Reaction Times For Correct Responses Research Articles

Estimating person-specific neural correlates of mental rotation: A machine learning approach.

Using neurophysiological measures to model how the brain performs complex cognitive tasks such as mental rotation is a promising way towards precise predictions of behavioural responses. The mental rotation task requires objects to be mentally rotated in space. It has been used to monitor progressive neurological disorders. Up until now, research on neural correlates of mental rotation have largely focused on group analyses yielding models with features common across individuals. Here, we propose an individually tailored machine learning approach to identify person-specific patterns of neural activity during mental rotation. We trained ridge regressions to predict the reaction time of correct responses in a mental rotation task using task-related, electroencephalographic (EEG) activity of the same person. When tested on independent data of the same person, the regression model predicted the reaction times significantly more accurately than when only the average reaction time was used for prediction (bootstrap mean difference of 0.02, 95% CI: 0.01-0.03, p < .001). When tested on another person's data, the predictions were significantly less accurate compared to within-person predictions. Further analyses revealed that considering person-specific reaction times and topographical activity patterns substantially improved a model's generalizability. Our results indicate that a more individualized approach towards neural correlates can improve their predictive performance of behavioural responses, particularly when combined with machine learning.

Association between attention performance and the different dimensions of DSM-5 depression symptoms.

Depressive symptoms can be assessed with self-reported questionnaires, such as the Patient Health Questionary-9 (PHQ-9). Previous studies have suggested that the PHQ-9 items can be grouped into somatic and non-somatic clusters. However, the classification of the PHQ-9 item "concentration difficulties" into somatic or non-somatic is still controversial. This controversy may be explained by difficulties experienced by subjects in accurately evaluating their attention problems. The primary objective of this study was to determine the correlation between objective attentional performance and the two clusters of depressive symptoms in hospital employees working in stressful conditions. The participants filled out the PHQ-9 to identify their depressive symptoms. Based on the PHQ-9, the somatic or non-somatic symptoms were measured without considering the question about subjective concentration difficulties. Then, a brief version of the Continuous Visual Attention Test (CVAT) was applied to assess four attentional subdomains. The CVAT is a Go/No-go task that measures number of correct responses (focused attention), number of incorrect responses (behavior-inhibition), average reaction time of correct responses (RT-alertness), and variability of reaction time (VRT-sustained attention). The entire task lasted 90 s. Correlation analyses assessed the relationships between attentional performance and the two dimensions of depressive symptoms. After applying the inclusion/exclusion criteria, 359 individuals were selected. Their age ranged from 20 to 70 years (mean = 40.5, SD = 10.37), and the majority was female (67.6%). A predominance in somatic depressive symptoms was present in 231 (64%) participants, whereas 59 (16%) showed a predominance of non-somatic symptoms. Sixty-nine participants (20%) did not show any predominance. Higher somatic scores were associated with higher RTs, whereas higher non-somatic scores were related to an increase in the number of incorrect responses. The predominance of the somatic cluster was related to lower alertness, whereas the predominance of non-somatic cluster was associated with impulsivity/hyperactivity. This result may explain the difficulties associated with correctly classifying the item concentration difficulties. A brief attentional task can be used as an auxiliary tool to correctly identify the different dimensions of attention that are associated with different clusters of depressive symptoms.

