Protective Role Of Vitamin Research Articles

Nephrotoxicity induced by titanium dioxide nanoparticles (TiO2 NPs) in albino mice and the possible protective role of vitamin E (A histological and molecular study)

Nephrotoxicity induced by titanium dioxide nanoparticles (TiO2 NPs) in albino mice and the possible protective role of vitamin E (A histological and molecular study)

Histological study of the effects of sodium fluoride and the protective role of vitamin E on the testis of albino rats.

Histological study of the effects of sodium fluoride and the protective role of vitamin E on the testis of albino rats.

The Injury in Pulmonary Tissue Following Fipronil Exposure in Male Albino Rats and The Protective Role of Vitamin E (Histological and Immune-Histochemical Study)

The Injury in Pulmonary Tissue Following Fipronil Exposure in Male Albino Rats and The Protective Role of Vitamin E (Histological and Immune-Histochemical Study)

Ovarian Oxidative Damage and Histological Changes Induced by Dimethoate and the Protective Role of Vitamin C in Female Albino Rat (Rattus norvegicus)

Ovarian Oxidative Damage and Histological Changes Induced by Dimethoate and the Protective Role of Vitamin C in Female Albino Rat (Rattus norvegicus)

Protective role of vitamin D status against COVID-19: a mini-review.

An outbreak of pneumonia caused by a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is called COVID-19 and has led to a pandemic worldwide. It is reasonable to investigate and control factors affecting disease severity and mortality. The relation between vitamin D and viral pneumonia has been previously reported. Vitamin D deficiency is common and may increase hospital admission and mortality rate in patients with COVID-19. This mini-review examines the pathways that show the association between vitamin D and COVID-19. On the other hand, it deals with the available evidence related to the relationship between vitamin D deficiency and the effect of vitamin D supplementation on the prevalence, severity, and mortality of COVID-19. Also, we described the pathophysiology of the organs’ involvement in COVID-19 and the effect of vitamin D on these outcomes. Vitamin D strengthens the innate and adaptive immune system, modulates immune responses, prevents lung and cardiovascular system damage, and reduces thrombotic events. Vitamin D exerts these effects in several pathways. Vitamin D prevents virus entry and replication by maintaining the integrity of the body’s physical barrier. Vitamin D reduces the damage to vital organs and thrombotic events by increasing the level of Angiotensin-converting enzyme 2 (ACE2), nitric oxide, and antioxidants or by reducing inflammatory cytokines and free radicals. Sufficient vitamin D may be reduced morbidity and mortality due to COVID-19. However, this issue should be investigated and confirmed by further research in the future.

Evaluation of the Effects of Azithromycin on the Kidney of Adult Albino Rats and the Possible Protective Role of Vitamin C Using Histological and Immuno-Histochemical Studies

Evaluation of the Effects of Azithromycin on the Kidney of Adult Albino Rats and the Possible Protective Role of Vitamin C Using Histological and Immuno-Histochemical Studies

Vitamin D deficiency in melanoma patients is associated with worse overall survival: a retrospective cohort study.

Recent interest has emerged in the protective role of vitamin D in melanoma survival and is the subject of multiple studies with heterogeneous results. Here, we present a retrospective cohort study of 264 patients with invasive melanoma from a tertiary university hospital. The aim of the study was to analyze the relationship between vitamin D levels and prognosis of melanoma patients. We found that lower vitamin D levels are independently associated with worse overall survival in melanoma patients in concordance with previous studies on other populations. Vitamin D deficiency could play a survival role in melanoma patients,. Future prospective studies are needed to investigate the effect of vitamin D supplementation on melanoma outcomes.

The possible protective role of vitamin E against deferasirox-induced injury of renal cortical tubules in adult male albino rat: A histological and immunohistochemical study

The possible protective role of vitamin E against deferasirox-induced injury of renal cortical tubules in adult male albino rat: A histological and immunohistochemical study

Efficient dermal delivery of ascorbic acid 2-glucoside with photoacoustic waves.

