Repair Sequences Research Articles

User practices in dealing with trouble in interactions with virtual assistants in German: Repeating, altering and insisting

Moments of trouble and miscommunication occur regularly when users interact with virtual assistants like smart speakers. To add to the understanding of how users treat moments of trouble in everyday interactions with a virtual assistant (VA) in German, this paper reports on a conversation analytic study of practices that users deploy after a request to a VA has failed. The repair sequences that we analyse show users orienting to different trouble sources and employing a range of practices to resolve trouble, including repeating, altering their formulations and formulating related (new) requests. Most often, troubles are resolved after one instance of repair. Other repair sequences include several instances of repair and show more complex and diverse practices being employed. In some of these sequences, users ‘insist’ on their initial goal and/or strategy and do not always observably orient to the VA’s local reactions. In these cases, the interactional history with the VA and previously successful requests seem to play a role as well in the users’ local conduct.

The muscle pump activator device: From evidence to lived experiences.

A chronic wound is one that fails to progress through a normal timely sequence of repair, or in which the repair process fails to restore anatomic and functional integrity after 3 months. The most common chronic wounds include venous, ischaemic and mixed leg ulcers, diabetic foot ulcers and pressure injuries. Chronic wounds place immense physical and psychosocial burden on patients and exact heavy costs for healthcare systems, with many patients continuing to live with chronic wounds even after all management options have been exhausted. The muscle pump activator (MPA) device can be used to bridge this therapeutic gap. By stimulating the common peroneal nerve to activate venous muscle pump of the leg and foot, the MPA device increases blood flow to the lower leg and foot to improve conditions for healing. Currently, evidence in the literature exist to show that the MPA device improves wound outcomes over standard compression therapy, decreases edema and increases wound healing rates. In this review, we also present a series of chronic wound patients treated with the MPA device in multicentre clinics to demonstrate the ability of the MPA device to improve wound outcomes, reduce pain and edema and improve patient quality of life.

A practical method for functional recovery analysis based on seismic resilience assessment of city building portfolios

Enhancing the seismic resilience of city building portfolios represents a pivotal strategy for mitigating the adverse effects of earthquakes. A practical method for functional recovery analysis is proposed to quantitatively assess the seismic resilience of city building portfolios. The proposed method involves quantifying delay time and developing repair scheduling schemes. The delay time considers the dependencies of normal functioning buildings on infrastructure service availability and road accessibility. It emphasizes the varying demands of buildings for critical versus general infrastructure services. The repair scheduling scheme, conducted in two steps, employs a rational repair priority index that integrates the post-earthquake residual functionality, service capacity, and relative importance of buildings. This scheme prioritizes the repair of life-rescue-related buildings, distinguishes the repair sequence for different occupancy types of buildings, and reflects the principles of local governments in repair decision-making. The effectiveness of this practical method is demonstrated through a case study. Recovery curves are compared under different earthquake scenarios and levels of labor force constraints. The concept of normalized time is introduced to allow for a comparative assessment of seismic resilience across different recovery scenarios in a more practical manner. The results can provide valuable guidance for formulating pre-earthquake risk reduction strategies, developing post-earthquake functional recovery schemes, and constructing more resilient cities.

Birds on a Wire: A discussion of Çevrim’s “The Vulture in the room”

ABSTRACT Birds on a Wire is a discussion of Mustafa Çevrim’s, ”The Vulture in the Room”, a beautifully intersubjectively focused clinical paper. This discussion focuses on the bidirectional, self (therapist)regulation and self with “other” (patient and therapist) regulation. Çevrim’s elegant adherence to contemporary Self Psychological/Intersubjective Systems theory is spotlighted, as the emergent self object twinship transference highlights the dyad’s shared understandings through their co-created metaphoric use of bird imagery. Çevrim’s application of a Brandchaftian model of systems of pathological accommodation and his tracking of therapeutic rupture and repair sequences reveals a process of transformation and growth for patient and analyst. Finally, there is a consideration of the impact of what I term, the analyst’s “generative thoughts” on therapeutic process and contextualization.

