Product Development Process Research Articles

Rapid Glyco-Qualitative Assessment of Recombinant Proteins Using a Fully Automated System.

Protein glycosylation, a critical post-translational modification, influences the stability, efficacy, and immunogenicity of recombinant proteins, including biopharmaceuticals. Glycan structures exhibit significant heterogeneity, varying with production cell types, culture conditions, and purification methods. Consequently, monitoring and evaluating the glycan structures of recombinant proteins is vital, particularly in biopharmaceutical production. The lectin microarray, a technique complementary to mass spectrometry, boasts high sensitivity and ease of use. However, it typically requires more than a day to yield results. To adapt it to non-glycoscience research or drug product process development, an automated, high-throughput alternative is needed. Therefore, the world's first fully automated lectin-based glycan profiling system was developed, utilizing the "bead array in a single tip (BIST)" technology concept. This system allows for the preparation and storage of lectin-immobilized beads in units of 1,000, with customizable parallel insertion orders for various purposes. This article presents a practical protocol for research involving "glyco-qualified" recombinant proteins. After testing their reactivity against 12 polyacrylamide-glycan conjugates, 15 lectins were selected to increase the system's versatility. In addition, the sample labeling process was optimized by switching from Cy3 to biotin, reducing the overall processing time by 30 min. For immediate data qualification, lectin-binding signals are displayed as a dotcode on the top monitor. The system's reliability was confirmed through day-to-day reproducibility tests, repeatability tests, and long-term storage tests, with a coefficient of variation of <10%. This user-friendly and rapid glyco-analyzer has potential applications in the quality monitoring of endogenous glycoproteins for biomarker evaluation and validation. This method facilitates analysis for those new to glycoscience, thereby broadening its practical utility.

Application of Quality Function Development (QFD) to Improve Quality and Develop Porang Rice Product XYZ

Porang rice is one of the alternatives to rice but porang rice producers are still very few and fairly new in the field. XYZ porang rice is one of the porang rice products that is quite in demand by various groups. The purpose of this research is to provide information to companies to develop their products. Because developing this product requires the voice of consumers in the product development process with the hope that if the company develops the product in accordance with consumer expectations, an increase in sales will occur. So that later this XYZ brand porang rice can continue to improve its products and services for consumers. In this study, the steps taken at the beginning were to deepen the strengths and weaknesses of the product using the EFAS and IFAS matrices This study uses the Quality Function Development (QFD) approach with the initial stage of identifying customer needs and getting 19 attributes of consumer expectations of XYZ brand porang rice products. After that, a customer satisfaction performance (CSP) is made by comparing other brand products. related to determining the CSP value, the CSP value for XYZ Brand Porang Rice is 4.75 with a durable attribute within a day and the lowest is on a more creative and attractive product packaging model with a value of 2.35 while for its competitors with Shirataki Rice with the K brand, the attribute that has the greatest value is the high fiber and the size of the intact rice grains with a value of 4.70 and the lowest is the attribute of the packaging model with a variety of sizes, namely 1.45. Then processed into HOQ calculations and obtained the results of the 3 largest value of priority improvements in the production tool, then followed by marketing, and the third is in the texture produced.

How is the textile product development process managed? Exploring multiple dimensions and best practices in different firms of the production chain

PurposeThis paper aims to describe the product development process (PDP) of companies in the textile industry, seeking to understand the dynamics of their management from different actors along the production chain.Design/methodology/approachQualitative empirical research adopted a multiple case studies design in five large Brazilian organizations, each representing a link in the production chain.FindingsTextile PDP follows structured steps. However, it is still an informal process. The use of methodologies and tools for decision-making and control gates throughout the process is limited. Performance indicators do not cover all dimensions of the PDP since sales and profit are the main parameters for assessing projects. The predevelopment macro phase varies according to the product type and the company's business model, whereas the postdevelopment macro phase is nonexistent. PDP projects are executed through collective efforts of multiple departments in cross-functional teams, except for the commodities firms.Practical implicationsThe study allows managers of Brazilian textile companies to understand the best practices in the PDP and those that require more attention, taking into account different business models and sectors of the production chain.Originality/valueOur results contribute to the literature and practitioners by providing an overview of PDP management in the textile industry, covering its different production chain actors, types of projects and companies' characteristics.

CRITICAL ROLES IN BALANCING CUSTOMER EXPECTATIONS AND SOFTWARE PRODUCT DEVELOPMENT: A BUSINESS PERSPECTIVE

In the quest for organisational agility in product development, critical roles emerge as vital connectors between client expectations and organisational capabilities. This paper explores the dynamic interplay of roles like product owners, innovation champions, and cross-functional teams in aligning innovation, technology, and people to meet customer demands. These roles serve as vital connectors, bridging the gap between customer expectations and product development constraints. Within the context of business agility and Agile methodologies, they orchestrate a harmonious balance that fuels innovation, enhances customer satisfaction, and ensures success in today's rapidly evolving business landscape. By fostering a culture of adaptability and collaboration, by fostering a culture of adaptability, collaboration, and responsiveness, organisations can enhance their ability to satisfy customers' evolving needs while ensuring the efficient execution of product development processes.