Ascorbic acid (i.e., vitamin C) is an important antioxidant present in skin. The protective role of vitamin C against photoaging motivated numerous attempts to promote its topical delivery, with a success limited by its chemical instability and poor skin permeability. Vitamin C precursors, such as ascorbic acid 2-glucoside (AA2G), which are metabolized to vitamin C by enzymes present in the skin, solve the problem of stability but are limited by low skin permeability. We developed a 2% (w/v) gel formulation of AA2G application (viscosity 4.30 × 104 Pa.s, pH5.94) and compared its passive dermal delivery with the delivery promoted by photoacoustic waves that transiently perturb the skin barrier. Photoacoustic (PA) waves were generated by laser pulses absorbed by piezophotonic (light-to-pressure) transducers. Pig skin samples were exposed to the 2% AA2G formulation alone or combined with 5 min of PA waves. One hour later, AA2G was extracted from the skin and quantified by reverse-phase HPLC. AA2G transdermal fluxes using Franz cells with 760 μm thick pig skin samples were also measured. Photoacoustic waves transiently enhanced skin permeability and increased dermal delivery of AA2G. AA2G was released from the formulation nearly quantitatively (92.6 ± 6.2%) in 24h, showing a non-Fickian behaviour controlled by diffusion and swelling. AA2G dermal delivery with exposure for 5 min to PA waves was compared with passive delivery to pig skin. PA waves increased the delivery of AA2G to the skin by a factor of 15-fold with respect to passive delivery, as measured from skin extracts after 1 h of contact of the formulation with the skin. Five minutes of exposure to PA waves is a safe and effective method to deliver large quantities of AA2G to the skin.

Histopathological Changes on Liver Architecture Due to Toxic Effect of Chromium with Protective Role of Vitamin E on Albino Rats: A Prospective Study

Abstract Introduction This histopathological study was done with an aim to learn about the biohazardous effects of chromium toxicity with protective role of alpha-tocopherol on liver parenchyma of albino rat when fed orally. Materials and Methods The study was conducted in the Department of Anatomy at Subharti Medical College, Meerut (Uttar Pradesh), India, in collaboration with Department of Pathology and Pharmacology.The experiment was conducted as per the guidelines of the Committee for Purpose of Control and Supervision of Experiments on Animals, with registration number 1204/PO/Re/S/2008/CPSEA, and with permission of the Animal Ethical Committee, on 36 adult male rats of ∼60 days of age; 140 ± 20 g of body weight was used; all the experimental animals were kept in polypropylene cage, and fed with pellet diet and water. Result When exposed to chromium for long, it resulted in toxicity and damaged the cellular components during reduction process of chromium by releasing of free radicals, leading to deoxyribonucleic acid damage, but the chain-breaking antioxidant effects of alpha-tocopherol played an important role by reversing the damage caused by chromium toxicity, hence proved hepatoprotective. Conclusion Vitamin E (alpha-tocopherol) is proved to be hepatoprotective against hepatotoxic effect of chromium metal.

Vitamin D and Pancreatitis: A Narrative Review of Current Evidence.

Emerging research indicates that vitamin D metabolic disorder plays a major role in both acute pancreatitis (AP) and chronic pancreatitis (CP). This has been demonstrated by studies showing that vitamin D deficiency is associated with pancreatitis and its anti-inflammatory and anti-fibrotic effects by binding with the vitamin D receptor (VDR). However, the role of vitamin D assessment and its management in pancreatitis remains poorly understood. In this narrative review, we discuss the recent advances in our understanding of the molecular mechanisms involved in vitamin D/VDR signaling in pancreatic cells; the evidence from observational studies and clinical trials that demonstrate the connection among vitamin D, pancreatitis and pancreatitis-related complications; and the route of administration of vitamin D supplementation in clinical practice. Although further research is still required to establish the protective role of vitamin D and its application in disease, evaluation of vitamin D levels and its supplementation should be important strategies for pancreatitis management according to currently available evidence.

Protective role of vitamin D against radiation hazards in rats fed on high fat diet

BackgroundBoth exposure to ionizing radiation and obesity have been linked to a variety of diseases. As a result, there is an urgent need to consider the combined impact of these risks, as well as the role of vitamin D as an antioxidant. PurposeThe current study aims to explore the potential role of vitamin D against the harmful effects of gamma irradiation on lung and heart of obese rats. Materials and methods40 male albino rats were divided into 5 equal groups: (1) a normal group, (2) an obese group fed a high-fat diet, (3) a normal group exposed to a single dose of ɤ-radiation (6Gy) before the end of experiment by 24 h, (4) an obese group exposed to radiation at same time as group3, and (5) and obese group injected intramuscular by vitamin D in the last three weeks of experiment, three times by week and exposed to radiation at same time as “G3” and “G4”. ResultsThere was a significant increase in the serum level of lipid, inflammatory agent, creatine kinase myocardial band, troponin and tissue levels of malondialdehyde in lung and heart, while there was a decline in the tissue level of glutathione. This biochemical alternation was accompanied by histological changes in the heart and lung tissues in the gamma irradiation group and the obese groups compared to the normal group. While, supplementation of vitamin D decreases these harmful effects as well as protects the heart and lung tissue from the injurious effects of obesity and gamma irradiation. In conclusionvitamin D has a potential role as an antioxidant and anti-inflammatory agent, which highlights the significance of vitamin D supplementation to obese and oncology patients during radiotherapy to protect or at least alleviate the harmful effects of radiotherapy.

