Abstract Methanol synthesis via non-thermal plasma (NTP) catalytic CO 2 hydrogenation provides a sustainable approach to chemical and fuel production with potential in carbon emissions reduction. However, the underlying mechanisms remain unclear. Here we evaluate the mechanism of NTP-catalytic CO 2 hydrogenation over Cu–Zn/ZSM-5 through operando X-ray absorption spectroscopy, diffuse reflectance infrared Fourier transform spectroscopy and in situ X-ray pair distribution function. We found that Zn enhances Cu dispersion and reducibility, as well as forming active Cu/ZnO interfacial sites. Beyond the conventional formate pathway on metallic Cu, these interfaces enable an additional CO hydrogenation route, enhancing methanol yield. NTP also promotes gas-phase CO 2 dissociation to CO, bypassing the reverse water–gas shift step required in thermal catalysis. No Cu/Zn alloy formation was observed, underscoring the importance of metallic Cu and Cu/ZnO interfaces under NTP conditions. Furthermore, NTP stabilizes reduced Cu species, preventing re-oxidation and ensuring sustained catalytic activity. These findings advance the mechanistic understanding of NTP-assisted catalysis.

Water-based lubricants have shown great potential in friction reduction, thermal management, cost control, and environment sustainability compared to oil-based lubricants. Among them, glycerol aqueous lubricants can achieve superlubricity (coefficient of friction ≤ 0.01) under suitable conditions but are susceptible to corrosion in metallic systems. In this study, three different corrosion inhibitors were incorporated into a glycerol aqueous lubricant with a water/glycerol weight ratio of 0.2 to evaluate their ability to maintain superlubricity. Tribological tests on a mini-traction machine with a ball-on-disk setup revealed that the corrosion-inhibitor-containing formulations maintained ultralow friction under identical loads and sliding speeds comparable to that found with the base glycerol aqueous solution. Complementary corrosion tests following a modified ASTM D1384 procedure showed that lubricants with the corrosion inhibitors provided protection against corrosion in multiple metal species, compared to the base fluid without the inhibitors. These results demonstrate that properly formulated glycerol aqueous lubricants can provide both ultralow friction and corrosion resistance, showing their potential as sustainable, water-based lubricants for engineering systems.

Photocatalysis offers a green and sustainable pathway to address the energy crisis and environmental pollution. Since single semiconductor materials often struggle to simultaneously achieve a broad light absorption range and strong redox ability, constructing heterojunctions is widely regarded as an effective strategy to enhance photocatalytic performance. Traditional Type-I, Type-II, and Type-III heterojunctions suffer from inherent limitations─such as significantly reduced redox ability due to carrier spatial confinement, insufficient redox potential, and band discontinuities that hinder charge separation. In contrast, two-dimensional (2D) direct Z-scheme heterojunctions effectively overcome these challenges by utilizing built-in electric fields to drive directional interfacial charge transfer, thereby achieving efficient carrier separation and strong redox ability, and demonstrating remarkable potential in photocatalytic H2 production, CO2 reduction, nitrogen fixation, and H2O2 synthesis. This review first systematically highlights the unique structural advantages of 2D direct Z-scheme heterojunctions and, through a combination of bibliometric analysis and representative literature, elucidates their development trends and key research directions. Second, we elaborate in detail on the core mechanisms, summarize the required potentials for different redox reactions, and discuss their applications in the four major photocatalytic fields mentioned, along with relevant construction and optimization strategies. Further, the role of nonadiabatic molecular dynamics simulations in analyzing ultrafast charge transfer dynamics is explored, while the potential of combining machine learning with high-throughput computing to accelerate material screening and design is also elaborated. Finally, we summarize the current challenges and propose potential directions for future development. This Perspective aims to provide a systematic reference framework and design guidance for the theoretical research and practical application of 2D direct Z-scheme heterojunctions, thereby promoting their further development in the field of efficient solar energy conversion and green synthesis.

