Background Psittacosis pneumonia, which is caused by Chlamydia psittaci, is a systemic inflammatory disease that often results in injury to multiple organs. Although liver and heart involvement are recognized, the incidence, risk factors, and predictors for acute kidney complications are not well known. Methods Our retrospective cohort study included 123 patients, comprising 47 individuals diagnosed with psittacosis pneumonia and 76 individuals with typical community-acquired pneumonia (CAP). These patients were admitted to Nanjing First Hospital, affiliated with Nanjing Medical University, between June 2019 and July 2024. The study conducted an analysis of clinical profiles, laboratory markers, and patient outcomes. The predictive efficacy of the Blood Urea Nitrogen to Albumin Ratio (BAR) and Lactate Dehydrogenase (LDH) in forecasting acute kidney injury (AKI) was assessed through the application of receiver operating characteristic (ROC) curve analysis. Results In comparison to typical CAP, psittacosis pneumonia is characterized by markedly elevated systemic inflammation, as evidenced by increased levels of procalcitonin (PCT), C-reactive protein (CRP), and interleukin-6 (IL-6). Additionally, it presents with more severe lymphocytopenia, hypoalbuminemia, and extensive multi-organ damage, with a pronounced impact on hepatic and myocardial tissues. The incidence of AKI was significantly greater in the psittacosis group compared to the control group (34.0% versus 12.1%, P= 0.003). In the psittacosis cohort, AKI demonstrated an independent association with increased levels of LDH ( P = 0.01) and the BAR ( P < 0.001), whereas no such association was observed with traditional inflammatory markers. The BAR (AUC = 0.88) and LDH (AUC = 0.79) demonstrated effective predictive capabilities for AKI, with their combined application enhancing sensitivity to 85.71% and specificity to 87.50%. The implementation of targeted therapy using omadacycline resulted in prompt clinical and biochemical improvements across all patients. Conclusion Psittacosis pneumonia constitutes a distinct systemic immuno-inflammatory syndrome that presents a significant risk for AKI. The composite biomarker BAR and the cellular injury marker LDH demonstrate superior predictive capabilities for AKI compared to traditional inflammatory indices, thereby providing accessible tools for early risk stratification. These findings emphasize the necessity of recognizing psittacosis as a unique clinical entity and advocate for vigilant monitoring of renal function in affected patients.

Background: Bangladesh has been experiencing large dengue outbreaks since 2019, the 2023 outbreak is the largest on record. Comparing dengue profiles and out comes between outbreaks is crucial for enhancing our understanding of dengue and improving clinical and public health responses to future outbreaks. This study com pared the profile and outcome of dengue patients admitted to the Pediatric Inten sive Care Unit (PICU) of a tertiary-level hospital in Chattogram, Bangladesh, during the 2022 and 2023 outbreaks. Materials and methods: This record-based study included 81 laboratory-confirmed dengue children admitted to the PICU of Chittagong Medical College Hospital. Using SPSS Windows version 23.0, the demographics, clinical manifestations, and outcomes of the cases were compared between two outbreaks. Results: Twenty-three and 58 patients were admitted between 2022 and 2023, respectively. Median age of children was 5 years in both years. Males were affected more, with a male-female ratio of 1.5:1 in 2022, which was reversed in 2023 with a male-to-female ratio of 0.9:1. Persistent vomiting and abdominal pain was noticed to be significantly higher among patients in 2023. The median length of PICU stay was significantly higher in 2023 than in 2022 (8 vs. 5 days, p<0.001). The PICU mortality rate was lower in 2023 than in 2022 (13.8% vs. 21.7%), though it was not statistically significant. Conclusion: Though the number of PICU-admitted cases is increasing, the mortality rate is decreasing with appropriate management. So, for district-level hospitals in Bangladesh, establishing a pediatric intensive care unit is the demand of time to manage this severe variety of dengue pediatric cases. ><0.001) The PICU mortality rate was lower in 2023 than in 2022 (13.8% vs. 21.7%), though it was not statistically significant. Conclusion: Though the number of PICU-admitted cases is increasing, the mortality rate is decreasing with appropriate management. So, for district-level hospitals in Bangladesh, establishing a pediatric intensive care unit is the demand of time to manage this severe variety of dengue pediatric cases Chatt Maa Shi Hosp Med Coll J; Vol.24 (2); July 2025; Page 62-65

