Role Of Electromagnetic Fields Research Articles

Central Causation of Autism/ASDs via Excessive [Ca2+]i Impacting Six Mechanisms Controlling Synaptogenesis during the Perinatal Period: The Role of Electromagnetic Fields and Chemicals and the NO/ONOO(-) Cycle, as Well as Specific Mutations.

The roles of perinatal development, intracellular calcium [Ca2+]i, and synaptogenesis disruption are not novel in the autism/ASD literature. The focus on six mechanisms controlling synaptogenesis, each regulated by [Ca2+]i, and each aberrant in ASDs is novel. The model presented here predicts that autism epidemic causation involves central roles of both electromagnetic fields (EMFs) and chemicals. EMFs act via voltage-gated calcium channel (VGCC) activation and [Ca2+]i elevation. A total of 15 autism-implicated chemical classes each act to produce [Ca2+]i elevation, 12 acting via NMDA receptor activation, and three acting via other mechanisms. The chronic nature of ASDs is explained via NO/ONOO(-) vicious cycle elevation and MeCP2 epigenetic dysfunction. Genetic causation often also involves [Ca2+]i elevation or other impacts on synaptogenesis. The literature examining each of these steps is systematically examined and found to be consistent with predictions. Approaches that may be sed for ASD prevention or treatment are discussed in connection with this special issue: The current situation and prospects for children with ASDs. Such approaches include EMF, chemical avoidance, and using nutrients and other agents to raise the levels of Nrf2. An enriched environment, vitamin D, magnesium, and omega-3s in fish oil may also be helpful.

Role of Electromagnetic Activity in Cellular Mechanics

The cell is the building block of life since it is the fundamental unit of all living things. Organelles, the cytoplasm, the nucleus, and other structures all have specific roles in cells. Genetic makeup, which controls cell growth, reproduction, and environmental response, determines the structure and function of cells. It is commonly known that cells communicate chemically and electrically. Cellular interactions via other physical fields are exactly the opposite. The electromagnetic field (EMF) is the most likely option for a different type of cellular interaction. This review delves into the role of electromagnetic fields in cells and their consequential impact on cell behavior. This gives a broad perspective on the basic construction and operation of cells, presents the notion of cellular mechanics, and deepens the understanding of the pivotal function of microtubules and centrosomes in cellular division. It also explores their interplay with the electromagnetic field. The discussion extends to how EMF influences ion channels on the cell membrane, a critical component in cellular communication, and the electrical properties of neurons. This review concludes by identifying the current limitations and gaps in EMF research in cells, such as constraints in experimental methods and technology, and the need for more comprehensive theories and models to fully understand these complex processes.

900 MHZ electromagnetic field exposure relieved AD-like symptoms on APP/PS1 mice: A potential non-invasive strategy for AD treatment

BackgroundEvidence shows that microwaves radiation may have various biological effects on central nervous system. Role of electromagnetic fields in neurodegenerative diseases, especially AD, has been widely studied, but results of these studies are inconsistent. Therefore, the above effects were verified again and the mechanism was preliminarily discussed. MethodsAmyloid precursor protein (APP/PS1) and WT mice were exposed to long-term microwave radiation for 270 days (900 MHz, SAR: 0.25–1.055 W/kg, 2 h/day, alternately), and related indices were assessed at 90, 180 and 270 days. Cognition was evaluated by Morris water maze, Y maze and new object recognition tests. Congo red staining, immunohistochemistry and ELISA were used to analyze Aβ plaques, Aβ40 and Aβ42 content. Differentially expressed proteins in hippocampus between microwave-exposed and unexposed AD mice were identified by proteomics. ResultsSpatial and working memory was improved in AD mice after long-term 900 MHz microwave exposure compared with after sham exposure. Microwave radiation (900 MHz) for 180 or 270 days did not induce Aβ plaque formation in WT mice but inhibited Aβ accumulation in the cerebral cortex and hippocampus in 2- and 5-month-old APP/PS1 mice. This effect mainly occurred in the late stage of the disease and may have been attributed to downregulation of apolipoprotein family member and SNCA expression and excitatory/inhibitory neurotransmitter rebalance in the hippocampus. ConclusionsThe present results indicated that long-term microwave radiation can retard AD development and exert a beneficial effect against AD, suggesting that 900 MHz microwave exposure may be a potential therapy for AD.

