Remote Function Research Articles

Biomimetic Total Syntheses of Amorfrutins A, B, (S)‐D and (R)‐D and Formal Synthesis of Amorfrutin C

AbstractBibenzyl natural products, such as the amorfrutins, contain a heavily substituted aromatic core and display a diverse range of biological activities (anti‐tumor, anti‐diabetic, antimicrobial, and antibiotic). In this study, we report unified syntheses of amorfrutin A to D either through total or formal synthesis by employing a dual biomimetic strategy of polyketide aromatization followed by remote terpene functionalization. The key core structures were synthesized from β‐keto dioxinone esters through a magnesium(II) mediated regioselective C‐acylation, palladium catalyzed decarboxylative allylic rearrangement, and dehydrative cyclization.

Sequential Tether-Directed Synthesis of New [3 : 2 : 1] Hexakis-Adducts of C60 with a Mixed Octahedral Addition Pattern.

A new concept for the regioselective synthesis of [3 : 2 : 1] hexakis‐adducts of fullerene C60 was developed. Based on sequential tether‐directed remote functionalizations, chiral [3 : 2] pentakis‐adducts with an incomplete octahedral addition pattern were synthesized via stepwise cyclopropanation of C60 with suitable macrocyclic tri‐ and bifunctional cyclomalonate tethers. The four resulting stereoisomers were isolated using chiral HPLC. The corresponding pairs of enantiomers show mirror image behavior in their CD‐spectra. The pentakis‐adducts served as suitable building blocks for the spatially controlled synthesis of mixed hexakis‐adducts. Implementation of functional group‐bearing monomalonates afforded octahedral [3 : 2 : 1] hexakis‐adducts suitable for the construction of larger molecular and supramolecular fullerene architectures in excellent yield.

IDS PROTOTYPE FOR INTRUSION DETECTION WITH MACHINE LEARNING MODELS IN IOT SYSTEMS OF THE INDUSTRY 4.0

Industry 4.0 significantly improves productivity by collecting and analyzing data in real time. This, combined with remote access functions, and cloud processing that allows Internet of Things IoT, provides information that optimizes processes and decision support. Also involves a great growth of new networks and systems with special features, which mean that they are vulnerable to different attacks. So new security requirements are emerging in the IoT network. To improve the security of an IoT system for a transparent way, it is proposed the development of a prototype intrusion detection system IDS, which detects anomalies in IoT environments using the MQTT protocol (Message Queuing Telemetry Transport), widely used in IoT systems. For this purpose, it is generated a dataset of an IoT system in which perform different attacks on the MQTT protocol. This dataset is used to train a machine learning model, which is implemented in the IDS that captures the network frames in real time from the system to classify and detect the different attacks. Keywords: IoT, industry 4.0, cybersecurity, IDS, MQTT protocol, Machine Learning.

Activity-stability benefits of Pt/C fuel cell electrocatalysts prepared via remote CeO2 interfacial doping

Ceria coated carbon nanotubes (CeO2@CNTs) were prepared as a versatile support material to improve both the activity and stability of platinum (Pt)-based catalysts. We demonstrated that the CeO2 nanoparticles (NPs) had an extrinsically remote functionalization effect on the Pt electrocatalysis. The CeO2 modulated the electronic structure, and facilitated the O2 adsorption property of Pt without any intrinsic chemical doping or Pt-alloying. This led to d-band electron filling in Pt, and delivery of active oxygens (O−) to the Pt surface via oxygen spillover at the Pt-CeOx interface, thus enhancing the ORR activity. Furthermore, due to the unique redox behavior between Ce3+ and Ce4+, the dissolved Ce ions could also participate in the radical scavenge reaction, which prevents the chemical degradation of polymeric components in the cell. A single cell using the Pt NPs supported on CeO2@CNT as a cathode catalyst delivered a superior electrochemical performance and a retained durability compared to the cells with pristine CNT supported Pt NPs.