0163 Impact of cold-water hand immersion on cognitive performance and sleepiness during sleep inertia

Abstract Introduction Sleep inertia is a state of impaired cognitive performance upon awakening that dissipates with time awake. Manipulation of the distal-to-proximal skin temperature gradient using cold water has been hypothesized as a potential countermeasure to sleep inertia, but not previously explored (Krauchi et al., 2004). This study examined the effects of cold-water hand immersion on subsequent cognitive performance and sleepiness during sleep inertia. Methods Ten healthy adults (mean±standard deviation [SD] age 23.2±4.96 years; 6M, 4F) have thus far completed an ongoing 8-day protocol. Prior to an overnight in-laboratory visit, participants maintained habitual 8h sleep schedules for 1 week at home. In-laboratory sleep opportunities were timed to coincide with habitual sleep time. Following at least 5-min of electroencephalogram (EEG) verified continuous slow wave sleep (SWS), participants were awakened twice during the night to submerge their non-dominant hand in warm (34 C) or ice-cold water (0 C) for 3 min in a randomized, crossover design. Sleep inertia was assessed with a Mathematical Addition Test (ADD) and the Karolinska Sleepiness Scale (KSS) at ~ 5, 15, and 25 min after each awakening. Outcomes included number of correct responses and median reaction time for correct responses on the ADD and KSS scores. Data were analyzed with mixed-model ANOVA with condition, condition order and time since awakening as fixed factors and subject as a random factor. Results The average (Mean±SD) amount of SWS prior awakening was similar before the cold 7.0±2.3 min and warm 6.6±1.0min conditions (p&amp;gt;0.10). Following cold water immersion, subjective sleepiness was reduced and the median reaction time for correct responses was faster compared with warm water immersion (main effects of condition, p’s&amp;lt; 0.05). The number of correct responses was not significantly different between conditions, nor were there any significant interaction effects among the fixed factors. Conclusion These preliminary findings indicate that cold-water hand immersion may reduce sleepiness and increase the speed of arithmetic calculations during sleep inertia, which could have important implications for military and first responders performing after awakenings from sleep. Support (if any) Office of Naval Research MURI N00014-15-1-2809; NIH RHL165343A and CTSA Grant UL1 TR002535; Undergraduate Research Opportunities Grant, University of Colorado Boulder.

Reaction times of correct and incorrect performances are highly correlated no matter age groups but older age affects accuracy and speed relationships in the Wisconsin Card Sorting Test

AbstractBackgroundThe detection of non‐amnestic Mild Cognitive Impairment with difficult tasks as the Wisconsin Card Sorting Test (WCST) is still under debate. Associations concerning performance and/or speed are not usually evaluated even though speed decreases with age and so, the WCST may be preferentially administered in a computerized format. Therefore, 3 types of relationships were looked for: 1) between reaction times (RT) of correct and incorrect answers; 2) between the percentage of correct responses and RT of correct responses; and lastly, 3) between the percentage of incorrect responses and RT of incorrect responses.MethodTwo age groups, one group of executives of the INEGI (National Institute of Statistics, Geography and Informatics) (n = 12, 46.71 ± 5) and another one of older adults (OAs) who attended a “Centro Gerontológico Integral” in the state of Hidalgo in Mexico (n = 17, 66.35 ± 6) were evaluated.ResultThe RT of correct and incorrect performances were highly correlated for both groups (INEGI group: r = 0.80, p = 0.01; OAs: r = 0.89, p = 0.01). Instead, the correlations between performance and speed were only negatively related for the percentage of correct responses and RT of correct responses in the group of the INEGI (r = ‐ 0.72, p = 0.02), while they had a tendency to be positive in OAs although not significant (r = 0.43, p = 0.10). The percentage of incorrect responses and RT of incorrect responses was positive and significant for the group of the INEGI (r = 0.84, p = 0.01) and tended to be negative and not significant for OAs (r = ‐ 0.48, p = 0.10).ConclusionA positive correlation between RT of correct and incorrect answers was found, suggesting a consistent speed within subjects no matter the performance. A negative correlation was found for the percentage of correct responses and RT of correct responses in the group of the INEGI. However, this late relationship and the one concerning wrong performance was not confirmed for OAs, indicating that speed when decision making and problem solving are assessed suffer from severe alterations with age.

Transient Modulation of Working Memory Performance and Event-Related Potentials by Transcranial Static Magnetic Field Stimulation over the Dorsolateral Prefrontal Cortex

Transcranial static magnetic field stimulation (tSMS) can modulate human cortical excitability and behavior. To better understand the neuromodulatory effect of tSMS, this study investigates whether tSMS applied over the left dorsolateral prefrontal cortex (DLPFC) modulates working memory (WM) performance and its associated event-related potentials (ERPs). Thirteen healthy participants received tSMS or sham stimulation over the left DLPFC for 26 min on different days. The participants performed a 2-back version of the n-back task before, during (20 min after the start of stimulation), immediately after, and 15 min after the stimulation. We examine reaction time for correct responses, d-prime reflecting WM performance, and the N2 and P3 components of ERPs. Our results show that there was no effect of tSMS on reaction time. The d-prime was reduced, and the N2 latency was prolonged immediately after tSMS. These findings indicate that tSMS over the left DLPFC affects WM performance and its associated electrophysiological signals, which can be considered an important step toward a greater understanding of tSMS and its use in studies of higher-order cognitive processes.

