Restoration Capacity Research Articles

IMPACT OF SEEDLING REMOVAL ON NATURAL REGENERATION IN THE SOUTHERN ATLANTIC FOREST REMNANT

ABSTRACT The use of a forest seedling bank has been recommended as an alternative to increase species richness in forest nurseries, as well as to produce seedlings of species that are diffi cult to propagate, especially those that belong to the late secondary and climax successional groups, which are not as commercially available. However, little is known about the impact of this method on forest dynamics. Thus, the present study aimed to examine the resilience and dynamics of a seedling bank in a remnant of a subtropical seasonal forest belonging to the Atlantic Forest Biome when subjected to different intensities of seedling removal. The experiment was conducted in a random block design in a factorial scheme (5 × 4), with treatments composed of fi ve intensities of removal of individuals from the seedling bank and the four seasons. The treatments were distributed into 18 blocks and the experimental units were composed of 1 m × 2.5 m plots. The resilience of the seedling community was assessed by examining effects of the fi ve removal intensities. The dynamics between the evaluation periods within each treatment were verifi ed by comparing the number of species and seedlings present before the treatments with those in the other evaluation periods. After one year, we found that tree-shrub vegetation had a partial capacity for restoration after withdrawal of individuals from the seedling bank. Our results show that the impact on the regeneration community can absorb the effects of up to 25% seedling removal. The technique of seedling transplantation may be recommended for species that have abundant regeneration, such as Actinostemon concolor, Eugenia rostrifolia, Trichilia claussenii and Nectandra megapotamica.

Asymmetry of Cerebral Peduncles for Predicting Motor Function Restoration in Young Patients Before Hemispherectomy

Hemispherectomy has been used successfully for patients with medically intractable epilepsy. However, it is difficult to predict postoperative motor function. The aim of the present study was to analyze whether the preoperative asymmetry of cerebral peduncles could be used to predict motor function restoration before hemispherectomy for young patients with medically intractable epilepsy. The clinical record and magnetic resonance imaging data of 53 patients were analyzed retrospectively. The correlation between preoperative cerebral peduncle asymmetry ratio (pCPAR) and pre- and postoperative changes in motor function was evaluated, as well as the influencing factors for pCPAR, such as duration and etiology factors. The restoration of motor function was defined as changes in pre- and postoperative hemiparesis. The pCPARs of patients with improved and unchanged hemiparesis were significantly greater than that of worsened patients. Patients with a pCPAR of more than 1.5 had an obvious restorative capacity of motor function of the intact hemisphere, and these patients had a lower risk of worsening hemiparesis. The duration in the improved/unchanged and worsened groups was 5.84 ± 3.85 years and 2.67 ± 2.03 years, respectively. Furthermore, there were more patients with no-progressive pathology in the group in whom pCPAR was more than 1.5. pCPAR is a useful and objective indicator for predicting the restoration of motor function in pediatric patients with medically intractable epilepsy before hemispherectomy. Most patients with nonprogressive pathology and a duration of more than 5 years presented with greater pCPARs, exhibited better restoration of motor function, and had less risk of worsening hemiparesis.

Which Firms Get Punished for Unethical Behavior? Explaining Variation in Stock Market Reactions to Corporate Misconduct

ABSTRACT:Although there is ample evidence that stock markets react negatively to unethical corporate behavior, our understanding of the mechanisms that shape variation in these reactions across different incidents of misconduct remains underdeveloped. We propose and test a framework for explaining this variation by focusing on the role of the media in disseminating initial information about misconduct. We argue that the signaling effects of this information are important for investors because corporations have strong incentives to limit the information they disclose about misconduct. More specifically, we hypothesize that investors are more likely to react negatively when the media presents clear and credible information that misconduct occurred, that the firm was responsible for it, and that the misconduct was the result of deeper organizational problems. We also predict that information which signals that a firm has restorative capacity tempers investor reactions when the media places blame for misconduct on the corporation rather than specific individuals. We test our hypotheses in a unique sample of 345 acts of corporate misconduct in five European countries. Our findings provide broad support for our hypotheses, and we discuss implications for research on corporate misconduct and the role of non-state actors in regulating unethical corporate behavior.

Resilience Analysis of a Remote Offshore Oil and Gas Facility for a Potential Hydrocarbon Release.

