Beam Scanning Research Articles

Cellular Nanointerface of Vertical Nanostructures: Impact of Size‐Modulated Nanopillar Arrays on Neuronal Morphology, Maturation, and Synapse Formation

Investigating the cellular mechanisms facilitated by highly ordered nanostructures in vitro neuronal networks is crucial for advancing biomedical research. However, the intricate effects of these nanostructures on cellular behavior remain unclear. Herein, we explore how variations in nanopillar (NP) array dimensions, defined by the spacing‐to‐diameter (S/D) ratio, influence cortical neuronal responses—including cellular morphology, mechanosensing, neuronal maturation, and synapse formation. NP arrays with a low S/D ratio accelerate neurite protrusion and enhance neuronal maturation. These topography‐driven changes are attributed to the degree of cell confinement on NPs, which can be visualized using focused ion beam scanning microscopy. Furthermore, the synaptic density in cortical neurons declines as the S/D ratio decreases, with neurons preferring to form synapses along the NPs. By utilizing correlative light and electron microscopy, the spatial organization of these synapses is mapped relative to the NP geometries, revealing specialized synaptic regions with remarkable clarity. This approach to designing high‐aspect‐ratio nanostructures with various S/D ratios holds broad applications in materials engineering, offering insights into nervous system engineering and neural‐interfacing bioelectronics.

Optimizing dose parameters for enhanced maskless lithography in MoS2-based devices

Maskless lithography simplifies the fabrication process and reduces costs compared to electron beam (E-beam) lithography, making it a more efficient choice for patterning nano-devices. Maskless lithography presents a promising avenue for expediting device fabrication by eliminating the need for masks. This technique can streamline the production of basic electronic devices, offering an efficient and low-cost alternative to traditional lithographic methods, like E-beam lithography. This study utilized a 405 nm photodiode to achieve pattern-writing with a minimum linewidth of 1 μm. Exploring optimal parameters includes adjustments in beam intensity, scan speed, and step size. Maskless lithography was applied to 2D transition metal dichalcogenides (TMDCs) material, MoS2, to investigate their electrical transport characteristics. The fabricated device exhibits an ON/OFF ratio of ∼1.7 × 106 and a mobility of ∼0.833 cm2/V·s, indicating a high switching efficiency. The results demonstrate optimized maskless lithography's potential for swift and cost-effective fabrication, offering intermediate-resolution patterning capabilities.

Real-time tracking of the Bragg peak during proton therapy via 3D protoacoustic Imaging in a clinical scenario

Proton radiotherapy favored over X-ray photon therapy due to its reduced radiation exposure to surrounding healthy tissues, is highly dependent on the accurate positioning of the Bragg peak. Existing methods like PET and prompt gamma imaging to localize Bragg peak face challenges of low precision and high complexity. Here we introduce a 3D protoacoustic imaging with a 2D matrix array of 256 ultrasound transducers compatible with 256 parallel data acquisition channels provides real-time imaging capability (up to 75 frames per second with 10 averages), achieving high precision (5 mm/5% Gamma index shows accuracy better than 95.73%) at depths of tens of centimeters. We have successfully implemented this method in liver treatment with 5 pencil beam scanning and in prostate cancer treatment on a human torso phantom using a clinical proton machine. This demonstrates its capability to accurately identify the Bragg peak in practical clinical scenarios. It paves the way for adaptive radiotherapy with real-time feedback, potentially revolutionizing radiotherapy by enabling closed-loop treatment for improved patient outcomes.

Long-term stability of a PTW 34070 large-area parallel ionization chamber in clinical proton scanning beams.

