AbstractMany group‐sequential test procedures have been proposed to meet the ethical need for interim analyses. All of these papers, however, focus their discussion on the situation where there are only one standard control and one experimental treatment. In this paper, we consider a trial with one standard control, but with more than one experimental treatment. We have developed a group‐sequential test procedure to accommodate any finite number of experimental treatments. To facilitate the practical application of the proposed test procedure, on the basis of Monte Carlo simulation, we have derived the critical values of α‐levels equal to 0.01, 0.05 and 0.10 for the number of experimental treatments ranging from 2 to 4 and the number of multiple group sequential analysis ranging from 1 to 10. Comparing with a single non‐sequential analysis that has a reasonable power (say, 0.80), we have demonstrated that the application of the proposed test procedure may substantially reduce the required sample size without seriously sacrificing the original power.