Patient and Provider Perspectives on Remote Monitoring of Pacemakers and Implantable Cardioverter-Defibrillators

The use of remote monitoring technology for cardiovascular electronic implantable devices has grown significantly in recent decades, yet several key questions remain about its integration into clinical care. We performed semi-structured interviews of patients, clinicians, and device clinic technicians involved in clinical remote monitoring of cardiovascular implantable devices at our institution. Twenty-eight interviews comprised of 15 patients and 13 clinicians were conducted from October 2019 through February 2020. Interview transcripts were analyzed using a mixed inductive and deductive approach. Perspectives among clinicians and patients varied regarding familiarity, educational experiences, and preferences regarding how remote monitoring data are handled. Three key domains emerged including knowledge and understanding, managing alerts, and cost transparency. Within these domains, key findings includedvery limited understanding of how remote monitoring functions and how alerts in particular are handled. These knowledge deficits (both patients and providers) appeared to arise in part from different equipment and platforms among manufacturers, the complexity of the technology, and lack of formalized education in remote monitoring. However, interviewees expressed generally high levels of trust in the technology and care systems supporting remote monitoring. Few respondents described concerns around cybersecurity, but patients in particular did raise concerns about cost transparency and frequent billing. In conclusion, conflicting perceptions around remote monitoring persist and indicate important knowledge gaps despite high trust in the care pathway. This qualitative analysis offers insight into patient and clinician understanding of and attitudes toward remote monitoring, and may guide future efforts to improve education and patient-centeredness of remote monitoring.

Rate Profiling the Impact of Remote Functional Groups on the Redox-Relay Heck Reaction.

The redox-relay Heck reaction is a powerful method for the construction of enantioenriched quaternary stereocenters remote from existing functional groups. However, there has been little success in the design of site-selective alkene functionalization based on these methods. Herein, we show that experimentally determined rates can be used to train a multivariate linear regression model capable of predicting the rate of a specific relay Heck reaction, allowing for the site-selective functionalization of diene substrates.

Institutional logics and innovation in times of crisis: Telemedicine as digital ‘PPE’

How do crises shape digital innovation? In this paper we examine the rapid adoption of digital telemedicine technologies in an Israeli hospital with a focus on the role of the institutional logics held by the stakeholders responding to emerging events. With the onset of COVID-19, the need for social distancing and minimal physical contact challenged and interrupted hospital practices. In response, remote audio-visual functionality of digital technologies were appropriated in different ways, as stakeholders – state actors, managers, health professionals, and family members – sought to improvise and enhance the protection of persons concerned. We show how emerging practices were guided by the dominant institutional logics of stakeholders responding to the crisis. Acting for many as a digital form of ‘personal protective equipment’ (PPE), the technologies enabled diverse action possibilities to become manifest in practices. We add to understanding the role of institutional logics in directing the attention of stakeholders to shape digital innovation in times of crisis.

Epigenomic features revealed by ATAC‐seq impact transgene expression in CHO cells

Different regions of a mammalian genome have different accessibilities to transcriptional machinery. The integration site of a transgene affects how actively it is transcribed. Highly accessible genomic regions called super-enhancers have beenrecently described as strong regulatory elements that shape cell identity. Super-enhancers have beenidentified in Chinese hamster ovary (CHO) cells using the Assay for Transposase-Accessible Chromatin Sequencing (ATAC-seq). Genes near super-enhancer regions had high transcript levels and were enriched for oncogenic signaling and proliferation functions, consistent with an immortalized phenotype. Inaccessible regions in the genome with low ATAC signal also had low transcriptional activity. Genes in inaccessible regions were enriched for remote tissue functions such as taste, smell, and neuronal activation. A lentiviral reporter integration assay showed integration into super-enhancer regions conferred higher reporter expression than insertion into inaccessible regions. Targeted integration of an IgG vector into the Plec super-enhancer region yielded clones that expressed the immunoglobulin light chain gene mostly in the top 20% of all transcripts with the majority in the top 5%. The results suggest the epigenomic landscape of CHO cells can guide the selection of integration sites in the development of cell lines for therapeutic protein production.