In the modeling of beam data for proton therapy planning systems, absolute dose measurements are performed utilizing a Bragg peak chamber (BPC), which is a parallel-plate ionization chamber. The long-term stability of the BPC is crucial for ensuring accurate absolute dose measurement. The study aims to assess the long-term stability of the BPC in clinical proton pencil beam scanning delivery. The long-term stability evaluation focused on the BPC-Type 34070 (PTW Freiburg, Germany), utilizing clinical proton scanning beams from December 2022 to November 2023. Monthly investigations were conducted to evaluate the response and cross-calibration factor of the BPC and a reference chamber, employing the spread-out Bragg peak (SOBP) field. Additionally, assessments were made regarding the BPC's response to monoenergetic beams, along with an examination of the impact of polarity and ion recombination on the BPC. The response and cross-calibration factor of the BPC varied up to 1.9% and 1.8%, respectively, while the response of the reference chamber remained within a 0.5% range. The BPC's response to the mono-energetic beams varied up to 2.0% across all energies, demonstrating similar variation trends in both the SOBP field and mono-energetic beams. Furthermore, the variations in polarity and ion recombination effect remained stable within a 0.4% range throughout the year. Notably, the reproducibility of the BPC remained high for each measurement conducted, whether for the SOBP field or mono-energetic beams, with a maximum deviation observed at 0.1%. The response and cross-calibration factor of the BPC demonstrated significant variations, with maximum changes of 1.9% and 1.8%, respectively. However, the reproducibility of the BPC remained consistently high for each measurement. It is recommended that when conducting absolute dose measurements using a BPC, its response should be compared and corrected against the reference chamber for each measurement.

Online MR-guided proton and ion beam radiotherapy: investigation of image quality

Objective.Magnetic resonance (MR) images free of artefacts are of pivotal importance for MR-guided ion radiotherapy. This study investigates MR image quality for simultaneous irradiation in an experimental setup using phantom imaging as well asin-vivoimaging. Observed artefacts are described within the study and their cause is investigated with the goal to find conclusions and solutions for potential future hybrid devices.Approach.An open MR scanner with a field strength of 0.25 T has been installed in front of an ion beamline. Simultaneous magnetic resonance imaging and irradiation using raster scanning were performed to analyze image quality in dedicated phantoms. Magnetic field measurements were performed to assist the explanation of observed artifacts. In addition,in-vivoimages were acquired by operating the magnets for beam scanning without transporting a beam.Main Results.The additional frequency component within the isocenter caused by the fringe field of the horizontal beam scanning magnet correlates with the amplitude and frequency of the scanning magnet steering and can cause ghosting artifacts in the images. These are amplified with high currents and fast operating of the scanning magnet. Applying a real-time capable pulse sequencein-vivorevealed no ghosting artifacts despite a continuously changing current pattern and a clinical treatment plan activation scheme, suggesting that the use of fast imaging is beneficial for the aim of creating high quality in-beam MR images. This result suggests, that the influence of the scanning magnets on the MR acquisition might be of negligible importance and does not need further measures like extensive magnetic shielding of the scanning magnets.Significance.Our study delimited artefacts observed in MR images acquired during simultaneous raster scanning ion beam irradiation. The application of a fast pulse sequence showed no image artefacts and holds the potential that online MR imaging in future hybrid devices might be feasible.

Full‐angle beam scanning leaky‐wave antenna array based on spoof surface plasmon polaritons

AbstractA design scheme of high‐gain and full‐angle frequency beam scanning leaky wave antenna (LWA) and array is proposed based on spoof surface plasmon polaritons (SSPPs) slow‐wave transmission line (TL) for radar field applications. A row of complementary split ring resonators is periodically etched near the SSPPs TL, which can transform the fundamental mode of SSPPs TL to the fast‐wave region and radiate electromagnetic waves, realising the full‐angle frequency beam scanning performance. A 1‐to‐2 microwave power divider is designed to feed the LWA array and realised good impedance matching covers 5.8–9.4 GHz bandwidth. Simulation and experimental results indicate that the designed LWA array can realise full‐angle beam scanning range of 180° (−90° to 90°) with a scanning rate of 3.83°/% performance. The peak gain values of the designed LWA element and array are 11.4dBi and 14.6 dBi, respectively, and the radiation efficiency of LWA array is maintained more than 80% within the operation frequency band.

