Long‐term chronic exposure to methamphetamine (MA) has been related to profound neural impact including, but not limited to, damage to monoamine nerve terminals. In turn, neural changes following repeated MA administration may be related to adverse effects on learning and other cognitive performance. However, the characterization of such neurobehavioral deficits remains incomplete. The present study assessed the effects of ongoing MA self‐administration on touchscreen‐based discrimination learning in nonhuman primates. Prior to daily sessions of MA self‐administration (i.e., 20‐hr after the previous day’s session), monkeys engaged in a repeated acquisition task in which changes in the rate of discrimination learning for a stimulus pair were assessed over the successive presentation of novel stimulus pairs. Results thus far indicate that ongoing MA self‐administration produces markedly deleterious effects on the development of learning sets in discrimination learning. Importantly, the magnitude of adverse effects on learning appears to be correlated with the level of daily MA intake among individual subjects.Grant Funding Source: Supported by grant K01‐DA035974 from NIDA