Psychological Well-being Of Patients Research Articles

The effect of sitting baduanjin in patients with ST-segment elevation acute myocardial infarction after percutaneous coronary intervention: A quasi-experimental study

BackgroundEarly cardiac rehabilitation plays a crucial role in the recovery of patients with ST-segment elevation acute myocardial infarction (STEMI) following percutaneous coronary intervention (PCI). This study sought to determine the effect of a program of sitting Baduanjin exercises on early cardiac rehabilitation. ObjectiveThe goal of this study was to investigate the effects of sitting Baduanjin exercises on cardiovascular and psychosocial functions in patients with STEMI following PCI. MethodsThis quasi-experimental study employed a randomized, non-equivalent group design. Patients in the intervention group received daily sitting Baduanjin training in addition to a series of seven-step rehabilitation exercises, whereas those in the control group received only the seven-step rehabilitation training, twice daily. Differences in heart rate variability (HRV) indicators, exercise capacity (Six-Minute Walking Distance; 6-MWD), anxiety (Generalized Anxiety Disorder-7; GAD-7), and depression (Patient Health Questionnaire-9; PHQ-9) between the two study groups during hospitalization were analyzed. ResultsPatients in the intervention group exhibited lower rates of abnormalities in the time domain and frequency domain parameters of HRV. The median scores of GAD-7 and PHQ-9 in both groups were lower than those at the time of admission, with the intervention group exhibiting lower scores than the control group (P < 0.001; P < 0.001, respectively). The 6-MWD after the intervention was greater in the intervention group compared to the control group (P = 0.014). ConclusionsWe found that sitting Baduanjin training has the potential to enhance HRV, cardiac function, and psychological well-being in patients with STEMI after PCI. This intervention can potentially improve the exercise capacity of a patient before discharge.

Informed consent in cancer clinical care: Perspectives of healthcare professionals on information disclosure at a tertiary institution in Uganda.

While there have been several studies examining the understanding and quality of informed consent in clinical trials of cancer therapies, there is limited empirical research on health practitioners' experiences on the informed consent process in cancer care, especially from low resource settings. This study explored health professionals' perspectives on information disclosure during the consenting process in cancer care. A qualitative descriptive approach was used to collect data. Face to face interviews were conducted with 10 purposively selected healthcare professionals who were actively involved in soliciting informed consent at a cancer treatment centre in Uganda. A thematic approach was used to interpret the results. There were five key themes, and these included information disclosure to patients; assessment of patients' cancer awareness, treatment preferences and expectations; informed consent practices; barriers to optimal informed consent and information disclosure; and recommendations for improving the consenting process. All respondents appreciated the value of disclosing accurate information to patients to facilitate informed decision making. However, the informed consent process was deemed sub-optimal. Respondents asserted that patients should be the psychological wellbeing of patients should be protected by mentally preparing them before disclosing potentially distressing information. All healthcare professionals were appreciative of the central role the family plays in the consenting process. Overall, informed consent practices were not ideal because of the several challenges. Inadequate time is devoted to information disclosure and patient education; there is lack of privacy; and informed consent documentation is poor. There is a need for significant improvement in informed consent practices and healthcare professional-patient communication.

Psychological and sexological assessment of patients with chronic prostatitis

Purpose: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is characterized by a multiform clinical presentation requiring a differentiated treatment based on different phenotypes including the psychosocial and sexual domains. The aim of this study was assessing the complex correlations between somatic, psychological, and sexual symptoms of CP/CPPS patients. Materials and methods: We performed a cross-sectional study on patients attending a Prostatitis Clinic. Patients were administered the following questionnaires: National Institutes of Health- Chronic Prostatitis Symptom Index (NIH-CPSI), International Prostate Symptom Score (IPSS), International Index of Erectile Function (IIEF), Premature Ejaculation Diagnostic Tool (PEDT), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder 7-item (GAD-7), Oxford Happiness Questionnaire (OHQ), and Temperament Evaluation of Memphis, Pisa, Paris and San Diego Autoquestionnaire (TEMPS-A). Results: Linear regression analyses show highly significant correlations between scores of the NIH-CPSI and the scores of the GAD-7, PHQ-9 and OHQ psychometric questionnaires. IPSS scores correlate significantly with the psychometric scores only when a non-parametric analysis is performed. IIEF and PEDT sexual function scores did not correlate with any of the psychometric tests. NIH-CPSI scores correlate positively with most of the TEMPS-A profiles but the hyperthymic profile correlated negatively with the total and QoL NIH-CPSI and with PEDT scores. Conclusions: Scores measuring anxiety, depression, and psychological well-being in patients with CP/CPPS are strictly correlated with prostatitis-like symptoms although they are poorly correlated with symptoms of prostatism, as measured by IPSS, and not correlated with scores of sexual dysfunctions, as measured by IIEF and PEDT. A hyperthymic temperament may increase resilience against the disease.