The Possible Protective Role of Vitamins C&E Supplemented Diet on the Testis of Adult Albino Rat with Induced–Diabetes, An Ultrastructural, Morphometrical and Biochemical Study

The Possible Protective Role of Vitamins C&E Supplemented Diet on the Testis of Adult Albino Rat with Induced–Diabetes, An Ultrastructural, Morphometrical and Biochemical Study

Pathological Effects of High Dose of Acrylamide on The Mammary Glands of Female Albino Rats and The Possible Protective Role of Vitamin E (Histological and Immunohistochemical study)

Pathological Effects of High Dose of Acrylamide on The Mammary Glands of Female Albino Rats and The Possible Protective Role of Vitamin E (Histological and Immunohistochemical study)

Evaluation of Sodium Valproate-Induced Hepatotoxicity and Protective Role of Vitamin C (Ascorbic Acid) and Silymarin in Adult Albino Rats

Background and Objectives: Drugs hepatotoxicity is one of the most prevalent problems seen in medical practice. Many medications are linked to hepatotoxicity, including acetaminophen, tamoxifen and sodium valproate (VPA). The objective of this study is to investigate the preventive impact of silymarin (SIL) and /or vitamin C (Vit.C) on hepatotoxic Sodium Valproate in albino Rats. 
 Methods: Thirty adult male albino rats were divided equally into six groups; group (I): normal control, group (II): VPA 700 mg/kg, group (III): VPA + SIL 50 mg/kg, group (IV): VPA+ Vit.C 50 mg/kg and group (VI): VPA + SIL +Vit.C, VPA. The animals were killed after 14 days, and livers were taken for histological and biochemical analysis.
 Results: After 14 days, animals were sacrificed, and livers were collected for histopathologic examination and biochemical assessment. VPA group exhibited a significant increase in serum alanine aminotransferase and aspartate aminotransferase. Liver sections showed loss of normal pattern of hepatocytes, inflammatory infiltration, congested central vein and fatty infiltration. Each of ascorbic acid and silymarin partially improved the histological pattern of the liver. When they were combined together, they depict marked improvement in the measured parameters and showed normal liver sections.
 Conclusion: silymarin (SIL) and /or vitamin C (Vit.C) has hepatoprotective effects against VPA induced toxicity on liver.

Recurrent viral-induced wheezing in young children – the protective role of vitamin D supplementation

Recurrent viral-induced wheezing in young children – the protective role of vitamin D supplementation

Association between Plasma 25-Hydroxyvitamin D and Breast Cancer Risk: A Matched Case-Control Study

Background: The protective role of vitamin D in the occurrence of breast cancer is nowadays a controversial matter. Based on conflicting results of the studies in this field and also considering the prevalence of vitamin D deficiency in Iranian women, this work was conducted to evaluate the association between vitamin D and breast cancer. Method: This matched case-control study was conducted on 70 newly diagnosed breast cancer patients and 70 controls with the same age, menopause status, and time of blood sampling in Zanjan. Information regarding demographic, reproductive, history of diseases, medication, use of dairy products, and sunlight exposure was collected using a questionnaire. The serum level of vitamin D was measured with ELISA method. The data were analyzed utilizing Chi-square test, Independent T-test, and Odds Ratios using Conditional logistic regression model. Results: The mean level of vitamin D was 39.04 and 63.34 ng/ml in the cases and controls, respectively (P=0.046). The proportion of the cases in the highest quartile of vitamin D was significantly smaller than that in the controls compared to the lowest quartile (Ptrend=0.028). Using Conditional logistic regression model, an inverse and independent association was observed between vitamin D and breast cancer after controlling main confounders. The risk of breast cancer was independently associated with BMI and low income. Conclusion: In this study, an inverse association was confirmed between vitamin D and breast cancer. Prospective intervention studies should be performed to explore its role in the prevention of breast cancer.

The Protective Role of Vitamin E Against Teratogenic Effects of Nicotine on Embryonic Bone Development

Aim: According to World Health Organization data, around 1.5 billion people in the world use tobacco products. Nicotine, the most common use of tobacco, is the main psychoactive substance that causes addiction. Exposure to nicotine during pregnancy increases the risk of low placenta weight, stillbirth, congenital heart disease, musculoskeletal defect. Antioxidants are used to protect against teratogenic substances such as nicotine. The purpose of the study was to determine the skeletal system malformations caused by low (3 mg/kg) and high (6 mg/kg) doses of nicotine during embryonic bone evolution by using the double skeletal staining method and the protector role of vitamin E in preventing these malformations.Material and Method: The rats were divided into 6 groups: the control, low-dose nicotine, high-dose nicotine, low-dose nicotine+vitamin E, high-dose nicotine+vitamin E and vitamin E. The development of the skeletal system of the fetuses was examined by the skeleton staining method. The anterior and posterior extremity images of the fetuses were examined under the stereomicroscope and then through photographing total bone length, ossification length and ossification rate were calculated in the ImageJ program. Results: There was an important decline in the total bone length, ossification length and ossification rate (p<0.05) in the bone measurements of the front and hind extremities, while it was found that the treatment groups approached the control group and the increases were important (p<0.05). Conclusion: It was concluded that being to nicotine during pregnancy delayed skeletal ossification and that vitamin E, which is an antioxidant, may be protective opposite the teratogenic effect of nicotine on the bone.

