Registration Committee Research Articles

Multi-institutional Registry of Large Bowel Cancer in Japan Conducted by the Japanese Society for Cancer of the Colon and Rectum in 2023: Cases Treated in 2015.

Colorectal cancer is the most prevalent malignant disease in Japan. This study aimed to publish data on colorectal cancer cases registered in 2023, involving initial treatments in 2015. Participating facilities of the Japanese Society for Cancer of the Colon and Rectum (JSCCR) registered cases treated in 2015 according to the 8th edition of the Japanese Classification of Colorectal Carcinoma. Data sent to the National Registration Committee in 2023 were analyzed. The study analyzed 12,804 cases. Endoscopic treatments were performed in 983 cases, endoscopic treatment followed by surgical resection in 734 cases, and surgeries were carried out in 10,884 cases. Notably, the proportion of laparoscopic surgeries increased significantly from 34.7% in 2010 to 63.5% in 2015. This report details the characteristics, treatment methods, and outcomes of colorectal cancer patients who received initial treatment in 2015 at JSCCR-participating facilities. These data should be helpful for patients to understand their disease accurately and for healthcare professionals to explain colorectal cancer and its treatments to patients.

Factors Associated with Postoperative Recurrence in Stage I to IIIA Non-Small Cell Lung Cancer with Epidermal Growth Factor Receptor Mutation: Analysis of Korean National Population Data.

Recent development in perioperative treatment of resectable non-small cell lung cancer (NSCLC) have changed the landscape of early lung cancer management. The ADAURA trial has demonstrated the efficacy of adjuvant osimertinib treatment in resectable NSCLC patients; however, studies are required to show which subgroup of patients are at a high risk of relapse and require adjuvant epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) treatment. This study evaluated risk factors for postoperative relapse among patients who underwent complete resection. Data were obtained from the Korean Association for Lung Cancer Registry (KALC-R), a database created using a retrospective sampling survey by the Korean Central Cancer Registry (KCCR) and the Lung Cancer Registration Committee. A total of 3,176 patients who underwent curative resection was evaluated. The mean observation time was approximately 35.4 months. Among stage I to IIIA NSCLC patients, the EGFR-mutant subgroup included 867 patients, and 75.2%, 11.2%, and 11.8% were classified as stage I, stage II, and stage III, respectively. Within the EGFR-mutant subgroup, 44 (5.1%) and 121 (14.0%) patients showed early and late recurrence, respectively. Multivariate analysis on association with postoperative relapse among the EGFR-mutant subgroup showed that age, pathologic N and TNM stages, pleural invasion status, and surgery type were independent significant factors. Among the population that underwent complete resection for early NSCLC with EGFR mutation, patients with advanced stage, pleural invasion, or limited resection are more likely to show postoperative relapse.

Building apatient-centred nationwide integrated cardiac care registry: intermediate results from the Netherlands.

This paper presents an overview of the development of an integrated patient-centred cardiac care registry spanning the initial 5years (September 2017 to December 2022). The Netherlands Heart Registration facilitates registration committees in which mandated cardiologists and cardiothoracic surgeons structurally evaluate quality of care using real-world data. With consistent attendance rates exceeding 60%, avaluable network is supported. Over time, the completeness level of the registry has increased. Presently, four out of six quality registries show over 95% completeness in variables that are part of the quality policies of cardiology and cardiothoracic surgery societies. Notably, 93% of the centres voluntarily report outcomes related to open heart surgery and (trans)catheter interventions publicly. Moreover, outcomes after implantable cardioverter-defibrillator and pacemaker procedures are transparently reported by 26centres. Multiple innovation projects have been initiated by the committees, signalling ashift from publishing outcomes transparently to collaborative efforts in sharing healthcare processes and investigating improvement initiatives. The next steps will focus on the entire pathway of cardiac care for aspecific medical condition instead of focusing solely on the outcomes of the procedures. This redirection of focus to acomprehensive assessment of the patient pathway in cardiac care ultimately aims to optimise outcomes for all patients.