Arabidopsis cryptochrome and Quantum Biology: new insights for plant science and crop improvement

Arabidopsis is the plant species in which Cryptochrome, the first known flavin-type blue light receptor, was identified after over 100 years of effort. Even beyond their critical importance to plants, Arabidopsis cryptochromes have had a transcendental impact on many other fields due to the occurrence of homologs in animals and even man with many conserved features. Cryptochromes have furthermore contributed to the emerging field of Quantum Biology, which involves the study of quantum physical phenomena in biology and medicine. Quantum theory predicts that magnetic fields can alter the reaction rates (product formation) of biochemical reactions, including those catalyzed by metabolic enzymes or the biological activity of flavoprotein receptors such as cryptochromes. Therefore, electromagnetic fields could theoretically regulate many agronomically important plant processes, as well as those of other organisms. In this communication we briefly summarize the known effects of magnetic fields in biological systems with the view to identifying possible conserved underlying mechanisms with practical applications for plants. Evidence that Arabidopsis cryptochromes could serve as magnetic field sensors will be reviewed, as well as the role of electromagnetic fields in the formation of ROS (reactive oxygen species). In conclusion, we will suggest workable methods to achieve low cost, environmentally friendly, and broadly applicable crop improvement strategies using tools from Quantum Biology that can be implemented today.

ANTITUMOR EFFECT OF ELECTROMAGNETIC FIELDS AND THEIR EFFECT ON PAIN IN EXPERIMENTAL AND CLINICAL ONCOLOGY

The review examined and analyzed scientific publications on the effect of electromagnetic fields (EMF) on various sys­tems of the human body and animals with tumors, as well as on pain in the experiment and the clinic. The theoretical foundations and practical results of the use of EMF in various modulations and modes in the goals and objectives of oncology, including how to optimize the process of anesthesia and correct the vital activity of the body's functional systems with a tumor, are consecrated. Information is given on possible physicochemical effects, features, and mecha­nisms of therapeutic influence at various levels of a living organism. The ability of electromagnetic waves to transfer in­formation both within a single biosystem and at the level of a whole living organism with a tumor is shown. Studies of combined action of EMF and chemotherapy were analyzed. It has been established that there are experimental prerequisites for using this factor in order to induce changes in the permeability of the membranes of tumor cells by in­creasing the internalization of chemotherapeutic agents and, thus, enhance the antitumor effect. The role of EMF in the induction of apoptosis in tumor cells is shown. It has been shown that chemotherapy together with electromagnetic fields induces apoptosis and has an inhibitory effect on DNA synthesis in osteosarcoma cells, breast cancer, colon cancer, melanoma and other tumors. The role of magnetic fields in order to enhance the analgesic effect was investigated. The analgesic effect is due to the cessation or weakening of nerve impulses from the painful focus due to the elimination of hypoxia, the improvement of microcirculation, and the reduction of edema, it has been shown. Transcranial magnetic therapy is used as an analgesic tool in onconurology. The therapeutic anti-pain effect is associated with the stimulation of the antinociceptive system, an increase in the synthesis of natural analgesics — endorphins with their subsequent release into the cerebrospinal fluid and blood. As it has already been shown, with the increase in the intensity of pain and its duration, all indicators of the quality of life and the results of treatment of the patient deteriorate, so the search for ways to improve the antitumor effectiveness of specialized treatment and eliminate the causes that prevent their im­plementation continue to be relevant and in demand.

Электромагнитные поля в биосфере: преимущества и опасность

This paper is written in order to summarizes the role of electromagnetic fields in the origin and evolution of life on Earth, as well as hazard and benefit from electromagnetic fields. It is an attempt to show that today the mankind and the entire biosphere are subjected to a global experiment conducted without protocol, monitoring and even knowing the parameters of the applied electromagnetic fields. At the same time, electromagnetic fields used in magnetotherapy has been proven to be beneficial in treatment of various health problems. Magnetotherapy is non-invasive, safe, and easily applied methods to directly treat the site of injury, the source of pain, and inflammation. The development of advanced communication technologies year after year increases the hazard for the biosphere and mankind. The paper discuses the contradiction between scientists and technological engineers in the line thermal or nonthermal are effects of electromagnetic fields. The specific problems with children health are analyzed. It focused on the facts that at the end of the second decade of this century more aggressive mobile communications, such as 4G and especially 5G are being introduced in the North America and Europe without any attempt to evaluate the hazard for civilization.

A novel hypothesis for atherosclerosis as a cholesterol sulfate deficiency syndrome.

