Reversible Myelopathy Research Articles

Progressive myelopathy due to treatable intracranial dural arterovenous fistulae

Intracranial dural arteriovenous fistulae (DAVF) can rarely have a perimedullary venous drainage (Cognard Type V) resulting in an aggressive but potentially treatable and reversible myelopathy. Early diagnosis is often challenging.

Subacute combined degeneration of the spinal cord masking motor neuron disease: a case report

BackgroundSubacute combined degeneration of the spinal cord is a potentially reversible myelopathy typically associated with vitamin B12 deficiency. There is predominant involvement of spinal cord posterior and lateral tracts, and manifestations include peripheral paraesthesia, impaired proprioception, gait disturbance, neuropathy and cognitive changes. Motor neuron disease (MND) is an unremittingly progressive neurodegenerative disorder involving upper and lower motor neurons with an average prognosis of 2–3 years. The diagnosis is clinical and may be supported by electromyography. A subset of MND occurs concurrently with frontotemporal dementia (FTD-MND) and may be initially misdiagnosed as a primary psychotic disorder.Case presentationWe describe a 57-year-old Caucasian woman who presented with confusion and dysarthria. Low vitamin B12 levels and MRI findings led to an initial diagnosis of subacute combined degeneration of the spinal cord. Despite treatment, persistent dysarthria and presence of both upper and lower motor neuron signs on clinical examination prompted further assessment. Electromyography supported the diagnosis of MND. Comorbid chronic paranoid schizophrenia complicated the diagnostic process. We discuss overlapping features between B12 deficiency and MND as well as the neuropsychiatric overlap of B12 deficiency, FTD-MND and chronic schizophrenia.ConclusionsFirstly, variability in neurocognitive and imaging manifestations of B12 deficiency can limit delineation of other pathologies. Failure to improve following correction of nutritional deficiencies warrants further investigation for an alternate diagnosis. Secondly, re-evaluation of patients with comorbid mental health conditions is important in reaching timely and accurate diagnoses.

Reversible myelopathy with vitamin B12 deficiency after cerebral infarction-like lesions

Reversible myelopathy with vitamin B12 deficiency after cerebral infarction-like lesions

Reversible myelopathy: an uncommon accompaniment of hypothyroidism

Atypical neurological presentations of hypothyroidism include myelopathy which has been seldom reported as presenting feature in patients. This case was one of those atypical presentations of hypothyroidism in which patient presented with neurological complication viz myelopathy which was timely diagnosed and treated. The symptoms including neurological findings reversed with thyroxin replacement. The case highlights the varied and vivid manifestations of hypothyroidism which treating physicians should be aware of while treating patients.

Reversible myelopathy in Plasmodium vivax malaria: Report of a case and review of literature

Reversible myelopathy in Plasmodium vivax malaria: Report of a case and review of literature

Reversible Myelopathy on Magnetic Resonance Imaging Due to Cobalamin Deficiency

Subacute combined degeneration (SCD) is known as myelopathy due to vitamin B12 deficiency. SCD always involves the posterior and lateral columns of the spinal cord, with the neuropathologic change showing vacuolation of the white matter. We describe 2 patients who presented with ataxic gait, impaired proprioception over limbs, and even mental change due to vitamin B12 deficiency. Magnetic resonance imaging (MRI) of the cervical spine showed increased signal intensity on T2-weighted imaging, and laboratory data showed low serum vitamin B12 level. The 2 patients were treated with vitamin B12 injection intramuscularly. There was clinical improvement after treatment along with normalization of the MRI.

Reversible myelopathy with pernicious anemia

Reversible myelopathy with pernicious anemia