Quantification of a sea lamprey (Petromyzon marinus) pheromone antagonist in river water using ion pairing solid phase extraction coupled with liquid chromatography-tandem mass spectrometry.

Introduction: Stroke survivors frequently experience depression, anxiety, and other neuropsychiatric issues. Despite this, limited research exists on post-stroke psychological disorders, particularly within the Indian context. Non-pharmacological interventions offer promise and warrant further exploration.Objective: To evaluate the effect of stroke recovery nursing interventional package among survivors of stroke.Methods: An assessment was carried out on 144 post-stroke patients.The experimental and control groups each received an equal number of participants, assigned non-randomly.The experimental group received a structured intervention twice weekly for four weeks. Evaluations were conducted at three key points: Initial Screening, Pre-intervention and post-intervention test.Results: Statistically significant improvements were observed in depression (mean difference: 3,73), anxiety (5,38), and resilience (26,83) at p<0,05. Weak positive correlations were found between resilience and both depression and anxiety. Statistically significant improvements were observed in depression (mean difference: 3,73), anxiety (5,38), and resilience (26,83) at p<0,05. Weak positive correlations were found between resilience and both depression and anxiety.”Conclusions: The intervention effectively reduced psychological symptoms, especially when combined with pharmacological treatment for severe cases.

Malaria, as a serious parasitic infectious disease, remains a major threat to global public security. This study investigated the metabolic mechanisms of patchouli alcohol (PA) and artemisinin sodium (SA) in treating malaria using pharmacodynamics and metabolomics. A Plasmodium berghei ANKA (PbA)-infected mouse model was established to evaluate the antimalarial effects of PA and SA combination therapy (SP). Pharmacodynamic results showed that the SP exhibited better therapeutic effects in infection suppression, weight recovery, and reduction of malaria pigment deposition compared with individual treatments. Untargeted metabolomics identified 146 plasma differential metabolites, including fatty acids, phospholipids, and inflammation-related factors, linked to pathways such as unsaturated fatty acid biosynthesis and glycerophospholipid metabolism. Tetradecanedioic acid (TDA) was identified as a potential biomarker, reflecting the drug interactions and therapeutic efficacy. TDA was quantified by targeted metabolomics to study the interactions of combination drugs. The findings suggest that PA and SA synergistically enhance antimalarial effects by modulating lipid metabolism and anti-inflammatory properties and influencing membrane fluidity. This study provides insights into the metabolic mechanisms of PA and SA combination therapy, supporting its clinical application as a novel antimalarial adjuvant.

A rapid LC-MS/MS method for the simultaneous quantification of 10 key folate cycle intermediates in human plasma.

The Audit Board (BPK) has authority under the Constitution to assess administrative state losses caused by treasurers and to apply a strict liability principle for reparations. In contrast, anti-corruption courts handle corruption cases and rule on a certain amount of state losses; they declare monetary compensation as an additional punitive measure. This study employs a normative legal approach to analyze the discrepancies in assessing the amount of state losses between the two institutions. These disparities impede the effectiveness of recovery of state losses, leading to higher transaction and opportunity costs. This study reveals that the divergence stems from differing methodological approaches: BPK adopts an administrative approach centered on compensation, whereas the courts emphasize punitive measures. This study proposes a multi-track enforcement model as a conceptual solution. It is justified by the cumulative sanctions theory and Article 62 of the State Treasury Law, which provides a legal basis for the simultaneous application of both administrative and criminal sanctions without violating the so-called ne bis in idem principle. This model ensures that criminal verdicts do not relieve the doer of the obligation to compensate for the loss declared by the BPK. Such an approach is essential to accelerate asset recovery, reinforce deterrence, and uphold the integrity of state finances as a top priority in public financial management.

