Bruck (1900) defined biomaterials as substances, whether synthetic or natural, designed for use in prosthetic, diagnostic, therapeutic, and storage applications involving contact with tissue, blood, and biological fluids. They must not harm living organisms or their components. Biomaterials interact with tissues and bodily fluids over extended periods. They fall into two main categories: natural biomaterials sourced from plants or animals, which can enhance, replace, or restore biological tissues with properties like in-vivo immunomodulation, detoxification, and biomimicry (e.g., proteins, gelatin, alginate, silk, fibrin, cellulose, chitin, chitosan); and synthetic biomaterials, manufactured in laboratories or industries by human effort (e.g., metals, ceramics, polymers). Natural and synthetic biomaterials notably differ in their ability to provoke host responses upon implantation, including inflammation, matrix formation, blood interactions, and the development of granulation or fibrous capsules