Voxel-Mirrored Homotopic Connectivity Associated With Change of Cognitive Function in Chronic Pontine Stroke.

Recent neuroimaging studies have shown the possibility of cognitive impairment after pontine stroke. In this study, we aimed to use voxel-mirrored homotopic connectivity (VMHC) to investigate changes in the cognitive function in chronic pontine stroke. Functional MRI (fMRI) and behavioral assessments of cognitive function were obtained from 56 patients with chronic pontine ischemic stroke [28 patients with left-sided pontine stroke (LP) and 28 patients with right-sided pontine stroke (RP)] and 35 matched healthy controls (HC). The one-way ANOVA test was performed for the three groups after the VMHC analysis. Results showed that there were significant decreases in the bilateral lingual gyrus (Lingual_L and Lingual_R) and the left precuneus (Precuneus_L) in patients with chronic pontine ischemic stroke compared to HCs. However, in a post-hoc multiple comparison test, this difference remained only between the HC and RP groups. Moreover, we explored the relationship between the decreased z-values in VMHC and the behavior-task scores using a Pearson's correlation test and found that both scores of short-term memory and long-term memory in the Rey Auditory Verbal Learning Test were positively correlated with z-values of the left lingual gyrus (Lingual_L), the right lingual gyrus (Lingual_R), and the left precuneus (Precuneus_L) in VMHC. Besides that, the z-values of Precuneus_L in VMHC were also negatively correlated with the reaction time for correct responses in the Flanker task and the spatial memory task. In conclusion, first, the lingual gyrus played an important role in verbal memory. Second, the precuneus influenced the working memory, both auditory-verbal memory and visual memory. Third, the right-sided stroke played a greater role in the results of this study. This study provides a basis for further elucidation of the characteristics and mechanisms of cognitive impairment after pontine stroke.

Deficits of sustained attention in pediatric obsessive-compulsive disorder comorbid with Tic disorders

BackgroundPediatric obsessive-compulsive disorder (OCD) and Tourette syndrome/chronic tics (tic disorders, TD), are associated with attention-deficit hyperactivity disorder (ADHD). Deficits in sustained attention are a core deficit in ADHD which can be captured by continuous performance tests (CPT). CPT data are used to examine deficits in sustained attention in youth with OCD, TD or both, and OCD symptom factors, to characterize the deficits in sustained attention in OCD and TD, testing the hypothesis whether comorbid OCD + TD is distinct from OCD only or TD only. MethodsA clinical registry of youth with OCD and/or TD included data on sustained attention, obtained with the Conner's CPT Test II (CPT-II). The CPT-II spans six time-blocks, capturing values for the capacity for sustained attention. The main outcome measure is the variability in the standard error (SE) of reaction time (RT) for correct responses (RT-SE), which is considered a core ADHD trait. Higher RT-SE values reflect a lack of uniformity in responses and is considered to reflect a deficit in sustained attention. Using generalized linear models (GLM), RT-SE is measured over the six time-blocks in three groups: OCD only, TD only and OCD + TS, with sex and age groups as moderators. Clinical ADHD diagnoses were contrasted between diagnostic groups while OCD dimensions (contamination-washing, aggressive-somatic, sexual-religious, counting-checking-repeating and hoarding) were tested for their effect on sustained attention. ResultsDeficits in sustained attention are significantly greater in the comorbid OCD + TD compared to OCD only and TD only, with the greatest differences apparent in blocks 5 and 6 (p < .001). While sex does not moderate sustained attention deficits, the higher RT-SE in blocks 5 and 6 is only seen in the younger age group (7–11 years), but not in adolescents (12–17 years). As expected, clinical ADHD is more prevalent in youth with comorbid OCD + TS (67%) compared to OCD only (21%) or TD only (33%) (p = .0002). The hoarding group, characterized by more frequent clinical ADHD diagnoses, has higher RT-SE for time blocks 3,4,5,6 compared to non-hoarders. Participants with contamination-washing symptoms, characterized by more prevalent anxiety disorders, have higher RT-SE than those with no contamination-washing symptoms for time block 4. ConclusionDeficits in sustained attention are associated with comorbid OCD + TD compared OCD only or TD only, evident only in a younger age group. Sustained attention deficits are also more common in youth with ADHD, OCD hoarding and OCD contamination-washing symptoms. In summary, sustained attention deficits are intrinsic to the comorbid OCD + TD group, suggesting a compounded developmental insult specific to sustained attention which tends to resolve by adolescence. A mechanistic commonality to sustained attention, tic disorders and OCD-related extinction learning may be aberrant oscillatory brain phenomena.