Post-inflammatory hyperpigmentation post-acne: possibilities of topical therapy

Post-inflammatory hyperpigmentation (PIH) is one of the most significant problems in patients with acne. The prevalence of PIH among patients with acne varies from 45 to 87%. Post-acne, including PIH, has an extremely negative impact on the quality of life and psychological well-being of patients, as it is often resistant to therapy and can persist for even several years. Successful acne treatment does not guarantee complete elimination of PIH and other post-acne symptoms. In the development of PIH, a key role is played by the mechanism associated with the production and distribution of melanin, which is activated by inflammation and the release of cytokines that promote an increase in the level of immunoreactive tyrosinase, which stimulates melanocytes, activation of melanogenesis and further transfer of melanosomes to surrounding keratinocytes. It is important for clinicians to recognize the psychosocial impact of PIH and manage inflammation, as well as proactively address residual PIH with appropriate treatment. Thus, prevention and correction of PIH should be one of the goals of acne treatment. Topical therapy for PIH in acne is considered the most acceptable and can be prescribed both as monotherapy and as part of combined methods. Tyrosinase is a target for topical anti-pigmentation agents, including hydroquinone, kojic acid, and resorcinyl thiazole derivatives. The latter includes isobutylamidothiazolyl resorcinol – thiamidol. The article provides a brief overview of data on the epidemiology of PIH, its pathogenesis, impact on the quality of life of patients and the perception of their image by people around them. Clinical experience with the use of anti-hyperpigmentation serum with thiamidol, licochalcone A and sodium hyaluronate is presented, which confirms the effectiveness, safety and feasibility of prescribing products with thiamidol for the treatment of PIH caused by acne.

A new way to approach ASD children in Dentistry.

To present an innovative dental approach for children with autism spectrum disorder to the scientific community, along with the 3 questionnaires formulated to evaluate its effectiveness. Development of the 3 questionnaires occurred in five stages: observation of the behaviours of ADS children and their caregivers attending the Dental Department in the year 2021; issues detection: anxiety in parents, crying, difficulty in waiting and hyperactivity of the children, fear of both parents and children; formulation of the questionnaires in order to obtain all the information necessary to assess the patient's psychological well-being; validation with submission of the questionnaires to two specialists; modification and final drafting. Using the 3 questionnaires, the dentist will be able to assess the wellbeing of the patient and his/her family when attending the dental environment, monitor oral hygiene manoeuvres and verify the usefulness of the orthodontic approach to ADS child while creating a trusting relationship with the patient and his/her caregivers.

The Efficacy of Emotion-Focused Psychotherapy on Perceived Stress and Psychological Well-being in Patients with Corona Anxiety during the Pandemic

Objective: The present study aimed to investigate the efficacy of emotion-focused psychotherapy on perceived stress and psychological well-being in patients with corona anxiety during the pandemic. Methods and Materials: This research was conducted using a quasi-experimental design with a pre-test, post-test, and a control group, along with a three-month follow-up period. The study population consisted of individuals suffering from corona anxiety who had contacted counseling centers in Isfahan for telephone counseling during the summer of 2021. Out of the study population, 33 individuals were selected through purposive sampling and randomly assigned to either the experimental or control group. Participants in the experimental group received emotion-focused psychotherapy over two months. The instruments used in this research included the Perceived Stress Scale (Cohen et al., 1983) (PSS), the Psychological Well-Being Questionnaire (Ryff, 1988) (PWBQ), and the Corona Disease Anxiety Scale (Alipour et al., 2019) (CDAS). The data were analyzed using mixed ANOVA with SPSS version 23. Findings: The results indicated that emotion-focused psychotherapy had a significant effect on perceived stress (P&lt;0.0001; Eta=0.59; F=44.99) and psychological well-being (P&lt;0.0001; Eta=0.68; F=66.28) in patients with corona anxiety. Conclusion: Based on the findings of the current study, emotion-focused psychotherapy, utilizing techniques of emotional awareness, emotional experience, regulation, transformation, and change, can be an effective method for reducing perceived stress and improving psychological well-being in patients with corona anxiety.

