Plantwide control (PWC) methodologies have gained significant importance given the high and increasing degree of integration in chemical processes due to material recycle, energy integration, and stringent product quality control, all of which though economically favorable, pose tough challenges to smooth plant operation. As part of the continuing search for more effective PWC system design methods, an integrated framework of heuristics and simulation was proposed [Konda et al. Ind. Eng. Chem. Res. 2005, 44, 8300−8313]. The basic idea behind this development is to make effective use of rigorous process simulators to aid in decision-making during the development of the heuristic-based PWC structure. Konda and co-workers have successfully applied the procedure to the toluene hydrodealkylation process. Though the integrated framework is promising, there is still a need to test its applicability to other complex industrial processes. The present contribution considers the development of a PWC structure for th...