Optimisation and application of the multi-residue analysis method for detection of 50 pesticides in cabbage by using LC-MS/MS- QuEChERS

ABSTRACT A multi-residue method for simultaneous determination of 50 pesticides in cabbage, belonging to different chemical classes has been developed by LC-MS/MS. The pesticides were analysed simultaneously in a single run using positive electrospray ionisation with multiple reaction monitoring (MRM) after extraction with modified QuEChERS method. The calibration curve for each analyte was linear with the concentration of 0.0025, 0.005 0.01, 0.025, 0.05 and 0.10 µg mL−1 with a correlation coefficient which ranged between 0.993 and 0.999. The mean recoveries obtained for four fortification levels (0.01, 0.025, 0.050 and 0.10 μg/g) were 77.96–119.67% with satisfactory precision (RSD < 20%). The matrix effects were found in range of 6.42 to 19.52% with optimised cleanup process. The developed method was used to investigate the occurrence of pesticides residue in cabbage head samples collected from different markets of the Varanasi region, India. All the 50 compounds were eluted from the column of the LC-MS/MS within the 7.961 min. The limit of quantification of the optimised method was 0.01 mg kg−1 for all the 50 pesticides. Therefore, it would be recommended as a very sensitive and quick method for estimation of multi-residue in cabbage. The developed method was successfully utilised for the analysis of the market samples collected from four different market of the Varanasi, India. Total five compounds namely thiamethoxam, carbendazim, imidacloprid, acetamiprid and dimethoate were detected in cabbage samples. Out of five compounds, only two compounds i.e. acetamiprid and dimethoate are recommended by Central Insecticide Board and Registration Committee (CIB&RC), Govt. of India.

Pesticide Residue and Bio-pesticides in Vegetable Crops

Intensive vegetable production using pesticides has biggest threat to growers and the consumers. In such instances the accumulation of pesticide residues is increased due to relatively short pre-harvest interval. Use of pesticides without knowing the label claim information increases the cost of production, increases the number of spray and labour cost, ultimately leading to decrease in farmers profitability. Hence, the adoption of pesticide as per label claim is very much essential. The level of residues should be below the maximum residue limit (MRL) at the time of harvest. Most of the detected pesticides in vegetables are not registered by Central Insecticide Board and Registration committee (CIBRC) for use on that specific vegetable which is the off label use of pesticides. Crops grouping is the development of a model that allows extrapolation of residue data from a few representative crops to many other crops in the same group. This allows establishment of residue tolerances for the entire group of crops based on the residue values from certain key crops that are similar. The acceptance of representative crop is a critical component of the savings from using the crop groups. IR-4’s involvement with efforts to remove pesticide residues as a barrier for exports for US-grown specialty crops has been growing in importance over the last 20 years. By establishing a common MRL on a specialty crop from a particular crop protection product use, trade irritants between the two countries can be prevented before they have the potential to become a major problem for specialty crop growers on each side of the border. The U.S./Canadian specialty crop partnership has yielded valuable results for all the stakeholders involved. IR4 signed MOUs with Canada, New Zealand, Brazil, Costa Rica, and Colombia. This model is also much needed for India to regulate the pesticide label claims for numerous crops.

The 18th Siam Physics Congress (Quantum Era : Together and Beyond; SPC2023)

The 18th Siam Physics Congress (SPC2023) was successfully held during 14–16 June 2023, co-hosted by the Thai Physics Society and the Chiang Mai University. To motivate collaborative academic environment, the congress was organized to be a 100% on-site meeting at the Empress Convention Center in Chiang Mai (Thailand).This year, we had 329 research abstracts submitted for both oral and poster presentations. There were 3 plenary speakers, 17 invited speakers, 110 accepted oral presentations, 187 accepted poster presentations, and 116 full papers submitted for possible publication in all 10 tracks(topics). The scientific program was announced on the SPC2023 website (https://spc2023.science.cmu.ac.th) and also distributed via email to all participants.The opening ceremony was given by the President of Thai Physics Society and the President of Association of Asia Pacific Physical Societies (AAPPS). After opening ceremony, Prof. Dr. Junichi Yokoyama (The University of Tokyo, Japan) gave the 1st plenary talk (onsite), Prof. Dr. Jian-Wei Pan (University of Science and Technology of China) gave this 2nd plenary talk (zoom), Assoc. Prof. Dr. Tawatchai Onjun (Thailand Institute of Nuclear Technology) gave the 3rd plenary talk (onsite), where the size of the audience attending the plenary talks is approximately 500 participants. The oral presentations were arranged into 5 parallel rooms in total of 10 sessions. Each invited speaker was allowed 30-minutes presentation while regular presenter had 15 minutes including questions and answers. The audience-size of each room varied between 30 and 50 people. The poster presentations were held in the poster hall and lasted for 2 hours, which offered extended opportunity to gain insights into the latest research. For full papers, authors of accepted abstracts were invited to submit their full-scale works through the Morressier website for a possible publication in the Journal of Physics : Conference Series.List of Topic, Plenary Speaker, Organizing Institutions, Advisory Committee, Organizing Committee, Scientific Committee, Ceremony Committee, Finance Committee, Registration Committee, Venue and Transportation Committee, Sponsorship and Fundraising Committee, Public Relations Committee, Audio Visual Aid Committee, Sponsors are available in this Pdf.