Introduction. Coronary artery bypass grafting performed via median sternotomy frequently leads to postural disturbances, reduced thoracic mobility, and diaphragmatic dysfunction, which may adversely affect pulmonary ventilatory function and exercise tolerance. Supplementing standard cardiac rehabilitation with physiotherapeutic interventions targeted at the thorax and diaphragm may enhance the effectiveness of functional recovery in patients after CABG. Aim of the Study. The aim of the study was to evaluate the effect of thoracic physiotherapy procedures on body posture, pulmonary ventilatory function, and exercise tolerance in patients after coronary artery bypass grafting. Material and Methods. The study included 80 patients (28 women and 52 men) after OPCAB surgery, qualified for phase II cardiac rehabilitation. The patients were randomly assigned to an experimental group (I) and a control group (II). Both groups followed a 3-week standard cardiac rehabilitation program, while the experimental group additionally received exercises aimed at improving posture, thoracic mobility, and manual therapy techniques targeting the diaphragm. Before and after physiotherapy, body posture, breathing pattern, spirometric parameters, and exercise tolerance in the 6-minute walk test were assessed. Repeated-measures ANOVA was used for statistical analysis. Results. After physiotherapy, both groups demonstrated a significant improvement in pulmonary ventilatory function and exercise tolerance (p < 0.05). The experimental group showed a significantly greater magnitude of changes in body posture, diaphragmatic function, spirometric parameters, and MET values in the 6-minute walk test compared with the control group. Conclusions. Physiotherapeutic interventions targeted at the thorax and diaphragm constitute a valuable adjunct to standard cardiac rehabilitation in patients after coronary artery bypass grafting, contributing to improved respiratory function and exercise tolerance.

ABSTRACT Tourism recovery is crucial for the long-term sustainability of tourism destinations. This study aims to assess the contribution of tourism recovery after the COVID-19 pandemic to Sustainable Development Goals (SDGs) 8 (decent work and economic growth) and 12 (responsible consumption and production). By integrating the Multi-Regional Input–Output (MRIO) model and qualitative interview methods, we develop an integrated evaluation framework for evaluating the economic, social, and environmental impacts of tourism. The effect of tourism recovery is demonstrated by comparing the systemic impacts of revenge tourism after lifting the restrictions with the average impacts of tourism during the lockdown. Findings reveal significant regional and sectoral disparities in the process of tourism recovery, with different destinations facing unique challenges. While the reconstruction of tourism in most regions shows a notable contribution to SDG 8, the contribution to SDG 12 remains relatively modest. This study contributes to sustainable tourism literature and to the widening debates on building resilience in the tourism ecosystem.

To address the issue of active suspensions requiring additional energy sources and the low vibration energy recovery efficiency of semi-active suspensions, this paper proposes a new electromagnetic linear power-feeding semi-active suspension and verifies its energy recovery efficiency. The study is carried out from four aspects: theoretical research, simulation model establishment, prototype assembly, and experimental data analysis. The results show that under a 1 Hz, 120 mm vibration input, the simulation recovery voltage peak of the Electromagnetic Linear Actuation-Energy Reclaiming Device (ELA-ERD) reaches 80.7 V, and the average power feeding in the simulation is 89.8 W. The performance test of the physical ELA-ERD is carried out using a damper comprehensive performance test bench paired with the Dspace testing system, under the same 1 Hz, 120 mm input. The test recovery voltage peak reaches 66.2 V, and the average power feeding is 73.6 W, the energy recovery effect has been enhanced by 75%, which means the experimental power feeding effect reaches 82% of the simulation result. The electromagnetic linear power-feeding semi-active suspension can effectively improve the low vibration energy recovery efficiency of semi-active suspensions, providing important technical support for the improvement of vehicle suspension performance.