Development of a control system with remote monitoring function for round baler

To improve the automation level of the round baler, an automatic net feeding control system with the function of remote monitoring was developed and tested both in the laboratory and the field. The system can automatically trigger the electromagnetic clutch to wrap the net based on the sensors. In order to avoid false alarms caused by tailgate vibration at the end of the bale formation, a time filter was developed in this system. A sensor-based logic was designed to feed the net correctly and count the bales accurately. The baling operation parameters were sent to the remote monitoring terminal by RS232 from the controller. The terminal acts as a hub to forward the work trajectory, bale number, and work area to the server, and receive commands from the server to enable or disable the control system. More than 3000 bales of corn straw baling experiments were carried out in the field. The experiments show that the baling procedure is valid and continuous baling is stable. The average feed net success rate is 98.90%, and the average bale counting accuracy rate is 98.89%. The average time per bale in the manual mode is 77.93 s, and in the automatic net feeding mode is 66.31 s. Compared with manual net feeding, the working efficiency of automatic feeding net is increased by 14.91%. The remote monitoring function is also verified. The entire control system was proven to be precise and reliable.

Design and Implementation of Medical Ultrasound Remote Control Software Based on Sensor Design.

With the development of medical technology, medical ultrasound technology is widely used in the diagnosis of human diseases. It has become an indispensable diagnostic method in modern clinical medicine by detecting the internal physiology or tissue structure of the human body by ultrasound and then discovering diseases. Based on this, this paper designs a medical ultrasonic remote control software based on sensor design. The system software communicates with the stimulator through the Bluetooth port of the mobile phone and can send the parameter information input by the mobile phone to the field-programmable gate array of the stimulator for compilation. The upper computer control interface with a remote communication function is written by Lab VIEW software. A socket is used to establish inter-network process connection, and medical ultrasonic equipment simulates hardware key input according to the received control instructions so as to achieve the purpose of remote control. Experiments show that, compared with other systems, the infrared human body temperature measurement system with the functions of environmental temperature compensation and distance compensation can effectively reduce the influence of environmental temperature, distance, and other factors and has the advantages of non-contact, low power consumption, fast response speed, high sensitivity, and high accuracy, which is suitable for rapid and accurate human body temperature measurement in crowded places with large traffic.

Radical‐Promoted Distal C−H Functionalization of C(sp3) Centers with Fluorinated Moieties

AbstractDue to their unique properties, fluorinated scaffolds are pivotal compounds in pharmaceuticals, agrochemicals, and materials science. Over the last years, the development of versatile strategies for the selective synthesis of fluorinated molecules by direct C−H bond functionalization has attracted a lot of attention. In particular, the design of novel transformations based on a radical process was a bottleneck for distal C−H functionalization reactions, offering synthetic solutions for the selective introduction of fluorinated groups. This Minireview highlights the major contributions in this blossoming field. The development of new methodologies for the remote functionalization of aliphatic derivatives with various fluorinated groups based on a 1,5‐hydrogen atom transfer process and a β‐fragmentation reaction will be showcased and discussed.

Radical-Promoted Distal C-H Functionalization of C(sp3 ) Centers with Fluorinated Moieties.

Due to their unique properties, fluorinated scaffolds are pivotal compounds in pharmaceuticals, agrochemicals, and materials science. Over the last years, the development of versatile strategies for the selective synthesis of fluorinated molecules by direct C-H bond functionalization has attracted a lot of attention. In particular, the design of novel transformations based on a radical process was a bottleneck for distal C-H functionalization reactions, offering synthetic solutions for the selective introduction of fluorinated groups. This Minireview highlights the major contributions in this blossoming field. The development of new methodologies for the remote functionalization of aliphatic derivatives with various fluorinated groups based on a 1,5-hydrogen atom transfer process and a β-fragmentation reaction will be showcased and discussed.