Facing the dual challenges of global protein resource shortages and carbon neutrality goals, developing new sustainable protein sources has become an urgent need. The black soldier fly, due to its high efficiency in converting organic waste, is gradually becoming an important alternative to traditional feed proteins. This paper systematically reviews the practical applications of black soldier fly in areas such as poultry and aquaculture feed from an application perspective and focuses on analyzing its potential in organic waste recycling and carbon emission reduction. Research indicates that black soldier fly larvae (BSFL) are rich in nutrients, possess great potential for replacing fishmeal and soybean meal in poultry and aquaculture feed, and can significantly improve animal growth performance and gut health. Its industry chain, through methods such as waste conversion, efficient bioconversion, and low-carbon processing, holds significant advantages in reducing greenhouse gas emissions; for example, converting aquaculture sludge can avoid methane emissions and achieve a high waste conversion rate. Finally, the paper proposes recommendations regarding policy support, technological optimization, and market-oriented promotion to foster the sustainable development of the black soldier fly industry chain.

This paper studies the multi-modal collaborative optimization problem of Internet of Things (IoT) information logistics supply chain based on Federated Learning and Digital Twin (FL-DT) architecture, proposes a distributed optimization framework that integrates federated learning and decision tree, and uses multi-modal data collected by IoT technology to improve supply chain efficiency. The experiment uses real-time IoT data and order, inventory and historical logistics data for analysis. The results show that the FL-DT architecture significantly optimizes supply chain performance: order processing time is shortened by 33.33%, inventory turnover rate is increased by 26.15%, logistics cost is reduced by 20.33%, response time is compressed by about 40% and order fulfillment accuracy rate is increased from 92% to 97%. Multi-modal data fusion makes the model accuracy reach 91.2%, which is 7.8% higher than that of single-modal, the transportation efficiency is increased by 23% and the carbon emission is reduced by 14%. The digital twin simulation shows that the transportation timeliness deviation is only −0.7%, but the inventory cost deviation is [Formula: see text]2.4%, and the fitting degree is 86.4%. The dynamic prediction needs to be improved. The FL-DT architecture has small loss fluctuations in abnormal events, which is better than traditional systems. The amount of communication data is reduced by 82% to 12.7 MB/round, demonstrating high efficiency and robustness. This study provides a new method for IoT supply chain optimization, verifies its potential in efficiency improvement, cost reduction and intelligent transformation, and can be expanded to more fields in the future.

Single-atom catalysts (SACs) have demonstrated their potential in photocatalytic CO2 reduction due to their fascinating properties and well-defined structure for forecasting the mechanism. Although remarkable progress has been achieved in enhancing SAC activity, the selective formation of C2+ hydrocarbons with higher energy densities remains a significant challenge, primarily due to the inherent limitations of isolated single-active sites in simultaneously enabling CO2 adsorption, activation, and C─C coupling. Therefore, in this review, recent advances in SAC-based strategies for promoting C2+ hydrocarbons production are summarized, with a particular focus on dual single-atom catalysts and hybrid SAC systems. The introduction of dual metal sites with tunable electronic structures and charge distributions is discussed can stabilize key intermediates (*CO, *CHO), mitigate electrostatic repulsion, enhance intermediate collision probability, influence intermediate adsorption configurations, and ultimately facilitate C─C coupling. By offering insights into the design principles, mechanistic pathways, and characterization techniques, this review aims to motivate future efforts toward the rational design of highly selective and efficient systems for solar-driven CO2 reduction into C2+ hydrocarbons.

The broader adoption of crumb rubber asphalt mixtures (CRAM) as sustainable pavement materials is currently limited by two key technical barriers. Firstly, there is a lack of standardized methods to evaluate mixing uniformity. Secondly, the material's tendency for elastic recovery after compaction remains problematic. These barriers ultimately hinder the realization of CRAM's full potential in vibration reduction, noise abatement, and resource recycling. To improve the performance evaluation system of CRAM and promote its development in engineering applications. Based on the distribution characteristics of crumb rubber in asphalt mixtures, this study established a crumb rubber distribution area moment model. It proposed a coefficient of area-distance variation to evaluate the mixing uniformity of CRAM. Through compaction tests and orthogonal tests, the effects of mixing process, mixing time, mixing temperature, compaction temperature, compaction times, and compaction method on the mixing uniformity and performance of CRAM are systematically investigated. The results show that, compared with specimens prepared by single compaction and compaction after high-temperature curing, CRAM specimens prepared by secondary compaction exhibit superior mechanical performance. The 24 h elastic recovery rate of these specimens is reduced to 24% of that in single-compacted specimens. The mixing process and mixing time have a significant impact on the mixing uniformity of CRAM. Pre-mixing crumb rubber with aggregates or extending the mixing time can improve the CRAM mixing uniformity by 45% and 18%, respectively. The mixing and compaction temperatures primarily affect the bulk density and Marshall stability of the specimens. When the mixing and compaction temperatures are 180 °C and 170 °C, respectively, the bulk density and Marshall stability of the molded specimens reach their maximum values. Through orthogonal analysis, the optimal mixing method for CRAM is determined as follows: mix aggregates and crumb rubber at 180 °C for 40 s, then add asphalt and continue mixing for another 80 s. The optimal process for secondary compaction is as follows: the first compaction at 170 °C, compacting each side 47 times, and the second compaction at 80 °C, compacting each side 23 times.