Problematic Possessivity: Possessive Pronouns and Repair Sequences in Historical German Dramas

Problematic Possessivity: Possessive Pronouns and Repair Sequences in Historical German Dramas

Multifunctional double-network hydrogel with antibacterial and anti-inflammatory synergistic effects contributes to wound healing of bacterial infection

Wound infection not only hinders the time sequence of tissue repair, but also may lead to serious complications. Multifunctional wound dressings with biocompatibility, excellent mechanical properties and antibacterial properties can promote wound healing during skin infection and reduce the use of antibiotics. In this study, a multifunctional dual-network antibacterial hydrogel was constructed based on the electrostatic interaction of two polyelectrolytes, hydroxypropyl trimethyl ammonium chloride chitosan (HACC) and sodium alginate (SA). Attributing to the suitable physical crosslinking between HACC and SA, the hydrogel not only has good biocompatibility, mechanical property, but also has broad-spectrum antibacterial properties. In vivo results showed that the hydrogel could regulate M2 polarization, promote early vascular regeneration, and create a good microenvironment for wound healing. Therefore, this hydrogel is an effective multifunctional wound dressing. Consequently, we propose a novel hydrogel with combined elements to expedite the intricate repair of wound infection.

Resilience-oriented repair crew and network reconfiguration coordinated operational scheduling for post-event restoration

This paper introduces a post-disaster load restoration approach for the distribution grid, utilizing network reconfiguration (NR) and dispatching of repair crews (RCs) to significantly enhance grid resilience. We propose an RC–NR coordinated model that leverages diverse flexible resources within the active distribution network (ADN), aimed at not only enhancing the grid’s resilience level but also efficiently mending the fault lines. The model introduces fault repairing and sequential NR coupled constraints to devise an optimal resilience strategy within temporal domain cooperation, focusing on minimizing repair and penalty costs associated with the restoration process. To tackle the challenge of computational complexity, the nonlinear model is reformulated into a mixed-integer second-order cone programming model. The efficacy of the approach is validated through case studies on an IEEE 33-bus system, in which simulation results demonstrate a considerable improvement in grid resilience, achieving optimal load recovery with reduced restoration time and costs. The proposed approach outperforms traditional methods with optimal repair sequence and RC scheduling, aligned with NR efforts, and contributes to an improved system resilience level.

Abstract LB404: ATR inhibitors synergize with DHFR inhibitors in rhabdomyosarcoma cells by disrupting DNA damage checkpoint

Abstract Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and adolescents. RMS tumors are classified into four subtypes: embryonal, alveolar, spindle cell/sclerosing, and pleomorphic. Treatment options for RMS include a combination of surgery, chemotherapy, and radiation therapy and regimens for patients with relapsed and metastatic RMS remain limited. However, a recent study has reported that pharmacological inhibitors targeting ataxia telangiectasia and Rad3-related protein (ATR) are currently undergoing phase I/II trials and may be utilized for the treatment of alveolar RMS. Interestingly, we identified that the gene signature of replication stress positively correlated with dihydrofolate reductase (DHFR) expression in the cancer cell line database (CellMinerCDB, discover.nci.nih.gov/cellminercdb; Pearson correlation (r)=0.66). DHFR is an important therapeutic target for cancer and autoimmune diseases, and its inhibitors are routinely used and clinically approved. DHFR inhibitors are known to exhibit their anticancer effects by inhibiting nucleotide synthesis and DNA replication. In this study, we aimed to explore a potential synergistic interaction using a combination treatment of ATR inhibitors (elimusertib and ceralasertib) and DHFR inhibitors (pralatrexate, methotrexate, and raltitrexated) in multiple RMS cell lines. We used a drug matrix reduction format and found that combined treatment of ATR inhibitors and DHFR inhibitors induced a synergistically decreased RMS cell viability, showing higher synergy in fusion-positive RMS cells than in fusion-negative RMS cells. Mechanistically, ATR inhibitors abrogated DNA damage response checkpoint CHK1 activation caused by DHFR inhibitor, leading to increased γH2AX and decreased DNA replication activity. Accordingly, the accumulation of DNA damage in combination with ATR inhibitor and DHFR inhibitor triggered higher cell cycle arrest and apoptotic cell death than single agent treatment of DHFR inhibitor. Our findings warrant further research into identifying genomic regions where the DNA damage is enriched in combination treatment by using END-sequencing and synthesis-associated with repair sequencing (SAR-seq). In conclusion, this study provides promising rationale for the combination treatment of ATR and DHFR inhibitors to treat RMS patients, including those with advanced, relapsed, and metastatic states. Citation Format: Ukhyun Jo, George K Annor, Jack F. Shern. ATR inhibitors synergize with DHFR inhibitors in rhabdomyosarcoma cells by disrupting DNA damage checkpoint [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr LB404.