Comparing the Effectiveness of Acceptance and Commitment Therapy (ACT) and Dialectical Behavior Therapy Skills Training (DBT-ST) on Self-Care and Psychological Well-being in Patients with Type 2 Diabetes

Objective: Diabetes is a chronic, multifaceted, threatening disease with significant psychological consequences. The present study aimed to compare the effectiveness of Acceptance and Commitment Therapy (ACT) and Dialectical Behavior Therapy Skills Training (DBT-ST) on self-care and psychological well-being in patients with Type 2 diabetes. Methods and Materials: The present study was a quasi-experimental, pre-test-post-test with a control group design. The population included all patients with Type 2 diabetes visiting a medical clinic in the city of Sari, among whom 45 were conveniently selected and randomly assigned into two experimental groups (Acceptance and Commitment Therapy and Dialectical Behavior Therapy Skills Training) and one control group. Data were collected using the Self-Care Questionnaire (Toobert et al., 2000), and the Psychological Well-being Scale (Ryff &amp; Keyes, 1995) at three stages: pre-test, post-test, and follow-up, and were analyzed using analysis of variance with repeated measures. Findings: The results showed that both Dialectical Behavior Therapy Skills Training and Acceptance and Commitment Therapy were effective on the scores of self-care and psychological well-being. However, the effect of Acceptance and Commitment Therapy was greater than that of Dialectical Behavior Therapy Skills Training on the scores of self-care and psychological well-being. Conclusion: Based on the results of this study, it can be stated that Acceptance and Commitment Therapy and Dialectical Behavior Therapy Skills Training, through cognitive coping strategies, can lead to the improvement of psychological indicators and enhance the mental and physical health of patients with Type 2 diabetes.

Does Managing Patients With Chronic Rhinosinusitis Improve Their Depression Score? Prospective Study.

To assess the risk of depression in patients with chronic rhinosinusitis (CRS) in a tertiary care center and the effect of treatment on depression scores. This prospective cohort study was conducted at King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia, between November 2021 and June 2022 and included adult patients (≥14 years) with CRS. The validated Arabic or English Sinonasal Outcome Test (SNOT-22) and Patient Health Questionnaire-9 (PHQ-9) were used before treatment and 3 to 6 months after surgery and maximal medical treatment. PHQ-9 scores were compared at baseline and follow-up visits. The relationship between changes in SNOT-22 and PHQ-9 scores were assessed using Spearman's correlation and simple linear regression. Overall, 38 participants with a mean ± SD age of 32.7 ± 12 years were enrolled. CRS with nasal polyps (55.26%) was the most frequently seen condition, followed by allergic fungal CRS (31.58%) and CRS without nasal polyps (13.16%). Six patients (15.7%) had PHQ-9 scores ≥10, indicating they had major depressive disorder. PHQ-9 and SNOT-22 scores improved significantly after treatment (3.7 ± 5.8 vs 6.5 ± 6.9 pretreatment, P = .001; 20.7 ± 20.5 vs 45.6 ± 28.9 pretreatment, P < .0001, respectively). Mean ± SD change in PHQ-9 and SNOT-22 scores was -2.7 ± 7 and -24.9 ± 29.8, respectively. SNOT-22 and PHQ-9 scores were positively correlated (r = .522, P < .001). PHQ-9 score change was significantly associated with SNOT-22 score change (β = .178, 95% confidence interval 0.12-0.23, P < .0001). CRS affects the quality of life and psychological well-being of patients. Patient-centered care with maximal medical and surgical treatment help overcome its deleterious consequences.

