Research Funds For Central Universities Research Articles

Association between antibiotic resistance and increasing ambient temperature in China: an ecological study with nationwide panel data

Antibiotic resistance leads to longer hospital stays, higher medical costs, and increased mortality. However, research into the relationship between climate change and antibiotic resistance remains inconclusive. This study aims to address the gap in the literature by exploring the association of antibiotic resistance with regional ambient temperature and its changes over time. Data were obtained from the China Antimicrobial Surveillance Network (CHINET), monitoring the prevalence of carbapenem-resistant Acinetobacter baumannii (CRAB), Klebsiella pneumoniae (CRKP) and Pseudomonas aeruginosa (CRPA) in 28 provinces/regions over the period from 2005 to 2019. Log-linear regression models were established to determine the association between ambient temperature and antibiotic resistance after adjustment for variations in socioeconomic, health service, and environmental factors. A 1°C increase in average ambient temperature was associated with 1.14-fold increase (95%-CI [1.07-1.23]) in CRKP prevalence and 1.06-fold increase (95%-CI [1.03-1.08]) in CRPA prevalence. There was an accumulative effect of year-by-year changes in ambient temperature, with the four-year sum showing the greatest effect on antibiotic resistance. Higher prevalence of antibiotic resistance was also associated with higher antibiotic consumption, lower density of health facilities, higher density of hospital beds and higher level of corruption. Higher prevalence of antibiotic resistance is associated with increased regional ambient temperature. The development of antibiotic resistance under rising ambient temperature differs across various strains of bacteria. The National Key R&D Program of China (grant number: 2018YFA0606200), National Natural Science Foundation of China (grant number: 72074234), Fundamental Scientific Research Funds for Central Universities, P.R. China (grant number: 22qntd4201), China Medical Board (grant number: CMB-OC-19-337).

Risk of hepatitis B virus reactivation following treatment with abatacept: A retrospective study of international pharmacovigilance databases

SummaryBackgroundAbatacept is a selective T-cell costimulation modulator approved for the treatment of rheumatoid arthritis, juvenile idiopathic arthritis, and psoriatic arthritis. Reports were recently published on hepatitis B virus reactivation (HBVr) in patients who were treated with abatacept. However, the literature is limited to case reports and series, and no study has investigated the relationship between HBVr and abatacept using extensive population-based databases.MethodsUsing the United States Food and Drug Administration Adverse Event Reporting System (FAERS) database, we collected all cases of HBVr between Jan 1, 2006 and June 30, 2021, for abatacept and other drugs. Disproportionality was analysed using the reporting odds ratio (ROR), which was considered significant when the lower limit of the 95% CI was >1. We also conducted a confirmatory analysis in the European pharmacovigilance database, EudraVigilance.FindingsDuring the study period, 77,669 adverse cases were reported for abatacept use. There were 2889 reports of HBVr with any drug during this period, of which 55 were reported with abatacept. The ROR for HBVr with abatacept was significantly elevated at 4·80 (95% CI 3·68–6·27). All 55 cases of HBVr with abatacept were reported as serious adverse events. Of them, six individuals were hospitalised and four died. Among 832 reports of HBVr with any drug in EudraVigilance, 43 were reported with abatacept; the ROR was 8·99 (95% CI 6·61–12·23).InterpretationWe identified a positive signal between abatacept exposure and HBVr. Future prospective studies should further confirm the relationship and provide evidence to develop strategies involving pre-treatment screening, monitoring, and utilisation of antiviral prophylaxis when using abatacept in patients with rheumatic diseases.FundingThis work was supported by the Fundamental Research Funds for Central Universities (xjh012019063).

Inelastic Interaction of Double-Valley Dark Solitons for the Hirota EquationSupported by the National Natural Science Foundation of China (Grant Nos. 11771151, 12022513, and 11775176), the Guangzhou Science and Technology Program (Grant No. 201904010362), the Fundamental Research Funds for Central Universities (Grant No. 2019MS110), and the Major Basic Research Program of Natural Science of Shaanxi Province (Grant No. 2018KJXX-094).