Teachers’ multimodal resources for delegated peer repair: Maximizing interactional space in whole‐class interaction in the foreign language classroom

AbstractIn classrooms, teachers play a fundamental role in managing students’ participation. As part of their classroom interactional competence to maximize interactional space for students’ learning, teachers use multimodal resources to orchestrate turn‐taking, allocate the next speaker, and manage repair sequences. However, little is known about how teachers employ these resources to engage learners in delegated peer repair, that is, repair sequences initiated by a student and solved by another classmate. Adopting a multimodal conversation analysis approach, this study aims to investigate how Spanish‐as‐a‐foreign‐language teachers multimodally manage delegated peer repair in whole‐group interaction by increasing interactional space to promote students’ participation. The findings show that teachers often resort to embodied resources such as gaze, gestures (pointing), and hand and body movements (stepping backward) to engage students in delegated peer repair, leading to increased student participation and autonomy. We end with some reflections on the relevance of the adopted methodology for better understanding how teachers employ multimodal resources to create interactional space and engage students in delegated peer repair, thus promoting learners’ interactional competence in the foreign language. It also suggests some potential implications for teachers’ professional development.

Managing the Flow of Talk: A Longitudinal Case Study of the Multiword Expression det er sant in L2 Norwegian Interactions

Abstract Drawing on recent scholarship integrating usage-based linguistics (UBL) and conversation analysis (CA) in the investigation of second language development, this paper reports on a microanalysis tracing one adult learner’s recurring, increasingly frequent, and diverse use of the multiword expression det er sant (it/that is true) (DES) in L2 Norwegian interactions over a time span of four months. While the use of DES did not undergo syntactic changes, the analysis revealed that the functions of the expression diversified as DES became more frequent in use. Initially functioning primarily as a means of expressing agreement, DES was increasingly used to preface disagreement and indicate the closing of self-initiated repair sequences. This functional diversification was accompanied by increasing morphophonological reduction indicating an ongoing process of routinization. We argue that these changes, also when non-linear and not complying with the target norm, allowed the learner to participate more actively in managing the flow of talk. The study provides insight into how interaction shapes L2 development and the role of education in providing access to situations that foster increased membership in the speech community.

On the division of labor in the maintenance of intersubjectivity: insights from the study of other-initiated repair in Vietnamese.

Few ideas have figured more centrally in the history of social theory than that of the division of labor. Here we ask whether conversational interaction, like other forms of social activity, exhibits a division of labor and, if so, what functions this serves and how it might be understood in relation to the theories of Marx and Durkheim. We begin by noting that, though conversational participants actively work to achieve and sustain understanding, much of the time this work is invisible and only its products are displayed in the form of sequentially fitted next turns at talk. However, in sequences of other-initiated repair, the work involved in the maintenance of intersubjectivity rises to the surface. On these occasions, we can see and thus describe what participants do to achieve and sustain what they take to be adequate understanding. In our data, which consist of video recordings of casual conversations among Vietnamese same-generation peers, participants continuously display an orientation to relations of relative seniority through the selection of terms used to accomplish interlocutor reference. This pervasive orientation is also reflected in practices of repair initiation. Specifically, seniors regularly initiate repair with so-called "open class" forms such as "huh?" and "ha?" which display a minimal grasp of the talk targeted, require little effort to produce and, at the same time, push responsibility for resolving the problem onto the trouble source speaker (i.e., the junior member of the dyad). In contrast, juniors often initiate repair of a senior participant's talk by displaying a detailed understanding of what has been said, either in the form of a repeat or a reformulation, and inviting the senior to confirm. We suggest then that this asymmetry in the distribution of initiation practices reflects a "division of intersubjective labor". We conclude with some thoughts on the theoretical implications of our findings and relate them not only to the theories of Marx and Durkheim but also to the writings of feminist sociolinguists who sought to describe the way in which women seem to be burdened more than men with what Fishman called "interactional shitwork."