Research Aims: This study aims to analyze the impact of AI implementation on the labor market by integrating the Maqashid Syariah perspective as an ethical framework. Methodology: This research employed a qualitative approach with library research methods. Data was collected from journals, books, research reports, and academic publications. Analysis was conducted using content analysis through data reduction, presentation, and drawing conclusions. Research Findings: The implementation of AI has three main effects on the labor market: (1) productivity effect, namely increased efficiency, productivity, and work safety, (2) replacement effect, namely the shift in human roles due to automation, especially in routine work, and (3) recovery effect, namely the creation of new jobs that require high skills and digital competencies. AI increases productivity and opens up new job opportunities, but also raises challenges such as structural unemployment, skills gaps, and ethical implications. From the perspective of Maqashid Syariah, these impacts can be directed so that technological progress remains oriented towards the benefit through the principles of hifz al-mal (protection of property), hifz al-nafs (protection of life), and hifz al-'aql (protection of reason). Theoretical Contribution: This research integrates Islamic ethics in understanding the transformation of the digital labor market. Research limitation and implication: This research is limited to literature sources without empirical data support. The implications of this research can form the basis for formulating inclusive and sustainable employment policies.

Purpose: The accumulation of lactic acid in muscle cells during intense exercise can decrease muscle and blood pH, leading to weakened muscle contractions and fatigue. The purpose of this study was to determine the effect of active recovery (jogging) on reducing blood lactate levels after a 400-meter sprint in male college students. Materials and Methods: An experimental study with a randomized control group and a pretest-posttest design was used. Twenty subjects were randomly divided into two groups of 10: a treatment group with active recovery (jogging) and a control group with passive recovery (sitting). Lactate levels were measured twice: after running and after a 5-minute recovery period. Data analysis used in this study included descriptive tests, normality tests, paired-samples t-tests, and independent-samples t-tests. Result: The research results show that active recovery significantly reduces lactate levels from an average of 16.88±3.28 mMol/L to 9.97±1.28 mMol/L, whereas passive recovery reduces them only from 16.55±2.37 mMol/L to 15.63±2.08 mMol/L. The paired t-test results showed a significant difference (p < 0.05) between the two recovery methods. Conclusion: These findings indicate that active recovery is more effective in accelerating the reduction of lactic acid levels, reducing the risk of muscle fatigue, and enhancing athletes' readiness for subsequent training or competitions.

The office environment significantly influences employees’ work efficiency and health. With the increasing prevalence of modern, enclosed and monotonous office settings, employees often work under high-intensity conditions for extended periods. This situation leads to physiological and psychological fatigue, which in turn affects work efficiency and overall well-being. This study explores how olfactory stimulation influences physiological and psychological fatigue in office environments. It also examines its effects on cognitive recovery. Through market research and user surveys, three types of scents were selected as experimental materials (floral, fruity, and forest scents). Utilizing multi-channel fatigue identification technology and wearable biosensors, the study monitored in real-time the physiological responses of employees to different olfactory stimuli, such as pupil diameter, heart rate variability (HRV), electromyography (EMG), and electroencephalogram (EEG) signals. Additionally, subjective evaluation questionnaires were used to comprehensively assess the effects of olfactory stimulation on psychological fatigue. The results showed that all three olfactory interventions to some extent alleviated employee fatigue and improved cognitive abilities. Among them, the floral intervention had a better effect on the recovery of physiological fatigue, the fruity intervention had a better effect on the recovery of psychological fatigue and cognitive abilities, and the forest intervention had a slightly inferior recovery effect but could effectively reduce time load. This research aims to provide new ideas for the design of sustainable office working environments. Introducing appropriate olfactory stimuli can effectively alleviate employees’ office fatigue, enhance their work efficiency and overall well-being.

