Back ground: Era of contraception, abortions, [20, 21 centuries] witnessed, global epidemic of degenerative diseases, auto immune diseases, neoplasms and rise in infectious diseases. Rise in environmental estrogen was documented. Objectives: Altruistic association of contraception [if any], with increasing degenerative, auto immune, infectious diseases and neoplasms was sought after; effects of contraception reversal on recovery of diseases was sought after as cause and effect phenomenon; Aborted blood, contraceptive menstrual blood pollution evidenced by rise in environmental estrogen favoring microbial growth, virulence, infectious diseases needed to be confirmed Methods: In 2012, retrospective analysis of data of various diseases in 350 patients of 20-35 years, 36-50 years, >50 years age groups, collected by convenient, stratified random sampling, from different geographical locations, from 2003-2012 and association with presence, absence of contraception, abortion was undertaken; simultaneously, serum estrogen levels obtained from 105 patients, was also analyzed;. The effect of contraception reversal including tubal recanalisation among 37 patients could be analyzed in relation to recovery of diseases though only 3 patients’ estrogen levels could be estimated after reversal. 4sea water samples, 3 river water samples were analyzed for estrogen levels. Hemoglobin electrophoresis was attempted in sea water to identify fetal, adult hemoglobin. Alpha feto protein, β Human chorionic gonadotropins were estimated in sea, river water samples. Results: Bio informatics analysis revealed 275% increased diseases in contraceptive users aged 20-35yrs, 3550yrs,[p<0.0005] associated with low estrogen levels in 61%.of contraceptive users [p<0.0005]; 500% increase in prevalence of diseases was detected after hysterectomy [p<0.0005] with endogenous estrogen as low as 0.4pg; Oil without cholesterol consumption had 50% increased osteoporosis, degenerative diseases[p<0.0005]. River water showed 3-5pg of estrogen, sea water showed 0.3-1pg of estrogen suggesting estrogen brought by the rivers gets diluted in the sea Routine hemoglobin electrophoresis measuring in grams could not detect any visible bands. Alpha feto protein was measured in sea, river water as <0.6ng; β human chorionic gonadotropins was detected in the sea, river water as <0.1miu/ml Conclusion: Retrospective analysis revealed 275%-500% increase in diseases in both partners with contraception, hysterectomy respectively , associated with decreased endogenous estrogen secondary to germ cell destruction; with contraception reversal 79.9% estrogen returns with halt of germ cells fragmentation, thereby decreasing diseases; Oil cholesterol being converted to our endogenous estrogen, androgen is essential fatty acid. Alpha feto protein, estrogen, β Human chorionic gonado tropin detected in the sea, river water suggested aborted blood, contraceptive menstrual blood pollution favoring infectious diseases.
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