Hand Surgery Landscape Article-Peer Review in Upper-Extremity Surgery: Essential Strategies for Reviewers.

The roles of intrinsically disordered proteins (IDPs) and regions (IDRs) in health and disease have gained increasing attention in recent years. Understanding their structure–activity relationships remains challenging, especially for integral membrane proteins. This manuscript reviews current knowledge on IDR functions in cross-membrane transport, with a focus on ion channels and transporters. It also examines how NMR and computational methods can provide atomic-level mechanistic insights into cross-membrane transport and link these findings to the roles of disorder in this process.

The under-representation of female individuals as research participants and manuscript authors is a longstanding issue in science in general and in the discipline of applied and exercise physiology. Over my ~50 years as an investigator, mentor, author, manuscript reviewer, and journal editor, my decisions obviously impacted these trends. To determine whether I was part of the problem or the solution, I audited my entire publication history and compared the results to a 50% aspirational census-based goal and to the composite across the histories of three leading exercise/applied physiology journals. 10,706 individuals were included in my 203 human studies - 49.8% were female individuals versus 42.5% female research participants for the other three journals. 40% of my studies had female research participants, which is above the composite 35% for the other journals. Of my single sex studies 23% included female participants, which is above the 15% for the three journals. The authors on my manuscripts are 16% female individuals which is below the composite 23% for the other journals. Thus, except for the inclusion of female research participants in my studies, I have contributed to the ongoing problem and not the solution to the under-representation of female individuals in the discipline of exercise/applied physiology. It remains for each of us to do some introspective thinking relative to this on-going issue because the decisions to rectify this situation have to come from individuals who choose to address this issue directly in their research programs.

Prevention and management of amivantamab-induced dermatologic toxicities: a European expert consensus and practical algorithm.

Therapeutic approaches for nonsense mutations in CFTR.

Abstract The monitoring and modeling of riverine floods have been covered extensively in the scientific literature with a substantial number of scientific contributions related to calibration/validation of hydraulic and hydrological models and assimilation of Earth Observation (EO) data into them. These models, when used for flood forecasting purposes, rely heavily on ground-based hydrological networks along with numerical weather models which, particularly in data-scarce regions, are often challenged by data sparsity. In these situations, EO data offer a viable solution to enhance the skill of these flood forecasting systems by providing global-scale observations of key hydrological variables such as precipitation, soil moisture, river discharge, water levels, and flood extent. This manuscript reviews and discusses the capability of these EO data in enhancing flood forecasting systems, by analyzing their accuracy, lead time, and reliability, while at the same time highlighting key challenges such as data latency, spatial–temporal resolution trade-offs, and model assimilation constraints. By leveraging recent advancements in remote sensing, data assimilation techniques, and artificial intelligence, EO-based flood forecasting has the potential to bridge existing observational gaps, particularly in vulnerable regions. The paper also outlines future research directions and technological developments needed to maximize the impact of satellite data in operational flood forecasting systems.

AI use in peer review: Strict regulation may still be needed.

This study critically examines the pedagogical approaches and ethical instruction mechanisms employed by mentors during the Eastern Renaissance, highlighting the profound role of the master-disciple relationship in the cultivation of intellectual, moral, and spiritual capacities among learners. Drawing upon a comprehensive review of historical manuscripts, philosophical treatises, and contemporary scholarly interpretations, the research elucidates the systematic methods through which moral virtues, ethical reasoning, and spiritual awareness were instilled within traditional Eastern educational frameworks.

The European Society of Cardiology (ESC) develops and updates clinical practice guidelines (CPGs) based on the latest evidence. However, their implementation remains suboptimal, leading to missed opportunities to improve cardiovascular (CV) outcomes. The success of CPG implementation is influenced by four key factors: (1) patient-related barriers, (2) health care professionals' engagement, (3) the clarity and usability of CPGs, and (4) the health care system and economic context in which care is delivered. To address these challenges, innovative strategies are needed to bridge the gap between CPG recommendations and clinical practice. The ESC has developed several initiatives to improve implementation, including (1) educational programmes, (2) examinations for cardiologists, (3) accreditation policies, and (4) registries. However, persistent gaps indicate that knowledge dissemination alone is insufficient. A more integrated, structured, and equitable approach to quality-of-care improvement is required. Despite the need for evidence-based implementation strategies, only a limited number of high-quality randomised controlled trials (RCTs) have evaluated individual approaches for CV conditions. Strategies such as text messaging, educational interventions, the involvement of non-physician health workers, structured order sheets, and financial incentives have been tested, but their feasibility and effectiveness can vary across health care systems. Future research should explore the potential of artificial intelligence (AI)-enhanced technologies to support and scale implementation efforts. This manuscript reviews current evidence on CPG implementation and proposes strategies to enhance the adoption of best practices in CV care.