In recent years, the production of tight reservoirs with waterflooding in China has entered a progressively declining phase with unstable oil rate and higher water cut, rising challenges to any further enhancement of oil recovery. Targeting the high water cut and complex pore structure characteristics typical of these reservoirs, this work evaluates the reservoir compatibility of a microspheres-alternating-nanoemulsion flooding process and optimizes its injection strategy. Representative reservoir scenarios were first established; laser-particle-size analyzers and other laboratory instruments were then employed to quantify formulation-reservoir compatibility. A multiscale numerical study has been performed with CMG-STARS v.2022. The core-scale simulations systematically examined the influence of key factors on displacement efficiency improvement and water cut reduction, matched with the experimental results of core flooding tests. The combined experimental/numerical workflow furnishes a theoretical framework for optimizing the injection scheme. Beyond assessing formulation compatibility, the study delivers optimized injection parameters and strategies for microspheres-alternating-nanoemulsion flooding, providing both theoretical analysis and practical technology reference for improving oil recovery in tight reservoirs with higher water cut. Specifically, when the microsphere concentration increased from 0.1% to 0.3%, the minimum water cut was reduced by approximately 5%, while further concentration increases showed no significant additional impact on water content. Compared with water flooding, the relative permeability curve of the microspheres-alternating-nanoemulsion flooding system shifted entirely to the right. Numerical simulation of representative well groups revealed that a slug design with a microsphere-to-nanoemulsion ratio of 1:3 yielded the optimal enhanced oil recovery effect, and after ten years of production, the recovery factor increased by 0.46%.

Abstract Layered oxide cathodes have garnered increasing attention in the field of sodium‐ion batteries (SIBs) owing to high specific capacity, excellent cyclability, and scalable synthesis processes. However, residual alkali species accumulate on the surface during the synthesis process, accompanied by irreversible lattice oxygen release and unstable cathode‐electrolyte interface, which trigger structural degradation. Herein, we propose a carbonate buffer solution to remove residual alkalis, construct a disordered sodium‐enriched layer, reducing the initial Mn oxidation state increases the discharge capacity by 67.1% (136.7 mAh g −1 ). Near‐surface reconstruction not only blocks the direct contact between electrolyte and bulk structure, but also provides a low‐energy barrier channel for ion transport. Dual strategy combining an additional electrochemical presodiation enhances the cycling stability, yielding 90.1% capacity retention after 100 cycles (versus 58.6% in pristine sample). Active Na + injected into P2‐type NLMFO (Na 0.7 Li 0.2 Mn 0.7 Fe 0.1 O 2 ) activates fully Mn 4+ /Mn 3+ redox reaction and retaines O 2 − /O n − (n<2) lattice oxygen activity, suppresses the Jahn‐Teller effect and compensates for Na deficiencies. The lattice structure recovery effect renders phase transition more reversible, reduces internal stress accumulation and improves structural stability. The results demonstrate that washing and presodiation dual synergistic strategy achieves surface reconstruction, meets requirements for energy density, durability, and safety of next‐generation SIBs.

INTRODUCTION. Speech disorders such as aphasia and dysarthria often occur in patients after a stroke. They are considered second only to motor disorders in terms of severity. Aphasia is one of the most common speech disorders. Due to the vast size of Russia, there are remote communities without qualified speech therapists to restore lost speech function. AIM. To study the available scientific data on the effectiveness of motor aphasia recovery in patients who have suffered ischemic stroke in a remote format. MATERIALS AND METHODS. We searched for publications, including 6 meta-analyses, 39 full-text and 16 review publications in Russian and English in the eLIBRARY.RU, PubMed, and Springer Nature Link databases. The search period for publications on remote rehabilitation methods for stroke patients with complex motor aphasia was five years, from January 2020 to February 2025. The review also included a number of earlier seminal works on speech recovery in patients after stroke with complex motor aphasia. Key words in Russian and English are as follows: stroke, complex motor aphasia, rehabilitation, telemedicine, remote format. RESULTS AND DISCUSSION. Remote patient management in the rehabilitation of motor aphasia is becoming increasingly necessary. This article analyzes available data on the effective use of remote methods for the rehabilitation of patients with motor aphasia. CONCLUSION. Telemedicine technologies and mobile applications represent a promising area in remote rehabilitation of patients after ischemic stroke with motor aphasia.