Resilience is the capability of a system to adjust its functionality during a disturbance or perturbation. The present work attempts to quantify resilience as a function of reliability, vulnerability, and maintainability. The approach assesses proactive and reactive defense mechanisms along with operational factors to respond to unwanted disturbances and perturbation. This article employs a Bayesian network format to build a resilience model. The application of the model is tested on hydrocarbon-release scenarios during an offloading operation in a remote and harsh environment. The model identifies requirements for robust recovery and adaptability during an unplanned scenario related to a hydrocarbon release. This study attempts to relate the resilience capacity of a system to the system's absorptive, adaptive, and restorative capacities. These factors influence predisaster and postdisaster strategies that can be mapped to enhance the resilience of the system.

Culture is new nature: comparing the restorative capacity of cultural and natural landscapes

Is the cultural landscape a restorative environment for mental stress? What is the restorative potential of cultural landscape, compared to the natural landscape? And what factors determine the restorative potential of cultural or natural landscape? These questions have not been studied previously. To fill the gap the present study conducts an experiment to compare the restorative capacity of cultural and natural landscapes in China, and explores the driving forces of 15 landscape characteristics on the restorative quality of the two landscape types. The results show that there are no significant differences of restoration between cultural and natural landscape. The 10 photographs representing cultural landscape have a bigger standard deviation (lower consensus) of restorative capacity than the 10 photographs representing natural landscape. More water features and the flat terrain are the significant promoters for the restoration of cultural landscape. Abundant colours, which usually imply a higher diversity of plant species, are vital to enhance the restorative capacity of natural landscape.

Resilient by design: the case for increasing resilience of buildings and their linked food-energy-water systems

The resilience of buildings and food, energy, and water systems (FEWS) to natural or manmade disruptions are closely linked. The resilience of a building goes beyond the safety of its structural elements and must include the resilience of its supporting systems and the services they supply. The resilience of FEWS, in turn, can increase through design elements of a building that affect generation and storage of FEW resources. In this commentary, I discuss increasing the resilience of buildings and their linked FEWS—improving their resistance, absorption, restoration, and adaptive capacities—through new integrated systems design practices. I begin with a discussion of the current state of building design at the FEW nexus. I then use the prior establishment and current use of sustainability design objectives as an analogue to developing and implementing resilience design objectives. I review progress and limitations of specific drivers for increasing resilient design practices, including economic incentives, regulations, extralegal programs and initiatives, and societal incentives. My recommendations for leveraging these drivers to increase resilient design include: for economic incentives, quantify the costs and benefits to make the business case for resilience; for formal regulations, specify increased building requirements with performance-based resilience objectives; for extralegal initiatves, integrate these resilience objectives with existing certification programs and award designs that address FEWS as an integrated network rather than as disparate systems; and for societal incentives, demonstrate public benefit to shift societal perceptions of resilience. Together, these actions will motivate the design of more resilient building and FEW systems to increase their longevity, performance, and robustness.

Network Restoration for Next-Generation Communication and Computing Networks

Network failures are undesirable but inevitable occurrences for most modern communication and computing networks. A good network design must be robust enough to handle sudden failures, maintain traffic flow, and restore failed parts of the network within a permissible time frame, at the lowest cost achievable and with as little extra complexity in the network as possible. Emerging next-generation (xG) communication and computing networks such as fifth-generation networks, software-defined networks, and internet-of-things networks have promises of fast speeds, impressive data rates, and remarkable reliability. To achieve these promises, these complex and dynamic xG networks must be built with low failure possibilities, high network restoration capacity, and quick failure recovery capabilities. Hence, improved network restoration models have to be developed and incorporated in their design. In this paper, a comprehensive study on network restoration mechanisms that are being developed for addressing network failures in current and emerging xG networks is carried out. Open-ended problems are identified, while invaluable ideas for better adaptation of network restoration to evolving xG communication and computing paradigms are discussed.

Estimating restorable wetland water storage at landscape scales.

Globally, hydrologic modifications such as ditching and subsurface drainage have significantly reduced wetland water storage capacity (i.e., volume of surface water a wetland can retain) and consequent wetland functions. While wetland area has been well documented across many landscapes and used to guide restoration efforts, few studies have directly quantified the associated wetland storage capacity. Here, we present a novel raster-based approach to quantify both contemporary and potential (i.e., restorable) storage capacities of individual depressional basins across landscapes. We demonstrate the utility of this method by applying it to the Delmarva Peninsula, a region punctuated by both depressional wetlands and drainage ditches. Across the entire peninsula, we estimated that restoration (i.e., plugging ditches) could increase storage capacity by 80%. Focusing on an individual watershed, we found that over 59% of restorable storage capacity occurs within 20 m of the drainage network, and that 93% occurs within 1 m elevation of the drainage network. Our demonstration highlights widespread ditching in this landscape, spatial patterns of both contemporary and potential storage capacities, and clear opportunities for hydrologic restoration. In Delmarva and more broadly, our novel approach can inform targeted landscape-scale conservation and restoration efforts to optimize hydrologically mediated wetland functions.