Reaction Time of Erroneous Responses in the Go/No-Go Paradigm.

Reaction time (RT) of erroneous responses in go/no-go tasks tends to be shorter than RT of correct responses. An opposite difference has been reported ( Halperin, Wolf, Greenblatt, & Young, 1991 ) which could be attributed to differences in go trial probability, or to high memory demand. Two experiments aimed here to test these two explanations, a simultaneous matching task with low memory load (Experiment 1), and a sequential matching task with high memory load (Experiment 2). Go trial probability was also manipulated. Short false positive RT was obtained only in the sequential matching task with high go trial probability, while long false positive RT was obtained in the other three conditions. Low go trial probability and high memory load were both found to be sufficient, by themselves, to create long false positives attributable to confusion. Short false positives in the high go trial probability/low memory load condition were attributed to failure of response inhibition.

Relations between a laboratory-based sustained attention task and traffic violations in an Iranian sample of drivers

The role of cognitive abilities regarding driver behavior is crucially important in the occurrence of traffic violations and preventing tragic motor vehicle collisions. Sustained attention is one cognitive ability that may contribute to safe driving behavior. The present study investigated the relation between sustained attention and traffic violations. One hundredand one Iranian male drivers (age: M = 37.17, SD = 8.37) with at least 2 years driving experience voluntarily participated in the study. Participants were categorized into two groups based on the number of driving rule violations they committed over the last 2 years (n = 48 clean record, n = 53 violators). Sustained attention was measured by performance on the Conjunctive Continuous Performance Task (CCPT). Four CCPT performance measures were computed: (1) Mean reaction time for correct responses (M-RT); (2) standard deviation of reaction times for correct responses (SD-RT); (3) percent of omission errors (failure to respond to target stimulus); (4) percent of commission errors (identification of a non-target stimulus as target). Results showed after controlling for age and education, there was a significant group difference on M-RT, indicating that individuals with no traffic violations had faster reaction times as compared to those who had 1 or more traffic violations. No effect of group on any of the other outcomes was present after correcting for alpha inflation. When assessing the effect of age and education, education was significantly related to average reaction time and percent of omission errors. No significant effect of age was apparent. Findings suggest cognitive function, specifically sustained attention measured with a laboratory-based measure, may be associated with safe driving behavior.

Comparison of Perimeters: Intuitive Interference in People who Are Blind

Introduction Difficulties in science and mathematics may stem from intuitive interference of irrelevant salient variables in a task. It has been suggested that such intuitive interference is based on immediate perceptual differences that are often visual. Studies performed with sighted participants have indicated that in the comparison-of-“perimeters” task, “area” was the irrelevant salient variable. Such studies have consistently shown that accuracy is higher and reaction times for correct responses are shorter in congruent trials (no interference of area), than in incongruent trials (interference of area). Methods Fifteen participants who are blind completed a comparison-of-area and a comparison-of-perimeters tasks, each in a different session. In each comparison trial, the participants explored two tactile geometrical shapes using both hands. To collect the participants’ responses and reaction times, the researchers used a Microsoft Excel Macro file designed for this study. Results Findings demonstrated that for both rate of correct responses and their reaction times, the performance pattern resembled the one observed previously for sighted participants. In addition, reaction times that were observed there were about five times longer compared to those observed previously for sighted participants. Discussion These findings indicated that interference of area in comparison to perimeters is evident for participants who are blind. They further suggest that, in mathematics, people who are blind experience interference that had previously been assumed to be tied to visual perception. Implications for practitioners The study suggests that interference of salient irrelevant variables could cause difficulties in science and mathematics for students who are blind. This knowledge could guide educators and curriculum developers for these students in selecting appropriate learning and instruction methods. In addition, the current findings point to the additional amount of time needed to access graphical information tactilely compared to visually.