Rapid recovery strategy for seismic performance of seismic-damaged structures considering imperfect repair and seismic resilience

In the emergency repair process of seismic-damaged structures, it is necessary to determine the optimal repair strategy according to damage assessment results, available repair resources and repair time. In this study, the applicable conditions of various member-level and structure-level damage indexes or models are compared. Then, considering the actual conditions of limited available repair resources and repair time in the emergency repair process, the determination method of the optimal imperfect repair strategy is established. On this basis, the determination method of the optimal repair sequence is proposed by taking seismic resilience as the evaluation index. Finally, a seismic fragility analysis method that considers uniform collapse risk and residual service life of structures is introduced, which can be used to analyze the seismic performance of seismic-damaged structures and to compare the repair effectiveness of different repair strategies. Taken a 5-story reinforced concrete structure as an example for analysis. The analysis results show the optimal imperfect repair strategy and the optimal repair sequence determined by the proposed methods can effectively improve the seismic performance of seismic-damaged structures. The fragility analysis results further confirm that the repair based on the optimal imperfect repair strategy can effectively reduce the collapse risk of seismic-damaged structures.

An exploration of linguistic mediation activities in repair sequences: The case of a plurilingual youth participant in an after-school digital storytelling project

This article uses Conversation Analysis (CA) to explore the linguistic mediation activities carried out by a plurilingual teenager in interaction with a linguistically and culturally diverse peer group, with a focus on repair sequences. The analysis centres on: 1) the placement of repair, that is, repair that is forward-oriented or backward-oriented; 2) the object of repair, focusing on repair directed at the code and repair directed at the message; 3) procedures by which the linguistic mediator is selected, that is by other-selection or self-selection; 4) interactional procedures for completing repair, focusing on translation and collaborative turn sequences. This study contributes to enhancing understandings of the mechanics of linguistic mediation in contexts of linguistic and cultural diversity from an interactional perspective, and among youth, in the context of an after-school educational program.

The Order of Operative Repair Does Not Influence Outcomes in Patients with Concomitant Popliteal Artery And Orthopedic Injuries

The most challenging lower extremity traumatic injuries involve concomitant vascular and orthopedic injuries with amputation rates approaching 50%. Controversy exists as to how to prioritize the vascular and orthopedic repairs. We reviewed patients with popliteal artery and lower extremity orthopedic injuries to analyze the sequence of the vascular and orthopedic repairs on outcomes. All adult patients with a diagnosis of concomitant popliteal artery and lower extremity fracture or dislocation were identified through a review of an institutional trauma registry performed at a level 1 trauma center from 2014 to 2019. Patient demographics, timing of presentation, injury severity score (ISS), surgical interventions, and limb outcome data were collected and examined. The sequence of operative repairs and factors influencing the operative order were analyzed. Twenty-nine patients were treated for popliteal artery injuries. Twelve of these 29 patients had concomitant popliteal artery and orthopedic fractures requiring surgical repair. Injury mechanisms included both blunt (50%, 6/12) and penetrating trauma (50%, 6/12); the majority involved femur fractures (58%, 7/12). Vascular repair included arterial bypass (75%, 9/12) or interposition grafts (25%, 3/12). Orthopedic repair included external fixation (83%, 10/12) and open reduction internal fixation (17%, 2/12). Vascular repair was performed first in 7/12 limbs (58%). Patients having vascular repair first had a trend toward lower blood pressure on arrival (P=0.068). There was no significant difference in emergency department to operating room (OR) time, OR time, ISS, mangled extremity severity score, estimated blood loss, or blood transfusion for the sequence of operative repair. Fasciotomy was nearly ubiquitous, present in 11/12 patients (92%). There were no graft complications related to orthopedic manipulation, and there were no reported limb-length to graft-length discrepancies. Early limb salvage trended lower in the cohort with revascularization first (71% vs. 100%, P=0.19). Of the remaining limbs available for follow-up, limb salvage at 4.25years is 100%. In this small study of patients with concomitant lower extremity popliteal artery and orthopedic injuries, the order of operative repair does not appear to influence the success of revascularization.