For a scalar integrable model, it is generally believed that the solitons interact with each other elastically, for instance, multi-bright solitons from the nonlinear Schrödinger equation and the Korteweg-de Vries equation, etc. We obtain double-valley dark solitons from the defocusing Hirota equation by the Darboux transformation. Particularly, we report a remarkable phenomenon for the inelastic interaction of the double-valley dark solitons, in contrast to the solitons interacting with each other elastically for a scalar integrable model in previous works. Furthermore, we give the explicit conditions for the elastic collision based on the asymptotic analysis results. It is shown that the double-valley dark solitons could also admit elastic interaction under the special parameters settings.

Nanoerythrocyte Membrane‐Enveloped ROS‐Responsive 5‐Aminolevulinic Acid Prodrug Nanostructures with Robust Atheroprotection

Part. Part. Syst. Charact. 2020, 37, 2000021 DOI: 10.1002/ppsc.202000021 The Acknowledgements section in the published article contains an incorrect funding number from the Chongqing Research Program of Basic Research and Frontier Technology. The correction Acknowledgements is as follows: This study was supported by the National Natural Science Foundation of China (31971301 and 31971242), the Chongqing Research Program of Basic Research and Frontier Technology (cstc2017jcyjAX0186 and cstc2019jcyjzdxmX0028), the Chinese National Key R&D Project (2016YFC1102305), and the Fundamental Research Funds for Central Universities (2018CDHB1B08 and 106112018CDPTCG0001-10). The authors are also thankful for the support from the Chongqing Engineering Laboratory in Vascular Implants, the Public Experiment Centre of State Bioindustrial Base (Chongqing), and the National “111 plan” (B06023). The authors apologize for any inconvenience caused.

Quantifying plasmon resonance and interband transition contributions in photocatalysis of gold nanoparticle* *Project supported by the National Key Research and Development Program of China (Grant No. 2020YFA0211300), the National Natural Science Foundation of China (Grant Nos. 92050112, 12074237, and 12004233), and the Fundamental Research Funds for Central Universities, China (Grant Nos. GK202103010 and GK202103018).

Localized surface plasmon has been extensively studied and used for the photocatalysis of various chemical reactions. However, the different contributions between plasmon resonance and interband transition in photocatalysis has not been well understood. Here, we study the photothermal and hot electrons effects for crystal transformation by combining controlled experiments with numerical simulations. By photo-excitation of NaYF4 : Eu3+ @Au composite structure, it is found that the plasmonic catalysis is much superior to that of interband transition in the experiments, owing to the hot electrons generated by plasmon decay more energetic to facilitate the reaction. We emphasize that the energy level of hot electrons plays an essential role for improving the photocatalytic activity. The results provide guidelines for improving the efficiency of plasmonic catalysis in future experimental design.

Zero-field skyrmions in FeGe thin films stabilized through attaching a perpendicularly magnetized single-domain Ni layer* *Project supported by the National Natural Science Foundation of China (Grant No. 11774045), the Joint Research Fund Liaoning-Shenyang National Laboratory for Materials Science (Grant No. 20180510008), and the Fundamental Research Funds for Central Universities, China (Grant No. N182410008-1).

A numerical study reports that the zero-field skyrmions in FeGe thin films are stabilized when a FeGe layer is exchange coupled to a single-domain Ni layer, which has been magnetized perpendicularly. Due to the small thickness, an easy-plane anisotropy in the FeGe layer is taken into account, and the skyrmion-crystal state is favored to appear for low anisotropies and intermediate FeGe/Ni interlayer exchange couplings, and finally transformed from a labyrinth-like and into an out-of-plane uniform state for the large couplings or into an in-plane state for the high anisotropies. Furthermore, the maximum skyrmion charge number is bigger for the periodic and fixed boundary conditions with an out-of-plane magnetization; on the contrary, the Bloch-type skyrmions can be frozen and stabilized for the larger couplings on the fixed boundary with an in-plane magnetization, similar to the experimental results of the magnetic-field-induced skyrmions. Finally, the skyrmion charge number and diameter both decrease if the nonmagnetic defects exist, and the skyrmion centers are prone to being captured by defect sites. This work evidences that the ensembles of homochiral skyrmions stabilized in the multilayers fabricated by well-established technologies present a roadmap to design new classes of the materials that can host skyrmions.