Interference in Geometrical Stoop like Task among Different Handed Persons

The Geometrical Stroop like task was administered to study the amount of interference in different handed persons in naming geometrical word and their shape when stimuli were presented in two different conditions congruent and incongruent in two visual fields (RVF and LVF). It was hypothesized that, the ability of visual perception can be differing of a person in terms of their handedness. 149 subjects were voluntary participated in this study in which 80 subjects were predominantly Right handed and rest of them were non-right handed, between 17 and 21 years old. Each pair of stimulus was presented for 180msec preceded by a fixation dot for 2000msec. Subjects were asked to respond as fast and as accurately as they could either the geometrical words or the shape or both, depending upon the conditions. Reaction times of correct responses were analyzed. As expected, the results of this study on the basis of Stroop-like experiment give us enough findings in support of hypothesis. The findings of current study indicate that congruency effect in both of the groups. A significantly higher accuracy rates were obtained in non right handed person under the Stroop interference condition. Under this same condition, reaction time analysis yielded also significant differences between two groups.

Impact of sleep inertia on visual selective attention for rare targets and the influence of chronotype.

Sleep inertia is affected by circadian phase, with worse performance upon awakening from sleep during the biological night than biological day. Visual search/selective visual attention performance is known to be sensitive to sleep inertia and circadian phase. Individual differences exist in the circadian timing of habitual wake time, which may contribute to individual differences in sleep inertia. Because later chronotypes awaken at an earlier circadian phase, we hypothesized that later chronotypes would have worse visual search performance during sleep inertia than earlier chronotypes if awakened at habitual wake time. We analysedperformance from 18 healthy participants [five females (22.1±3.7years; mean±SD)] at ~1, 10, 20, 30, 40 and 60min following electroencephalogram-verified awakening from an 8h in-laboratory sleep opportunity. Cognitive throughput and reaction times of correct responses were impaired by sleep inertia and took ~10-30min to improve after awakening. Regardless whether chronotype was defined by dim light melatonin onset or mid-sleep clock hour on free days, derived from the Munich ChronoType Questionnaire, the duration of sleep inertia for cognitive throughput and reaction times was longer for later chronotypes (n=7) compared with earlier chronotypes (n=7). Specifically, performance for earlier chronotypes showed significant improvement within ~10-20min after awakening, whereas performance for later chronotypes took ~30min or longer to show significant improvement (P<0.05). Findings have implications for decision making immediately upon awakening from sleep, and are consistent with circadian theory suggesting that sleep inertia contributes to longer-lasting impairments in morning performance in later chronotypes.

The Effect of Light-Intensity Cycling on Mood and Working Memory in Response to a Randomized, Placebo-Controlled Design.

Prior attempts to measure psychological responses to exercise are potentially limited by a failure to account for participants' expectations, the absence of a valid exercise placebo, and demand characteristics. The purpose of this study was to explore the main and interactive effects of a manipulation designed to increase expectations about the psychological benefits of an acute bout of active, light-intensity (treatment), and passive (placebo) cycling on mood and cognition. Demand characteristics were attenuated during recruitment, informed consent, and interactions with test administrators by communicating to participants that the study purpose was to assess the effects of active and passive cycling on respiration, heart rate, and muscle activation. A repeated-measures, randomized, placebo-controlled design (n = 60) was used with cycling (active, passive) and information (informed, not informed) as between-subjects factors. State anxiety, feelings of energy, and working memory (percent accuracy and reaction time for correct responses) were measured at baseline (time 1), immediately after cycling (time 2) and 20 minutes after cycling (time 3). Most participants did not guess the purpose of the study (~92%) or expect a reduction in state anxiety (85%) or an increase in energy (80%) or cognitive performance (~93%). Mood and cognitive performance were not improved by active or passive cycling (all p values ≥ .12). The methods used here to disguise the experimental hypotheses provide a potential framework for reducing demand characteristics and placebo responses in future investigations of psychological responses to exercise.

Proportional Reasoning

Abstract. Comparison of ratios is difficult for children and adults. We studied the role of salience and congruity in comparison of ratios using reaction time and functional magnetic resonance imaging (fMRI). Participants were asked to decide which of two mixtures of red and white paint drops (presented in Arabic numerals) was darker. In congruent trials the mixture with more red drops was darker and in incongruent trials it was lighter. Half of the trials were red salience (more red than white drops in both mixtures) and half of them were white salience. Interaction between congruity and salience was observed. Behaviorally, accuracy was higher and reaction time of correct responses (RTC) was shorter in congruent red salience and incongruent white salience conditions. For these conditions higher activation in a fronto-parietal numerical network was observed in fMRI. These findings suggest that automatic processing of natural numbers supports or suppresses the comparison of ratios as a function of congruity and salience.