Accurate tissue flap reconstruction method based on the quadratic surface developability for head and neck soft tissue defects

Soft tissue defects resulting from head and neck tumor resection seriously impact the physical appearance and psychological well-being of patients. The complex curvature of the human head and neck poses a formidable challenge for maxillofacial surgeons to achieve precise aesthetic and functional restoration after surgery. To this end, a normal head and neck volunteer was selected as the subject of investigation. Employing Gaussian curvature analysis, combined with mechanical constraints and principal curvature analysis methods of soft tissue clinical treatment, a precise developable/non-developable area partition map of the head and neck surface was obtained, and a non-developable surface was constructed. Subsequently, a digital design method was proposed for the repair of head and neck soft tissue defects, and an in vitro simulated surgery experiment was conducted. Clinical verification was performed on a patient with tonsil tumor, and the results demonstrated that digital technology-designed flaps improved the accuracy and aesthetic outcome of head and neck soft tissue defect repair surgery. This study validates the feasibility of digital precision repair technology for soft tissue defects after head and neck tumor resection, which effectively assists surgeons in achieving precise flap transplantation reconstruction and improves patients' postoperative satisfaction.

SLEEP quality in patients with psoriatic arthritis and its relationship with disease activity and comorbidities: a cross-sectional study

The assessment of psoriatic arthritis is complex and multidimensional. It is increasingly common to include the patient perspective using patient-reported outcomes. Although some research has explored sleep quality in patients with psoriatic arthritis, most studies have had small sample sizes, failed to assess sleep quality considering the inflammatory process together with the psychological well-being of patients, and have not described any use of sleep medication. Further, research to date has not provided data on the relationship of sleep quality with axial forms. In this context, the objective of this study was to assess sleep quality in patients with psoriatic arthritis and its relationship with clinical characteristics, disease activity, functioning, disease impact, fatigue and psychological status. A cross-sectional study was conducted including 247 consecutive patients with PsA recruited during 2021. Sleep quality was measured using the Pittsburgh Sleep Quality Index. We assessed correlations of Pittsburgh Sleep Quality Index score with peripheral disease activity (Disease Activity Index for PSoriatic Arthritis), axial disease activity (Ankylosing Spondylitis Disease Activity Score-C-reactive protein and Bath Ankylosing Spondylitis Disease Activity Index), functioning (Bath Ankylosing Spondylitis Functional Index and Health Assessment Questionnaire), impact (Psoriatic Arthritis Impact of Disease questionnaire), anxiety, depression (Hospital Anxiety and Depression Scale) and fatigue (Functional Assessment of Chronic Illness Therapy-Fatigue) scores. A multiple linear regression model was constructed with PSQI as the dependent variable and as independent variables those that could influence sleep quality. Nearly two-thirds (63.15%) of patients had poor sleep quality. Poorer sleep quality was associated with being female, higher joint counts, greater peripheral and axial disease activity, fatigue, anxiety and depression, functioning and disease impact (p < 0.001). Multiple linear regression analysis found that pain (β: 0.3; p < 0.007) and fatigue β: − 0.1; p < 0.001 contributed 40% to the sleep quality model. Poor sleep quality was common among patients with psoriatic arthritis. Emotional factors (fatigue, anxiety) seemed more important than inflammatory factors in sleep quality.

Etiology, Classification, and Restorative Management of Amelogenesis Imperfecta Among Children and Young Adults: A Scoping Review.

Amelogenesis imperfecta (AI) is a rare genetic disorder affecting children and adults. Knowledge about AI is limited to clinical representation and radiographical findings. Various treatments are provided to children with AI, yet no definitive treatment guideline has been suggested in the literature. This scoping review highlights the knowledge of the etiology and classification of AI and synthesizes these findings in a comprehensive review, focusing mainly on the various forms of AI in children and management with a restorative conservative approach. Five electronic databases, namely, PubMed, Google Scholar, Embase, Web of Science, and Scopus, were searched for the relevant articles. The search was performed in two phases: first for title and abstract, and second for full-text articles. The studies included in this scoping review were published from 2013 to August 2023. The data extraction was done on a customized sheet. A total of 33 studies were included in this review, of which 19 were reports and series, seven were observational, and seven were reviews. Most patients included in this review suffered from the hypoplastic type of AI (54%), followed by hypomatured(36%), and hypocalcified (10%). The treatment modalities explained were divided into the following three phases: temporary, transient, and permanent. Almost all included reports suggested the requirement for guidelines for treating AI among young children. This scoping review suggests the need for guidelines for treating AI in children. Moreover, pediatric dentists should prioritize early diagnosis and treatment and long-term follow-up for AI in children to effectively enhance the patient's psychological well-being and overall quality of life.