The Short Isoform TET1s Retards Oscillatory Shear Flow-Induced Atherosclerosis Through CX40-Dependent Endothelial Cell Barrier Enhancement

Background: TET1 has been implicated in regulating inflammation and cardiovascular disease, but a newly discovered short isoform of TET1 (termed TET1s) exhibits higher expression in adult tissues than full-length TET1. However, the precise role of TET1 in cardiovascular disease remains undefined. Methods: To assess the function of TET1s in atherosclerosis development, ApoE-/-TET1-/- mice and ApoE-/-TET1cs/cs mice were generated. Atherosclerotic plaques were evaluated by Oil red staining and endothelial permeability was accessed by Evans blue staining. Oscillatory shear stress (OSS) model generated by carotid artery ligation. Overexpressing TET1s in primary HUVECs was used to access the function of TET1s in vitro. Findings: We found that TET1s deletion in TET1-/- mice resulted in more serious atherosclerotic lesions in the whole aorta than TET1cs/cs in the ApoE-/- background mice. Atherosclerotic lesions were dramatically localized in the aortic arch, abdominal aorta and ligated LCA, where they were exposed to OSS. Furthermore, the OSS-induced depression of TET1s in vitro and in vivo impaired the vascular intimal barrier. TET1s upregulation enhanced vascular endothelial barrier function by increasing CX40 expression through increases histone acetylation levels in the CX40 promoter via its interaction with Sin3a. Interpretation: These data demonstrate TET1s expression to protect OSS-induced atherosclerosis through enhancing vascular endothelial barrier by increasing CX40 expression in ECs Funding: The work is supported by the Natural Science Foundation of China (31971242, 12032007), Chongqing Science and Technology Bureau (cstc2019jcyj-zdxmX0028) and Fundamental Research Funds for Central Universities (2019CDYGZD008, 2019CDYGYB016, 2021CDJCGJ007). Declaration of Interest: All authors declare no conflict of interest Ethical Approval: All animal procedures and patients sample study were reviewed and approved by the Animal Care and Ethic Committee of Chongqing University.

Improved efficiency and stability of perovskite solar cells with molecular ameliorating of ZnO nanorod/perovskite interface and Mg-doping ZnO* *Project supported by Beijing Natural Science Foundation, China (Grant No. 2202030), the National Natural Science Foundation of China (Grant No. 41422050303), the Program of Introducing Talents of Discipline to Universities (Grant No. B14003), and the Fundamental Research Funds for Central Universities, China

Despite the advanced efficiency of perovskite solar cells (PSCs), electron transportation is still a pending issue. Here the polymer polyvinylpyrrolidone (PVP) is used to enhance the electron injection, which is thanks to the passivation of the defects at the interface between the ZnO electron transporting layer (ETL) and the perovskite. The application of the PVP layer inhibits the device degradation, and 80% of the primary efficiency is kept after 30 d storage in air condition. Additionally, the efficiency of the device is further enhanced by improving the conductivity and crystallinity of the ZnO ETL via Magnesium (Mg) doping in the ZnO nanorods (ZnO NRs). Moreover, the preparation parameters of the ZnO NRs are optimized. By employing the high-crystallinity ZnO ETL and the PVP layer, the power conversion efficiency (PCE) of the champion device is increased from 16.29% to 19.63%. These results demonstrate the advantages of combining mesoscale manipulation with interface modification and doping together.

Shear-Banding Evolution Dynamics during High Temperature Compression of Martensitic Ti-6Al-4V Alloy* *Supported by the National Natural Science Foundation of China (Grant No. 51471136), and the Fundamental Research Funds for Central Universities.