Protective Role of Vitamin C Against Biochemical Enzymes Alterations Induced by Exposure of Allethrin Based Mosquito Coil Smoke on Cerebellum of Male Albino RatsAn Experimental Study

Introduction: Among synthetic pyrethroids allethrin is widely used as active ingredient in mosquito coils. Many experimental studies have proved that pyrethroids cause neurotoxicity and result into derangements of biochemical enzymes including oxidative stress markers and antioxidant levels in brain. Aim: To study alterations in biochemical markers (oxidative and antioxidant enzymes) in cerebellum of male albino Wistar rats induced by the exposure of allethrin based mosquito coil smoke along with protective role of withdrawal and exogenously administered vitamin C on these markers. Materials and Methods: This experimental study was conducted in the Department of Anatomy, King George's Medical University, Lucknow, Uttar Pradesh, India, during October 2014-September 2015. Total 42 male albino Wistar rats were divided into four groups. The first group contained 12 rats was used as control, group II with 12 rats was given 8 hours daily exposure of allethrin based mosquito coil smoke via whole body inhalation for 6 days in a week for a total of 12 weeks. Group III contained eight rats and was given exposure same as group II and were further kept for 8 weeks to see the withdrawal effect. Group IV with 10 rats was given same exposure as group II, along with oral administration of 20 mg/kg body weight vitamin C. After 12 weeks of exposure cerebellum was dissected and then sent for biochemical enzyme estimation. Rats in group III were dissected after 8 weeks post 12 weeks of exposure. Comparisons were made between groups by using one way Analysis of Variance (ANOVA). Results: The exposure Group II showed significant rise (p<0.001) in level of oxidative stress marker enzyme Malondialdehyde (MDA) and significant (p<0.001) reduction in activities of antioxidants Glutathione Peroxidase (GPO), reduced Glutathione (GSH), Superoxide Dismutase (SOD) and Catalase (CAT) in comparison to Group I, III and IV. In vitamin C administered group IV the above parameters were found to be less affected. Intergroup comparison of oxidative stress markers level showed significant intergroup difference between Group I, II, group II, III and group II, IV. Conclusion: Allethrin based mosquito coil smoke causes oxidative stress in cerebellum of albino Wistar rats and vitamin C has ameliorative effect on biochemical alterations induced by sub-chronic whole body exposure of mosquito coil smoke.

Counter effects of Vitamin E against Outcomes of Alcohol Toxicity in Pancreatic Acini: Histomorphometric Study

Aim: To evaluate the effects of alcohol on the microscopic morphology of the exocrine pancreas and blood serum amylase and to explored that if vitamin E has a protective role against alcohol-induced damage in the pancreas of rabbits. Study design: Analytical experimental study Place and duration of study: Departments of Anatomy, Pathology and Pharmacology in Peshawar Medical College Pakistan from 1st January 2019 to 30th June 2019. Methodology: Eighteen healthy adult male domestic rabbits weighing 1-1.5 kg were chosen (oryctolaguscuniculus). The control group A received proper food and normal saline as drinking water, experimental group B received proper diet and 30 percent ethanol solution (30ml/kg/day) orally daily with normal saline, and experimental group C received proper diet, 30 percent ethanol solution (30ml/kg/day), vitamin E (50mg/kg/day) orally daily with normal saline. Each rabbit's blood was taken for serum amylase. Morphology of acinar cells included: 1) number of cells, (10 acini/field, 2) size of acini, 3) size of acinar cells, and 4) size of acinar nuclei. Results: Normal value of serum amylase in rabbits was found. The difference in serum amylase levels between the control and experimental groups for both E4 and E8 animals was not statistically significant. There was no significant difference in the number of pancreatic acinar cells, size of pancreatic acini, the pancreatic acinar cell size, and pancreatic acinar cells nuclear size in the control and experimental groups for both E4 and E8 animals. Conclusion: Alcohol consumption had no influence on the histomorphology of the rabbits' pancreatic acini in a short period (4-8 weeks). No significant variation was noted in the pancreatic acinar cells count & size, pancreatic acinar cells nuclear count and size, and pancreatic acini size. Therefore, protective role of vitamin E was not usefully identified. Keywords: Alcohol, Pancreas, Histomorphology, Vitamin E, Serum amylase