PERFORMANCE EVALUATION OF HEXACOPTER UAV (ANGRAU- PUSHPAK) SPRAYING FOR MANAGEMENT OF CHILLI THRIPS (Thrips parvispinus)

The study aimed at evaluating efficacy of UAV spraying in managing invasive thrips, Thrips parvispinus on chilli. The experiment was conducted at operational research project (ORP) site at Lam village of Guntur district during kharif 2022-23 with restricted randomized block design. The recommended doses of pesticides issued by Central Insecticide Board and Registration Committee(CIB&amp;RC), GoI, New Delhi were adapted. The treatments imposed were of 100%, 75% and 50% RDP with UAV and 100% RDP with human backpack sprayer and a control plot with only water spraying with drone for asserting the efficacy of drone spraying when sprayed at low volume spraying (25 L ha-1).The first spray to control thrips was carried out 112 DAS (Days After Sowing) with a spinetoram 11.7% SC on with analysis of pre and post spraying (5 days after spraying) results showed that the bio-efficacy when sprayed with 100% RDP (T1), 75% RDP(T2), 50% RDP (T3) with drone and 100% RDP with human back pack sprayer (T4) and control(T5)reduced number of thrips per flower from 7.57 to 5.8, 7.55 to 6.40, 7.55 to 10.22, 8.05 to 8.22, 8.05 to 12.95, respectively with a percent reduction over control of 50.75, 46.19, 23.65 and 36.57, respectively. The second spray was carried out at 119 DAS with Flubendiamide 19.92% +Thiacloprid 19.92% SC. The pre and post spraying (5 days after spraying) data analysis revealed that the reduction of thrips per flower over control in T1, T2, T3, T4 and T5 to 7.37, 8.32, 12.12, 10.25 and 16.03 and the percent reduction over control in T1, T2, T3 and T4 are 52.22%, 44.88%, 24.29% and 36.78%, respectively. The third spray with Fipronil 80% WG was carried out at 126 DAS and the pre and post spraying data analysis revealed that the number of thrips per flower are 5.27, 6.47, 10.55, 8.05 and 16.83 with a percent reduction over control of 68.83, 62.34, 22.08 and 38.96, respectively. The fourth spray was carried out at 133 DAS with spirotetramat 25.31% w/w OD and the pre and post spray data analysis revealed that the number of thrips per flower are of 5.12, 5.75, 9.5, 8.5 and 18.22 in T1, T2, T3, T4 and T5 and the percent reduction over control in T1, T2, T3 and T4 are 66.59, 61.68, 40.89 and 46.92, respectively. During the four sprays, it was observed that in all treatments, there was no phytotoxicity due to these chemicals spraying and the NDVI values recorded were 0.77, 0.76, 0.64, 0.72 and 0.34, respectively in the treatments T1, T2, T3, T4 and T5. The yields recorded were found to be 58.6, 55.2, 34.5, 53.8 and 14.1 q ha-1. The incremental cost-benefit ratio (ICBR) was found to be highest (4.46) in 75% RDP spray with drone, when compared to 3.58 in 100% RDP, 2.82 in 50% RDP and 2.98 in 100%RDP with human backpack sprayer respectively. The bio-efficacy of all the chemicals revealed that 100% RDP and 75% RDP sprayed with drone are on par with each other, which offers an opportunity to reduce the dosage by25% if sprayed with drone for the same bio-efficacy with highest ICBR.

Report of the Registration Committee

AbstractThe Registration Committee was established at the Nomenclature Section of the XIX International Botanical Congress (IBC) in Shenzhen, China in 2017. It followed the previous Special Committee on Registration of Algal and Plant Names (including fossils). A clear majority of Registration Committee members support having named taxa associated with a unique universal digital identifier in order to secure and facilitate the exchange of information by electronic means. However, discussions within the Committee showed that mandatory referencing of a unique universal digital identifier was not a solution. The Committee recommends that authors provide nomenclatural repositories with a reference to an actual and current publication for indexing purposes, or to register voluntarily.