The isothermal compression dynamics of ternary Ti-6Al-4V alloy with initial martensitic structures were investigated in the high temperature range 1083–1173 K and moderate strain rate regime 0.01–10 s−1. Shear banding was found to still dominate the deformation mechanism of this process, despite its nonadiabatic feature. The constitutive equation was derived with the aid of Zener–Hollomon parameter, which predicted the apparent activation energy as 534.39 kJ/mol. A combination of higher deformation temperature and lower strain rate suppressed the peak flow stress and promoted the evolution of shear bands. Both experiments and calculations demonstrated that a conspicuous temperature rise up to 83K could be induced by severe plastic deformation. This facilitated the dynamic recrystallization of deformed martensites, as evidenced by the measured microhardness profiles across shear bands.

Fluorine Effects for Tunable C–C and C–S Bond Cleavage in Fluoro-Julia–Kocienski Intermediates

Classical Julia–Kocienski fluoroolefination represents an indispensable platform for the construction of monofluoroalkenes. Nevertheless, its complex multistep mechanistic manifold along with the u...

Modular Synthesis of Diarylalkanes by Nickel-Catalyzed 1,1-Diarylation of Unactivated Terminal Alkenes

A nickel-catalyzed 1,1-diarylation of electronically unbiased alkenes has been developed, providing straightforward access to diarylalkanes from readily available materials. Importantly, both the e...

LukS-PV Induces Apoptosis and Inhibits Proliferation Through Methyltransferase SET8 in Human Acute Myeloid Leukaemia Cells

Background: Histone modifiers contribute to leukaemia pathogenesis. LukS-PV is a component of the Panton-Valentine leukocidin (PVL) cytotoxin secreted by Staphylococcus aureus. We previously reported that LukS-PV induces apoptosis in human acute myeloid leukaemia (AML) cells (THP-1 and HL-60). However, it is unclear whether LukS-PV exerts biological effects through epigenetic regulation. We aimed to investigate the epigenetic regulatory mechanisms underlying the effects of LukS-PV. Methods: SET8 expression was quantified through reverse-transcription PCR and western blotting in patient-derived AML cells. To determine whether LukS-PV influences apoptosis and proliferation via SET8, AML cell lines HL-60 and NB-4 were treated with LukS-PV, and SET8 expression was quantified. Chromatin-immunoprecipitation (ChIP) was performed to determine whether LukS-PV regulates H4K20me1 via SET8, and transcriptional targets were determined through ChIP-seq and bioinformatic methods. Findings: Methyltransferase SET8 was upregulated in primary AML blasts and downregulated in LukS-PV-treated AML cells HL-60 and NB4. LukS-PV induced apoptosis and inhibited proliferation by downregulating SET8. Furthermore, LukS-PV regulated H4K20me1 through SET8. Genome-wide analysis identified PIK3CB as the direct target of LukS-PV-mediated H4K20me1. Furthermore, PIK3CB inhibitor GSK2636771 induced apoptosis and inhibited proliferation in HL-60 and NB4 cells. Moreover, LukS-PV induced apoptosis and inhibited proliferation in primary AML blasts. Conclusions: The present results indicate that LukS-PV induces apoptosis and inhibits proliferation in AML cells by downregulating SET8 and regulating downstream molecular targets, suggesting that SET8 is a potential target for AML therapy using LukS-PV for anti-leukaemia treatment. Funding Statement: This work was supported by the Anhui Natural Science Foundation(Grant No.1808085QH259), the Fundamental Research Funds for Central Universities (WK9110000107) and National Natural Science Foundation of China (Grant No.81572065). Declaration of Interests: The authors declare no conflict of interest. Ethics Approval Statement: This study was approved by the Ethics Committee and Institutional Review Board of University of Science and Technology of China, Anhui, China (Approval number: 2019-N(H)-101).

Thermal desorption characteristic of helium ion irradiated nickel-base alloy**Project supported by Special Funds for Fundamental Research Funds for Central Universities, China (Grant Nos. 2018 NTST29 and 2018 NTST04), the National Natural Science Foundation of China (Grant No. 61176003), Chinese Postdoctoral Science Foundation (Grant No. 2019M650524), and Guangdong Province Key Area R&D Program, China (Grant No. 2019B090909002).