A wide angle beam scanning CRLH leaky-wave antenna with non-identical elements per unit-cells

In this research article, a wide-angle scanning leaky-wave antenna (LWA) based on the composite right/left-handed (CRLH) metamaterial (MTM) operating over the C-band spectrum for mobile applications is proposed, investigated, and realized. The proposed LWA includes nine CRLH-MTM-based unit-cells. The properties of CRLH-MTM have been applied using series slots and shunt metallic via-holes. Each unit cell consists of three patches, two external patches, and one smaller middle patch implemented between them. One slot has been etched on each external patch; the width of these two slots is unequal. Moreover, the distance of the middle patch with each side patch is different. The results show that using this method of realizing non-identical elements caused the achievement of proper return-loss at the transition frequency and provided the balanced CRLH metamaterial condition. Additionally, using CRLH-MTM properties by realizing series capacitance (slot) and shunt inductance (via-holes) made the wide-angle scant from backward to forward radiation pattern. The results demonstrate that the LW antenna with small dimensions of 251.5 × 30 × 1.575 mm3 operates over a frequency range of 4.8–6.13 GHz covering a wide beam scanning range from −63° to +65° with broadside radiation at the center frequency of 5.46 GHz. The radiation gain of the proposed antenna varies from 6.2–13.1 dB. The achievements confirm the effectiveness of the proposed methods to realize a high-performance LW-antenna with the advantages of simple design, low profile, low cost, and easy of manufacture for mobile applications.

Hitless two-dimensional focal plane switch array based on Mach-Zehnder interferometer-embedded micro-ring resonators

Empowered by compact micro-ring (MRR) arrays, wavelength-division-multiplexing (WDM)-based focal plane switch array (FPSA) chip is a promising solution for light detection and ranging (LiDAR) due to its parallelism and high-level integration. However, an MRR channel with a shifting central wavelength may interrupt another channel by dropping an optical signal with an unexpected wavelength, which causes discontinuous beam scanning. To overcome this bottleneck, we propose and fabricate a hitless two-dimensional (2-D) FPSA chip based on a 2 × 8 Mach-Zehnder interferometer-embedded micro-ring resonator (MZER) array. The FPSA chip realizes a beam divergence of 0.18° × 0.05°, a field of view (FoV) of 9.07° × 6.42° with single-ended emission, and a FoV of 10.75° × 6.42° with dual-ended field-of-view splicing technology. Besides, we demonstrate the hitless function of our FPSA chip by performing continuous wavelength sweeping and further applying it to a free-space optical communication link. The experimental results validate the feasibility of our proposed hitless FPSA chip, which efficiently prevents signal interruptions during beam steering.

Development of a three-dimensional scintillation detector for pencil beam verification in proton therapy patient-specific quality assurance.

Pencil Beam Scanning proton therapy has many advantages from a therapeutic point of view, but raises technical constraints in terms of treatment verification. The treatment relies on a large number of planned pencil beams (PB) (up to thousands), whose delivery is divided in several low-intensity pulses delivered a high frequency (1kHz in this study). The purpose of this study was to develop a three-dimensional quality assurance system allowing to verify all the PBs' characteristics (position, energy, intensity in terms of delivered monitor unit-MU) of patient treatment plans on a pulse-by-pulse or a PB-by-PB basis. A system named SCICOPRO has been developed. It is based on a 10×10×10cm3 scintillator cube and a fast camera, synchronized with beam delivery, recording two views (direct and using a mirror) of the scintillation distribution generated by the pulses. A specific calibration and analysis process allowed to extract the characteristics of all the pulses delivered during the treatment, and consequently of all the PBs. The system uncertainties, defined here as average value + standard deviation, were characterized with a customized irradiation plan at different PB intensities (0.02, 0.1, and 1 MU) and with two patient's treatment plans of three beams each. The system's ability to detect potential treatment delivery problems, such as positioning errors of the treatment table in this work (1° rotations and a 2mm translation), was assessed by calculating the confidence intervals (CI) for the different characteristics and evaluating the proportion of PBs within these intervals. The performances of SCICOPRO were evaluated on a pulse-by-pulse basis. They showed a very good signal-to-noise ratio for all the pulse intensities (between 2×10-3MU and 150×10-3MU) allowing uncertainties smaller than 580µm for the position, 180keV for the energy and 3% for the intensity on patients treatment plans. The position and energy uncertainties were found to be little dependent from the pulse intensities whereas the intensity uncertainty depends on the pulses number and intensity distribution. Finally, treatment plans evaluations showed that 98% of the PBs were within the CIs with a nominal positioning against 83% or less with the table positioning errors, thus proving the ability of SCICOPRO to detect this kind of errors. The high acquisition rate and the very high sensitivity of the system developed in this work allowed to record pulses of intensities as low as 2×10-3MU. SCICOPRO was thus able to measure all the characteristics of the spots of a treatment (position, energy, intensity) in a single measurement, making it possible to verify their compliance with the treatment plan. SCICOPRO thus proved to be a fast and accurate tool that would be useful for patient-specific quality assurance (PSQA) on a pulse-by-pulse or PB-by-PB verification basis.

