Background: Convalescent plasma therapy (CPT) has been explored for Coronavirus disease 2019 (COVID-19), but limited data exists for Chronic Kidney Disease (CKD) patients. Since the effects of COVID-19 therapies are still under study, CPT remains an option for these patients in the absence of other effective therapy. Aims: This study aimed to compare the clinical outcome of severe to critical COVID-19 patients with CKD on RRT who received COVID-19 CPT versus those who did not. Methods: Retrospective study. Primary outcome was clinical improvement defined as mortality or whether discharged alive or improvement in WHO 6-point severity scale within 28 days. Secondary outcomes include factors associated with clinical improvement such as CPT’s effect on pulmonary status, timing of CPT, effects on hematologic profile and inflammatory markers. Results: Total of 44 CKD patients were included. Half were given CPT, half were not. Mean age was 59±12.7 and 51±15.6 respectively; 68.2% male, 31.8% female. No significant difference was found in the clinical outcome of severe to critical COVID-19 CKD patients who received CPT and those who did not. However, significant reduction in HsCRP, procalcitonin and ferritin pre and post CPT was found. This provide support in the role of CPT in reducing the inflammatory cytokine course of COVID-19 in CKD patients. Image:Summary/Conclusion: Convalescent plasma transfusion did not show significant difference in the clinical outcome of severe to critical COVID-19 CKD patients, but was associated with decreasing trends of HsCRP, procalcitonin and ferritin, which are poor prognosticators of COVID-19 disease.