The nickel-base alloy is one of the leading candidate materials for generation IV nuclear reactor pressure vessel. To evaluate its stability of helium damage and retention, helium ions with different energy of 80 keV and 180 keV were introduced by ion implantation to a certain dose (peak displacement damage 1–10 dpa). Then thermal desorption spectroscopy (TDS) of helium atoms was performed to discuss the helium desorption characteristic and trapping sites. The desorption peaks shift to a lower temperature with increasing dpa for both 80 keV and 180 keV irradiation, reflecting the reduced diffusion activation energy and faster diffusion within the alloy. The main release peak temperature of 180 keV helium injection is relatively higher than that of 80 keV at the same influence, which is because the irradiation damage of 180 keV, helium formation and entrapment occur deeper. The broadening of the spectra corresponds to different helium trapping sites (He–vacancies, grain boundary) and desorption mechanisms (different HenVm size). The helium retention amount of 80 keV is lower than that of 180 keV, and a saturation limit associated with the irradiation of 80 keV has been reached. The relatively low helium retention proves the better resistance to helium bubbles formation and helium brittleness.

Microstructure evolution and passivation quality of hydrogenated amorphous silicon oxide (a-SiOx:H) on 〈100〉- and 〈111〉-orientated c-Si wafers**Project supported by the National Key Research and Deveopment Program of China (Grant No. 2018YFB1500402), the National Natural Science Foundation of China (Grant Nos. 61674084 and 61874167), the Fundamental Research Funds for Central Universities, China, the Natural Science Foundation of Tianjin City, China (Grant

Hydrogenated amorphous silicon oxide (a-SiOx:H) is an attractive passivation material to suppress epitaxial growth and reduce the parasitic absorption loss in silicon heterojunction (SHJ) solar cells. In this paper, a-SiOx:H layers on different orientated c-Si substrates are fabricated. An optimal effective lifetime (τeff) of 4743 μs and corresponding implied open-circuit voltage (i Voc) of 724 mV are obtained on 〈100〉-orientated c-Si wafers. While τeff of 2429 μs and i Voc of 699 mV are achieved on 〈111〉-orientated substrate. The FTIR and XPS results indicate that the a-SiOx:H network consists of SiOx (Si-rich), Si– OH, Si– O– SiHx, SiO2≡Si– Si, and O3 ≡S– Si. A passivation evolution mechanism is proposed to explain the different passivation results on different c-Si wafers. By modulating the a-SiOx:H layer, the planar silicon heterojunction solar cell can achieve an efficiency of 18.15%.

The NMN Module Conducts Nodule Number Orchestra.

Legumes control nodule number through nodulation and autoregulation of nodulation (AON) pathways. Nodule Inception (NIN) is essential for rhizobial infection and nodule organogenesis in legumes. The GmNINa-miR172c-NNC1 (NMN) module, which consists of two positive regulators, GmNINa and miR172c, and a suppressor, NNC1, integrates both pathways. GmNINa activates miR172c to downregulate NNC1, leading to nodulation, while NNC1 inhibits miR172c expression, forming a negative feedback loop. GmNINa and NNC1 interact with each other and antagonistically fine-tune GmRIC1/RIC2 expression, turning AON on and off. Conversely, activation of AON inhibits GmNINa and miR172c expression, thereby reducing their inhibitory effects on NNC1 to attenuate both nodulation signaling and AON. The NMN module functions not only as an “accelerator” of the nodulation signal to promote nodulation but also as a “brake” on the signal by activating AON to orchestrate nodule number.