Purpose Regulatory Emotional Self-Efficacy (RESE) is defined as an individual’s confidence and self-assessment of his or her ability to regulate emotions, and is inextricably linked to daily life. To overcome the limitations of traditional dimensional analyses in revealing the overall combination of characteristics, the present study used latent profile analysis to explore the latent profile structure of RESE and to analyze its relationship with physical activity level and key demographic characteristics. Methods Using latent profile analysis to explore the latent profiles of RESE. R3STEP analysis and multivariate logistic regression were used, respectively, to explore the associations of physical activity and demographic variables with the latent profiles of RESE. Results RESE can be categorized into four latent profiles: Low Negative Regulatory Emotional Self-Efficacy (8.9%), Low Positive Regulatory Emotional Self-Efficacy (40.9%), Moderate Regulatory Emotional Self-Efficacy (30.0%), and Proficient Regulatory Emotional Self-Efficacy (20.2%). Follow-up analyses revealed that physical activity and gender were associated with RESE. Conclusion (1) RESE identified four potential profiles in a population of high school students. (2) Gender was a significant predictor of the attribution of latent profiles of RESE. Females were more likely than males to fall into the Low Negative Regulatory Emotional Self-Efficacy group. (3) Physical activity is a significant predictor of RESE profiles. The lower the level of physical activity, the higher the likelihood of being classified into the two low Regulatory Emotional Self-Efficacy groups.

Sexually minoritized men (SMM) experience sexual minority stress, a product of exposure to prejudice, discrimination, and heterosexism. This study sought to identify the latent profiles of sexual minority stress among SMM with HIV who use methamphetamine and to examine the correlates associated with profile membership. A cross-sectional examination of 104 participants in San Francisco self-reported their experiences with sexual minority stress. A latent profile analysis was used to characterize the underlying "profiles" or subgroups of participants. ANOVA and Chi-square analysis were used to examine sociodemographic characteristics, psychological health, substance use, and HIV-related health associated with each profile. Participants' mean age was 43 years old (SD = 9); most identified as Black, Hispanic, or Other racial and ethnic identities (57%), and had been diagnosed with HIV for 13 years (SD = 9) on average. Our findings revealed four distinct profiles: (1) High Concealment, Moderate Prejudice Events, (2) Low Concealment, High Prejudice Events, (3) Low Sexual Minority Stress, and (4) High Sexual Minority Stress. Members of the High Sexual Minority Stress profile had the highest mean addiction severity scores and the greatest endorsement of feelings of shame and guilt. Notably, each profile had clinically significant PTSD and depression scores, even among those who experienced stressful events to a lesser extent. Our findings suggest that sexual minority stress plays a critical role in substance use and mental health outcomes. Additional research is needed to elucidate the other facets of stress in SMM that use substances.

