Brain and red bone marrow dose coefficients for children and adults chronically exposed to radon as basis for brain tumor and leukemia risk analysis.

Multidimensional quantitative modeling fusion analysis of safety risks in hydrogen refueling stations: A case study of a station in Beijing

Markers predicting lymphoma development in Sjögren disease: current status and future perspectives.

Recent approaches in psychosis research have emphasized the importance of the combined analysis of risk and resilience factors. A resilience-integrated approach offers a more comprehensive understanding of the mechanisms underlying symptom associations and progression in individuals at clinical high-risk (CHR) for psychosis. Network analysis allows the examination of relationships among mental health conditions together with both risk and resilience factors. To our knowledge, this is the first study that investigated associations between resilience, risk factors, and psychosis-risk using network analysis. This secondary analysis of data from the ZInEP study (Zurich Early Recognition Program) examined 116 individuals at CHR for psychosis aged 18-35years. We investigated the relationships between two candidate resilience factors (self-efficacy and self-esteem), daily hassles as a candidate risk factor, functioning level, and psychosis risk symptoms using network analysis. Self-esteem and self-efficacy were negatively associated with general symptoms, negative symptoms, and daily hassles. Resilience factors and daily hassles were not associated with positive and disorganized symptoms, nor with functioning level. Centrality analyses further revealed that self-esteem had stronger node strength and bridge strength than self-efficacy. This study emphasizes the utility of a resilience-oriented approach in psychosis risk. Self-esteem and self-efficacy may play a crucial role in negative and general symptoms. Resilience factors may enrich our theoretical understanding of psychosis risk and help pave the way for resilience-based interventions.

Impact of ABO compatibility on outcomes after allogeneic hematopoietic cell transplantation (HCT): increased risk of acute GVHD with ABO bidirectional mismatch, independent of traditional and emerging GVHD prophylaxis strategies.

Layout optimization and risk analysis of chemical devices under the synergistic effects of multiple fires

A novel integrated model for risk analysis of soil PAHs and PTEs based on Monte Carlo simulation: a case study of Shenyang, China

To examine the impact of frailty on 30-day outcomes of open reduction internal fixation (ORIF) alone or ORIF + total hip arthroplasty (THA) (fix-and-replace) for the treatment of acetabular fractures. . Retrospective Cohort. A total of 700 hospitals in the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database. Included were patients aged 60 years or older undergoing ORIF ± THA for OTA/AO type 62 A-C fractures from 2015 to 2020. Preoperative frailty was assessed by the revised Risk Analysis Index (not frail: <21, prefrail: 21-30, frail: 31-40, severely frail: >40) and the 5-Item Modified Frailty Index factor. All outcome measures were in-hospital or within 30 days postoperatively, including the "favorable outcome," defined as no readmission, length of stay (LOS) < cohort median, and no major complication or death. There were 585 patients included [ORIF (88%): mean age-70.5 ± 14.2, sex-41.4% female; ORIF + THA (12%): mean age-77.0 ± 13.4; sex-65.7% female]. Frail patients (n = 353, 65.5%) were more likely to experience a complication [OR: 3.31, CI: (1.83-5.96)] and mortality (3.7% vs. 0.0%). ORIF + THA had higher association with postoperative transfusion [OR: 2.70, CI: (1.63-4.48)] but lower association with LOS >3 days [OR: 0.41, CI: (0.24-0.72)] and nonhome discharge [OR: 0.52, CI: (0.27-0.98)] than ORIF. Prefrail and frail patients undergoing ORIF + THA were more likely to achieve favorable outcomes than those nonfrail or severely frail [OR: 9.69, (3.40-27.57)]. Surgical intervention for acetabular fractures carried a 30-day complication risk of 12%-19% for frail patients. Frailty had similar predictability to age for early morbidity after surgery to treat acetabular fractures. Open reduction and internal fixation with the addition of an acute THA was associated with a higher rate of blood transfusion and shorter hospital LOS in frail patients with acetabular fractures. Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.

Assessment of Heavy Metal Accumulation in Commercially Important Spiny Lobster Species from the Bay of Bengal and Implications for Consumer Health Risks.