Impact of interplay effects on spot scanning proton therapy with motion mitigation techniques for lung cancer: SFUD versus robustly optimized IMPT plans utilizing a four-dimensional dynamic dose simulation tool

BackgroundThe interaction between breathing motion and scanning beams causes interplay effects in spot-scanning proton therapy for lung cancer, resulting in compromised treatment quality. This study investigated the effects and clinical robustness of two types of spot-scanning proton therapy with motion-mitigation techniques for locally advanced non-small cell lung cancer (NSCLC) using a new simulation tool (4DCT-based dose reconstruction).MethodsThree-field single-field uniform dose (SFUD) and robustly optimized intensity-modulated proton therapy (IMPT) plans combined with gating and re-scanning techniques were created using a VQA treatment planning system for 15 patients with locally advanced NSCLC (70 GyRBE/35 fractions). In addition, gating windows of three or five phases around the end-of-expiration phase and two internal gross tumor volumes (iGTVs) were created, and a re-scanning number of four was used. First, the static dose (SD) was calculated using the end-of-expiration computed tomography (CT) images. The four-dimensional dynamic dose (4DDD) was then calculated using the SD plans, 4D-CT images, and the deformable image registration technique on end-of-expiration CT. The target coverage (V98%, V100%), homogeneity index (HI), and conformation number (CN) for the iGTVs and organ-at-risk (OAR) doses were calculated for the SD and 4DDD groups and statistically compared between the SD, 4DDD, SFUD, and IMPT treatment plans using paired t-test.ResultsIn the 3- and 5-phase SFUD, statistically significant differences between the SD and 4DDD groups were observed for V100%, HI, and CN. In addition, statistically significant differences were observed for V98%, V100%, and HI in phases 3 and 5 of IMPT. The mean V98% and V100% in both 3-phase plans were within clinical limits (> 95%) when interplay effects were considered; however, V100% decreased to 89.3% and 94.0% for the 5-phase SFUD and IMPT, respectively. Regarding the significant differences in the deterioration rates of the dose volume histogram (DVH) indices, the 3-phase SFUD plans had lower V98% and CN values and higher V100% values than the IMPT plans. In the 5-phase plans, SFUD had higher deterioration rates for V100% and HI than IMPT.ConclusionsInterplay effects minimally impacted target coverage and OAR doses in SFUD and robustly optimized IMPT with 3-phase gating and re-scanning for locally advanced NSCLC. However, target coverage significantly declined with an increased gating window. Robustly optimized IMPT showed superior resilience to interplay effects, ensuring better target coverage, prescription dose adherence, and homogeneity than SFUD.Trial registration: None.

Analysis of rain effects on China-France oceanography satellite scatterometer backscatter measurements

ABSTRACT The rotating fan beam scanning observation mechanism of China-France oceanography satellite (CFOSAT) scatterometer provides more comprehensive ocean measurements. However, its data quality is often impacted by rain contamination. In this study, we analysed the effect of rain on CFOSAT SCATterometer (CSCAT) backscatter measurements by collocating CSCAT data, the Integrated Multi-satellitE Retrievals (IMERG) rain data, and the wind reanalysis from European Centre for Medium-Range Weather Forecasts (ECMWF). The research findings indicate that, rain exhibits an intensification effect on backscatter at low wind speeds, but this effect gradually diminishes with increasing wind speeds, eventually transitioning to an attenuation effect at a wind speed between 10–20 m·s−1. At extremely high wind speeds above 20 m·s−1, the rain initially increases and then decreases CSCAT normalized radar cross section (σ 0) as the rain rate increases. The sensitivity of CSCAT σ 0 to rain rate decreases as the incidence angle increases. Its sensitivity to wind speed decreases as the rain rate increases. The azimuthal modulation becomes more pronounced with higher wind speeds and smaller incidence angles. However, rain weakens the asymmetry and anisotropy. Furthermore, the HH polarization exhibits a more pronounced susceptibility to rain compared to the VV polarization.