Down syndrome (DS) is the most common chromosomal abnormality associated with intellectual disabilities. Many metabolic issues begin in childhood, and children without DS are reported to have a high prevalence of metabolic syndrome (MS) according to various studies. However, our understanding of the risk of MS in children with DS is limited. A cross-sectional study assessed the prevalence of MS in DS children aged 10-18 during 2022-2024. Demographic details and anthropometric measurements were recorded for all participants. Fasting blood samples were collected for blood glucose, insulin, and lipid profile analysis. The modified NCEP-ATP III criteria were used to classify the MS. We also evaluated insulin resistance (IR) using HOMA-IR and body adiposity patterns with a DEXA scan in DS children aged 6-18. Seventy-six children aged 10-18 and 38 aged 6-9 were enrolled. The prevalence of MS was 18% in our cohort. Dyslipidemia (high triglycerides and low HDL) was observed in 21% and 15.8% of children aged 6-9 and 10-18, respectively. IR was observed in 27.6% and 7.8% of children aged 10-18 and 6-9, respectively. IR was positively correlated with BMI, whereas no correlation was observed with MS or dyslipidemia. Total body fat mass was positively correlated with MS. Our study observed a higher prevalence (18.0%) of MS than age-matched general population studies (pooled prevalence: 5.0%). Additionally, we observed a high prevalence of dyslipidemia and IR from 6 years of age. The results indicate the need to review the management guidelines and consider incorporating metabolic workups.

Cherry tomatoes are prone to postharvest deterioration and spoilage at room temperature, whereas chemical preservatives pose safety and environmental risks. Clove essential oil (CEO) has excellent antibacterial activity but is limited by high volatility, poor water solubility and dosage sensitivity. Cyclodextrin metal-organic frameworks (β-CD-MOFs) can improve CEO stability, but their poor processability and aqueous dispersibility hinder fruit preservation applications. Chitosan (CS), a natural hydrogel with film-forming and antibacterial properties, offers an ideal matrix to address these limitations. A CEO-loaded CS/β-CD-MOFs composite coating (CS-CEO/MOFs) was constructed and evaluated on cherry tomatoes stored at 25 °C via physicochemical analysis, electronic eye color detection and texture profile analysis (TPA). Compared with control, CS and high-concentration CEO-chitosan (CS-CEO-H) groups, high-concentration CS-CEO/MOFs (CS-CEO/MOFs-H) delayed spoilage. Principal component analysis of electronic eye data showed the recognition index (a parameter reflecting the distinguishability of color characteristics among groups) increased from -3 (day 0) to 97-98 (days 6-21), indicating distinct inter-group ripening rate differences. TPA results indicated CS-CEO/MOFs-H slowed hardness decline (effect positively correlated with hydrogel concentration) and maintained higher soluble sugar, vitamin C and titratable acid contents, as well as reduced weight loss, extending room-temperature shelf life to 21 days. The CS-CEO/MOFs coating combined the gas barrier property of CS and the controlled release capability of β-CD-MOF, forming a synergistic fresh-keeping mechanism. As a safe, natural preservative, it provides a promising solution to reduce cherry tomato postharvest losses and lays a foundation for the development of plant-derived composite preservatives with controlled-release and gas barrier synergistic properties. © 2026 Society of Chemical Industry.

Rising obesity and shifting disease patterns in Saudi Arabia: a nine-year population-based analysis of chronic disease burden and multimorbidity profiles

Typologies of co-occurring experiences of interpersonal violence among adults in Norwegian Sport.

Impact of social and psychological factors on foot self-care in diabetic foot patients: Based on variable-centered and individual-centered analysis.

ABSTRACT Artificial intelligence (AI) is increasingly embedded in the industrial economy, reshaping work practices and the demands for skilled labor. These transformations have promoted vocational education to integrate AI into teaching and training systems, for which teachers’ AI literacy constitutes a critical prerequisite. However, research on AI literacy of vocational education teachers remains limited, particularly from a typological perspective. This study developed and validated an AI literacy scale specifically designed for teachers in Chinese higher vocational colleges. The instrument comprised five dimensions: AI application concepts, AI foundational knowledge and skill, AI application practices, AI ethics and responsibility, and AI-supported professional development. Drawing on survey data from 1,637 teachers and applying Latent Profile Analysis (LPA), four distinct AI literacy profiles were identified: exploratory, conceptual, balanced, and innovative. Chi-square analyses further indicated that both individual characteristics (e.g. gender, teaching experience, professional title) and contextual factors (e.g. region, major, school category) were significantly associated with profile membership. These findings illuminated the structural features and profile differences of AI literacy among teachers in Chinese higher vocational college, providing empirical evidence and practical insights for developing targeted and profile-based professional development strategies to enhance teachers’ AI literacy.