BackgroundDespite a vast literature, atherosclerosis and the associated ischemia/reperfusion injuries remain today in many ways a mystery. Why do atheromatous plaques make and store a supply of cholesterol and sulfate within the major arteries supplying the heart? Why are treatment programs aimed to suppress certain myocardial infarction risk factors, such as elevated serum homocysteine and inflammation, generally counterproductive?MethodsOur methods are based on an extensive search of the literature in atherosclerotic cardiovascular disease as well as in the area of the unique properties of water, the role of biosulfates in the vascular wall, and the role of electromagnetic fields in vascular flow. Our investigation reveals a novel pathology linked to atherosclerosis that better explains the observed facts than the currently held popular view.ResultsWe propose a novel theory that atherosclerosis can best be explained as being due to cholesterol sulfate deficiency. Furthermore, atheromatous plaques replenish the supply of cholesterol and sulfate to the microvasculature, by exploiting the inflammatory agent superoxide to derive sulfate from homocysteine and other sulfur sources. We argue that the sulfate anions attached to the glycosaminoglycans in the glycocalyx are essential in maintaining the structured water that is crucial for vascular endothelial health and erythrocyte mobility through capillaries. Sulfate depletion leads to cholesterol accumulation in atheromas, because its transport through water-based media depends on sulfurylation. We show that streaming potential induces nitric oxide (NO) release, and NO derivatives break down the extracellular matrix, redistributing sulfate to the microvasculature. We argue that low (less negative) zeta potential due to insufficient sulfate anions leads to hypertension and thrombosis, because these responses can increase streaming potential and induce nitric-oxide mediated vascular relaxation, promoting oxygen delivery. Our hypothesis is a parsimonious explanation of multiple features of atherosclerotic cardiovascular disease.ConclusionsIf our interpretation is correct, then it would have a significant impact on how atherosclerosis is treated. We recommend a high intake of sulfur-containing foods as well as an avoidance of exposure to toxicants that may impair sulfate synthesis.

Harmonic oscillators: the quantization of simple systems in the old quantum theory and their functional roles in biology

This article introduces quantum physics into biology in an intuitive and non-intimidating manner. It extends the quantum aspects of harmonic oscillators, and electromagnetic fields, to their functional roles in biology. Central to this process are the De Broglie wave-particle duality equation, and the adiabatic invariant parameters, magnetic moment, angular momentum and magnetic flux, determined by Ehrenfest as imposing quantum constraints on the dynamics of charges in motion. In mechanisms designed to explain the generation of low-level light emissions in biology we have adopted a biological analog of the electrical circuitry modeled on the parallel plated capacitor, traversed by helical protein structures, capable of generating electromagnetic radiation in the optical spectral region. The charge carrier required for the emissions is an accelerating electron driven, in a cyclotron-type mechanism, by ATP-induced reverse electron transfer with the radial, emission, components, mediated by coulombic forces within the helical configurations. Adenine, an essential nucleotide constituent of DNA, was examined with its long wavelength absorption maximum determining the energetic parameters for the calculations. The calculations were made for a virtual 5-turn helix where each turn of the helix emits a different frequency, generating a biological quantum series. The components of six adiabatic invariant equations were found to be embedded in Planck's constant rendering them discrete, finite, non-random, non-statistical-Planck's constant precludes probability. A mechanism for drug-induced hallucination is described that might provide insights as to the possible role of electromagnetic fields in consciousness. Sodium acceleration through a proposed nerve membrane helical channel generated electromagnetic emissions in the microwave region in confirmation of reported microwave emission for active nerves and may explain saltatory nerve conduction. Theoretical calculations for a helical DNA system gave a conduction resistance in agreement with a experimentally determined parameter.

Power frequency magnetic field exposure and gap junctional communication in Clone 9 cells