An energy-efficient intrinsic functional organization of human working memory: A resting-state functional connectivity study

Working memory (WM) is the active maintenance of currently relevant information that was just experienced or retrieved from long-term memory but no longer exists in the external environment; however, the intrinsic functional organization of the brain underlying human WM performance remains largely unknown. We hypothesize that the intrinsic functional organization of human WM is an energy-efficient system. We tested this hypothesis by analyzing associations between WM performance (reaction times of correct responses) at different task difficulties (2-back and 3-back tasks) and the resting-state functional connectivity density (FCD) and strength (FCS) in 282 healthy young adults. Voxel-based FCD analysis showed that the reaction times were negatively correlated with the FCD values of several brain regions known to be engaged in WM performance: the right inferior parietal lobule and inferior frontal gyrus for both the 2-back and the 3-back tasks and the right superior parietal lobule, supramarginal gyrus, left inferior parietal lobule and bilateral middle occipital gyrus for the 3-back task. Further analyses showed that the FCS values of these regions with several frontal, parietal and occipital regions were also negatively correlated with the reaction times; the 3-back task was associated with much more functional connections than the 2-back task. These findings suggest that the intrinsic working memory network is an energy-efficient and hierarchical system. A simple working memory task is controlled only by the core subsystem; however, a complex working memory task is associated with more nodes and connections of the system.

The objects of visuospatial short-term memory: Perceptual organization and change detection.

We used a colour change-detection paradigm where participants were required to remember colours of six equally spaced circles. Items were superimposed on a background so as to perceptually group them within (a) an intact ring-shaped object, (b) a physically segmented but perceptually completed ring-shaped object, or (c) a corresponding background segmented into three arc-shaped objects. A nonpredictive cue at the location of one of the circles was followed by the memory items, which in turn were followed by a test display containing a probe indicating the circle to be judged same/different. Reaction times for correct responses revealed a same-object advantage; correct responses were faster to probes on the same object as the cue than to equidistant probes on a segmented object. This same-object advantage was identical for physically and perceptually completed objects, but was only evident in reaction times, and not in accuracy measures. Not only, therefore, is it important to consider object-level perceptual organization of stimulus elements when assessing the influence of a range of factors (e.g., number and complexity of elements) in visuospatial short-term memory, but a more detailed picture of the structure of information in memory may be revealed by measuring speed as well as accuracy.

A functional neuroimaging investigation of brain pathways involved in patients during active mania using Stroop Colour Word Test

Introduction Cognitive deficits are characteristic features of mania but their underlying pathways are not well defined. Aims and objectives The present study was conducted to explore the various brain regions implicated in response inhibition in active mania. Methods After obtaining ethical clearance from the Institute Review Board, we recruited 30 subjects with active mania and 15 healthy controls using purposive sampling. Computerized version of the Stroop Colour Word Test was used. Results The two groups were similar on socio-demographic variables. No difference in performance was seen in the two groups on the total number of correct and incorrect responses and reaction times for correct responses on incongruent condition of the Stroop Test. However, subjects in the mania group were quicker in making incorrect responses. During incongruent condition of Stroop test, in the mania group (Fig. 2), only left fusiform gyrus was activated in comparison to the control group (Fig. 1), which had left cingulate gyrus, right frontal lobe, and superior temporal gyrus activation. Discussion It is evident that mania group performed relatively poorly on response inhibition task since they took lesser time to make incorrect responses. This may be explained by the non-activation of frontal areas, responsible for the executive functioning.

Cognitive dysfunction predicts poorer emotion recognition in bariatric surgery candidates.

