. Experiences with accessing research, generating research, and interacting with researchers were mostly limited to senior managers. Research was chiefly used by senior managers to support changes, followed by understanding blood collection issues, and informing policy development. Although present, research use was often not visible to frontline staff. To increase research engagement and use, organizations should invest in strengthening their tools and systems, providing opportunities to increase individual knowledge and skills to engage with research, and increase the visibility of research and how it has been used.

The aim of the article is to study peculiarities of organising events in the qualification improvement for librarians at the National Library of Ukraine named after V. I. Vernadsky under the martial law conditions. The methodological basis of the article is formed by a complex of approaches to scientific knowledge (objectivity, connection between theory and practice), a principle of unity of interconnection with modern conditions and methods (analysis, cognitive method, structural-functional method, mathematical method, descriptive method, synthesis). Scientific novelty. The changes that occurred in organising advanced training for librarians at the National Library of Ukraine named after V. I. Vernadsky with the martial law introduction in Ukraine are highlighted. Main conclusions. It is found that the full-scale invasion of the russian federation troops into the territory of sovereign Ukraine shifted the emphasis in the scientific and methodological activities of the National Library of Ukraine named after V. I. Vernadsky as the main methodological centre of the National Academy of Sciences of Ukraine. Under the martial law conditions in Ukraine, thanks to NLUV, 11 events for improving the library staff’s skills were organised and held. Compared to the pre-war period, the following features of such events are identified and characterised: a change in the topic with an emphasis on the preservation of historical and cultural funds, effective use of all available channels for informing about new meetings, an updated format of the event holding (in 2022, exclusively online on the Zoom platform, previously – mixed one), a significant expansion of the geography of participants, an invitation of speakers from various institutions in the library area. The offered ranking by the speakers’ institution during the events in professional development held by the National Library of Ukraine named after V. I. Vernadsky in 2022–2025 showed the following: a total of 63 speakers were invited (56 speeches were delivered), in addition to NLUV specialists, (36 speakers present, 33 speeches were delivered), there were specialists of national and state book collections, speakers-representatives of higher education institutions (Kyiv National University of Culture and Arts, National Academy of Managerial Personnel of Culture and Arts, Kharkiv National Medical University, Uzhgorod National University) and Ivan Fedorov Book Chamber of Ukraine, which confirmed the importance of consolidating library science, education and practice in the field of improving the workers’ professional level in the information and library sphere.

Exactly 50 years ago, on December 12, 1975, ninety-eight Brazilian orthopedic surgeons gathered, at the invitation of Professor Manlio Mario Marco Napoli, to take part in the founding of the Brazilian Society of Podiatry—today known as the Brazilian Association of Foot and Ankle Medicine and Surgery (ABTPé). The founding ceremony was held at the headquarters of the São Paulo Medical Association and was honored by the presence of two world-renowned icons of Foot and Ankle Medicine and Surgery of that era, Dr. Antonio Viladot Pericé (Spain) and Dr. Hampar Kelikian (USA), who encouraged and strongly supported this Brazilian initiative. At that same meeting, the principal objectives of the new society were established: To bring together physicians interested in the clinical practice and surgery of the foot and ankle. To encourage, improve, and disseminate studies, knowledge, and practice in foot and ankle medicine and surgery. To maintain close cultural and scientific relationships with the Brazilian Society of Orthopedics and Traumatology (SBOT), the Brazilian Medical Association (AMB) and their regional branches, as well as with other official national entities and corresponding international organizations. To promote congresses, scientific meetings, symposia, and other academic activities. To publish and disseminate scientific and technical advances related to this field of medical knowledge. These objectives, defined half a century ago, remain alive and actively pursued in the daily work of ABTPé. Celebrating fifty years of history is an achievement that reflects the commitment, dedication, and scientific excellence that ABTPé has consistently upheld over the years. Its contribution to the development of the specialty—both in Brazil and throughout the region—represents a fundamental pillar for the advancement of knowledge, the training of highly qualified professionals for society, and the continuous improvement of patient care. It is deeply gratifying to recognize that, over the decades and through the dedication of successive boards and generations of members, we have preserved our focus and built a strong, cohesive, and effective society. United, we have continuously fulfilled and refined the goals inherited from our founders: We have disseminated scientific knowledge through 21 national congresses, numerous scientific meetings and thematic courses, national and international Foot Clubs, webinars, and the publication of textbooks dedicated to the specialty. We actively participate in the Latin American Federation (FLAMECiPP) and the International Federation of Foot and Ankle Societies (IFFAS), while maintaining close collaboration with federations in Europe, North America, Latin America, and the Asia-Pacific region. The Journal of the Foot and Ankle, the official scientific journal of the Latin American societies and Portugal, represents yet another original dream that has become a reality. In this year marking our fiftieth anniversary, we extend our sincere gratitude to each and every member of this Association who, in their own way, contributed to the many achievements we celebrate today.