The status of resistance to phosphine in common bruchid species infesting edible stored pulses in India

Bruchids or pulses beetles or bean weevils (Coleoptera: Chrysomelidae: Bruchinae) are serious pests of stored pulses, and the only curative chemical option approved for use in India is fumigation with phosphine. Relative phosphine resistance was ascertained in 79 bruchid populations from 74 diverse locations of India, in comparison to their susceptible laboratory conspecifics. The populations' response to phosphine was varied vis-à-vis species, locations, and storage conditions. Overall, the populations recorded the relative resistance ratio of 1.1–4.5 folds over their susceptible laboratory conspecifics, however the LC99 values indicated populations are still susceptible to recommended phosphine dosage by Central Insecticide Board and Registration Committee. The relative resistance levels in decreasing order for species was Callosobruchus maculatus > C. analis > C. chinensis. The populations from small-scale storage conditions exhibited relatively lower level of resistance than those from large-scale storage conditions. The relative resistance was varied between populations representing different states and regions of India. The populations from places where pulses are grown, stored and protected with phosphine on a large-scale and regular basis showed higher relative resistance. When compared to species infesting stored cereals, the relative resistance levels recorded in bruchid populations was rather low; however, the observed levels warn of further escalation to an alarming level in the events of inappropriate and indiscriminate phosphine usage. Consequently, the Indian pulses storages fully reliant on this fumigant may face a significant bruchid threat in the near future. Therefore, the current study provides a valuable source of information on phosphine resistance status in bruchids infesting edible stored pulses across India.

Study Design of the Japanese Association of Cardiac Rehabilitation Registry (J-CARRY) - Protocol for a Prospective, Multicenter, Open Registry.

Background: Guidelines for the prevention and management of cardiovascular disease (CVD) highly recommend cardiac rehabilitation (CR) on the basis of abundant evidence of its effectiveness. However, the current understanding and dissemination of CR in Japan are far from sufficient. Methods and Results: The Japanese Association of Cardiac Rehabilitation Registry (J-CARRY) is an academic society-led prospective multicenter observational registry conducted by the Registration and Facility Accreditation System Committee of the Japanese Association of Cardiac Rehabilitation. Data are collected prospectively using an electronic data capture system. Items related to patients' clinical background and CR, as well as mortality and major adverse cardiac and cerebrovascular events, will be collected in all cases. This Registry started in May 2014, and the number of participating medical institutions is expected to increase to >30; the targeted number of cases exceeded 3,000 per year as of April 30, 2022. Focusing on late Phase II data collection is a novel and significantly different approach compared with previous studies. The results of this study are currently under investigation. Conclusions: J-CARRY will provide real-world data regarding the current status and prognosis of CVD in patients who undergo Phase II CR in Japan.

Comprehensive registry of esophageal cancer in Japan, 2015

BackgroundThe registration committee for esophageal cancer in the Japan Esophageal Society (JES) has collected the patients' characteristics, treatment, and outcomes of patients who underwent any treatment during 2015 in Japan.MethodsWe analyzed patients' data who had visited the participating hospitals in 2015. We collected the data using the National Clinical Database with a web-based data collection system. We used the Japanese Classification of Esophageal Cancer 10th edition by JES and the TNM classification by the Union of International Cancer Control (UICC) for cancer staging.ResultsA total of 9368 cases were registered from 355 institutions in Japan. Squamous cell carcinoma and adenocarcinoma accounted for 86.7% and 7.4%, respectively. The 5-year survival rates of patients treated by endoscopic resection, concurrent chemoradiotherapy, radiotherapy alone, and esophagectomy were 87.2%, 33.5%, 24.2%, and 59.9%, respectively. Esophagectomy was performed in 5172 cases. Minimally invasive approaches were selected for 60.6%, and 54.4% underwent thoracoscopic esophagectomy. The operative mortality (within 30 days after surgery) was 0.79% and the hospital mortality was 2.3%. The survival curves showed an excellent discriminatory ability both in the clinical and pathologic stages by the JES system. The survival of pStage IV was better than IIIC in the UICC system because pStage IV included the patients with supraclavicular lymph node metastasis (M1 LYM).ConclusionWe hope this report improves all aspects of diagnosing and treating esophageal cancer in Japan.