Energy-based devices (EBDs) are increasingly used to manage acne and its sequelae. While literature supports the use of appropriate skin care for acne, few studies address how to effectively integrate skincare with EBDs. Six dermatologists from North America, participated in a live meeting to develop an acne treatment algorithm integrating skincare and EBDs. Six additional advisors contributed through a pre-meeting survey (along with 94 other physicians). The eleven dermatologists (authors) from Asia, Europe, Australia, and North America participated in algorithm development and manuscript review. The proposed algorithm describes how to integrate skin care with the use of EBDs in clinical practice. This algorithm provides an approach for managing acne and best practices for integrating skin care with EBDs when treating acne and acne sequelae. &nbsp.

The diagnosis of spinal epidural abscess (SEA) is often delayed, as initial symptoms may be undifferentiated or mimic musculoskeletal disorders. The aim of this systematic review was to elucidate the demographics, symptoms and signs of patients with SEA. A systematic review of relevant manuscripts published from 1990 to September 2023 was performed. Quality appraisal of the studies was performed using the Newcastle-Ottawa Scale (NOS). The prevalence of each risk factor, symptoms and signs were extracted and pooled using a random effects model. There were 79 manuscripts included in this review. Most patients with SEA were male (61.3%), with an average age of 55.7 years. Most patients underwent surgical treatment (n = 4950; 69%). Overall mortality was reported in 759 (11%) patients from 44 studies. There were 17 variables identified as risk factors for SEA, with bacteraemia, smoking, and diabetes most commonly reported. The most common symptoms were back pain and fever. The most frequently observed signs were motor and sensory deficit, though 40% presented without neurological deficit. A wide range of risk factors and clinical presentation have been attributed to SEA. While heterogeneity in the literature precludes confidence in accurately classifying the variables, the range of variables corresponded to the anatomy and pathophysiology of the disease. Knowledge of the more commonly reported variables is essential for earlier diagnosis of this critical condition.

Integrating molecular diagnostics and artificial intelligence in chronic microbial disease.

Shared Decision-Making for Marginal Kidney Transplants: a Review of Health Communication and Risk Assessment Manuscript for Submission to Current Transplantation Reports

In July 2023, version 3.0 of standard terminology for peer review was published by the National Information Standards Organization. The terminology approaches four aspects of the peer review process: identity transparency, reviewer interacts with, review information published, and post-publication commenting. Using examples of open peer review models with public participation implemented by open access journals covering different subjects, the inclusion of two new categories in the next version of the terminology is proposed herein: manuscript review and pre-publica-tion commenting.

Journal of Food Research wishes to acknowledge the following individuals for their assistance with peer review of manuscripts for this issue. Their help and contributions in maintaining the quality of the journal are greatly appreciated. Journal of Food Research is recruiting reviewers for the journal. If you are interested in becoming a reviewer, we welcome you to join us. Please contact us for the application form at: jfr@ccsenet.org Reviewers for Volume 15, Number 1 Alex Augusto Gonçalves, Federal Rural University of Semi-Arid (UFERSA), Brazil Alfredo C. Benitez-Rojas, Universidad Popular Autónoma del Estado de Puebla, Mexico Antonello Santini, University of Napoli "Federico II", Italy Elke Rauscher-Gabernig, Austrian Agency for Health and Food Safety, Austria Elsa M Goncalves, Instituto Nacional de Investigacao Agrária (INIA), Portugal Gongjian Fan, Nanjing Forestry University, China Jerish Joyner Janahar, Mississippi State University, USA Jintana Wiboonsirikul, Phetchaburi Rajabhat University, Thailand Jose Maria Zubeldia, Clinical Regulatory Consultant for the HIV & Hepatitis C initiative at Drugs for Neglected Diseases Initiative, Spain Khamphone Yelithao, Souphanouvong University, Laos Liana Claudia Salanta, University of Agricultural Sciences and Veterinary Medicine, Romania Maria Margareth Veloso Naves, Federal University of Goias, Brazil Mariana de Lourdes Almeida Vieira, Centro Federal de Educação Tecnológica de Minas Gerais, Brazil Marie Lys Irakoze, Dedan Kimathi University of Technology, Rwanda Mehana E. E. Hamouda, Alexandria university, Egypt Mohd Nazrul Hisham Daud, Malaysian Agricultural Research & Development Institute, Malaysia Rania I.M. Almoselhy, Agricultural Research Center, Egypt Rozilaine A. P. G. Faria, Federal Institute of Science, Education and Technology of Mato Grosso, Brazil Sani Jirasatid, Burapha University, Thailand