Drying is a thermodynamic process involving moisture phase transition and migration, crucial for extending the shelf life of traditional Chinese medicinal materials and reducing postharvest degradation. Eriobotryae folium (EF), the dried leaf of Eriobotrya japonica (Thunb.) Lindl. (Rosaceae), is valued for its medicinal and functional food applications. The retention of its bioactive compounds is strongly influenced by drying methods. In this study, the effects of shade drying, hot air-drying (50°C, 75°C, 100°C), microwave drying, and vacuum freeze-drying on the chemical composition and antioxidant activity of EF were systematically evaluated. Using fingerprint profiling and multivariate statistical analysis, chlorogenic acid, cryptochlorogenic acid, and neochlorogenic acid (CGAs) were identified as key differential components. Spectrum-effect relationship analysis, based on Pearson product-moment correlation analysis (PPMC) and gray relational analysis (GRA), confirmed these three compounds as not only distinguishing markers under different drying conditions but also major bioactive constituents contributing to EF's therapeutic effects. Thus, they are proposed as potential quality markers. A reliable quantitative method was developed for their determination, combined with final moisture content and visual assessment of appearance, to analyze which drying method yielded samples with the best overall quality. CGAs were confirmed as key differential components. Spectrum-effect relationship analysis confirmed these three compounds as distinguishing markers and major bioactive constituents. Microwave-dried samples exhibited the best overall quality. This study established an integrated evaluation system-"fingerprint profiling-spectrum-effect correlation-targeted component quantification"-providing a practical and scientific approach for EF quality control and offering a reference for standardizing processing of leaf-derived herbal medicines.

Background Approximately 70% of pediatric pulmonary arterial hypertension (PAH) is associated with congenital heart disease causing increased pulmonary blood flow (IPF). The developing neonatal lung is highly susceptible to hemodynamic stress, yet the direct causal link and mechanisms of neonatal IPF-induced pulmonary vascular remodeling remain poorly understood due to the lack of suitable animal models that recapitulate this critical developmental window. Methods We established a novel neonatal mouse model of IPF by performing an aortocaval fistula (ACF) on postnatal day 7(P7). Pulmonary hemodynamics were assessed by ultrasound at P30. Vascular remodeling was evaluated through histology (H&E, α-SMA immunofluorescence) and molecular analysis of phenotypic markers (Spp1, Myh11). Transcriptomic profiling (RNA-seq) and pathway enrichment analysis were employed to uncover underlying mechanisms, with flow cytometry and immunosuppression (Cyclosporin A) and type I interferon receptor blocker (MAR1-5A3) used for functional validation. Results The neonatal ACF model successfully induced a left-to-right shunt, resulting in significant IPF and right ventricular volume overload. IPF mice exhibited pronounced pulmonary small vessel remodeling, evidenced by increased α-SMA intensity, elevated synthetic-phenotype marker (Spp1) expression, and decreased contractile-phenotype marker (Myh11). Transcriptomic analysis revealed a dominant immune signature, with the most enriched pathways being antiviral and interferon-response related (response to virus and IL-17 signaling). This was corroborated by a significant increase in pulmonary CD4+ and CD8+ T cells. Crucially, immunosuppressive treatment and type I interferon receptor blocker attenuated vascular remodeling. Conclusions We provide the direct experimental evidence that neonatal IPF alone is sufficient to drive pulmonary small vessel remodeling. The process is fundamentally mediated by an activated immune response characterized by an antiviral-like signature, a mechanism distinct from those reported in classic adult PAH models. This novel model offers a critical platform for investigating the developmental-specific pathogenesis of pediatric PAH and bridging the translational “valley of death.”