The Implementation of a Complete Systematic Land Registration Program in Kebumen Regency, Indonesia

Implementation of land policies continues to encounter several barriers; thus, the community continues to experience many land conflicts. This study aims to identify and analyze aspects of communication, resources, disposition, and bureaucratic structure in relation to the success of implementing the complete systematic land registration program in Kebumen Regency. This study was undertaken in the Kebumen Regency setting and employed qualitative methodology. Through interviews, observation, and documentation, data was collected. Using the approach of interactive model analysis and the triangulation procedure, the validity of the data was determined. The findings of the research indicate that the communication element, comprising the publishing mechanism, coordination system, and information dissemination, has been operating effectively. First, the lack of human resources as a driving team; second, the mutually agreed-upon self-financing is considered too costly for such individuals; and third, the government subsidies offered by the Kebumen Regency are insufficient. Such factors include things such as aspects of the disposition and organization of personnel. The regions with a high degree of complete systematic land registration programs that can be mobilized independently in areas that manage them have a low district government's commitment and involvement in setting the budget for complete systematic land registration, an adjudication committee that does not meet the structure, and a lack of support from the village government to mobilize community participation. The complete systematic land registration committee creation at the village level did not even go as well as it should have in terms of the people who did the work. Keywords: Bureaucratic Structure, Communication, Disposition, Implementation, Land Policy, Resources

Biopesticides as Eco-friendly Substitutes to Synthetic Pesticides: An Insight of Present Status and Future Prospects with Improved Bio-effectiveness, Self-lives, and Climate Resilience

Synthetic pesticides are well-known not just for their efficiency in pest control, but also for their adverse effects on humans, ecology, and living biome's ecological relationships. Biopesticides are biodegradable, environment-friendly, and non-destructive insecticides that are safe for creatures. They leave no harmful residues in food or feed. Botanical, microbiological, and biochemical biopesticides are the three types of biopesticides. 3,000 tons of biopesticides are produced every year, accounting for around 2.5% of the overall pesticide market. Biopesticides are currently accessible in a variety of forms, including dust, granules, powders, emulsions, suspension concentrates, and so on. The Central Insecticide Board and Registration Committee (CIBRC) in India requires data on chemistry, bioefficacy, toxicity, packaging, and labeling to register biopesticides. Although India has registered 970 biopesticide products, lesser effectiveness, shorter shelf-life, lack of knowledge, and lengthy registration process remain hurdles. New and improved formulation methods might improve biopesticide efficacies, self-lives, and climate resiliency while lowering prices and making them economically competitive with synthetic chemicals. The main types of biopesticides, their benefits and downsides, worldwide and Indian market scenarios, formulations, registration procedures, and current advancements for users and environment-friendly applications and sustainable agriculture are all covered in this review article.

Using real-world data to monitor and improve quality of care in coronary artery disease: results from the Netherlands Heart Registration.

Worldwide, quality registries for cardiovascular diseases enable the use of real-world data to monitor and improve the quality of cardiac care. In the Netherlands Heart Registration (NHR), cardiologists and cardiothoracic surgeons register baseline, procedural and outcome data across all invasive cardiac interventional, electrophysiological and surgical procedures. This paper provides insight into the governance and processes as organised by the NHR in collaboration with the hospitals. To clarify the processes, examples are given from the percutaneous coronary intervention and coronary artery bypass grafting registries. Physicians who are mandated by their hospital to instruct the NHR to process their data are united in registration committees. The committees determine standard sets of variables and periodically discuss the completeness and quality of data and patient-relevant outcomes. In the case of significant variation in outcomes, processes of healthcare delivery are discussed and good practices are shared in a non-competitive and safe setting. To create new insights for further improvement in patient-relevant outcomes, quality projects are initiated on, for example, multivessel disease treatment, cardiogenic shock and diagnostic intracoronary procedures. Moreover, possibilities are explored to expand the quality registries through additional relevant indicators, such as resource use before and after the procedure, by enriching NHR data with other existing data resources.Supplementary InformationThe online version of this article (10.1007/s12471-022-01672-0) contains supplementary material, which is available to authorized users.