Differential effects of late gestation maternal overnutrition on the regulation of surfactant maturation in fetal and postnatal life.

Offspring of overweight and obese women are at greater risk for respiratory complications at birth. We determined the effect of late gestation maternal overnutrition (LGON) in sheep on surfactant maturation, glucose transport and fatty acid metabolism in the lung in fetal and postnatal life. There were significant decreases in surfactant components and numerical density of surfactant producing cells in the alveolar epithelium due to LGON in the fetal lung. However, there were no differences in the levels of these surfactant components between control and LGON lambs at 30days of age. The reduced capacity for surfactant production in fetuses as a result of LGON may affect the transition to air breathing at birth. There was altered glucose transport and fatty acid metabolism in the lung as a result of LGON in postnatal life. However, there is a normalisation of surfactant components that suggests accelerated maturation in the lungs after birth. With the increasing incidence of obesity worldwide, the proportion of women entering pregnancy overweight or obese has increased dramatically. The fetus of an overnourished mother experiences numerous metabolic changes that may modulate lung development and hence successful transition to air breathing at birth. We used a sheep model of maternal late gestation overnutrition (LGON; from 115days' gestation, term 147±3days) to determine the effect of exposure to an increased plane of nutrition in late gestation on lung development in the fetus (at 141days' gestation) and the lamb (30days after birth). We found a decrease in the numerical density of surfactant protein positive cells, as well as a reduction in mRNA expression of surfactant proteins (SFTP-A, -B and -C), a rate limiting enzyme in surfactant phospholipid synthesis (phosphate cytidylyltransferase 1, choline, α; PCYT1A), and glucose transporters (SLC2A1 and SLC2A4) in the fetal lung. In lambs at 30days after birth, there were no differences between Control and LGON groups in the surfactant components that were downregulated in the LGON fetuses. However, mRNA expression of SFTP-A, PCYT1A, peroxisome proliferator activated receptor-γ, fatty acid synthase and fatty acid transport protein were increased in LGON lambs compared to controls. These results indicate a reduced capacity for surfactant production in late gestation. While these deficits are normalised by 30days after birth, the lungs of LGON lambs exhibited altered glucose transport and fatty acid metabolism, which is consistent with an enhanced capacity for surfactant synthesis and restoration of surfactant maturity in these animals.

Fast polarimetric dehazing method for visibility enhancement in HSI colour space

Image haze removal has attracted much attention in optics and computer vision fields in recent years due to its wide applications. In particular, the fast and real-time dehazing methods are of significance. In this paper, we propose a fast dehazing method in hue, saturation and intensity colour space based on the polarimetric imaging technique. We implement the polarimetric dehazing method in the intensity channel, and the colour distortion of the image is corrected using the white patch retinex method. This method not only reserves the detailed information restoration capacity, but also improves the efficiency of the polarimetric dehazing method. Comparison studies with state of the art methods demonstrate that the proposed method obtains equal or better quality results and moreover the implementation is much faster. The proposed method is promising in real-time image haze removal and video haze removal applications.

The nature-disorder paradox: A perceptual study on how nature is disorderly yet aesthetically preferred.

Natural environments have powerful aesthetic appeal linked to their capacity for psychological restoration. In contrast, disorderly environments are aesthetically aversive, and have various detrimental psychological effects. But in our research, we have repeatedly found that natural environments are perceptually disorderly. What could explain this paradox? We present 3 competing hypotheses: the aesthetic preference for naturalness is more powerful than the aesthetic aversion to disorder (the nature-trumps-disorder hypothesis); disorder is trivial to aesthetic preference in natural contexts (the harmless-disorder hypothesis); and disorder is aesthetically preferred in natural contexts (the beneficial-disorder hypothesis). Utilizing novel methods of perceptual study and diverse stimuli, we rule in the nature-trumps-disorder hypothesis and rule out the harmless-disorder and beneficial-disorder hypotheses. In examining perceptual mechanisms, we find evidence that high-level scene semantics are both necessary and sufficient for the nature-trumps-disorder effect. Necessity is evidenced by the effect disappearing in experiments utilizing only low-level visual stimuli (i.e., where scene semantics have been removed) and experiments utilizing a rapid-scene-presentation procedure that obscures scene semantics. Sufficiency is evidenced by the effect reappearing in experiments utilizing noun stimuli which remove low-level visual features. Furthermore, we present evidence that the interaction of scene semantics with low-level visual features amplifies the nature-trumps-disorder effect-the effect is weaker both when statistically adjusting for quantified low-level visual features and when using noun stimuli which remove low-level visual features. These results have implications for psychological theories bearing on the joint influence of low- and high-level perceptual inputs on affect and cognition, as well as for aesthetic design. (PsycINFO Database Record

