Present wound care techniques are primarily visual and entail repeated visits to the clinics. A biosensing system that can provide direct longitudinal measures of lesion healing and tissue recovery can assist to bridge the time between occurrence of a wound and its effective management. The correlation of purine precursors with wounds is well established. Products of the purine metabolic pathway, xanthine and uric acid, are known to have high correlation with wound chronicity and healing. With increased breakdown of cells, the concentrations of these analytes reportedly increase with increased reactive oxygen species (ROS) to promote healing. This work explores the biochemical pathway of purine metabolism and provides a method for continuous monitoring of healing on a multimodal sensing platform. This system employs the enzymes xanthine oxidase and uricase, known to be stable at an alkaline pH, for specific detection of the respective analytes. pH of a wound changes from alkaline to acidic as a wound heals, shifting the potential of detection. This has been addressed by the integration of a pH sensor on the same platform, enabling real-time calibration and providing a thorough assessment of underlying tissue recovery.