SummaryObjectiveDeficits in traditional cognitive domains (e.g. executive function and memory) are common in persons with severe obesity, but it is unclear if this pattern of dysfunction extends to social cognition. The present study examined whether cognitive impairment was associated with poorer emotion recognition in bariatric surgery candidates.MethodsOne hundred sixteen bariatric surgery candidates (mean age = 43.62 ± 11.03; 81% female) completed the computerized Integneuro test battery as part of a larger study visit. In addition to assessing traditional cognitive domains, the Integneuro also includes an emotion recognition measure. This task presents 48 faces (eight different individuals depicting neutral, happiness, fear, sadness, anger and disgust), and participants must choose the correct verbal label from six expression options. Number of correct responses and average reaction time for correct responses served as primary dependent variables.ResultsStepwise multiple regression analyses revealed that older age, more maze errors, and history of hypertension predicted less accuracy in emotion recognition (adjusted R 2 = .22, F[3, 111] = 11.86, p < .001) and that slower switching of attention‐digits, worse long‐delay recall, and older age predicted speed of responses (adjusted R 2 = .26, F[3, 111] = 13.00, p < .001).DiscussionResults show that cognitive dysfunction is associated with poorer performance on a computerized test of emotion recognition, consistent with those in persons with a range of psychiatric and neurological disorders. Additional work is needed to clarify the mechanisms and functional impact of these impairments, especially in relation to weight loss following bariatric surgery.

Cognitive Performance Scores for the Pediatric Automated Neuropsychological Assessment Metrics in Childhood-Onset Systemic Lupus Erythematosus.

To develop and initially validate a global cognitive performance score (CPS) for the Pediatric Automated Neuropsychological Assessment Metrics (PedANAM) to serve as a screening tool of cognition in childhood lupus. Patients (n = 166) completed the 9 subtests of the PedANAM battery, each of which provides 3 principal performance parameters (accuracy, mean reaction time for correct responses, and throughput). Cognitive ability was measured by formal neurocognitive testing or estimated by the Pediatric Perceived Cognitive Function Questionnaire-43 to determine the presence or absence of neurocognitive dysfunction (NCD). A subset of the data was used to develop 4 candidate PedANAM-CPS indices with supervised or unsupervised statistical approaches: PedANAM-CPSUWA , i.e., unweighted averages of the accuracy scores of all PedANAM subtests; PedANAM-CPSPCA , i.e., accuracy scores of all PedANAM subtests weighted through principal components analysis; PedANAM-CPSlogit , i.e., algorithm derived from logistic models to estimate NCD status based on the accuracy scores of all of the PedANAM subtests; and PedANAM-CPSmultiscore , i.e., algorithm derived from logistic models to estimate NCD status based on select PedANAM performance parameters. PedANAM-CPS candidates were validated using the remaining data. PedANAM-CPS indices were moderately correlated with each other (|r| > 0.65). All of the PedANAM-CPS indices discriminated children by NCD status across data sets (P < 0.036). The PedANAM-CPSmultiscore had the highest area under the receiver operating characteristic curve (AUC) across all data sets for identifying NCD status (AUC >0.74), followed by the PedANAM-CPSlogit , the PedANAM-CPSPCA , and the PedANAM-CPSUWA , respectively. Based on preliminary validation and considering ease of use, the PedANAM-CPSmultiscore and the PedANAM-CPSPCA appear to be best suited as global measures of PedANAM performance.

Attention system functions and their relationship with self-reported health in patients with brain damage due to tumor

To compare parameters of attention in healthy people and patients with neoplasms in different regions of the cerebral cortex and to evaluate quality of life (QoL) indices with regard to impairment of different attention systems. Twenty patients with oncological lesions of the brain (mean age 56.5±8.8 years) who did not undergo surgery were studied. Tumor localization was confirmed using contrast-enhanced computed tomography, the tumor type was histologically verified. A control group included 18 healthy people matched for age, sex and education level. To determine attention system functions, we developed a computed version of the Attention Network Test. Error rate and reaction time for correct responses to the target stimulus, displayed along with neutral, congruent and incongruent signals, were the indicators of the efficacy of selective processes. QoL indices were assessed using SF-36 health survey questionnaire. The readiness to respond to incoming stimuli was mostly impaired in patients with brain tumors. Efficacy of executive attention, assessed as the increase in the number of errors in selection of visual stimuli, was decreased while temporary parameters of the functions of this system were not changed in patients compared to controls. The SF-36 total score was stable in patients with marked reduction in scores on the Role and Emotional Functioning scales. The most severe health impairment measured on the SF-36 scales of role/social emotional functioning and viability was recorded in patients with the lesions of frontal cortical areas compared to temporal/parietal areas. The relationship between SF-36 Health self-rating and attention systems was found. This finding puts the question of the importance of attention characteristics and QoL for survival prognosis of patients with brain tumors.