Remote monitoring system of branch circuit in the family

In order to estimate and predict human real-time heating demand and optimize the existing electric heating control methods, a large number of household electricity data samples are required for training. This article mainly introduces the method of obtaining data samples, and realizes the monitoring of household branch circuit information by establishing a modern remote monitoring system. The author gives the detailed hardware design and software function introduction of the system. Each collection terminal in the system uses LAN, LTE and Wi-Fi modes to establish communication with the monitoring center, completing the basic functions of collecting electricity information for each branch circuit in the family, and having a remote upgrade function makes the system more complete. An experiment conducted in a family in Jinan City, Shandong Province, China tested the function of the verification system. The proposed remote monitoring system can be a useful tool to grasp the power consumption of each line of the family and study the energy demand of users.

IoTorch: Reliable LED-to-Camera Communication Against Inter-Frame Gaps and Frame Drops

LED-to-camera communication for smartphones promises to enable low-cost, small-size, and intuitive data access to Internet-of-things (IoT) devices. However, for fast and reliable communication under the rolling shutter effect, the packet losses caused by inter-frame gaps and frame drops must be dealt with. In this paper, we introduce LED-to-camera communication between a commercial smartphone and an IoT device with LED flashlight, where the user can intuitively acquire the desired data transmitted from the IoT device to the smartphone. Specifically, we present IoTorch, a fast and reliable LED-to-camera communication that efficiently prevents the packet losses. IoTorch consists of two core mechanisms: 1) a minimum-repetition one-way reliable transmission focusing on the periodicity of inter-frame gaps and 2) an acknowledgement mechanism to overcome frame drops by using a smartphone's built-in flash focusing on its delay characteristics. Additionally, we propose an optimization method to increase the throughput up to 2.92 kbps (i.e., 2.43 times faster than that of the state-of-the-art method that overcomes the inter-frame gaps). Furthermore, we realize a remote wake-up function by using the smartphone's flash as the data transmission trigger. To demonstrate the benefit of IoTorch, we present a sensor data viewer using Arduino and a smartphone console system on TelosB.

Development of a walking aid with remote electrocardiogram measurement and global positioning system function

ABSTRACT The aging population has become one of the major issues in the world and in Taiwan. Among many aging diseases, heart disease and dementia are the main problems that affect the daily lives of the elderly and their family members. In this study, we have developed a smart walking aid with remote electrocardiogram (ECG) measurement and global positioning system (GPS) functions. The hardware of the walking aid consists of a brass column sensor with a self-developed ECG sensing circuit, a location module comprising a GPS and antenna, and a wireless transmission module with a microprocessor control unit and a Wi-Fi module. The software includes two parts: a self-developed ECG program for identifying arrhythmia with a human–machine interface to display the results and a self-developed location program integrated with Google Maps. The smart walking aid we have developed in this study was aiming to help family members or medical staff to monitor the physical conditions of their elderly family or patients who suffer from heart disease or dementia and identify their location when they experience disorientation.

RETRACTED: Application and development prospects of 5°G communication technology in aerobics sports