Stroke continues to impose an enormous morbidity and mortality burden worldwide. Stroke survivors often incur debilitating consequences that impair motor function, independence in activities of daily living and quality of life. Rehabilitation is a pivotal intervention to minimize disability and promote functional recovery following a stroke. The Internet of Medical Things, a network of connected medical devices, software and health systems that collect, store and analyze health data over the internet, is an emerging resource in neurorehabilitation for stroke survivors. Technologies such as asynchronous transmission to handle intermittent connectivity, edge computing to conserve bandwidth and lengthen device life, functional interoperability across platforms, security mechanisms scalable to resource constraints, and hybrid architectures that combine local processing with cloud synchronization help bridge the digital divide and infrastructure limitations in low-resource environments. This manuscript reviews emerging rehabilitation technologies such as robotic devices, virtual reality, brain-computer interfaces and telerehabilitation in the setting of neurorehabilitation for stroke patients.

Annual acknowledgement of manuscript reviewers.

Although general-purpose artificial intelligence (GPAI) is widely expected to accelerate scientific discovery, its practical limits in biomedicine remain unclear. We assess this potential by developing a framework of GPAI capabilities across the biomedical research lifecycle. Our scoping literature review indicates that current GPAI could deliver a speed increase of around 2x, whereas future GPAI could facilitate strong acceleration of up to 25x for physical tasks and 100x for cognitive tasks. However, achieving these gains may be severely limited by factors such as irreducible biological constraints, research infrastructure, data access, and the need for human oversight. Our expert elicitation with eight senior biomedical researchers revealed skepticism regarding the strong acceleration of tasks such as experiment design and execution. In contrast, strong acceleration of manuscript preparation, review and publication processes was deemed plausible. Notably, all experts identified the assimilation of new tools by the scientific community as a critical bottleneck. Realising the potential of GPAI will therefore require more than technological progress; it demands targeted investment in shared automation infrastructure and systemic reforms to research and publication practices.Supplementary InformationThe online version contains supplementary material available at 10.1038/s41598-025-32583-w.

The mendem panca dhatu ritual is a sacred practice of Balinese Hindus performed in the context of constructing and purifying holy sites. This ritual affirms the Balinese cosmological worldview that emphasizes harmony between humans, nature, and the divine through reverence for natural elements as instruments of spiritual purification and symbols of cosmic interconnectedness. However, amid modernization and the shifting values of religiosity, the meaning of this ritual tends to be simplified, potentially neglecting the profound ethical and spiritual dimensions embedded within it. This condition calls for an in-depth study to reveal the substantive meaning of the ritual as an expression of religious consciousness and as a value system that sustains the social, moral, and ecological life of Balinese society sustainably. This study aims to examine the ethical and spiritual values within the mendem panca dhatu ritual in Desa Adat Delod Tukad by employing the concepts of shuddha-bhava (inner purity) and cinmaya-bhava (spiritual awareness) as its main analytical framework. The research applies a qualitative method with an ethnographic approach. Informants were selected purposively, involving traditional leaders, priests, and community ritual practitioners. Data were collected through participatory observation, in-depth interviews, and literature review of lontar manuscripts, religious texts, and previous studies. Data validation was conducted through source triangulation, methodological triangulation, and member checking to ensure the credibility of the findings. The results indicate that the ethical values of the ritual function as moral guidance and social legitimacy that strengthen communal solidarity. Spiritually, the ritual emphasizes human connectedness with the transcendent through disciplined purity, self-control, and collective awareness in maintaining sacred spaces. The synergy of ethics, spirituality, and cultural identity in this ritual underscores its relevance to the preservation of religious traditions, the formation of social morality, and the maintenance of cosmic harmony within Balinese Hindu society.

Abstract: This article study reexamines the emergence and development of Hasidic literature and reassesses its relationship with the Hasidic movement. A comprehensive review of extant manuscripts and printed sources pertaining to the earliest writings associated with the movement challenges their traditional attribution mainly to Dov Ber, the Maggid of Mezritsh, revealing them instead as the product of a prolonged, collective, and largely anonymous literary enterprise. In addition to discourses of the Maggid transcribed by some of his disciples, this corpus includes an influential work composed by an anonymous disciple of the Israel Ba‘al Shem Tov (the Besht) as well as substantial later material stemming from the Maggid’s circle. This study further explores the reception and influence of these early writings, their role in the anti-Hasidic controversies, and the ambivalence displayed toward them by some Hasidic leaders. By reassessing the nature and origins of the earliest corpus of Hasidic writings and uncovering its various components and layers, this essay sheds new light on the complex role played by literature in the transformation of Hasidism from a small local phenomenon into a mass movement.