Aspergillus fumigatus is the leading cause of invasive mold infections in immunocompromised patients. Current antifungal treatment primarily depends on the triazole antifungals, which act by inhibiting Erg11/Cyp51, a key enzyme in the ergosterol biosynthetic pathway. However, resistance is emerging at an increasing rate, reducing treatment efficacy and patient survival. Confirmed resistance mechanisms in clinical isolates include mutations in cyp51A, cyp51B, hmg1, hapE, cox10, and the overexpression of drug efflux pumps. To identify additional determinants of triazole resistance, we grew A. fumigatus wild-type and Δcyp51A mutant strains under increasing concentrations of voriconazole. Sequencing of the resultant resistant strains identified known mutations in cyp51A and cyp51B, and novel mutations in hmg1, abcC (cdr1B), ptaB, erg25B, and srbA. Mutations of hmg1 and ptaB occurred early during evolution, while mutations of erg25B and srbA occurred later. Reintroduction of the novel mutations in hmg1, abcC, ptaB, and erg25B into wild-type A. fumigatus and correction of the srbA mutation in the evolved strain validated their contribution toward triazole resistance. Sterol profiling analysis indicated that mutation or deletion of erg25B is associated with a decrease in the accumulation of methylated sterols. Mutation or deletion of ptaB resulted in increased cyp51A, cyp51B, and erg25A expression. Sequence analysis of clinical isolates revealed enrichment of missense mutations in ptaB, hmg1, abcC, and srbA among triazole-resistant strains.

Objectives This study aimed to investigate the current status of career calling among novice nurses, to identify potential subtypes and their population characteristics, and to further explore the factors associated with the different subtypes. Methods A cross-sectional descriptive study was used. From January to February 2024, 845 novice nurses from 11 hospitals in Shanxi Province were selected for an online questionnaire survey using convenience sampling. The demographic questionnaire, transition shock of newly graduated nurses scale, medical staff resilience scale, and career calling scale were used as study instruments. Latent profile analysis (LPA) was used to explore the subtypes of novice nurses’ career calling, and multifactorial logistic regression was used to analyze the related factors of novice nurses’ career calling. Results Three subtypes of career calling of novice nurses in this study were identified, namely, lacking-calling group (10.3%), stable-calling group (50.0%), and sufficient-calling group (39.7%). Education, weekly working hours, weekly frequency of night shifts, reasons for choosing nursing, level of transition shock, and level of resilience were significantly associated with the three latent profiles of career calling of novice nurses in this study. Conclusion Novice nurses’ career calling presents 3 latent profiles and is heterogeneous in this study. Nursing administrators could pay attention to the differences in the level of career calling of novice nurses and adopt targeted management strategies based on the type of characteristics of the population in order to improve the level of career calling of novice nurses, help them develop their careers, and stabilize the nursing workforce.

Apoptosis, a programmed cell death process mediated by caspases, is crucial for immunity and development. Caspases are categorized into initiator and effector types, regulating apoptosis via intrinsic and extrinsic pathways, and are also involved in pyroptosis and other cellular processes. In fish, diverse caspase genes have been identified and shown to participate in embryonic development and immune responses against bacterial infection. However, their role in largemouth bass against Aeromonas hydrophila-a pathogen causing severe intestinal inflammation and septicemia-remains unclear. This study identifies caspase genes in largemouth bass and investigates their expression and evolution post-infection, providing insights into their immune functions. This study presents the first comprehensive genomic analysis of caspases in largemouth bass, identifying 19 caspase genes: 3 inflammatory (caspase-1 orthologs), 6 effector (caspase-3/6/7), 8 initiator (caspase-2/8/9/10/20), and 2 unclassified (caspase-17) caspases. Functional and evolutionary analyses demonstrated a high level of homology between largemouth bass caspases and those of other teleosts. The sequence diversity analysis revealed that caspase genes in largemouth bass are subject to extensive mutational changes, predominantly through nonsynonymous single nucleotide variants, which may play a role in immune adaptation and resistance to disease. Alternative splicing analysis revealed multiple splicing sites and events in caspases of largemouth bass. Differential alternative splicing analysis showed significant induction of MsCASP8_1 variants after infection with Aeromonas veronii. Gene structure and sequence alignment analyses demonstrated that these isoforms result from alternative splicing events involving the 5th exon. Transcriptome profiling and qRT-PCR analyses revealed that most caspase genes in largemouth bass are responsive to Aeromonas hydrophila infection. This study systematically analyzed the characteristics of the caspase gene family in largemouth bass and identified associative patterns consistent with potential roles in innate immune responses, providing testable hypotheses for future functional validation. This study comprehensively identified the caspase gene family in largemouth bass, analyzing their genomic organization, evolutionary relationships, sequence diversity, alternative splicing patterns, and expression responses to Aeromonas hydrophila infection. The findings provide valuable insights for further investigation into caspase-mediated apoptosis and immune mechanisms in teleost fish under Aeromonas hydrophila stress.