Planning resilient motor-fuel supply chain

Two major extreme-weather events occurred in New York State between 2011 and 2012. Each with the odds of a 100-year occurrence suggesting that such extreme events are the region’s “new normal.” City and state policy-makers, in response, are studying how to develop a network of robust, resilient critical infrastructure facilities. These studies, however, typically fail to address interdependencies among critical infrastructures and lack a quantitative tool to investigate the maximum resilience possessed by a given infrastructure facility in the face of climate-change-induced hazards.We propose a multi-stage stochastic mathematical program to maximize network resilience given: i) random arrival of extreme events; ii) the network’s inherent capacity to withstand and cope with the aftermath of exogenous shocks; iii) pre-, during-, and post-event strategies available to enhance system operability; and iv) budgeting and technological restrictions facing policy-makers.Our approach allows both qualitative and quantitative paradigms to interact. Our model thus clarifies how to allocate resources proactively and how the network’s absorptive, adaptive, and restorative capacities can be coordinated to enhance overall system resilience. Our findings suggest that an integrated planning approach combined with smart allocation of resources across a network’s main elements creates a greater degree of resilience while utilizing less costly resilience-enhancing strategies.

Interpreting variation to advance predictive restoration science

Summary Ecological restoration is a global priority that holds great potential for benefiting natural ecosystems, but restoration outcomes are notoriously unpredictable. Resolving this unpredictability represents a major, but critical challenge to the science of restoration ecology. In an effort to move restoration ecology toward a more predictive science, we consider the key issue of variability. Typically, restoration outcomes vary relative to goals (i.e. reference or desired future conditions) and with respect to the outcomes of other restoration efforts. The field of restoration ecology has largely considered only this first type of variation, often focusing on an oversimplified success vs. failure dichotomy. The causes of variation, particularly among restoration efforts, remain poorly understood for most systems. Variation associated with restoration outcomes is a consequence of how, where and when restoration is conducted; variation is also influenced by how the outcome of restoration is measured. We propose that variation should decrease with the number of factors constraining restoration and increase with the specificity of the goal. When factors (e.g. harsh environmental conditions, limited species reintroductions) preclude most species, little variation will exist among restorations, particularly when goals are associated with metrics such as physical structure, where species may be broadly interchangeable. Conversely, when few constraints to species membership exist, substantial variation may result and this will be most pronounced when restoration is assessed by metrics such as taxonomic composition. Synthesis and applications. The variability we observe during restoration results from both restoration context (how, where and when restoration is conducted) and how we evaluate restoration outcomes. To advance the predictive capacity of restoration, we outline a research agenda that considers metrics of restoration outcomes, the drivers of variation among existing restoration efforts, experiments to quantify and understand variation in restoration outcomes, and the development of models to organise, interpret and forecast restoration outcomes.

Understanding liver regeneration to bring new insights to the mechanisms driving cholangiocarcinoma

Cancer frequently arises in epithelial tissues subjected to repeated cycles of injury and repair. Improving our understanding of tissue regeneration is, therefore, likely to reveal novel processes with inherent potential for aberration that can lead to carcinoma. These highly conserved regenerative mechanisms are increasingly understood and in the liver are associated with special characteristics that underlie the organ’s legendary capacity for restoration of size and function following even severe or chronic injury. The nature of the injury can determine the cellular source of epithelial regeneration and the signalling mechanisms brought to play. These observations are shaping how we understand and experimentally investigate primary liver cancer, in particular cholangiocarcinoma; a highly invasive malignancy of the bile ducts, resistant to chemotherapy and whose pathogenesis has hitherto been poorly understood. Interestingly, signals that drive liver development become activated in the formation of cholangiocarcinoma, such as Notch and Wnt and may be potential future therapeutic targets. In this review, we summarise the work which has led to the current understanding of the cellular source of cholangiocarcinoma, how the tumour recruits, sustains and is educated by its supporting stromal environment, and the tumour-derived signals that drive the progression and invasion of the cancer. With few current treatments of any true efficacy, advances that will improve our understanding of the mechanisms driving this aggressive malignancy are welcome and may help drive therapeutic developments.