A sport in which a single connection hard with the competition aerobics and gymnastics elements competitive. This sport is for young people to compete with adult people while maintaining the artistry and fun of bodybuilding and generates a sport that requires gymnastics so that less risk the development of mobile communication technology from 4 G to 5 G. Related to the previous group, 5 G is, the auto-pilot is postponed to provide risk facilities as an actual AI handheld program and remote control functions. It is a Multi-access Edge (MAE) necessary technological calculations are closer latency-critical services. 5 G user support to ensure ultra-low latency by allocating computing resources at the network's edge is centralized. Some explode overload of computing resources so local, can place the traffic caused, there are loopholes multi-access edge computing architecture. 5 G, the media provider, is also a leading that has been studied, Amdocs's software and Services Company, according to its ovum in the communication company, to change the stadium, the sports experience of the home fans. To provide a new multi-screen pay-tv service to watch the 5 G plan, home sports events and 88% of the operator's knowledge. 5 G is to increase the range of content available to a mobile audience, beyond the consumer range of electronic devices and services. To improve mobile TV and video quality describes concentrated cloud computing and resources of the multi-source code. Our goal is, is referred to as a communication architecture that is a hybrid improvement that combines the advantages of this- is to propose a cloud computing access edge. The performance of the proposed network architecture is evaluated using a discrete event simulation model. Finally, the various advantages and disadvantages of network architecture are discussed.

Asynchronous effects

We explore asynchronous programming with algebraic effects. We complement their conventional synchronous treatment by showing how to naturally also accommodate asynchrony within them, namely, by decoupling the execution of operation calls into signalling that an operation’s implementation needs to be executed, and interrupting a running computation with the operation’s result, to which the computation can react by installing interrupt handlers. We formalise these ideas in a small core calculus, called λ æ . We demonstrate the flexibility of λ æ using examples ranging from a multi-party web application, to preemptive multi-threading, to remote function calls, to a parallel variant of runners of algebraic effects. In addition, the paper is accompanied by a formalisation of λ æ ’s type safety proofs in Agda, and a prototype implementation of λ æ in OCaml.

Remote Data Transmission of Intelligent Cloud Robot Based on Google Protobuf

With the maturity of robotic remote control technology, it plays an important role in military, exploration and industry. Their application in the field of daily life is also expanding. The development of 4G Mobile Internet and cloud computing technology provides a new platform for robot remote control technology. In order to realize the communication function of robot remote control, this paper designs a data transmission method based on protobuf tool. According to the characteristics of various operating systems, we choose the Linux system as the robot platform, the Alibaba Cloud server as the relay platform, and the windows application program as the implementation platform. After the system test, when the network is in good condition, through the control terminal, the real-time video collected by the robot can be viewed smoothly, and the command can be sent to control the motion of the robot.

Research of Intelligent Temperature Measuring Robot System

With the outbreak of novel coronavirus pneumonia worldwide, a kind of epidemic prevention robot is urgently needed in society. The intelligent temperature measurement robot system mainly includes the robot’s high stability multi-attitude omnidirectional movement module, robot path planning and autonomous navigation module, robot environment information acquisition and recognition module, robot remote control module, and robot system integration. According to the design principle of the wheeled robot, high stability and multi attitude omni-directional mobile platform of temperature measuring robot are constructed; path planning and autonomous navigation of robot are realized based on sensor data fusion; temperature detection and remote care function are realized by thermal imaging sensor system by capturing the thermal radiation emitted by the human body, and based on open modular control system architecture. Based on the existing research foundation, the intelligent temperature measurement robot system is established by integrating the robot multi attitude omni-directional mobile system, robot path planning, and autonomous navigation system, robot environment information acquisition and recognition system, and robot remote control system.

Visible light photoredox-catalysed remote C-H functionalisation enabled by 1,5-hydrogen atom transfer (1,5-HAT).

The generation of heteroatom-centred radicals (X˙), followed by intramolecular 1,5-hydrogen atom transfer (1,5-HAT) and the functionalisation of the translocated carbon-centred radicals, is the basic mechanism of the classic Hofmann-Löffler-Freytag (HLF) reaction and the Barton reaction. The chemoselectivity of the 1,5-HAT process is different from that of the transition metal-catalysed counterpart, providing, therefore, a complementary tool for remote C(sp3)-H bond functionalisation. There is a recent resurgence in this research field due to the emergence of visible light photocatalysis. This tutorial review summarises the recent progress in the remote functionalisation of C-H bonds featuring a key 1,5-HAT step with particular focus on photoredox-catalyzed remote C-H functionalisation.