Aims To identify latent professional identity profiles among nursing interns and to examine the influencing mechanisms of workplace violence (WPV) and psychological capital (PsyCap) on these profiles. Background Developing a strong professional identity is crucial for nursing interns’ transition to clinical practice and addressing the global nursing shortage. However, professional identity formation varies, and its heterogeneity among interns remains poorly understood. Identifying distinct identity subgroups and clarifying influencing mechanisms can help provide tailored educational support. Methods Convenience sampling recruited 313 nursing interns from tertiary hospitals across 9 provinces in China between November 2023 and April 2024. The survey included general information questionnaires, workplace violence scales, professional identity questionnaire, and positive psychological capital questionnaire. Analyses of latent profiles and mediations were performed. Results Among 301 participants, latent profile analysis revealed 3 distinct profiles: identity deficient (10.3%), moderate identity (47.2%), and high identity-low autonomy (42.5%). The results showed that self-efficacy, hope, and emotional abuse among nursing interns emerged as significant predictors of the category of professional identity ( p < 0.001). The mediating effect value of PsyCap between WPV and professional identity was −0.171 (95% CI: −0.286 to −0.086), accounting for 63.10% of the total effect. Conclusion The analysis revealed heterogeneity in nursing interns’ professional identities. WPV and PsyCap are key factors influencing this heterogeneity, with PsyCap serving as a partial mediator. Targeted interventions based on identity profiles are recommended, alongside ensuring clinical safety and integrating PsyCap training into education to support the stability of the nursing workforce.

Dyslexia with and without developmental language disorder: Profile analysis.

This study analyzes the hydro-morphological dynamics of the lower 40 km of the Magdalena River (Colombia), with particular emphasis on the reach between Malambo and the river mouth at Bocas de Ceniza. Bathymetric profiles obtained from three field campaigns conducted between 2017 and 2018 were used to characterize riverbed morphology and to quantify the evolution of subaqueous bedforms (dunes) under different flow conditions. The results reveal a systematic increase in dune height and wavelength with increasing discharge. The dominant discharge during the observation period was approximately 7400 m3/s, associated with a total measured sediment load of about 2000 kton/day, corresponding to a volumetric concentration of 0.12%. Variations in the Manning roughness coefficient were identified, ranging from 0.020 to 0.037, primarily driven by changes in discharge and, to a lesser extent, by spatial variability in hydraulic roughness, particularly in port areas. Bedforms exhibit significant growth during high-flow periods, consistent with findings reported in the literature. Analysis of mean velocity profiles indicates that the von Kármán coefficient varies with sediment concentration and turbulence intensity. Finally, a nature-based solution is proposed for the river mouth, consisting of reconfiguring the Thalweg in the final kilometers of the channel to replicate the meandering pattern of the adjacent bend. This intervention aims to enhance Thalweg stability, reduce saline wedge intrusion, promote sediment and flow dispersion toward the natural submarine canyon, and improve navigability at the river mouth.