Analysis of cytosine deamination events in excision repair sequencing reads reveals mechanisms of incision site selection in NER.

Nucleotide excision repair (NER) removes helix-distorting DNA lesions and is therefore critical for genome stability. During NER, DNA is unwound on either side of the lesion and excised, but the rules governing incision site selection, particularly in eukaryotic cells, are unclear. Excision repair-sequencing (XR-seq) sequences excised NER fragments, but analysis has been limited because the lesion location is unknown. Here, we exploit accelerated cytosine deamination rates in UV-induced CPD (cyclobutane pyrimidine dimer) lesions to precisely map their locations at C to T mismatches in XR-seq reads, revealing general and species-specific patterns of incision site selection during NER. Our data indicate that the 5' incision site occurs preferentially in HYV (i.e. not G; C/T;not T) sequence motifs, a pattern that can be explained by sequence preferences of the XPF-ERCC1 endonuclease. In contrast, the 3' incision site does not show strong sequence preferences, once truncated reads arising from mispriming events are excluded. Instead, the 3' incision is partially determined by the 5' incision site distance, indicating that the two incision events are coupled. Finally, our data reveal unique and coupled NER incision patterns at nucleosome boundaries. These findings reveal key principles governing NER incision site selection in eukaryotic cells.

Analyzing L2 Classroom Dynamics: A Conversation Analysis Perspective

This paper explores the reflexive relationship between pedagogy and interaction in second language (L2) classrooms, employing Seedhouse’s (2004) model and Conversation Analysis (CA) methodology. The analysis covers three contextual dimensions: form-and-accuracy, meaning-and-fluency, and task-oriented contexts. The study reveals the dynamic interplay between pedagogical focus and interactional organization, showcasing how participants negotiate linguistic forms, repair sequences, and engage in turn-taking to accomplish pedagogical goals. Despite critiques emphasizing the emic perspective’s limitations, the paper underscores CA’s contribution to understanding language use in teaching, offering pedagogical insights for language educators.

An advanced assessment framework for seismic resilience of railway continuous girder bridge with multiple spans considering 72h golden rescue requirements

Given the common sense that people in danger could survive with high probability in the golden rescue time of 72 h after earthquakes, railway bridges that are important transportation hubs and the lifelines for earthquake relief have been required to satisfy the necessities of safe passage and fast traffic for emergency response personnel in this critical period. To ensure the post-earthquake temporary functionality of the railway bridges to a sufficient safety level in golden rescue scenario, an advanced resilience assessment framework, including seismic resilience determinations for individual bridge components based on residual responses with respect to the plastic capacities originated from performance limit state definitions, definitions of three recovery levels considering repair efficiency for different recovery phases, and the series-parallel and parallel-serial system resilience models developed in temporal and spatial domains, was established. A commonly constructed irregular railway multi-span continuous girder bridge was chosen to verify the practicability of the aforementioned framework. The finite-element model of the illustrative bridge was developed taking abutment-girder interaction effects and nonlinear seismic behaviors of girder into account. Average spectral acceleration was taken as the intensity measure (IM) to consider the response variations originated from higher modes and natural period extension during earthquakes, and the site-matched and IM-based scaled ground records were adopted in the multiple stripe analysis to obtain instantaneous peak and residual seismic responses. Based on the framework, post-event resilience characteristics of bridge components were discussed, four recovery strategies were proposed for bridge system, and the seismic resilience of the illustrated bridge was assessed at system level. The research shows that the response contribution of fundamental dominant mode is only 64.37 %, indicating the dynamic response contributions from higher modes are considerable and the case bridge can show a strong irregularity during seismic events. Obvious nonlinear seismic behaviors occur to the superstructure where material strain in girder critical sections can increase to 0.00422 during earthquakes, which illustrates the inaccuracy of girder modeling only taking elastic behavior into consideration. Also, the prestress loss after earthquakes can reach 31.14 % and attention should be paid to the prestress recovery in subsequent repair works. Most components can satisfy the easy recovery resilience level, and the resilience is closely related to ground intensities and repair-waiting time; earthquake-induced functionality reduction can be 46.57 %, and resilience can increase by 25.35 % if the waiting time is shortened by 5 h. System resilience is influenced by the similar factors with component and varies in cases of different repair sequences due to the accumulation effect of repair-waiting time for various subsystems.

