Recurrent Apthous Stomatitis Research Articles

Correlating Salivary Levels of Immunoglobin E and Human Eosinophil Cationic Protein in the Aseer Cohort with Recurrent Apthous Stomatitis.

Repeated Aphthous Stomatitis (RAS) is the most prevalent inflammatory disorder of the oral mucosa, characterized by recurrent emergence of single or numerous painful ulcers. RAS usually affects healthy people without systemic illnesses.There is evidence linking atopy to the progression of this illness. Immunoglobulin E (IgE) and human eosinophil cationic protein (HECP) levels in the saliva of individuals with aphthous stomatitis were assessed as allergy-related indicators. Sixty people were assessed for this study. 30 patients with RAS were included in the patient group, while 30 healthy individuals made up for the control group. Sixty participants' non-stimulated saliva was taken and IgE and HECP were evaluated using enzyme-linked immunosorbent assay (ELISA). Data were analyzed in SPSS 20 through the Mann-Whitney test and p<0.05 was considered significant. The salivary level of HECP was significantly (p 0.05) higher among cases (0.83 0.70) compared to controls (0.170 0.15), whereas the salivary level of IgE was not significantly (p = 0.41) higher among cases (35.60 11.19) compared to controls (67.42 18.34). Even though this study found a positive correlation between elevated HECP levels and RAS, additional research with larger sample sizes is required to identify the biological mechanisms responsible for the observed associations and to include salivary HECP levels in the RAS patient's evaluation.

Application of soft tissue laser in the management of recurrent apthous stomatitis

Apthous ulcers are relatively common pathology and are very painful, so in order to facilitate the relief in pain and healing of these ulcers application of LLT has been done in the present study. The purpose of this study was to assess the efficacy of Low Level Laser Therapy in the treatment of recurrent aphthous ulcers. 30 patients of both sexes and all age groups with two recurrent aphthous ulcers were included in the study. One ulcer in each subject was subjected to Low Level Laser Therapy as study group and one ulcer in each subject was considered for the Sham Control group. The Student’s t-test was used for statistical evaluation of the data. The study group (LLLT) showed a statistically significant reduction in pain as compared to the sham controlled group. Complete resolution of the ulcers in the study group was observed to be 4.7 ± 1.2 days and control group was 8.4 ± 2.6 days. On comparison with the sham group, the complete healing time for the study group (LLLT) was found to be highly significant, with a p value of &lt;0.001.

Dermoscopy of Oral Mucosal Lesions: Experience from a Tertiary Care Center in North India and Review of Literature.

Background:Patients with mucosal lesions form a significant number of routine outpatients presenting to the dermatology department where diagnostic confirmation using histopathological examination of mucosal biopsy is neither feasible nor warranted in every patient.Objective:To study the dermoscopic features of various mucosal lesions affecting the oral cavity and to assess the reliability of mucoscopy vis-a-vis clinico-laboratory findings.Materials and Methods:An observational, cross-sectional, hospital-based study was conducted over a period of 2 years from March 2019 to February 2021 in the dermatology outpatient department. Patients presenting with oral mucosal lesions, with or without associated cutaneous involvement, were recruited for mucoscopic evaluation after taking an informed written consent. A detailed history and clinical examination, with emphasis on mucocutaneous examination, was performed and findings were recorded on a standard predesigned proforma. Mucoscopy of oral mucosa was carried out using a handheld dermoscope as well as Universal Serial Bus connected video-dermoscope in both nonpolarized and polarized modes. The different mucoscopic features were seen at these sites, compared with each other, analyzed and findings were recorded. A diagnosis was made on the basis of mucoscopic findings and correlated with clinical diagnosis. The data was analyzed using appropriate statistical tests.Results:The mean age of patients was 34.3 years and the mean lesional duration was 68.2 weeks. Oral lichen planus (18.66%) was the most common disorder studied, followed by recurrent apthous stomatitis (16.00%), pigmentary lesions (12.66%), vascular disorders (12.00%), mucocele (5.33%), pemphigus vulgaris (4.66%), and discoid lupus erythematosus (4.66%).Conclusion:Dermoscopy in oral lesions facilitates the visualization of the mucosal surface and provides quick confirmation of diagnosis in various mucosal disorders with advanced diagnostic accuracy. Mucoscopy was found helpful in differentiating the oral ulcers, which are a presenting feature of various serious mucocutaneous disorders. Mucoscopy could be a helpful aid in diagnosing pigmented skin lesions and alleviating the apprehension regarding oral melanoma and serve as a screening tool in case of squamous cell carcinoma lips.Limitations:Confirmatory histopathological analysis and correlation with mucoscopic findings could not be established in our study.