Introduction. Modern linguistics shows a great interest in discourse analysis of rap lyrics as a marker of cultural and language dynamics. American rap lyrics is currently in the focus of song lyrics studies due to its dominant status in the global rap culture. The aim of the study is to reveal the vocabulary features of American rap lyrics of the XXI century and define the pragmatic intentions of the rap singers. Materials and Methods. The study material included the rap lyrics by popular American rappers of the XXI century. The number of analyzed lyrics totalled 20 rap songs. The method of content analysis, classification of lexical units, pragmatic analysis were used. Results. The classification of lexical units frequently used in modern American rap lyrics was developed, which includes slang, obscene vocabulary, abbreviations, metaphors, name-dropping, phrasal verbs and idioms. The thematic groups of the lexical units were defined. The analysis of rap lyrics by Kendrick Lamar and Cardi B showed the differences in their vocabulary choices and pragmatics of the vocabulary use revealing individual stylistic preferences of the rappers. Discussion and Conclusion. The study expands scientific knowledge of the lexical and semantic features of English-language rap lyrics and demonstrates how vocabulary choices can show pragmatic intentions of the rappers. The study results can be useful for further studies of English-language rap lyrics in the framework of gender linguistics, cultural linguistics, sociolinguistics.

The gut–brain axis (GBA) interaction is important for human health and disease prevention. Organ chips are considered a solution for GBA research. Three-dimensional (3D) cultures and microfluidics engineered in an organ chip could improve the scientific knowledge in the GBA interactions field. In this study, a novel organ chip is developed, which achieves multicellular three-dimensional cultivation by utilizing a decellularized matrix. In addition, this paper reports the rapid prototyping process of the GBA microfluidic chip in polydimethylsiloxane (PDMS) using 3D printing interconnecting poly(ethylene/vinyl acetate) (PEVA) microchannel templates. In comparison to the static culture system of the transwell model, the intestinal epithelial barrier (IEB) and blood–brain barrier (BBB) models on our chip demonstrated superior barrier function and the efflux functionality of transporters under appropriate fluidic conditions. Additionally, it is observed that butyrate protected against BBB dysfunction induced by gut-derived lipopolysaccharide (LPS) via enhancing intestinal barrier function. These results demonstrate that this multicellular, three-dimensional cultivation integrated with a fluidic shear stress simulation chip offers a promising tool for gut–brain interaction study to predict therapy of intestinal and neurological disorders.

ABSTRACT Borage pressed cake, a by‐product of borage oil extraction, currently remains an underutilized resource despite its high protein content (~32%, w/w). Scientific knowledge on borage seed proteins remains limited; therefore, this study aimed to characterize the composition and properties of borage seed proteins to address this gap and explore their potential as a novel protein source. Protein fractionation based on Osborne's classification identified glutelin as the predominant protein class, while a substantial proportion of the protein remained insoluble under standard Osborne extraction conditions, indicating the presence of structurally complex or aggregated protein forms. Polypeptide profile analysis using SDS‐PAGE revealed polypeptides characteristic of 2S‐albumin, 11S‐globulin, 7S‐globulin, and glutelin‐like proteins. Borage proteins demonstrated high thermal stability, with denaturation peaks at 109°C–110°C. Protein solubility was low across pH 2–10, with a minimum between pH 4–6 and a notable increase at pH 12. Functional assessments indicated water holding capacity of 0.59–0.67 g/g and oil holding capacity of 1.03–1.14 g/g. Lysine was found as the limiting amino acid in borage protein, with moderate digestibility resulting from in vitro protein digestibility corrected amino acid score (IVPDCAAS). Comparative analyses between laboratory‐prepared and commercially processed pressed‐cakes revealed differences in protein structure, functionality, and digestibility, likely due to processing variations. These findings highlight the nutritional and functional properties of borage pressed cake. However, this is the first scientific study focused on borage seed proteins. Further investigations are necessary to develop borage as a novel and sustainable protein source for plant‐based protein applications.