Abstract By 2035, Geneva aims to cover up to 30% of its heating needs with district heating networks (DH), 80% of which will be supplied by renewable or recovered energies. To integrate these energies effectively, DH temperatures need to be reduced, while respecting the individual requirements of substations (SSTs). We investigate the issues and potentials of temperature reduction on Geneva’s main DH, which supplies 359 GWh/year at supply/return temperatures of 110°C/70°C. Using the excess flow method and a measurement campaign targeting a selection of SSTs, coupled with analysis of the number of transfer units (NTUs), the study identified priority substations for optimization and the source of high return temperatures. Contrary to expectations, building distribution systems show relatively low return temperatures between 40°C and 50°C, while temperatures on the primary side of their heat exchangers vary between 60°C and 90°C. This indicates that the heat exchangers are undersized, with NTU values between 0.5 and 1.5, well below the Scandinavian reference design value of 4. Replacing or adding a second heat exchanger would, in most cases, make it possible to achieve the desired temperature reduction without modifying the buildings’ secondary distribution systems, which are generally not under the responsibility of the DH operator.

Mn-based oxide catalysts have promising potential in the selective catalytic reduction of NO with NH3 (NH3-SCR) due to their excellent low-temperature activity. However, poor N2 selectivity severely restricts their large-scale practical applications. In this study, we achieved an improvement in both activity and selectivity of Mn-based SCR catalysts by W modification and revealed the mechanism by which the formation of Mn-W dinuclear active sites enhances their performance. By combining experimental measurements and density functional theory (DFT) calculations, the improved NH3-SCR performance of the MnW/TiO2 catalyst was attributed to the significant redox role of W, resulting from the formation of strongly interacting Mn-W dinuclear sites. The entire NH3-SCR reaction pathway over the Mn-W dinuclear site was elucidated at the atomic level, confirming that the W sites played a redox role in the reaction, specifically by directly participating in the oxidative activation of NH3. This work elucidates the working principle of dinuclear active sites in the NH3-SCR reaction and provides valuable insight for the development of future generation high-performance SCR catalysts.

IntroductionColorectal cancer (CRC) is a prevalent malignant tumor of the digestive tract. The FOLFOX regimen (oxaliplatin + calcium folinate + 5-fluorouracil) serves as the primary treatment for advanced CRC clinically, yet its application is significantly limited by substantial toxic side effects. Erianin, a natural compound from Chinese medicine Dendrobium chrysotoxum Lindl, demonstrates significant potential in both tumor growth inhibition and chemotherapy toxicity reduction. This study aims to investigate the potential of Erianin in reducing the toxicity of the FOLFOX regimen while enhancing its antitumor efficacy.MethodsThis study integrated network toxicology and molecular docking to predict the potential targets of Erianin in alleviating FOLFOX-induced side effects. Using an orthotopic MC38 CRC transplantation model, we conducted a comprehensive evaluation of the effects of Erianin in mitigating FOLFOX-induced changes in body weight changes, hematological parameters, and histopathology of major organs (heart, liver, spleen, kidneys, and intestines). IHC analysis elucidated alterations in intestinal barrier proteins, AKT1/mTOR pathway, and tumor proliferation and apoptosis biomarkers. Tumor progression was dynamically monitored by in vivo imaging.ResultsThe results showed that Erianin improved weight loss, pathological changes in organs, and reduction in peripheral blood cell counts (WBC, RBC, HGB, PLT, HCT) caused by FOLFOX in mice. Erianin reversed the inhibition of intestinal tight junction proteins (e.g. ZO-1, Occludin, Claudin-5) and AKT1/mTOR pathway caused by FOLFOX. In addition, the tumor size was significantly reduced in the combination group, and the expression of the apoptosis marker Cleaved Caspase-3 was up-regulated, and the proliferation markers Ki67/PCNA were down-regulated.DiscussionErianin can enhance the anti-CRC effect of FOLFOX, and mitigates FOLFOX-induced toxicity by activating the AKT1/mTOR pathway.