MiR-34a Suppression Ameliorates Bone Marrow Mesenchymal Stem Cell Senescence by Targeting Nampt and Regulating NAD <sup>+</sup>-Sirt1 Pathway

Background: Expansion-mediated replicative senescence and age-related natural senescence have adverse effects on MSC regenerative capability and functionality, thus severely impairing the extensive applications of MSC-based therapies. Emerging evidences suggest that miR-34a has been implicated in the process of MSC senescence; however, the molecular mechanisms with regard to how miR-34a influencing MSC senescence remain largely undetermined. Methods: We undertake a systematic study on the functional effects of miR-34a exerting on MSC senescence via gene manipulation. Mechanistically, bioinformatics analysis and dual-luciferase reporter gene assay were applied to decipher the interactions between miR-34a and its potential target Nampt. Findings: miR-34a overexpression in young MSCs resulted in senescence-associated characteristics as displayed by senescence-like morphology, prolonged cell proliferation, declined osteogenic differentiation potency, heightened senescence-associated-β- galactosidase activity, and up-regulated expression levels of the senescence-associated factors. Conversely, miR-34a suppression in replicative senescent and natural senescent MSCs contributed to diminished senescence-related phenotypic features. We identified Nampt as a direct target gene of miR-34a. Additionally, miR-34a repletion resulted in prominent reductions in Nampt expression levels, NAD+ content, NAD+/NADH ratio, and Sirt1 activity, whereas anti-miR-34a treatment exerted the opposite effects. Furthermore, miR-34a-mediated MSC senescence was evidently rescued following the co-treatment with Nampt overexpression. Interpretation: This study identifies a significant role of miR-34a playing in MSC replicative senescence and natural senescence via targeting Nampt and further mediating by NAD+-Sirt1 pathway, possibly carrying great implications for optimal strategies for MSC therapeutic applications. Funding Statement: This study was supported by projects of National Natural Science Foundation of China (Grant number: 81571370), Jilin Province Science and Technology Development Projects (Grant number: 20150414029GH), Science and Technology Projects of the Education Department of Jilin Province (Grant Number: JJKH20190007KJ) and the Fundamental Research Funds for Central Universities, JLU. Declaration of Interests: The authors declare no conflict of interest. Ethics Approval Statement: Experimental investigations involving animals were permitted by the Institutional Animal Care and the Ethic Committee of Jilin University (permit number: SYXK 2013-0005) and were conducted in compliance with the ethical standards and regulations, the Declaration of Helsinki and national and international guidelines.

Prediction of the Number of New Cases of 2019 Novel Coronavirus (COVID-19) Using a Social Media Search Index

Purpose: Predicting number of novel Coronavirus Disease 2019 (COVID-19) new-suspected or confirmed cases is crucial in prevention and control of COVID-19 outbreak. Methods: Social media search indexes (SMSI) for dry cough, fever, chest distress, coronavirus, and pneumonia were collected from December 31, 2019, to February 9, 2020. The new-suspected cases of COVID-19 data were collected from January 20, 2020, to February 9, 2020. We used lagged series of SMSI to predict new-suspected COVID-19 case numbers during this period. To avoid overfitting, five methods, namely subset selection, forward selection, lasso regression, ridge regression, and elastic net, were used to estimate coefficients. We selected optimal method to predict new-suspected COVID-19 case numbers over subsequent 20 days. We further validated optimal method for new-confirmed cases of COVID-19 from December 31, 2019, to February 17, 2020. Results: The new-suspected COVID-19 case numbers were significantly correlated with lagged series of SMSI. SIMI could be earlier detected 6–9 days than new-suspected cases of COVID-19. The optimal method was subset select, which had lowest estimation error and a moderate number of predictors. The subset selection method was also significantly correlated with new-confirmed COVID-19 cases after validation. SMSI findings on lag day 10 were significantly correlated with new-confirmed COVID-19 cases. Conclusions: SMSI could be a significant predictor of number of COVID-19 infections. Funding Statement: Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, supports SzuYuan Wu’s work (Funding Number: 10908 and 10909). Lei Qin's work is supported by University of International Business and Economics Huiyuan outstanding young scholars research funding (17YQ15), the Fundamental Research Funds for central Universities in UIBE (CXTD10-10). Ben-Chang Shia’s work was also supported by an institutional grant from Taipei Medical University (Taipei, Taiwan) for New Faculty Research (TMU103-AE1-B22). Declaration of Interests: The authors have no potential conflicts of interest to declare.