Survey-Based Study on Farmers’ Knowledge and Pattern of Using Insecticide on Different Crops in Aligarh District of Uttar Pradesh, India

Background: Agrochemicals can play a significant role in enhancing post-harvest crop productivity and protection. But over the years, there’s growing concern about the inaccurate use of pesticides in agriculture.Objective: To assess knowledge of farmers about pest management, perceptions of the kind and frequencies as well as severity of pests and disease, sources of information, awareness of farmers and safety measures followed during pesticide application.Methods: A random survey was conducted employing a standard structured questionnaire among 100 farmers in Wheat, Mustard and Paddy cultivating areas across the ten villages of Aligarh district, Uttar Pradesh, India.Results: Most ordinarily used pesticides applied by the farmers on different crops were Malathion, Cypermethrin and Chlorpyriphos. It was also observed during the survey that most of the farmers stored the pesticide bottles at safe places and the remaining in unsafe areas with no safety measures. It was found that no farmer was familiar even with Government Central Insecticides Board and Registration Committee (CIBRC)’s roles and guidelines about the use of labeled and unlabelled pesticide application. However, most of the farmers were mainly dependent by the recommendation of pesticide dealers.International Journal of Human and Health Sciences Vol. 06 No. 02 April’22 Page: 193-199

Annual report of organ procurement in Japan: Report from the Registration Committee of the Japan Society for Transplantation (2022)

Annual report of organ procurement in Japan: Report from the Registration Committee of the Japan Society for Transplantation (2022)

Plant Germplasm Registration System in ICAR – Achievements

The Plant Germplasm Registration Committee (PGRC) was constituted by the Indian Council of Agricultural Research in 1996 to provide recognition to researchers involved in identifying, describing and documenting potentially valuable genetic materials and to incorporate these into the public domain for their efficient use by the breeders and researchers. In the last 25 years a total of 48 meetings of PGRC have been held and 1,948 crop genetic materials have been registered belonging to 249 crop species. Among these, highest number of germplasm are registered for resistance against biotic stress (601) followed by quality and nutritional traits (583). In major food crops like cereals, oilseeds and grain legumes, maximum registration is for biotic stresses while in ornamentals, fruit crop, medicinal and aromatic crops, tea and coffee, maximum germplasm is registered for quality traits.

IJU this issue

This issue contains two Review Articles, 11 Original Articles, three Urological Notes and five Editorial Comments. The number of people with diabetes rose rapidly. The prevalence in Japan is estimated to be approximately 10%. Sodium–glucose-linked transport protein 2 (SGLT2) inhibitors are newly developed drugs, used for the treatment of type 2 diabetes mellitus, that act on the proximal convoluted tubules of the nephrons to prevent resorption of glucose from the filtrate. In this issue Chandrashekar et al. (Brisbane, Australia) reviewed the urological implications of these drugs. Increased glycosuria is thought to result in genital infections and urinary tract infections. Genital infections in males, which can be increased by up to fivefold, include balanitis and balanoposthitis. SGLT2 inhibitors might also cause Fournier’s gangrene. Unexpectedly, one large-scale study failed to show the increased risk for severe and non-severe urinary tract infection events among cases treated with SGLT2 inhibitor, compared with those among cases treated with dipeptidyl peptidase-4 inhibitors or glucagon-like peptide-1 agonists. Pollakiuria and nocturia, which might have impacts on quality of life, were the most prevalent lower urinary tract symptoms after initiation of SGLT2 inhibitors. Notably, the authors recommended that SGLT2 inhibitors should be ceased perioperatively, because perioperative use increases the risk of euglycemic diabetic ketoacidosis. Three original articles and one urological note on renal cell carcinoma (RCC) appear in this issue. Ishiyama et al. (Tokyo, Japan) reviewed their 23 patients who underwent extracorporeal circulation-assisted surgery with or without using deep hypothermic circulatory arrest (DHCA). They found that surgical time, estimated blood loss, perioperative complication rate, 90-day mortality rate and hospital stay days were similar between these two groups. In addition, oncological outcomes (cancer-specific and overall survival) did not differ between groups. They concluded that the use of DHCA did not result in inferior perioperative outcomes. Although DHCA often requires longer operative time and are thought to be related with platelet dysfunction and coagulopathy, the authors successfully showed the safety and usefulness of DHCA. Wakita et al. (Kobe, Japan) reported on the surgical outcomes of the complex tumors of the kidney treated with robot-assisted partial nephrectomy (RAPN). They retrospectively analyzed 348 patients who underwent RAPN at a single center; 299 had non-complex tumors (RENAL score <10) and 49 had complex tumors (RENAL score ≥10). Although more perioperative complications and lower postoperative renal function with longer ischemia time and console time were observed in the complex tumors group, positive surgical margin rate and recurrence-free survival did not differ between groups. They concluded that RAPN for complex renal tumors is safe, with no difference in oncological outcomes despite more complications and decreased renal function. For the complex tumors, radical nephrectomy or open partial nephrectomy tend to be carried out, even in this era. The authors clearly showed the effectiveness and safety, along with limitation, of RAPN for the complex tumors. Several risk factors for recurrence or survival in pT3a RCC patients have been proposed. In this issue Ohsugi et al. (Hirakata, Japan) performed a retrospective study assessing the predictors of postoperative recurrence in non-metastatic patients with pT3a RCC. Analyzing 114 patients, they identified three predictors for recurrence-free survival on multivariate analysis, perinephric fat invasion, sarcomatoid or rhabdoid features and necrosis. They found that high-risk pT3a cases with two or three of these predictors had poor prognosis, and that the recurrence-free survival was similar between high-risk pT3a cases and those with pT3b or greater. Previously, the impact of perinephric fat invasion on cancer-specific survival was analyzed using 2998 patients from the RCC registry of The Cancer Registration Committee of JUA.1 Perinephric fat invasion was associated with advanced age and aggressive pathological features, and was an independent prognostic factor in non-metastatic RCC especially in larger tumors. Nivolumab plus ipilimumab is widely used for the first-line therapy for advanced RCC. Ishihara et al. (Tokyo, Japan) reviewed their 16 advanced RCC cases without prior nephrectomy. They found that tumor response between primary and metastatic lesions was generally parallel. Interestingly, the magnitude of tumor response ranged more widely in metastatic lesions than in primary lesions. As unresectable RCC is not rare, this study provides us useful clinical information on decision-making. None declared.