To develop and validate a rapid, sensitive, and selective LC - MS/MS method for quantifying polmacoxib (POL) in rat plasma and integrating for preclinical pharmacokinetic evaluation. POL was quantified using LC - MS/MS on a Varian C8 column with an isocratic mobile phase of methanol and 2 mM ammonium acetate (90:10, v/v; 0.4 mL/min) with run time of 6 min. Detection employed negative ion electrospray and MRM (m/z 360 → 296 for POL; m/z 313 → 257 for rofecoxib as IS). The method was validated as per USFDA guidelines. Male Sprague - Dawley rats received a single oral dose of 10 mg/kg POL, and plasma samples were collected up to 72 h. The method showed linearity (1.56-800 ng/mL, r2 = 0.9994), LLOQ 1.56 ng/mL, and acceptable accuracy, precision, recovery, and matrix effects. Pharmacokinetics: Cmax 643 ± 32 ng/mL, Tmax 4 h, T1/2 10.4 ± 0.8 h, AUC0-∞ 5326 ± 106 ng*h/mL. The validated assay is robust, sensitive, and suitable for pharmacokinetic, bioequivalence, and drug - drug interaction studies of POL.

Oxidative damage is induced by reactive oxygen species, which leads to protein denaturation and subsequently triggers various diseases. Antioxidant peptides represent an effective approach for treating oxidative damage. In this study, a non-natural peptide library with antioxidant properties was designed. The effective antioxidant peptide CVAGVA was isolated from the peptide library through chromatographic and mass spectrometry analyses. The Fukui index and various chemical evaluation results indicated that CVAGVA was a more efficient antioxidant peptide. Experiments using a cell oxidative damage model confirmed that this peptide can effectively scavenge reactive oxygen species within cells and mitigate the damage effect. This article established models of sunburn, liver injury, keratitis, burns, etc. in mice. The results demonstrated that CVAGVA increased the treatment and recovery rate of sunburn by approximately 20% and enhanced the treatment effect of carbon tetrachloride-induced liver injury by approximately 16.7%. It can safeguard collagen in skin tissue and reduce the inflammatory response during long-term ultraviolet exposure. Regarding keratitis prevention, the recovery effect of CVAGVA was approximately 15% higher than that of glutathione. When CVAGVA was loaded onto zinc alginate hydrogel for burn treatment, the therapeutic effect was approximately 33.3% higher compared to the treatment without CVAGVA. These experiments have verified that the synthesized non-natural antioxidant peptides exhibit excellent antioxidant performance.

This study examines the effect of interactional justice, procedural justice, and distributive justice on customer loyalty through recovery satisfaction and service quality among carwash customers in Jabodetabek. Using a quantitative method with SEM-PLS analysis, 135 active carwash customers who experienced service failure participated in this research. Results show that distributive justice significantly influences recovery satisfaction. Furthermore, procedural justice strongly impacts overall satisfaction. Service quality plays a critical role in determining both satisfaction and customer loyalty. The findings underscore the importance of justice dimensions and service quality in enhancing customer satisfaction and loyalty after service failure recovery in the carwash industry

Introduction: Perineal wounds are among the most common complications experienced by postpartum mothers, contributing to discomfort, delayed recovery, and increased risk of puerperal infection. One non-pharmacological treatment widely used in Indonesian traditional medicine is betel leaf (Piper betle) decoction, which contains antibacterial, antiseptic, and anti-inflammatory compounds that may support tissue healing. Despite its extensive use, scientific evidence regarding its effectiveness in perineal wound recovery remains limited, particularly within primary healthcare settings. This study aimed to analyze the effect of betel leaf decoction on perineal wound healing among postpartum mothers in the working area of BLUD UPT Puskesmas Cina. Methods: This quantitative research applied a pre-experimental posttest-only control group design. The study involved 44 postpartum mothers with first- and second-degree perineal wounds selected through purposive sampling. The intervention group received betel leaf decoction treatment twice daily for four days, while the control group received standard postpartum care. Wound healing was assessed using the REEDA scale (Redness, Edema, Ecchymosis, Discharge, Approximation). Data were analyzed using univariate and bivariate techniques to compare healing outcomes between groups. Results: The findings showed that mothers who received betel leaf decoction demonstrated significantly faster wound healing, as reflected by lower REEDA scores compared to the control group. Improvements were observed in reduced redness, edema, and better wound approximation within the first week postpartum. Conclusion: Betel leaf decoction is effective in accelerating perineal wound healing among postpartum mothers. Its traditional use is supported by empirical evidence, indicating potential as a safe, accessible, and affordable complementary therapy in maternal care