MELK promotes Endometrial carcinoma progression via activating mTOR signaling pathway.

BackgroundEndometrial carcinoma (EC) is one of the most common gynecological malignancies among women. Maternal embryonic leucine Zipper Kinase (MELK) is upregulated in a variety of human tumors, where it contributes to malignant phenotype and correlates with a poor prognosis. However, the biological function of MELK in EC progression remains largely unknown.MethodsWe explored the MELK expression in EC using TCGA and GEO databases and verified it using clinical samples by IHC methods. CCK-8 assay, colony formation assay, cell cycle assay, wound healing assay and subcutaneous xenograft mouse model were generated to estimate the functions of MELK and its inhibitor OTSSP167. qRT-PCR, western blotting, co-immunoprecipitation, chromatin immunoprecipitation and luciferase reporter assay were performed to uncover the underlying mechanism concerning MELK during the progression of EC.FindingsMELK was significantly elevated in patients with EC, and high expression of MELK was associated with serous EC, high histological grade, advanced clinical stage and reduced overall survival and disease-free survival. MELK knockdown decreased the ability of cell proliferation and migration in vitro and subcutaneous tumorigenesis in vivo. In addition, high expression of MELK could be regulated by transcription factor E2F1. Moreover, we found that MELK had a direct interaction with MLST8 and then activated mTORC1 and mTORC2 signaling pathway for EC progression. Furthermore, OTSSP167, an effective inhibitor, could inhibit cell proliferation driven by MELK in vivo and vitro assays.InterpretationWe have explored the crucial role of the E2F1/MELK/mTORC1/2 axis in the progression of EC, which could be served as potential therapeutic targets for treatment of EC.FundingThis research was supported by National Natural Science Foundation of China (No:81672565), the Natural Science Foundation of Shanghai (Grant NO:17ZR1421400 to Dr. Zhihong Ai) and the fundamental research funds for central universities (No: 22120180595).

Critical mass for a two-species chemotaxis model with two chemicals in **Supported by the Key Project of Education Department of Liaoning Province (Grant No. LZD201701), the Science Foundation of Liaoning Education Department (Grant No. LYB201601) and the Fundamental Research Funds for Central Universities (Grant No. 3132019178).

In this paper, we study a two-species chemotaxis model with two chemicals in . Let be the initial mass of the two species respectively. The critical mass of the model is established as a curve of the form . That is to say the solutuons exist globally if , and the finite time blow-up of solutions may occur if .

Theoretical analyses of stock correlations affected by subprime crisis and total assets: Network properties and corresponding physical mechanisms**Project supported by the National Natural Science Foundation of China (Grant Nos. 11705042 and 71874172), the China Postdoctoral Science Foundation (Grant Nos. 2018T110040 and 2016M590041), the Fundamental Research Funds for Central Universities, China (Grant No. JZ2018HGTB0238), Curriculum Planning and Design Research Project, China

In the field of statistical mechanics and system science, it is acknowledged that the financial crisis has a profound influence on stock market. However, the influence of total asset of enterprise on stock quote was not considered in the previous studies. In this work, a modified cross-correlation matrix that focuses on the influence of total asset on stock quote is introduced into the analysis of the stocks collected from Asian and American stock markets, which is different from the previous studies. The key results are obtained as follows. Firstly, stock is more greatly correlated with big asset than with small asset. Secondly, the higher the correlation coefficient among stocks, the larger the eigenvector is. Thirdly, in different periods, like the pre-subprime crisis period and the peak of subprime crisis period, Asian stock quotes show that the component of the third eigenvector of the cross-correlation matrix decreases with the asset of the enterprise decreasing. Fourthly, by simulating the threshold network, the small network constructed by 10 stocks with large assets can show the large network state constructed by 30 stocks. In this research we intend to fully explain the physical mechanism for understanding the historical correlation between stocks and provide risk control strategies in the future.