Porous Nanohydroxyapatite/Collagen Scaffolds Loading Insulin PLGA Particles for Restoration of Critical Size Bone Defect.

Insulin is considered to be a classical central regulator of energy homeostasis. Recently, the effect of insulin on bone has gained a lot of attention, but little attention has been paid to the application in bone tissue engineering. In this study, porous nanohydroxyapatite/collagen (nHAC) scaffolds incorporating poly lactic-co-glycolic acid (PLGA) particles were successfully developed as an insulin delivery platform for bone regeneration. Bioactive insulin was successfully released from the PLGA particles within the scaffold, and the size of the particles as well as the release kinetics of the insulin could be efficiently controlled through Shirasu porous glass premix membrane emulsification technology. It was indicated that the nHAC/PLGA composite scaffolds possessed favorable mechanical and structural properties for cell adhesion and proliferation, as well as the differentiation into osteoblasts. It was also demonstrated that the nHAC/PLGA scaffolds implanted into a rabbit critical-size mandible defect possessed tissue compatibility and higher bone restoration capacity compared with the defects that were filled with or without nHAC scaffolds. Furthermore, the in vivo results showed that the nHAC/PLGA scaffolds which incorporated insulin-loaded microspheres with a size of 1.61 μm significantly accelerated bone healing compared with two other composite scaffolds. Our study indicated that the local insulin released at the optimal time could substantially and reproducibly improve bone repair.

P111 寒冷地におけるクマイザサの再生力に関するフィールド調査(ポスター発表)

P111 寒冷地におけるクマイザサの再生力に関するフィールド調査(ポスター発表)

Postcards from the Field

Increasingly, botanic gardens and arboreta are highlighted as effective partners to conserve plant species diversity and restore natural communities at a time when the need for these activities has become more urgent. Capacity for restoration and conservation at botanic gardens comes directly from staff expertise for horticulture and research. Botanic gardens make good partners for connecting botanical science with conservation practice. They are in a position to communicate information about rare plant species to owners and managers of public and private lands, and they can be instrumental in creating networks for effective conservation action. Several examples from south-eastern United States of America illustrate how this has been put into practice. These examples provide evidence that efforts to expand collaboration between federal agencies, states and non-governmental organisations can lead to effective alliances to conserve plant biodiversity, especially when plants receive a disproportionately low share of resources for conservation.

ACL injury reduces satellite cell abundance and promotes fibrogenic cell expansion within skeletal muscle.

Anterior cruciate ligament (ACL) injuries are associated with significant loss of strength in knee extensor muscles that persists despite physical therapy. The underlying mechanisms responsible for this protracted muscle weakness are poorly understood; however, we recently showed significant myofiber atrophy and altered muscle phenotype following ACL injury. We sought to further explore perturbations in skeletal muscle morphology and progenitor cell activity following an ACL injury. Muscle biopsies were obtained from the injured and non-injured vastus lateralis of young adults (n = 10) following ACL injury, and histochemical/immunohistochemical analyses were undertaken to determine collagen content, abundance of connective tissue fibroblasts, fibrogenic/adipogenic progenitor (FAP) cells, satellite cells, in addition to indices of muscle fiber denervation and myonuclear apoptosis. The injured limb showed elevated collagen content (p < 0.05), in addition to a greater abundance of fibroblasts and FAPs (p < 0.05) in the injured limb. Fibroblast content was correlated with increased accumulation of extracellular matrix in the injured limb as well. A higher frequency of interstitial nuclei were positive for phospho-SMAD3 in the injured limb (p < 0.05), providing some evidence for activation of a fibrogenic program through transforming growth factor β following an ACL injury. The injured limb also displayed reduced satellite cell abundance, increased fiber denervation and DNA damage associated with apoptosis (p < 0.05), indicating alterations within the muscle itself after the ligament injury. Injury of the ACL induces a myriad of negative outcomes within knee extensor muscles, which likely compromise the restorative capacity and plasticity of skeletal muscle, impeding rehabilitative efforts. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:1876-1885, 2017.