Exposure to a power-frequency magnetic field has been reported to produce a statistically significant inhibition of gap junctional communication (GJC) in Clone 9 cells that have been pre-stressed by treatment with low concentrations of chloral hydrate (CH) [C.F. Blackman, J.P. Blanchard, S.G. Benane, D.E. House, J.A. Elder, Double blind test of magnetic field effects on neurite outgrowth, Bioelectromagnetics, 19 (1998) 204–209]. This observation might provide mechanistic insight into the possible role of electromagnetic fields (EMFs) in the carcinogenic process, since cancer cells frequently show decreased or absent GJC, and tumor promoting chemicals have been observed to inhibit GJC. Magnetic field exposure conditions were 45 Hz, 23.8 μT rms+parallel DC 36.6 μT, for 30 min of exposure. The responses of Clone 9 cells to the GJC-inhibiting effects of the tumor promoter 12- O-tetradecanoylphorbol 13-acetate and the chemical CH were evaluated and compared to reported results [S.G. Benane, C.F. Blackman, D.E. House, Effects of perchloroethylene and its metabolites on intercellular communication in Clone 9 rat liver cells, J. Toxicol. Environ. Health, 48 (1996) 427–437]. Before magnetic field exposure, cells were exposed for 24 h to either 3 (nine experiments) or 5 mM (11 experiments) CH to produce GJC of 67% or 50%, respectively, relative to unexposed controls. GJC was assessed microscopically using the scrape-loading technique and a blinded protocol. No statistically significant effect was observed due to magnetic field exposure with either CH concentration.

Acute promyelocytic leukaemia: epidemiology and risk factors. A report of the GIMEMA Italian archive of adult acute leukaemia. GIMEMA Cooperative Group.

Acute promyelocytic leukaemia (APL) exhibits peculiar epidemiological, clinical, cytogenetic and molecular features, compared to the other acute myeloid leukaemias (AML). Data on epidemiology and occupational risk factors for APL desumed from the GIMEMA archive are reported and compared with those of the other AML. An exploratory case-case study was designed on AML patients from 56 haematology centres in Italy. Overall, 4296 patients older than 15 yr with a new diagnosis of acute leukaemia were recorded between July 1992 and July 1997. Of these, 335 were classified as APL, and 2894 as other AML. The median age of APL patients was 43 compared to 59 yr for the other AML (p < 0.00001). In order to identify peculiar risk factors for APL development, different parameters were compared in the 2 groups. After adjusting by age no significant differences were observed with regard to education, lifetime prevalence of cancer among siblings and previous diseases in the patient's history. Occupational exposure as a possible risk factor for APL showed no increased risk compared to other AML among farmers, builders and leather workers. A significant association was found in electricians (OR=4.4, 95% CI=2.0-9.7) and a weak association was found in wood workers (OR=3.2, 95% CI=0.8-10.8). The proportion of APL with respect to other AML was significantly higher in the north east of Italy compared to the rest of the country (OR=1.7, 95% CI=1.3-2.2). These data confirm the younger age of APL patients compared to the other AML. A possible role of electromagnetic fields is suggested by the higher risk of APL in electrical workers and in the more industrialized areas of the country.

A review of the epidemiologic literature on magnetic fields and cancer.

Since 1979 several studies have been published that suggest that residential exposure to electromagnetic fields could increase the risk of childhood cancer. Such studies have also been published for adults. In addition there are several studies suggesting that people in "electrical" occupations are at an increased risk of cancer. The objective of this review was to determine whether the role of electromagnetic fields in the origin of cancer can be established from the epidemiologic literature. Several of the studies suffer from methodological or other shortcomings, but it is not clear whether these problems are likely to explain the results. No conclusion can be drawn about the role of electromagnetic fields in the origin of cancer on the basis of current data. The existing literature, however, strongly suggests that research in this area should be pursued.

Chronic electromagnetic stressors in the environment: A risk factor in human cancer

CHRONIC ELECTROMAGNETIC STRESSORS IN THE ENVIRONMENT:A RISK FACTOR IN HUMAN CANCERAndrew A. Marino and *Don H. MorrisDepartment of Orthopaedic Surgery*Veterans Administration Medical CenterandDepartment of Surgery and Oral and Maxillofacial SurgeryLouisiana State UniversitySchool of Medicine in ShreveportP.O. Box 33932Shreveport, LA 71130—3932Contents: I. Introduction, II. Epidemiology, III. Role of ElectromagneticFields in Clinical Cancer, IV. Mechanism of Action, V. SummaryI. INTRODUCTIONElectromagnetic fields are real, physical, incorporeal entities thatarise from the existence and motions of atomic charges. Electromagneticwaves are electromagnetic fields that propagate through space and, aftergeneration by the source, are physically unconnected to it. Typicalexamples are radar, microwave ovens, and radio and television signals.The second class of electromagnetic fields consists of electric andmagnetic fields. They are distinct but frequently superimposed fieldsthat arise in the vicinity of wires carrying electric currents. Althoughthese fields are stationary in the sense that they do not propagatethrough space, their magnitude or direction may be time-dependent. The