A Configurable Multiport Wire Antenna for Wideband Beamforming and Beam Scanning

A Configurable Multiport Wire Antenna for Wideband Beamforming and Beam Scanning

Analysis of electrothermal damage in a radome exposed to electromagnetic radiation

Abstract After nearly 9 months of electromagnetic irradiation with a power density of 10 W/cm2, the unit blocks of an A-sandwich radome in the electromagnetic beam scanning area experienced electrothermal damage. Both the inner skin and core layer foam of the A-sandwich unit blocks in that area present different levels of damage. The inner skin is wrinkled and cracked, and the core layer foam is locally charred, carbonized, and ablated. The temperature images recorded through the infrared thermal beam method show that the temperature distribution of the unit blocks in the beam irradiation area is abnormal and strongly related to the discontinuous structure distribution of the core foam and resin. The non-uniformity of core material is the main cause of the electrothermal damage to unit blocks. By process improvements, the shaping of the polyurethane foam core layer is changed from cutting, resin bonding, and splicing to one-step foaming without resin binder, and the continuity of the core layer material is ensured. The usage results of unit blocks made by the new process show that the temperature field distribution is uniform, with a maximum temperature of only 31.3°C, which is 71.62% lower than the maximum temperature of 110.3°C in the damaged block.

Setting the Stage: Feasibility and Baseline Characteristics in the PARTIQoL Trial Comparing Proton Therapy Versus Intensity Modulated Radiation Therapy for Localized Prostate Cancer

Men with localized prostate cancer may receive either photon-based intensity modulated radiation therapy (IMRT) or proton beam therapy (PBT). The PARTIQoL trial (NCT01617161) demonstrates the feasibility of performing a large, multicenter phase 3 randomized trial comparing IMRT with PBT for localized prostate cancer. Here, we report baseline features of patients enrolled on this trial and present strategies to improve feasibility of other similar trials. Patients with low- or intermediate-risk prostate cancer were randomly assigned to either PBT or IMRT with stratification by institution, age, use of rectal spacer, and fractionation schedule (conventional fractionation: 79.2 Gy in 44 fractions vs moderate hypofractionation: 70.0 Gy in 28 fractions). The primary endpoint is a change from baseline bowel health using the Expanded Prostate Index Composite score 24 months after radiation therapy. Secondary objectives include treatment-related differences in urinary and erectile functions, adverse events, and efficacy endpoints. Between July 2012 and November 2021, 450 patients were successfully accrued. Patients were randomly assigned to either PBT (N = 226) or to IMRT (N = 224); 13 were ineligible or withdrew before treatment. The median age of 437 analyzed patients was 68 years (range, 46-89 years). A total of 41% of patients had low-risk and 59% had intermediate-risk disease. In total, 49% of patients were treated with conventional fractionation and 51% with moderately hypofractionation. 48% of patients used a rectal spacer. For patients receiving PBT, pencil beam scanning was used in 48%. PBT and IMRT arms were balanced for baseline variables. Despite significant challenges, the PARTIQoL trial demonstrated that, with targeted recruitment approaches, multicenter collaboration, payer engagement, and protocol updates to incorporate contemporary techniques, it is feasible to perform a large phase 3 randomized clinical trial to assess whether PBT improves outcomes. We will separately report primary results and continue to monitor participants for longer follow-up and secondary endpoints.

Online Adaptive Proton Therapy Facilitated by Artificial Intelligence–Based Autosegmentation in Pencil Beam Scanning Proton Therapy