THE USE OF LAZOLEX DURING COMPLEX TREATMENT OF CHRONIC RECURRENT APTHOUS STOMATITIS

The aim of our research was to study efficiency of applying the new national gel Lazolex (5%) during the treatment of chronic recurrent apthous stomatitis. To achieve this aim we examined and treated 19-55 years old 54 patients. The patients were devided into two groups. Each group included 27-27 patients. We used the same treatment in both groups, but in the first group during the local treatment we applied the gel Lazolex and in the second group we used the ointment zovirax(5%). Studies of our examination showed that the 19 patients (70,37±0,42%) from the first group 27(50±50) had important improvement, 6 patients (22,22±1,87%) had improvement. there was no efficiency in 2 patients (7,41±1,87%) with grave forms of chronic recurrent apthous stomatitis. In the second group after applying Zovirax only five patients from 27 (50±0,5%) had important improvement with the easy forms of chronic recurrent apthous stomatitis (18,52±0,9%) improvement was shown with 15 patients (55,6±0,8%). 7 patients (26,16±1,67%) from which 2 had grave forms and 5 had medium forms of disease had no efficiency. It is concluded that applying of national gel Lazolex (5%) accelerates the epithelisation on lips and skin and growth the remission process of disease. It does not have side effects . Thus, it is recommended to apply Lazolex during the treatment of chronic recurrent apthous stomatitis.

THE USE OF LAZOLEX DURING COMPLEX TREATMENT OF CHRONIC RECURRENT APTHOUS STOMATITIS

The aim of our research was to study efficiency of applying the new national gelLazolex (5%) during the treatment of chronic recurrent apthous stomatitis. To achieve this aim we examined and treated 14-60 years old 50 patients. The patients were devided into two groups. One group included 20 patients (40±0,77%) -control group and the second one -30 patients (60 ±0,63%)- the main group . We used the same treatment in both groups, but in the main group during the local treatment we applied the gel Lazolex (5%) and in the control group we used vitamin A, vitamin E and briar oil. Studies of our examination showed that in the control group the aphtes during phibrinal form started epithelization in 7-14 days - remission was 3-4 month. aphtes during necrotic forms started epithelization in 10-21 days - remission was 2-4 month. aphtes during glandular forms started epithelization in 14-20 days - remission was 1-2 month. After applying Lazolex epithelization started in 3-6 days during phibrinal form - remission was 6-9 month, in 7-14 days during necrotic form - remission was 4-6-7month, in 9-14 days during glandular forms - remission was 3-5 month. Thus, it is recommended to apply Lazolex during the treatment of chronic recurrent apthous stomatitis “Lazolex” is national, cheap, herbal gel that accelerates epithelization and growth the remission precess.. It does not have side effects.

Academic Stress on the Incidence of Recurrent Aphthous Stomatitis: A Cross Sectional Study

Background: Oral and dental diseases experienced by Indonesians is recurrent apthous stomatitis with a national prevalence of 8.0%. Stress can afflict children, adolescents, adults and the elderly even in a school environment, so stress can happen to anyone, anywhere. People who experience stress result in decreased concentration ability, deteriorating health, depression and sleep disorders and even dental and oral health problems, one of which is recurrent aphthous stomatitis. Objective: To determine the relationship between academic stress and the incidence of recurrent aphthous stomatitis. Methodology: this type of analytic observational study with cross sectional design. The research was conducted on students of the Department of Dental Health, Jakarta Health Polytechnic I. Collecting data using an observation sheet for the incidence of recurrent aphthous stomatitis and a questionnaire to determine the level of academic stress. Data analysis using Chi-Square. Results: it was found that academic stress on the incidence of recurrent aphthous stomatitis showed the p-value was 0.047 (p &lt;0.05). Conclusion: There is a significant relationship between academic stress and the incidence of recurrent aphthous stomatitis&#x0D; Keywords: Academic stress, recurrent aphthous stomatitis

Salivary irisin: potential inflammatory biomarker in recurrent apthous stomatitis patients.

