For the detoxification of mycotoxin aflatoxin B1 in the feeding of poultry, various probiotic feed preparations based on living beneficial microorganisms and antioxidants, which significantly improve the intestinal microflora, immunity, digestibility and digestibility of nutrients feed, which has a positive effect on productivity. This article presents experimental data that suggest that to increase the growth rate, digestibility and digestibility of nutrients in the feed for quails based on barley grain, sorghum and soybean meal with a tolerant level of aflatoxin B1 should be added together probiotic Bioximin «Chicken» at a dose of 1500 g/t and vitamin C at a dose of 500 g/t feed. In comparison with the control analogues in poultry of 3 experimental groups in increasing the safety of livestock by 6 %, the average daily gain of live weight - by 12.48 % while reducing feed consumption per 1 kg of increase - by 11.84 %. Feeding probiotic and vitamin C contributed to a significant (p<0.05) increase in the digestibility coefficients of dry matter by 3.08 %, organic matter - by 3.10 %, crude protein - by 3.30 %, crude fiber - by 3.06 % and BEV - by 3.33 %. Better digestibility of raw protein of feed was promoted by joint additives of probiotic and antioxidant.