A novel series of 1,2,4-oxadiazoles based on benzo[d]imidazole-1,3,4-oxadiazole fused 1,2,4-oxadiazoles, were synthesised. The proposed chemical structures of the novel hybrids were confirmed by a variety of spectroscopic methods, including HRMS, NMR (1H/13C), and infrared. The antibacterial properties of these compounds showed that compound 8b (37 ± 1.20 mm) and compound 8i (6.9 ± 1.01 µM) had the highest zone of inhibition (ZI) and lowest minimum inhibitory (MIC) values against S. aureus ATCC 29213, which was verified by in silico evaluation. Compound 8f exhibited considerably better antibacterial activity (31 ± 0.19 mm) against S. epidermidis ATCC 12228, and scaffold 8f showed a significantly higher antibacterial effect (31 ± 0.19 mm) against S. pyogenes ATCC 19615 compared to moxifloxacin (29 ± 0.16 mm). Finally, in silico research that includes molecular modelling also validates an in vitro investigation and explains the strong binding pattern of 8b, 8f, 8i, and 8k against E. coli Topoisomerase IV (PDB: 3FV5) and S. aureus GyrB (PDB: 4URN). Extending our exploration, an analysis of the ADME-Tox profiling confirmed the safe use of these newly synthesized scaffolds, paving the way for promising therapeutic applications in the field of antimicrobial therapy.

Background Fear of progression (FoP) is a prevalent psychological issue among stroke patients. Previous studies failing to distinguish characteristics of patient groups with varying FoP levels. Latent profile analysis (LPA) classifies individuals into distinct subgroups via continuous FoP indicators, boosting classification accuracy by accounting for variable uncertainty. Given FoP’s heterogeneity, investigating FoP profiles and their influencing factors in stroke patients is clinically significant for personalized psychological care and improved patient quality of life. Methods A total of 366 stroke patients were selected as study subjects through convenience sampling, and a cross-sectional survey was conducted. FoP was assessed using the Fear of Progression Questionnaire-Short Form (FoP-Q-SF, 2 dimensions, 12 items). Independent variables included demographic characteristics, clinical indicators, the Recurrence Risk Perception Scale for Stroke patients (RRPSS), and the Medical Coping Modes Questionnaire (MCMQ). LPA was performed on the FoP-Q-SF items to identify subgroups. The R3STEP method was used to analyze influencing factors of subgroup membership, and the BCH method was applied to compare differences in distal outcomes across subgroups. Statistical significance was set at p < 0.05. Results The study sample had a mean age of 63.93 ± 10.58 years, with 70.5% males and 65.0% first-ever stroke patients. Two latent profiles were identified: Low-FoP Adaptive Type (C1, 48.6%) and High-FoP Sustained Type (C2, 51.4%). The R3STEP showed that age 18–59 years (OR = 0.476, 95%CI = 0.245–0.924, p = 0.028), hypertension comorbidity (OR = 0.402, 95%CI = 0.237–0.683, p = 0.001), higher RRPSS score (OR = 0.971, 95%CI = 0.946–0.995, p = 0.022), MCMQ-confrontation (OR = 0.920, 95%CI = 0.863–0.982, p = 0.011), and MCMQ-avoidance (OR = 0.796, 95%CI = 0.723–0.876, p < 0.001) were significant influencing factors (all p < 0.05). BCH analysis indicated that C2 patients had higher RRPSS score ( p < 0.001), higher NIHSS score ( p = 0.002) and lower adaptive coping ability than C1. Conclusion This study revealed significant heterogeneity in FoP among stroke patients. Age, hypertension comorbidity, excessive recurrence risk perception, MCMQ-confrontation, and MCMQ-avoidance were associated with high FoP. Healthcare providers should prioritize identifying high-risk individuals and develop tailored interventions to reduce FoP and improve rehabilitation outcomes.