Factors Associated With Loneliness Among Chinese Patients With Cancer: A Cross-sectional Study.

Loneliness has a significant impact on the physical and psychological well-being of patients with cancer. However, the specific factors contributing to loneliness among patients with cancer within the context of Chinese culture remain poorly understood. The objective of this study was to identify the factors associated with loneliness among patients with cancer in China. A cross-sectional study was conducted using convenience sampling, involving a sample of 205 patients with cancer from a tertiary hospital in Guangzhou, China. Participants completed several validated questionnaires, including the Cancer Loneliness Scale (CLS), Hospital Anxiety and Depression Scale (HADS), Cancer-Related Negative Social Expectations Scale (C-rNSES), and Social Support Rating Scale (SSRS). Multiple linear stepwise regression analysis was employed to explore the relationships between loneliness and psychosocial factors. The median score for loneliness among patients with cancer was 13, with an interquartile range of 8. The multiple linear stepwise regression analysis revealed that negative social expectations, social support, and depression were significantly associated with loneliness in this population. Collectively, these factors accounted for 50.1% (R2 = .501) of the variance in loneliness. The findings of this study highlight the importance of addressing negative social expectations and depression and improving social support to prevent or reduce loneliness among patients with cancer. Health care providers should consider these factors when developing interventions aimed at preventing or alleviating loneliness in this population.

Nursing Support for Nausea and Vomiting in Patients With Cancer: A Scoping Review.

Nausea and vomiting are symptoms commonly experienced by patients with advanced cancer and have a wide range of causes, including pharmacological interventions. Additionally, multiple factors often simultaneously cause nausea and vomiting. These highly distressing symptoms may be directly or indirectly related to the disease and can significantly impact both the physical and psychological well-being of patients. This study aims to identify the nursing support provided to reduce nausea and vomiting experienced by patients with cancer. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews checklist and Arksey and O'Malley's framework. We searched the PubMed, the Cumulative Index to Nursing and Allied Health Literature, the Cochrane Central Register of Controlled Trials in the Cochrane Library, and the Ichushi-Web of the Japan Medical Abstract Society databases for all content published from the inception of each database through July 31, 2023. A total of 4,625 scientific articles were identified after literature screening. In total, 58 articles were included for full-text review, and 10 articles were finally selected for review. The types of study designs comprised six randomized controlled trials, three prospective observational studies, and one before-after study with no controls. The types of cancers included in the articles were colorectal, breast, lung, pancreatic, gynecological, stomach, and sarcoma. The total sample size of the study population was 793 patients (range = 12-281) for intervention studies and 4,333 patients (range = 20-4,197) for observational studies. Nursing support, extracted from the 10 articles, was classified into the following six types: massage therapy, acupressure, early palliative care, psychosocial support, self-symptom monitoring, and coordinated care. The review yielded six classifications of nursing support for nausea and vomiting in cancer patients. Future research should examine the feasibility of providing nursing support for nausea and vomiting in cancer patients.

THE PERFORMANCE OF PHYSIOTHERAPY IN PATIENTS WITH OSTEOSARCOMA AND OTHER ONCOLOGICAL CONDITIONS

Physiotherapy plays a fundamental role in the treatment and rehabilitation of cancer patients, especially those diagnosed with osteosarcoma. This narrative review addressed the importance of physiotherapy in various stages of cancer treatment, from diagnosis to post-surgical rehabilitation. Cancer pain, often debilitating, is a major concern, and physiotherapy offers techniques and approaches for its effective management. In palliative care, physiotherapy seeks to alleviate symptoms and improve quality of life, while in post-surgical rehabilitation, the focus is on restoring functionality and promoting the patient’s reintegration. In addition to physical interventions, physiotherapy also addresses the emotional and psychological well-being of patients, offering a holistic approach to cancer care. In short, physiotherapy is essential to improve the quality of life and functionality of cancer patients, addressing physical, emotional and social challenges.