Recurrent Aphthous Stomatitis (RAS) is the most common inflammatory condition of the oral mucosa characterised by recurrent onset of single or multiple painful ulcers mainly affecting the nonkeratinized oral mucosa. RAS mostly occurs in healthy individuals with no associated systemic diseases. Irisin is a newly identified adipomyokine and research has revealed that it has anti-inflammatory effects. The aim of this study was to investigate the significance of salivary irisin levels in patients with recurrent apthous stomatitis (RAS). In this investigation, 80 individuals were evaluated. The patient group included 30 patients diagnosed with RAS and each control group consisted of 25 smoker and non-smoker healthy individuals. Saliva samples were collected and salivary irisin, interleukin-2 (IL-2) and interferon-ɣ (IF-ɣ) levels were determined using enzyme-linked immunosorbent assay (ELISA). IL-2 and IF-ɣ levels in RAS patients were significantly higher than control smoker and non-smoker groups (p=0.0001, p=0.0001, respectively). Irisin level was higher in RAS patients than smoker controls and non-smoker controls. The level of irisin was found as sensitive and specific as IL-2 and more sensitive and specific than IF-ɣ. The salivary levels of pro-inflammatory cytokines IL-2 and IF-ɣ and irisin were higher in RAS group compared to controls. This is the first report evaluating the irisin an adipo-myokine as an inflammatory biomarker in RAS.

Management of recurrent apthous stomatitis-current trends &amp; perspective

Recurring oral ulcers are among most common oral disease encountered by oral physicians in day to day practice. Recurrent apthous stomatitis (RAS) is a common disorder characterized by recurring ulcers confined to the oral mucosa with no other signs of systemic diseases. It affects approximately 20% of general population. Clinically it is classified as minor ulcers, major ulcers and herpetiform ulcers. This article insights the current trends in management of this commonly occurring disease. Keywords:Recurrent Aphthous Stomatitis, Oral ulcers, Etanercept, Autoimmune diseases

Prevalence of smoking in patients with aphthous stomatitis: A retrospective case-control study

Apthous stomatitis represents one of the most common ulcerations occurring in the oral cavity. This ulcer has an exclusive predilection of affecting the non-keratinized mucosa only. The aim of this study was to assess the prevalence of smoking in patients with apthous stomatitis. Seventy-six patients with recurrent apthous stomatitis attending Saveetha Dental Hospital, Chennai were included in the study. The data gathered was entered into an excel table, and the data analysis was done in SPSS. The data analysis revealed that the mean age of the collected samples of 76 patients was 32.21 years, and 67.1% of the samples were males. Analyzing the clinical variants, 70 patients had minor apthous stomatitis, five patients had major apthous stomatitis, and one patient had herpetiform apthous stomatitis. Results showed that patients who are not smokers have a higher rate of recurrence of recurrent apthous stomatitis compared to patients who are smokers with 6.6% being the prevalence rate for smokers and 93.4% being the prevalence rate for non-smokers. Data analysis was done using a chi-square analysis between the clinical variants of recurrent apthous stomatitis and smoking habits (chi-square-1.132; df-2; p-0.05) we found the results were statistically significant (P=0.05) which implies there were less self-reported diabetics in this study Prevalence of smoking in patients with recurrent apthous stomatitis is significantly lower than patients who are not smokers. The reason for the decreased occurrence of apthous stomatitis in smokers may be due to the increased keratinization of the mucosa.

Evaluation of 5% Amlexenox Oral Paste and Rebamipide Tablets in Treatment of Recurrent Apthous Stomatitis and Comparison with Dologel CT.