IntroductionNeoadjuvant chemoimmunotherapy (NACI) has drawn considerable attention in Head and neck squamous cell carcinoma (HNSCC) owing to its potential in functional preservation and treatment-failure reduction. Yet whether the surgical extent can be narrowed following NACI is largely debatable due to a potential non-centripetal tumor regression may result in scattered microfoci residing beyond the narrowed margin.MethodsIn this pilot study, we characterized the tumor regression pattern in a post-NACI HNSCC cohort using a whole-mount histopathological approach. The MRI examinations before and after NACI were used to evaluate the objective response rate (ORR).ResultsOf the 52 patients enrolled, the ORR was 75%. Pathological complete response (pCR) rate was 15.4%, and the major pathological response (MPR) rate was 40.4%. Two major regression patterns were identified in whole-mount tumor sections, centripetal regression and non-centripetal regression. Centripetal regression was observed in 37 patients (71.2%) and was subcategorized into complete regression (Ia, 15.4%), unifocal centripetal regression (Ib, 36.5%), and multifocal centripetal regression (Ic, 19.2%). Non-centripetal regression was seen in 15 patients (28.8%) and was subcategorized into scattered regression (IIa, 25.0%) and non-regression (IIb, 3.8%). Moreover, we found a pre-NACI CPS higher than 20 or post-NACI (18)F-FDG SUVmax reduction exceeding 50% were potential predictive factors for the centripetal regression pattern.DiscussionWe revealed for that centripetal regression was the predominant pattern of regression after NACI in HNSCC. Hence, our data presumably supports a reduced surgical extent in post-NACI HNSCC patients. Future studies should focus on identifying accurate predictive factors for the regression pattern, which may eventually assist in risk stratification and surgical decision making.ConclusionsThe pattern of tumor pathological regression after NACI for HNSCC is mainly divided into centripetal and non-centripetal regression, with the former accounting for the major portion of the regression.

Evaluating the co-control potential of CO2 and air pollutant emission reductions in the cement industry in China: A case in Henan

Superhydrophobic coatings possess distinct wettability characteristics and hold significant potential in metal corrosion protection and underwater drag reduction. However, their practical application is often hindered by poor durability arising from the fragility of their micro/nanostructured surface roughness. In this study, a durable superhydrophobic coating featuring a hierarchical, hydrangea-like micro/nanostructure was successfully fabricated on an aluminum alloy substrate via a simple one-step cold-spraying technique. The coating consisted of hydrangea-shaped SiO2 nanoparticles modified with 1H,1H,2H,2H-perfluorodecyltrimethoxysilane (PFDT) to produce multiscale roughness, while epoxy resin (EP) served as the binding matrix to enhance mechanical integrity. The hydrangea-like SiO2 nanostructures were characterized by solid cores and wrinkled, petal-like outgrowths. This unique morphology not only increased the surface roughness but also provided more active sites for air entrapment, thereby enhancing the coating’s overall performance. The h-SiO2@PFDT-EP composite coating exhibited excellent superhydrophobicity, with a WCA of 170.1° ± 0.8° and a SA of 2.7° ± 0.5°. Durability was evaluated through sandpaper abrasion, tape peeling, acid and alkali immersion, artificial weathering, and salt spray tests. The results demonstrated that the coating retained stable superhydrophobic performance under various environmental stresses. Compared with bare 6061 aluminum and EP coatings, its corrosion current density was reduced by four and three orders of magnitude, respectively. Furthermore, the coating achieved a maximum drag-reduction rate of 31.01% within a velocity range of 1.31–7.86 m/s. The coating also displayed excellent self-cleaning properties. Owing to its outstanding durability, corrosion resistance, and drag-reducing capability, this one-step fabricated superhydrophobic coating showed great promise for applications in marine engineering and defense.