Comprehensive registry of esophageal cancer in Japan, 2014

BackgroundThe registration committee for esophageal cancer in the Japan Esophageal Society (JES) has collected the patients' characteristics, treatment, and outcomes annually.MethodsWe analyzed the data of patients who had visited the participating hospitals in 2014. We collected the data with a web-based data collection system using the National Clinical Database. We used the Japanese Classification of Esophageal Cancer 10th edition by JES and the TNM classification 7th edition by the Union of International Cancer Control (UICC) for cancer staging.ResultsA total of 9026 cases were registered from 344 institutions in Japan. Squamous cell carcinoma and adenocarcinoma accounted for 87.9% and 7.1%, respectively. The 5-year survival rates of patients treated using endoscopic resection, concurrent chemoradiotherapy, radiotherapy alone, and esophagectomy were 87.1%, 33.7%, 25.3%, and 59.3%, respectively. Esophagectomy was performed in 5204 cases. Concerning the approach used for esophagectomy, 48.1% of the cases were treated thoracoscopically. The operative mortality (within 30 days after surgery) was 0.75%, and the hospital mortality was 2.0%. The survival curves showed an excellent discriminatory ability both in the clinical and pathologic stages by the JES system. The survival of pStage IV was better than IIIC in the UICC system, because pStage IV included the patients with supraclavicular lymph-node metastasis (M1 LYM).ConclusionWe hope that this report contributes to improving all aspects of diagnosing and treating esophageal cancer in Japan.

Commercialization, Diffusion and Adoption of Bioformulations for Sustainable Disease Management in Indian Arid Agriculture: Prospects and Challenges.

Trichoderma spp. is one of the most popular genus of fungi commercially available as a plant growth promoting fungus (PGPF) and biological control agent. More than 80 species of Trichoderma are reported in the literature. However T. asperellum, T. harzianum, T. viride, and T. virens are most commonly utilized as biocontrol agents. Studies were initiated to explore the potential of biocontrol agents in order to develop a cost effective and practical management strategy. Analysis of large number of soil samples collected from western parts of the region led to isolation of native biocontrol agents viz., Trichoderma harzianum, Aspergillus versicolor, and Bacillus firmus from different agricultural systems. These biocontrol agents have proved their antagonistic ability in laboratory tests and field trials. In India, two species of Trichoderma i.e., T. viride and T. harzianum are commercially registered for usage against soil borne plant pathogens mostly as a seed treatment or soil application. There are published scientific papers on the efficacy of T. asperellum and T. virens in India for suppressing pathogens but these are not yet registered under Central Insecticide Board and Registration Committee (CIB & RC). This review article focuses on the uses, commercialization and adoption issues of various fungal and bacterial consortium products in sustainable disease management.