The present collection addresses the place and role of phonology (as an object of study, not as a scientific field) within a wider range of neighboring domains. Generally, the relevance of phonological structure in language may be claimed to derive from the fact that phonology constitutes a domain of its own within language (along with syntax, semantics, morphology), but also interfaces intimately with other domains such as cognition, articulation, and perception in general. From this dual nature, it follows that phonology may be an object of linguistic description and theory (for an overview see Goldsmith, 1995; de Lacy, 2012) as well as an object of cognitive and behavioral studies (for an overview see Cohn et al., 2012). Ideally, however, theoretical and empirical studies keep this dual nature of phonology in mind and pay attention to both sides of the coin. Articles in the present Research Topic attempt to capture different aspects of this overall discussion. The starting point for this Research Topic was a Priority Programme on experimental research in phonology and phonetics funded by the German Science Foundation (DFG; SPP 1234). Based on this programme, the aim of this Research Topic is to draw together empirical work in the field of segmental and prosodic processing and representation and phonological theory. Contributions address the interface of the speech sound systems investigated in phonology, the representations of articulated speech, perception, acquisition and processing established in phonetics, psycholinguistics, and neurolinguistics. Main topics of investigation include: (1) sounds and sound-changing processes—systemic and functional aspects, (2) prosodic units such as syllables and metrical feet—systemic properties, processing, and phonetic consequences, and (3) tones as building blocks of the sentence melody—their relation to the level of linguistic expressions on the one hand, their phonetic realization (e.g., tonal height and contours) and perception on the other hand. In addition, topics (1) and (2) extend to the question how phonological representations are stored in the mental lexicon: specified minimally in terms of categorical phonological information or as variable phonetic imprint of the exemplars in the input. Diagonally to these thematic domains, the present Research Topic shows a strong focus on up-to-date experimental methods. Contributions go far beyond traditional linguistic analysis, and make use of psycho- and neuro-linguistic methods.