Expert System To Determine Psychological Disorders In Chronic Kidney Failure (CKD) Patients Undergoing Hemodialysis Therapy Using Certainty Factor Method

Chronic Kidney Failure (CKD) is damage to the kidneys both in structure and/or function that lasts for 3 months or more. Hemodialysis is a prolonged therapy that can significantly impact the physical and psychological well-being of patients with chronic kidney disease. This therapy has a big effect on sufferers. The psychological impact that appears can affect the success of therapy so it is important to recognize these symptoms and provide appropriate treatment to overcome them. Based on research at Delia General Hospital, patients who will undergo Hemodialysis therapy must come to the hospital to receive comprehensive therapy by a doctor. Long patient queues when undergoing therapy can make patients tired and remember the patient's condition in order to get information and therapy. Handling of these problems can be overcome by building a system that can determine psychological disorders in patients. Expert systems are computer-based systems that use knowledge, facts and reasoning techniques in solving problems that usually can only be solved by an expert in a particular field. Certainty Factor (CF) is a method capable of defining the degree of certainty of a rule or fact in describing an expert's belief in the problem at hand. With an expert system, it can help identify and determine early on psychological disorders in patients. From the results of trials conducted by expert systems to determine psychological disorders in patients with kidney failure using the Certainty Factor method, the highest value is depression with a percentage of 94.59%.&#x0D;

The influence of glioblastoma on patients' cognitive and demographic characteristics and psychological well-being of patients and caregivers: a single-centre retrospective study.

Glioblastoma, the most aggressive primary brain tumour in adults, poses significant challenges for patients and their caregivers. This study investigates a range of clinical parameters, such as symptoms, tumour characteristics, presence of seizures, mental status, and depression/anxiety, in glioblastoma patients. The rapid deterioration of physical and cognitive functions experienced by patients can have profound effects on both patients and their relatives throughout the course of the disease. The objective of this study was to examine and compare psychological symptoms between glioblastoma patients and their relatives. The study included 98 adult patients with glioblastoma who underwent pre- and postoperative cognitive assessments using the Mini-Mental State Examination (MMSE). The Hospital Anxiety and Depression Scale (HADS) was also used to evaluate and compare psychological symptoms of patients and their relatives over time. Seizures were seen in 45.9% of patients, and the mean age of the patients was 60.1 ± 13.8 years. The patients were evaluated at various time intervals before and after surgery, and the data were retrospectively analyzed. The study found that before surgery, the anxiety levels of caregivers were significantly higher than those of patients during all evaluation periods. Additionally, the depression scores of caregivers were significantly higher than those of patients only in the first month following the operation. There were no significant differences in depression scores between patients and caregivers in the other assessment intervals. The average cognitive level of patients, as assessed by the MMSE scale was 22.4 before the operation and 20.9 after the operation. Glioblastoma has a significant impact on the mental health and emotional well-being of both patients and their relatives. This study highlights the importance of providing early support to both patients and their relatives before surgery. The study's strength is that it focuses on an early time point, prior to surgery, where both patients and their relatives are already affected and may require additional support. The results of this study can help healthcare professionals to better understand the psychological impact of glioblastoma and provide more targeted support to patients and their caregivers.

The Impact of an Intensive Care Diary on the Psychological Well-Being of Patients and Their Family Members: Longitudinal Study Protocol.

Thanks to medical and technological advancements, an increasing number of individuals survive admission to intensive care units. However, survivors often experience negative outcomes, including physical impairments and alterations in mental health. Anxiety, depression, cognitive impairments, post-traumatic stress disorders, and functional disorders are known collectively as post-intensive care syndrome (PICS). Among the key triggering factors of this syndrome, memory impairment appears to play a significant role. This study aims to evaluate the impact of an intensive care diary on the psychological well-being of patients and their relatives after discharge from the ICU. Prospective observational study. The results of this study evaluate the impact of an ICU diary on the quality of life of ICU survivors and their family members.