Edaphic constraints on seed germination and emergence of three Acacia species for dryland restoration in Saudi Arabia

In situ edaphic factors affecting seed germination and seedling emergence of three framework species of Acacia were investigated with the intent of developing fundamental and scalable restoration capacity for Arabian dryland restoration. Direct seeding represents the most efficient means to restore vegetation at the landscape scale and this study provides insight into edaphic and ecological limitations, as well as effective protocols governing the use of native seeds for restoration in hyper-arid environments. The study was conducted in extant Acacia woodland habitat on conserved land (Thumamah Nature Park) in close proximity to Riyadh, Saudi Arabia. Broad-scale direct seeding using un- and pretreated Acacia gerrardii, A. tortilis, and A. ehrenbergiana seed, and two seed burial depths were implemented across three sites with distinct soil surface characteristics. Eight weeks post-sowing, random samples for each species × seed treatment × burial depth combination were excavated, sieved, and categorized as follows: failed to germinate, germinated but died prior to emerging, or successfully emerged. We show that germination and emergence of Acacia gerrardii, A. tortilis, and A. ehrenbergiana were driven by a three-way interaction among species, site, and seed burial depth. Treating seed with the signaling compound Moddus did not have a definitive effect, positive or negative, on any of the species investigated. Acacia gerrardii was the only species that exhibited widespread emergence, though emergence was not consistent across sites or burial depths. Germination was highest in disturbed soil (up to 69% for A. gerrardii), but very few (<2%) successfully emerged; a greater proportion of germinants in sandy soil emerged (up to 44% for A. gerrardii) even though the overall germination was less. Though species-dependent, a 2-cm sowing depth was most effective in sand; while in disturbed soil, sowing depths of 1 and 2 cm were comparable; and no germination was observed in gravelly clay soil. Sandy soil exhibited rapid water infiltration (107.6 mm min−1), and post-sowing surface crusting was a non-factor (0.44 kg cm−2). Disturbed soil exhibited moderate water infiltration (1.46 mm min−1) and post-sowing surface crusting was double that of sand (0.88 kg cm−2) and restrictive on seedling emergence. Gravelly clay exhibited extremely poor water infiltration (0.12 mm min−1), and surface crusting was severe (4.49 kg cm−2) and an order of magnitude greater than sand. The medium-coarse sand fraction, a key driver of the observed soil surface processes, was greatest in sand (55%) and significantly less and uniform in the disturbed (22%) and gravelly clay (22%) soils. Our findings demonstrate that soil surface characteristics and associated processes can dictate ecological processes at depths as shallow as 1–2 cm, and that soil crusts that slow water infiltration and impede seedling emergence rapidly reconstitute after disturbance; both are important considerations for restoring dryland vegetation.

Impact of Baseline Ischemia on Outcome in Older Patients Undergoing Endovascular Therapy for Acute Ischemic Stroke.

Background and PurposeThe outcome for older stroke patients who undergo endovascular revascularization remains unsatisfactory. We aimed to determine the effect of the extent of baseline ischemia on outcome according to age, testing the hypothesis that the restorative capacity for recovery is only marginal in older patients.MethodsTwo hundred and thirteen patients who underwent endovascular revascularization due to occlusion in the M1 segment of the middle cerebral artery (with or without internal carotid artery occlusions) were selected for analysis. Patients were categorized into three age groups: group A (<66 years), group B (66–75 years), and group C (>75 years). Using pretreatment diffusion-weighted imaging (DWI), the Alberta Stroke Program Early CT Score (ASPECTS) and lesion volume were independently measured and analyzed in relation to a favorable outcome.ResultsA favorable outcome was achieved in 111 of 213 patients overall: in 60 of the 94 (63.8%) patients in group A, in 36 of the 70 (51.4%) patients in group B, and in 15 of the 49 (30.6%) patients in group C (p=0.001). In older stroke patients (group C), a DWI ASPECTS ≥9 and lesion volume ≤5 mL were found to predict a favorable outcome, which was more restrictive than the cutoffs for their younger counterparts (groups A and B; DWI ASPECTS ≥8 and lesion volume ≤20 mL).ConclusionsThe age-adjusted pretreatment DWI lesion volume and ASPECTS may represent useful surrogate markers for functional outcome according to age. The use of more-restrictive inclusion criteria for older stroke patients could be warranted, although larger studies are necessary to confirm these findings.