The global prevalence of obesity and its related complications continue to rise, emphasising the need for effective treatment strategies. Tirzepatide, a novel glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide dual agonist, has emerged as a promising pharmacological option in obesity management due to its potential in weight reduction and cardiometabolic improvement. We conducted a systematic review and meta-analysis following PRISMA guidelines, including randomised controlled trials (RCTs) comparing the efficacy and safety of Tirzepatide with placebo in adults with obesity, with or without type 2 diabetes. We searched PubMed, Cochrane Library, and EMBASE databases up to December 15, 2024. Ten RCTs were included, comprising 6257 participants. Tirzepatide significantly reduced body weight compared to placebo, with a total pooled mean difference of -11.62 kg (95% confidence interval: -14.24 to -9.01, p < 0.001). In the highest dosage group of 15 mg, 88.1%, 63.3%, and 51.8% of participants achieved weight reductions exceeding 5%, 10%, and 15% respectively. Significant improvements were also noted in cardiometabolic risk factors, including haemoglobin A1C, waist circumference, body mass index, and lipid profiles. Tirzepatide showed a favourable safety profile, without increasing the risk of serious adverse events or impacting mortality rates. Tirzepatide has demonstrated effectiveness in achieving significant weight loss and enhancing cardiometabolic health in adults with obesity. While it maintains a favourable safety profile, further studies are essential to investigate its long-term safety and determine the optimal duration of treatment.

Neutral inverse-sandwich lanthanum arene complexes with the parent benzene tetraanion are still limited. Here, we report the neutral inverse-sandwich lanthanum benzene complexes [(CpAr5)La(THF)n]2(μ-η6:η6-C6H6) (CpAr5 = η5-C5Ar5, Ar = iPr2-C6H3-3,5; n = 0, 2; n = 1, 2-THF) supported by a superbulky penta-arylcyclopentadienyl ligand. Complex 2 was isolated from the reduction of the half-sandwich lanthanum diiodide precursor [(CpAr5)LaI2(THF)2] (1) in benzene by the K/KI reductant, yielding 69%. The reaction of complex 2 with 0.5 equiv of (HBBN)2 enabled C-H bond functionalization of the benzene tetraanion, generating a novel borylated product [(CpAr5)La]2(μ-η6:η6-C6H5BBN) (3). NMR analyses, single-crystal X-ray diffraction, and UV-vis spectroscopic studies demonstrated that complexes 2, 2-THF, and 3 share a [La3+-(arene)4--La3+] electronic structure, which was further confirmed by density functional theory (DFT) calculations. Moreover, treatment of complex 2 with Me3SiN3 afforded a product [(CpAr5)La{N(SiMe3)2}]2(μ-N3)2 (4) via four-electron reduction and subsequent Si-N bond activation. Additionally, the dimeric peroxo complex [(CpAr5)La(THF)]2(μ-η2:η2-O2)2 (5) was detected in the reaction of 2 with O2. The redox reactivity of 2 shows its great potential in the multielectron reduction of unsaturated substrates, functioning as a La(I) synthon.

Rice bran protein fibril and chitin nanofiber complexes as a new material for fat substitution and saltiness enhancement.

By harnessing the power of photocatalysis, there is a promising pathway to develop sustainable carbon cycles, which can significantly reduce our reliance on fossil fuels and advance the goal of sustainable energy development. MOFs, with their ordered porous structures, have shown tremendous potential in photocatalytic CO2 reduction. These materials are characterized by their excellent structural tunability, large surface areas, and outstanding CO2 capture capabilities, making them ideal candidates for photocatalytic reactions. In the context of CO2 reduction, the photocatalytic performance of MOFs is critically influenced by their light absorption properties, material design, and CO2 capture efficiency. In recent years, researchers have made significant progress in exploring and developing MOF materials specifically for reducing CO2 to carbon monoxide (CO). This paper reviews some of the most representative MOF materials in this domain, discussing their performance, advantages, and the challenges they face in practical applications. By synthesizing these research outcomes, we can gain a deeper understanding of the operational mechanisms of MOFs, providing valuable insights and guidance for future research directions.

