SESSION TITLE: Pediatrics SESSION TYPE: Original Investigations PRESENTED ON: 10/20/2019 2:15 PM - 3:15 PM PURPOSE: To evaluate the utility of TBA in assessing reversibility to bronchodilator in children METHODS: This is a cross-sectional study. A total of 72 subjects were classified as to doubtful and probable asthma based on the questionnaire adopted from 2017 GINA guidelines. The TPEF/TE and VPEF/TE were measured using Jaeger Masterscreen Baby Body Pediatric System and all subjects where exposed to bronchodilator salbutamol to deteremined reversibility and response. RESULTS: The doubtful and probable range of TPTEF/TE pre-bronchodilator were 25.91 + 8.61 and 25.07 + 7.54 while VPEF/TE values pre-bronchodilator revealed 28.88 + 6.75 and 28 + 6.34 respectively. Bronchodilator response in children with TPTEF/TE in doubtful asthma revealed 18 (50%) and 16 (44.44%) non-responders. VPEF/TE had 19 (54.29%) responders and 15 (40.54%) non-responders. There were 18 (50%) responders and 20 (55.56%) non-responders with TPTEF/TE in probable asthma group. The cut-off value of TPTEF in this study is > 12.4 with 100% sensitivity and specificity while VPEF salbutamol response cut-off value of > 12 with 100% sensitivity and 94.59% specificity. CONCLUSIONS: This study showed that TBA (TPTEF/TE and VPEF/TE) pre-bronchodilator values of 25.91 + 8.61 and 28.88 + 6.75 can be used as a reference value for patients with doubtful and probable asthma. However, the utility of TBA as a tool to determine the reversibility to bronchodilator is statistically not significant. Cut-off value of TPTEF/TE and VPEF/TE for reversibility to bronchodilator showed > 12.4 and > 12 respectively. Both showed 100% sensitivity and 94.9% specificity for VPEF/TE. CLINICAL IMPLICATIONS: Asthma is a heterogeneous disease, usually characterized by chronic airway inflammation . It may be difficult to make a confident diagnosis of asthma in children 5 years and younger, because episodic respiratory symptoms such as wheezing and cough are also common in children without asthma, particularly in those 0-2 years old. These patients may subject to Tidal Breathing Analysis (TBA) in order to identify patients with expiratory obstruction and reversibility to salbutamol nebulization. Numerous study has been published to emphasize the usefulness of tidal breathing analysis to diagnosed probable asthma/obstructive airway disease. However, there has been limited studies regarding the range of significant values of TBA parameters in assessing airway obstruction and reversibility after bronchodilator challenge. This study proved that TBA can be used to delineate patients with doubtful and probable asthma and will give the sensitivity and specificity cut-off values for reversibility to bronchodilator. DISCLOSURES: No relevant relationships by Brenda Lou Lovely Abanilla, source=Web Response