An integrated 3D risk analysis framework using CFD tools for fire, explosion, and toxic gas hazards in a semiconductor cleanroom

Early cracking risk analysis of large precast box girders based on thermo-hygro-mechanical coupling

Chronological age is an imperfect proxy for risk assessment in geriatric oncology. There is an urgent need for an objective, easily measurable biological aging signature to refine patient stratification and personalize therapeutic decisions. We analyzed a panel of seven aging-related biomarkers (including markers of inflammation, anabolic reserve, and telomere status) in 244 nonmetastatic breast cancer patients from two age groups ("Old", ≥70 years, N = 162; "Young", ≤60 years, N = 82). We used Latent Class Analysis (LCA) to integrate these markers and identify distinct biological risk profiles. These profiles were then evaluated for their association with Overall Survival (OS) and Cancer-Specific Death (CSD) via Competing Risk Analysis. LCA identified two patient profiles. The Unfavorable Biologic Profile (56.1% of the cohort) was defined by a triad of high MCP-1, high Chitinase activity, and low IGF-1. This profile was strongly associated with poorer OS (Age-adjusted HR=1.82, p = 0.018). Crucially, 15% of chronologically "Young" patients were assigned to this high-risk profile, while 23% of "Old" patients were assigned to the Favorable Profile. Furthermore, the Unfavorable Profile was more strongly and specifically associated with CSD (Subdistribution HR: 2.05, p = 0.012) than with Non-Cancer Death. Our results delineate an unfavorable, trans-chronological biological profile that identifies patients with low host reserve, largely driven by inflammaging and catabolism. This integrated signature provides a robust, objective screening tool to identify biologically frail patients, validating the need for Comprehensive Geriatric Assessment (CGA) and biomarker-guided therapeutic de-escalation (e.g., avoiding adjuvant chemotherapy) to improve individualized outcomes in oncology. BS32220096117.

Risk analysis of real-time reservoir scheduling decisions based on probabilistic inflow process forecasting

Nanomaterials in the food industry: applications and potential health risks.

A risk analysis model for Arctic escort operations based on STPA and Bayesian Networks

Second derivatives for optimizing MCMC in rare event risk analysis, and first passage problems

Smoking has been reported to be inversely associated with Parkinson disease (PD). However, the higher premature mortality among smokers may act as a competing risk, potentially confounding the inverse association. Because smoking behavior is dynamic, the long-term impact of changes among current smokers remains unclear. We investigated the association between longitudinal changes in smoking status and the risks of PD and all-cause mortality using a competing risk framework and an age-based time scale with left truncation. This large-scale retrospective cohort study included current smokers aged 40 years or older who participated in all 3 examination periods of the Korean National Health Screening. Based on longitudinal changes from the initial smoking status to 2 subsequent time points, participants were categorized into 4 groups: persistent smokers, recent quitters, sustained quitters, and relapsed smokers. Cumulative incidence functions for PD were estimated, with all-cause mortality as a competing event, and subdistribution hazard ratios (sHRs) with 95% CIs were obtained using Fine-Gray models. Data were obtained from 410,489 eligible participants (mean age 51.7 ± 9.0 years; 93.5% male). During a median 9.1-year follow-up, persistent smokers exhibited the lowest risk of PD. Both recent quitters and sustained quitters had higher PD risk than persistent smokers (sHR 1.60 [1.41-1.82] and 1.61 [1.42-1.81]), whereas relapsed smokers did not differ from persistent smokers (sHR 1.05 [0.87-1.28]). For all-cause mortality, recent and sustained quitters had 3% and 17% lower risks, respectively, compared with persistent smokers, whereas relapsed smokers showed no significant difference. The observed pattern of PD risk was suggested to be primarily associated with current smoking status rather than cumulative smoking exposure, as relapsed smokers and recent quitters, who had the same number of smoking time points, showed distinctly different risks. Furthermore, 1 time point (∼2 years) of short-term abstinence did not attenuate the protective association. Mortality was lowest in sustained quitters while recent quitters showed a marginal trend toward lower risk, supporting the benefit of early cessation. Interpretation should be cautious because smoking status was assessed at 3 time points, subsequent changes were unknown, and most participants were male.

Urinary arsenic levels and risk of breast cancer among women in the Canadian health measures survey: a population-based prospective study.

A bayesian network approach for systemic risk analysis in unmanned aerial vehicle (UAV) operations.

Lead exposure in children around a Lead Battery Recycling Plant: an environmental health approach for clinical and community management.