Recurrent aphthous stomatitis (RAS) is a frequently seen oral ulcerative lesion, manifesting as multiple, recurrent, shallow, irregular ulcers encircled by an erythematous halo. The precise etiopathogenesis is obscure, although the recent understanding suggests an underlying immune-mediated etiology. However, there is no defined management protocol and the principal therapy aims to attain symptomatic respite. 150 clinically diagnosed RAS patients of both sexes in the age range of 15-65years were randomly allocated and divided into two cohorts, namely Group A (75 RAS patients receiving 5% Amlexanox paste + 100mg Rebamipide tab.) and Group B (75 RAS patients receiving Dologel CT). Effectiveness of 5% Amlexanox oral paste and Rebamipide tablets in diminution of the ulcer size, erythema and pain was assessed and compared with Dologel CT therapy. The study showed an equal gender distribution. Majority of the patients were in the younger age range (25-35years) and labial and buccal mucosa were the commonest affected sites. Although, both 5% Amlexanox and Rebamipide tablets and Dologel CT showed statistically significant resolution in the ulcer size, erythema, and associated pain. However, 5% oral Amlexanox paste and Rebamipide tablets are more efficacious in the treatment of RAS and tend to heal the ulcer at a more accelerated pace. Our research concluded that 5% oral Amlexanox paste and Rebamipide tablets tend to heal the ulcer at a more accelerated pace as compared to Dologel CT.

Publication trends in journal of clinical and experimental dentistry.

BackgroundJournal of Clinical and Experimental Dentistry (J Clin Exp Dent; JCED) is an English language journal published by the Spanish Society of Oral Surgery, and has been online since 2009. It is indexed in PubMed Central and Scopus since 2012, with monthly publications since 2016. The purpose of this article was to review and analyse the publications in this journal since its inception, over a period of 11 years (2009-2019). Material and MethodsThis paper assessed the number, type and subjects of the articles published in the journal over 11 years. The institutions of the first authors, number of PubMed citations and the Hirsch (h5) index was assessed and analysed. ResultsThe manuscripts published in JCED have gradually increased over the years, with Original research articles accounting for the bulk of contributions. The journal publishes articles mainly from the subjects of Oral Pathology and Operative Dentistry and Endodontics. Articles published in JCED are indexed in PubMed Central (since 2012), Scopus, DOI system, and Google Scholar. A country-wise mapping of the (first) author’s institutions revealed significant contributions from researchers from all over the world. With an h5 index of 26, the journal was ranked among the top six multispeciality journals. The most cited articles were the literature reviews on common oral lesions (recurrent apthous stomatitis and candidiasis). ConclusionsThe journal has contributed to the growth of scientific literature pertaining to subjects from all the fields of dentistry. Over the past 11 years, JCED has served as a platform for large number of manuscripts in all the disciples of dentistry, from researches all over the world. Key words:Publication trends, Journal of Clinical and Experimental Dentistry, Bibliometrics.

Recurrent Apthous Stomatitis: A Review With Evidence Based Management

Recurrent Apthous Stomatitis: A Review With Evidence Based Management

Efficacy of alum in recurrent aphthous stomatitis

Aphthous ulcers are the most common lesions encountered in the oral cavity. The mild recurrent apthous stomatitis (RAS), is an extremely painful condition. Various treatment modalities are tried for RAS. Alum is also tried and found to be successful. Alum is used in traditional medicine for the treatment of oral ulcers without significant side effect. Aim: To assess the efficacy of alum for the treatment of recurrent aphthous stomatitis. Settings and Design: Longitudinal study was carried out in the Department of Oral Medicine and Radiology under institution setting. Methods and Materials: This study was conducted on 50 patients with RAS, aged between 15 and 40 years. The diagnosis of RAS was made based on its clinical appearance and the history provided by the patient. Application of alum on aphthous ulcers was done. Statistical Analysis Used: The data obtained was tabulated and subjected to statistical analysis. Results: In 50 patients reporting to the Department of Oral Medicine with RAS, 70% were female and 30% were male. Majority of cases found in the range of 21–30 years. The majority of patients gave VAS 0 on the second day of application. The rest of the patients gave a VAS 0 on the third day of application. Complete healing of the ulcer was seen in 85% of the patients on third day and the rest of the patients showed healing on fourth day. Conclusions: The results showed that alum significantly reduces the severity of pain and duration of healing without any side effects.