Claiming insufficient knowledge in pairwork and groupwork classroom activities

This conversation analytic paper explores how students in pair and groupwork tasks produce and respond to claims of insufficient knowledge (CIKs). Based on 7 h of video recordings of peer interaction from 18 English as a Foreign Language (EFL) classes in Czech secondary schools, we analyze how students express and negotiate their epistemic status using CIKs: when producing a CIK, the current speaker assumes a not-knowing status, thus making the imminent speaker change more relevant, as the next speaker then typically reveals his or her epistemic status. We also show that when a CIK is produced dyadic interactions in second position, the first speaker then produces a knowledge display response, or another CIK, resulting in abandoning the question, which differs from sequences that can be found in frontal teaching. The findings also show that CIKs can be used to resume task-related talk and initiate repair sequences focusing on language issues that the task comprises. Thus, CIKs can be viewed as central interactional resources for students to manage the task, i.e., to invite others to contribute, to resume their talk, or to abandon the current question, and to initiate repair sequences focusing on problematic items from the task.

Multi-agent deep reinforcement learning based decision support model for resilient community post-hazard recovery

After a city-scale natural hazard, policymakers should plan sound decisions on the repair sequence to ensure the resilient recovery of the community, which consists of interdependent infrastructures. Stochastic scheduling for repairing interdependent infrastructure systems is a difficult control problem with huge decision spaces. This study proposes a novel decision support model to determine the optimal restoration policies for the purpose of maximizing disaster resilience. A simulation environment is first developed, consisting of hazard intensity assessment, components damage evaluation, system recovery simulation, and resilience quantification. The graph theory is utilized to represent the interdependencies among different systems, and the heterogeneous graph neural network is integrated into this framework to extract the topology and interdependency information of the whole community. The optimal repair policies approximated by neural networks are trained by a multi-agent deep reinforcement learning algorithm, considering uncertainties of the restoration process. The superiority and efficiency of the proposed method are demonstrated through a case study of the Tsinghua University campus, where different decision-making objectives are considered. The results show that the recovery trajectories determined by the proposed model have the highest performance compared to conventional methods. Besides, the proposed methodology based on transfer learning can achieve high computational efficiency for new damage scenarios. This model is promising to be a high-performance, robust decision-support tool for post-hazard repairing decisions.

Embodied-Visual Practices during Conversational Repair: Scoping Review

ABSTRACT Repair organization provides a powerful mechanism for handling problems of mutual understanding in natural conversation. Our study reviews past research on repair initiation and resolution practices involving embodied-visual practices, including eye gaze, facial expressions, hand gestures, and head and body movements. We charted details of theoretical background, methodology, and main findings for 31 studies. Embodiment was studied equally in connection with self- (SIR) and other-initiated repair (OIR); gaze and gestures were the most commonly studied embodied-visual practices. In OIR sequences, research has focused on upper body and gaze. In SIR sequences, more gestures were examined, but this may be specific to word search, which was predominant in SIR studies. In addition, embodied-visual practices can form gestalts independently from talk, and can occur early in the repair sequence, even pre-trouble source. Data were in Argentine Sign Language, Cha’palaa, Danish, English, Finnish, French, German, Italian, Japanese, Korean, Mandarin, Turkish, and Yélî Dnye.