Gait analysis provides objective, quantitative parameters essential for assessing mobility, identifying movement impairments, and monitoring the progress of rehabilitation. While traditional lab-based systems offer high accuracy, wearable Inertial Measurement Units (IMUs) enable portable, cost-effective gait assessments outside the laboratory environment. However, the reliability and applicability of IMU-derived data across diverse populations and walking conditions require robust datasets. This paper presents a lower limb kinematic dataset acquired with the Xsens Awinda IMU system. Data were collected from 92 unique participants: healthy adults (n = 25), healthy adolescents (n = 27), and individuals with ACL injuries assessed before surgery (n = 40), with 27 completing a follow-up three months post-reconstruction. Participants walked overground at self-selected slow, normal, and fast speeds. The dataset contains spatiotemporal parameters, as well as lower limb joint kinematics. It enables research on normative gait across age groups, the effects of ACL injury and early recovery on movement patterns, and the development of IMU-based gait analysis methods under different walking speeds and clinical conditions.

HighlightsWhat are the main findings?Only proximal-to-distal kinesiology taping produced a significant increase in muscle oxygenation (SmO2) after fatiguing exercise.No significant intergroup differences were observed in grip strength, pressure pain threshold, or total hemoglobin.What are the implications of the main findings?The KT direction may transiently enhance local muscle oxygenation, suggesting a potential circulatory effect.Further studies are needed to determine the clinical or performance relevance of these acute physiological responses.Background/Objective: Kinesiotaping (KT) is widely used in sports and rehabilitation; however, evidence regarding its acute physiological effects on strength, pain sensitivity, and muscle oxygenation remains inconsistent. This study aimed to examine the acute effects of forearm KT on maximal grip strength, pressure pain threshold (PPT), and muscle oxygenation in healthy, physically active adults who performed a fatiguing exercise protocol. Methods: A randomized controlled trial was conducted with 28 participants (56 forearms), each randomly assigned to one of four conditions: KT applied proximal-to-distal, KT applied distal-to-proximal, placebo taping (no tension), or no taping (control). All assessments were performed within a single session, before and after a standardized forearm fatigue protocol. The outcomes included maximal and average grip strength (digital dynamometer), PPT (digital algometer), muscle oxygen saturation (SmO2) and total hemoglobin (THb) measured using near-infrared spectroscopy (NIRS). Data were analyzed using two-way ANOVA (time × group) with Bonferroni-adjusted post hoc tests. Results: All groups showed significant within-group reductions in grip strength after the fatigue protocol (Δ −2.8 to −7.9 kg; all p ≤ 0.01), confirming the effectiveness of fatigue induction. Between-group analysis revealed a significant effect only for SmO2 (p < 0.001; η2p = 0.317), with the proximal-to-distal KT group showing the largest post-fatigue increase (Δ +22.4; p < 0.001; Cohen’s d = 2.99) in SmO2. However, a comparable increase in SmO2 was also observed in the control group, suggesting a possible nonspecific reperfusion or oxygenation recovery effect. No between-group differences were observed in THb (p = 0.061), maximal grip strength (p = 0.092), average grip strength (p = 0.465), or PPT (p = 0.431). Conclusions: In healthy, physically active adults, forearm kinesiotaping did not produce significant acute effects on grip strength, pain threshold, or total hemoglobin levels following fatigue. Although a transient increase in SmO2 was observed with proximal-to-distal taping, this change likely reflects a non-specific post-fatigue reperfusion response rather than a direct enhancement of perfusion. These findings support a physiological, rather than clinical, interpretation of KT’s effects. Future studies should include clinical or athletic populations and explore whether repeated applications produce cumulative adaptations in muscle oxygenation and recovery processes.