English

This study aimed to determine a possible correlation between oral mucosal disease and salivary concentrations of the antimicrobial peptides human beta-defensin-1 (hbetaD-1) and human beta-defensin-2 (hbetaD-2). The present work focussed on the establishment of a reversed phase-high performance liquid chromatography (RP-HPLC) procedure to quantify human beta-defensins (hbetaD-1 and hbetaD-2) in saliva samples of patients with oral diseases such as lichen planus (n = 10), Behçet (n = 10) and recurrent apthous stomatitis (n = 10). Linear calibration range for hbetaD-1 and hbetaD-2 defensins was 1.67-200 microg mL-1 and 3.13 -100 PG mL-1 with R2 values of 0.9998 and 0.996, correspondingly. The concentration of beta-defensins in saliva was determined by comparing the peak areas of eluted hbetaD-1 and hbetaD-2 with that of their standards. The variation of the amount of beta-defensins was evaluated by comparisons of the results obtained from the patients with oral mucosal diseases before and after treatments and the control subjects. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 1.62 microg mL-Sand 5.39 microg mL-1 for hbetaD-1 and 0.94 mig mL-1 and 3.13 microg mL-1 for hbetalD-2, respectively. The salivary beta-defensin concentration was significantly higher in patients with oral mucosal diseases than in healthy volunteers; furthermore, in patients with oral mucosal diseases, the concentration was significantly higher before treatment than after treatment.

Comparative evaluation of the efficacy of topical amlexanox 5% oral paste and triamcinolone acetonide 0.1% oral paste in the treatment of Recurrent Aphthous Stomatitis (RAS)

Background: A double-blind randomized control trial was conducted to compare the clinical efficacy of topical triamcinolone acetonide 0.1% and amlexanox 5% in recurrent apthous stomatitis (minor). Materials and Methods: Forty adult patients were assessed for erythema, ulcer size, pain scores, and ulcer healing on three evaluation visits within 24 h of ulcer formation, third day, and fifth day. All participants were monitored for compliance with treatment protocols of four times daily application of calibrated quantity of medication. Results and Discussion: Ninety percent of controls when compared with 65% of the participants in the amlexanox group showed complete improvement of peri-ulcer erythema. Pain reduction was marked from the first to the fifth day (F = 15.249, P = 0.000). The control participants showed 90% reduction in pain in comparison to 70% in the amlexanox group. The mean ulcer size was shown to reduce from the first to fifth day in both groups (F = 18.611, P = 0.000). Completely healed ulcers were seen in 70% of the participants in the control group compared with 75% of the participants in the amlexanox group. Conclusion: The data suggest that the clinical efficacy of topical amlexanox 5% is comparable to topical 0.1% triamcinolone acetonide and may be considered a substitute except in pain control, which was marginally less for the treatment for recurrent apthous stomatitis (minor).

A novel treatment modality for recurrent aphthous stomatitis – Single application of doxycycline hyclate

Background and Objectives: Recurrent aphthous ulcers are common painful mucosal conditions affecting the oral cavity. Despite of so many treatment modalities, there is no specific and definitive treatment. Hence a study was carried out to evaluate the clinical effects Single Application of Doxycycline Hyclate 100 mg for Recurrent apthous Stomatitis (RAS). Materials and Methods: Forty study subjects were included in the study. Patients were randomly assigned into two groups. There were 20 patients in each group; Group A patients received Doxycycline Hyclate 100 mg in the first visit, Group B patients received placebo. The results were analyzed with unpaired 't' test. Results: The data indicated a significant reduction in pain in group A (i.e., faster reduction in pain) compared with group B. Interpretation and Conclusion: A single application of doxycycline hyclate decreased pain and speeded recovery.

Mean Platelet Volume: A Reliable Marker of Inflammation in Recurrent Apthous Stomatitis and Behçet Disease?