e13531 Background: Monoclonal antibodies (mAbs) are being increasingly used for many diseases but can be cost prohibitive. Hematology Oncology Pharmacy Association (HOPA) has recommended rounding mAbs to the nearest vial size within 10% of the prescribed dose 1 . Previous work using pharmacokinetic simulations with reduced dosing schedules resulted in $1.00B savings with Trastuzumab alone 2 , and about 11-28% of total cost savings when expanded to several other mABs 3 . Methods: Cerner EMR at Stony Brook University Hospital was queried to identify patients who received infliximab, rituximab, and trastuzumab from November 2019 to November 2024. The doses of each medication were reduced by 5% or 10%, without overlap, to the nearest vial size, to create hypothetical doses and number of vials that would be required. Prices for each drug were obtained from the Stony Brook University Hospital Pharmacy Department and costs were calculated as: actual cost and cost with dose reductions of 5% or 10%. Data was analyzed to determine the financial benefits. Results: 7,306 patients were identified with a combined total of 41,780 vials used. The drug distribution was: 17,441 infliximab, 7,043 infliximab DYYB, 9,813 rituximab (10mL vials), 1,086 rituximab (50mL vials), 6,397 trastuzumab. After hypothetical dose reductions of 5% or 10%, a total of 4,889 vials and $1,269,589 were saved. See table 1 for full results. Conclusions: The impressive savings of over $1 million in a span of five years, at a single institution, using only four mAbs underscores the significant potential of small dose reductions. If these calculations were applied across all mAbs, some of the financial burden placed on patients and institutions could be alleviated. The data posed here, as well as in similar studies, emphasizes the potential for considerable cost savings while still adhering to clinical practice dosing recommendations. 1. Bott, A. M. (2017). Dose rounding of biologic and cytotoxic anticancer agents . Dose Rounding of Biologic and Cytotoxic Anticancer Agents A Position Statement of the Hematology/Oncology Pharmacy Association. 2. Hsieh P-H, Kacew AJ, Dreyer M, et al. Alternative trastuzumab dosing strategies in HER2-positive early breast cancer are associated with patient out-of-pocket savings. Nature News. March 14, 2022. 3. Heine R ter, Heuvel MM van den, Piet B, et al. A systematic evaluation of cost-saving dosing regimens for therapeutic antibodies and antibody-drug conjugates for the treatment of lung cancer - targeted oncology. SpringerLink. April 21, 2023. Cost savings stratified by drug. Drug Total Cost per vial Vials saved with 5% or 10% dose reductions Cost savings with 5% or 10% dose reductions Infliximab 100mg 17,441 $187.87 1,812 $340,420 Infliximab- DYYB 100mg 7,043 $88.39 753 $66,557 Rituximab 10mg/mL 10mL 9,813 $82.03 1,459 $119,681 Rituximab 10mg/mL 50mL 1,086 $441.10 0 $0 Trastuzumab 150mg 6,397 $858.88 865 $742,931 41,780 4,889 $1,269,589

Urban morphology’s effects on carbon dioxide reduction and sustainable development have drawn more attention. The county scale is crucial in influencing urban development and is the central element of China’s recent urbanization. To achieve scientific urban planning and fully explore its potential in carbon emission reduction, local governments need to investigate the impact of urban morphology on carbon emissions (CE). However, previous studies have predominantly focused on provincial capitals and urban clusters. To address this gap, this study quantified four aspects of urban form, combined energy consumption, and nighttime light data to estimate CE in Chinese counties from 2000 to 2020 and analyzed the effects of these factors on CE using multiscale geographically weighted Regression(MGWR) models and geographic detectors. The following are the main findings: (1) Total CE at the county scale in China has consistently increased from 2000 to 2020. (2) The largest patch index (LPI) is the most influential urban morphological factor on CE, while the impact of Class Area (CA) has been increasing. (3) Bi-factor enhancement and nonlinear enhancement are the two primary interaction types of urban morphological factors; the most important interaction is between LSI and CA. (4) The urban morphological factors exhibit varying degrees of spatial heterogeneity, with the influencing factors ranked as CA &gt; LPI &gt; path density (PD) &gt; edge density (ED) &gt; patch cohesion index (COHESION), where LPI and CA consistently show a positive effect on CE. This study’s findings establish a scientific foundation for land spatial planning and tailored emission reduction methods at the county scale in China.

Phononic crystals have broad application prospects in solving the problem of suppressing low-frequency vibration and noise. In this paper, a phononic-like crystal plate model is designed to explore new building materials with outstanding low frequency vibration suppression and noise reduction capabilities. The band structure of the proposed model is calculated by the finite element simulation, and the effectiveness of the simulation method is verified by equivalent spring-mass model. On this basis, the influence of position randomness on the bandgap is discussed. The results show that the proposed model has multiple bending wave bandgap within 240 Hz with the coverage is approximately 150 Hz, and the bandgap characteristics are not affected by position randomness. Through the finite element calculation, it is found that the structure has superior performance of vibration damping and sound isolation. Moreover, two optimization schemes are presented on the basis of the proposed model, which further improves its damping and noise reduction ability. The excellent vibration and noise reduction effects are verified through experiments. The model presented in this paper has great application potential in vibration and noise reduction and provides a new idea for the design of phononic crystal.