Examination of the level of tolerance of uncertainty and psychological wellness of patients with epilepsy

AimThis study was conducted to examine the level of intolerance of uncertainty and the psychological well-being of patients with epilepsy (PWE). MethodsThis descriptive and cross-sectional study was conducted with 201 patients in a university hospital in Van, which is a province in eastern Turkey. Personal information form, intolerance of uncertainty scale, and the psychological well-being scale were prepared by the researcher in line with the literature and used to collect data. An independent sample t-test, one-way analysis of variance (ANOVA), post hoc (Tukey, LSD), correlation, and regression analyses were used to analyze the data. ResultsIn this study, the mean total score of PWE for the intolerance to uncertainty scale was found as 37.144 ± 9.202. Among the sub-dimensions, the mean prospective anxiety score was found as 21.821 ± 5.416 and the mean inhibitory anxiety score was 15.323 ± 4.695. The mean total score of the psychological well-being scale was found as 28.975 ± 6.622. It was determined that there was a significant relationship between the total score of the intolerance of uncertainty scale and the total score of the psychological well-being scale of the PWE who participated in the study (F = 14.314; p = 0.000 < 0.05). It was observed that the total score of intolerance of uncertainty was decreased as the total level of psychological well-being was increased (ß = −0.186). ConclusionIt was found that PWE had higher levels of intolerance of uncertainty and lower levels of psychological well-being. It was also determined that the total score of psychological well-being was decreased as the total score of intolerance of uncertainty was increased. RecommendationsFor preventing the negative consequences of intolerance of uncertainty in PWE, it is recommended to inform nurses to increase the level of psychological well-being as a result of raising awareness about their concerns by conducting studies to increase the level of intolerance to uncertainty. It is also recommended to carry out studies on intolerance of uncertainty and psychological well-being in advanced and larger sample groups.

Rehmannioside A Inhibits TRAF6/MAPK Pathway and Improves Psoriasis by Interfering with the Interaction of HaCaT Cells with IL-17A.

As a common chronic inflammatory skin disease, psoriasis seriously affects the physical health and psychological well-being of patients. Various clinical treatments for psoriasis have their own drawbacks, so it is important to find effective and safe drugs. Rehmannioside A (ReA) has anti-inflammatory properties and is the main active ingredient in Fuzhengzhiyanghefuzhiyang decoction (FZHFZY), an herbal compound for the treatment of psoriasis. But no studies have been conducted to determine whether ReA alone can treat psoriasis. Therefore, this study was designed to investigate the effect of ReA in the treatment of psoriasis and its potential mechanism of action. HaCaT cells were treated with ReA and IL-17A alone for 24 h and 48 h, and the most effective concentrations of ReA and interleukin (IL)-17A were found at 25 μg/mL and 100 ng/mL, respectively. A psoriasis cell model was constructed by stimulating HaCaT cells with IL-17A, followed by intervention with ReA. Cell viability and cell cycle distribution were measured by MTT assay and flow cytometry. The expression levels of keratin family members and chemokines were detected by real-time quantitative PCR (RT-qPCR), the levels of pro-inflammatory cytokines by enzyme-linked immunosorbent assay (ELISA), and key proteins of TRAF6/MAPK signaling pathway by Western blot. ReA weaken cell viability, down-regulate the expression of keratin family members (KRT6 and KRT17), restore cell cycle distribution to normal distribution, inhibit the release of pro-inflammatory cytokines (IL-6, IL-8 and IL-1β) and lower the expression of chemokines (S100A7, S100A9 and CXCL2) by interfering with the interaction between HaCaT cells and IL-17A. Thus, it exerts an anti-psoriatic effect by reducing the inflammatory response and inhibiting abnormal proliferation of HaCaT cells. Mechanistically, ReA inhibited the TRAF6/MAPK signaling pathway activated by IL-17A stimulation in HaCaT cells. ReA has in vitro anti-psoriatic effects and may be a new therapeutic agent for psoriasis.

Psychological Wellbeing in Patients with Glaucoma: A Newer Perspective in Glaucoma Management

Psychological Wellbeing in Patients with Glaucoma: A Newer Perspective in Glaucoma Management