Background:Mean platelet volume (MPV) is an indicator of platelet activation and aggregation. MPV has been found to be related with the inflammation of certain disorders in recent studies.Aims:We sought to investigate whether MPV could be an indicator of inflammation in patients with Behçet disease (BD) and recurrent apthous stomatitis (RAS).Materials and Methods:Our study was designed as a retrospective case-control study and data was retrieved from our institutional database. We randomly generated a total of three study groups from our clinical archive. All controls were sex and age-matched and randomly selected by computer. Eighty-five patients with BD, 82 patients with RAS, and 721 healthy controls were included for the study design. We compared mean MPV values in the patient groups and controls.Results:We found no difference in the mean MPV value between BD group and BD-control group. The mean MPV value was significantly higher in patients with RAS than that in the RAS-control group (9.11 ± 1.01 fL vs. 8.76 ± 1.15 fL, P = 0.045). There was no difference in mean MPV level between BD and RAS group.Conclusion:The association between MPV and inflammatory skin diseases such as BD and RAS should be investigated prospectively in case-control studies.Limitations:Retrospective study design.

Clinical Effectiveness of Aloe Vera in the Management of Oral Mucosal Diseases- A Systematic Review.

Aloe vera is well known for its medicinal properties which lead to its application in treating various diseases. Its use in treating oral lesions has not been much documented in literature. Although, systematic reviews on aloe vera and its extracts have been done earlier, but in relation to oral diseases this is the first systematic review. The aim of the present systematic review was to compile evidence based studies on the effectiveness of Aloe vera in treatment of various oral diseases. Computerized literature searches were performed to identify all published articles in the subject. The following databases were used: PUBMED [MEDLINE], SCOPUS, COCHRANE DATABASE, EMBASE and SCIENCE DIRECT using specific keywords. The search was limited to articles published in English or with an English Abstract. All articles (or abstracts if available as abstracts) were read in full. Data were extracted in a predefined fashion. Assessment was done using Jadad score. Fifteen studies satisfied the inclusion criteria. Population of sample study ranged from 20 patients to 110 patients with clinically diagnosed oral mucosal lesions. Out of 15 studies, five were on patients with oral lichen planus, two on patients with oral submucous fibrosis, other studies were carried on patients with burning mouth syndrome, radiation induced mucositis, candida associated denture stomatitis, xerostomic patients and four were on minor recurrent apthous stomatitis. Most studies showed statistically significant result demonstrating the effectiveness of Aloe vera in treatment of oral diseases. Although there are promising results but in future, more controlled clinical trials are required to prove the effectiveness of Aloe vera for management of oral diseases.

Recurrent Apthous Stomatitis: A Short Review

Recurrent Apthous Stomatitis (RAS) is a common condition, restricted to the mouth, that typically starts in childhood or adolescence as recurrent small, round, or ovoid ulcers with circumscribed margins, erythematous haloes, and yellow or gray floors. There etiopathogenesis is uncertain for which symptomatic therapy only is available. This article reviews the etiopathogenesis, diagnosis and management of RAS.

Role of Depression, Anxiety and Stress in Patients with Oral Lichen Planus: A Pilot Study.

Context:Lichen planus is a psychosomatic disease. Higher frequency of psychiatric symptoms, poor quality of life, higher level of anxiety and neuroendocrine and immune dysregulations, all these factors, will enhance the exacerbation of the disease.Aims:The present study was to assess depression, anxiety and stress levels in patients with oral lichen planus.Materials and Methods:The psychometric evaluation using the Depression Anxiety Stress Scale (DASS)-42 questionnaire was carried out, by the same investigator on all members of group 1 (Oral Lichen Planus) and group 2 (Control). DASS-42 questionnaire consists of 42 symptoms divided into three subscales of 14 items: Depression scale, anxiety scale, and stress scale.Statistical Analysis Used:The Student t test was used to determine statistical difference for both the groups and to evaluate for significant relationships among variables.Results:Psychological assessment using DASS-42 reveals lichen planus patients showed higher frequency of psychiatric co morbidities like depression, anxiety and stress compared to control group.Conclusions:This study has provided evidence that the DASS-42 questionnaire is internally consistent and valid measures of depression, anxiety, and stress. Psychiatric evaluation can be considered for patients with oral lichen planus with routine treatment protocols are recommended. DASS-42 Questionnaire can also be used to determine the level of anxiety, stress and depression in diseases of the oral mucosa like recurrent apthous stomatitis, burning mouth syndrome and TMD disorders.