PurposeOnline adaptive proton therapy (oAPT) is essential to address interfractional anatomical changes in patients receiving pencil beam scanning proton therapy (PBSPT). Artificial intelligence (AI)-based auto-segmentation can increase the efficiency and accuracy. Linear energy transfer (LET)-based biological effect evaluation can potentially mitigate possible adverse events caused by high LET. New spot arrangement based on the verification CT (vCT) can further improve the re-plan quality. We propose an oAPT workflow that incorporates all these functionalities and validate its clinical implementation feasibility with prostate patients. Methods and MaterialsAI-based auto-segmentation tool AccuContourTM (Manteia, Xiamen, China) was seamlessly integrated into oAPT. Initial spot arrangement tool on the vCT for re-optimization was implemented using raytracing. An LET-based biological effect evaluation tool was developed to assess the overlap region of high dose and high LET in selected OARs. Eleven prostate cancer patients were retrospectively selected to verify the efficacy and efficiency of the proposed oAPT workflow. The time cost of each component in the workflow was recorded for analysis. ResultsThe verification plan showed significant degradation of the CTV coverage and rectum and bladder sparing due to the interfractional anatomical changes. Re-optimization on the vCT resulted in great improvement of the plan quality. No overlap regions of high dose and high LET distributions were observed in bladder or rectum in re-plans. 3D Gamma analyses in PSQA confirmed the accuracy of the re-plan doses before delivery (Gamma passing rate = 99.57 ± 0.46%), and after delivery (98.59 ± 1.29%). The robustness of the re-plans passed all clinical requirements. The average time for the complete execution of the workflow was 9.12 ± 0.85 minutes, excluding manual intervention time. ConclusionThe AI-facilitated oAPT workflow was demonstrated to be both efficient and effective by generating a re-plan that significantly improved the plan quality in prostate cancer treated with PBSPT.

Compact Slow-Wave Half-Mode SIW Periodic Leaky-Wave Antenna With Continuous Beam Scanning and High Gain

Compact Slow-Wave Half-Mode SIW Periodic Leaky-Wave Antenna With Continuous Beam Scanning and High Gain

Determination of the optimal number of detectors for the multiangle wire beam scanning method

The implementation of control over the characteristics of the beam is an important stage in the conduct of experiments within the field of accelerator physics. The multiangle scanning method based on the reconstruction of the electron beam profile image from projection data can be used to determine the distribution of beam intensities in the transverse plane. In order to reduce the time required for measurement, it is proposed that a set of detecting elements be used in place of a single detecting element when employing this method. This work presents a scheme for optimized data collection using the multiangle scanning method and evaluates the applicability of the modernized approach. For this, a numerical experiment was conducted to determine the beam profile using different numbers of detecting elements. The results of this study demonstrate that the use of multiple detecting elements for the implementation of the multiangle scanning method reduces the measurement time and ensures high quality of the reconstructed beam profile images. It was demonstrated that the minimum number of detecting elements necessary to ascertain a specific beam profile is ten.

A Microstrip Leaky-Wave Antenna with Scanning Beams Horizontal to the Antenna Plane

A Microstrip Leaky-Wave Antenna with Scanning Beams Horizontal to the Antenna Plane

708: Clinical Efficacy & Dose Analysis of Salvage Prostate Cancer Retreatments using Proton Beam Scanning

708: Clinical Efficacy & Dose Analysis of Salvage Prostate Cancer Retreatments using Proton Beam Scanning

Dynamic near-field and far-field radiation manipulation using a reprogrammable guided-wave-excited metasurface

The dynamic and integrated control of near- and far-field electromagnetic waves is essential for advancing emerging intelligent information technology. Metasurfaces, distinguished by their low-profile design, cost-effectiveness, and ease of fabrication, have successfully revolutionized various electromagnetic functions. However, current research on the dynamic integrated manipulation of near-field and far-field electromagnetic waves using a single metasurface remains relatively constrained, due to the complexity of element-level control, restricted dynamic tuning range, and tuning speed. Herein, we propose an element-level controlled, versatile, compact, and broadband platform allowing for the real-time electronic reconstruction of desired near/far-field electromagnetic wavefronts. This concept is achieved by precisely regulating the 1-bit amplitude coding pattern across a guided-wave-excited metasurface aperture loaded with PIN diodes, following our binary-amplitude holographic theory and modified Gerchberg–Saxton (G–S) algorithm. Consistent findings across calculations, simulations, and experiments highlight the metasurface’s robust performance in 2D beam scanning, frequency scanning, dynamic focusing lens, dynamic holography display, and 3D multiplexing holography, even under 1-bit control. This simplified and innovative metasurface architecture holds the promise of substantially propelling forthcoming investigations and applications of highly integrated, multifunctional, and intelligent platforms.