Development of an HSV-1 production process involving serum-reduced culturing and bead-to-bead transfer

Herpes simplex virus type 1 (HSV-1) plays an important role in the field of gene therapy and viral vaccines, especially as an oncolytic virus. However, the mass production of HSV-1 viral vectors remains a challenge in the industry. In this study, a microcarrier-mediated serum-reduced medium culture was used to improve the bioprocess of HSV-1 production and increase HSV-1 yields. The composition of the culture media, which included a basal medium, serum concentration, and glutamine additive, was optimized. The process was successfully conducted in a 1 L bioreactor, and virus production was threefold greater than that of conventional processes with a 10% serum medium. The bead-to-bead transfer process was also developed to further increase scalability. In spinner flasks, the detachment rate increased from 49.4 to 80.6% when combined agitation was performed during digestion; the overall recovery proportion increased from 37.9 to 71.1% after the operational steps were optimized. Specifically, microcarrier loss was reduced during aspiration and transfer, and microcarriers and detached cells were separated with filters. Comparable cell growth was achieved with the baseline process using 2D culture as the inoculum by exchanging the subculture medium. To increase virus production after bead-to-bead transfer, critical parameters, including shear stress during digestion, TrypLE and EDTA concentrations in the subculture, and the CCI, were identified from 47 parameters via correlation analysis and principal component analysis. The optimized bead-to-bead transfer process achieved an average of 90.4% overall recovery and comparable virus production compared to that of the baseline process. This study is the first to report the optimization of HSV-1 production in Vero cells cultured on microcarriers in serum-reduced medium after bead-to-bead transfer.Key points• An HSV-1 production process was developed that involves culturing in serum-reduced medium, and this process achieved threefold greater virus production than that of traditional processes.• An indirect bead-to-bead transfer process was developed with over 90% recovery yield in bioreactors.• HSV-1 production after bead-to-bead transfer was optimized and was comparable to that achieved with 2D culture as inoculum.

Need Analysis Research: the Development on the Literacy Instillation and the Islamic Character Building of College Students

Purpose: Based on the description and previous research, the researcher is interested in developing the Social Media-Based Online Comics in order to instill literacy and building Islamic character to students. Theoritical framework: Theories related to student literacy abilities, Islamic characters and the development of comic media. Method: The method used in this research is a needs analysis survey related to development of instilling literacy and building Islamic character in students. The media used in this study was google forms, observation sheets of student activities and interviews with lecturers, teachers and students. Result and Discussion: The results of this study revealed that on average they have never had received any training in creating online comic media. As a result, this hinders them from developing online comic media. The result of the analysis showed that the training on the product development process, especially online comic media is urgently needed so that respondents no longer experience difficulties in developing learning product, such as online comic media. Schools and relevant Education institution need to put special attention to the formation of skills development in providing media and learning processes that are interesting and effective. Originality: The novelty of this study is that researchers develop comics in order to improve students' literacy skills and students' Islamic character. In addition, the comics are digital and social media-based designs so that they have high selling power and easily accessible by all users.

Contextual Knowledge Framework in CAD Education from the Perspectives of Practicing Engineers

The contemporary industry landscape requires engineering graduates to have expertise in utilizing advanced Computer-Aided Design (CAD) tools. However, prevailing practices reveal a lack of contextual knowledge among Mechanical Engineering undergraduates and fresh graduate engineers in effectively employing 3D CAD modelling software for optimal product design development. Consequently, this study was undertaken to address this issue, with a specific focus on the integration of contextual knowledge into 3D CAD modelling. The study aims to elucidate the fundamental elements of contextual knowledge regularly employed by practicing engineers in their daily design endeavours, specifically in 3D CAD modelling. A transcendental phenomenology approach was used, and four engineers from the engineering department of a shipbuilding company in Peninsular Malaysia were purposefully selected as respondents. The analysis yielded three recurring themes central to the application of contextual knowledge in visualizing and presenting models through 3D CAD modelling: Realization, Design Intention, and Normalization. These elements are pivotal in assisting engineers in contextualizing their design work during the modelling and presentation stages of the new product development process.

A Cognitive Approach for Modeling Customer Demand Dynamics for Optimal Product Release Strategies

Abstract As agile processes are increasingly adopted for product design, and as consumer preferences are rapidly evolving with increasing information available from digital media, there is a need for a demand model that can accommodate the dynamics of product development. However, existing models of demand estimation, such as the discrete-choice models, do not capture the dynamics of product development and decision-making processes and thus are unable to effectively capture the effect of product updates and the release of information. To address this gap, we present a dynamic demand model and demonstrate how it can be used to determine the optimal time to release product updates. The demand model is based on decision field theory (DFT), which enables the modeling of the dynamic behavior of human decision makers. The contributions of this article are as follows. First, we formulate a computational model for demand modeling built on DFT and demonstrate the viability of using the model to determine product release strategies. Second, we provide analytical approximations of the demand model and compare the accuracy of the approximated demand against the demand predicted by the dynamics model. Third, we show an example of a game played by competitors trying to optimize demand for their products by choosing the optimal update time relative to each other. Finally, we demonstrate the feasibility of parameter estimation using only the demand data.

The effect of consumer participation during the new product development process on consumer brand identification: A gaming industry study

AbstractThis study examines the role of consumer participation in the new product development process within the gaming industry, focusing on its impact on Consumer Brand Identification (CBI), with brand attractiveness as a mediating factor. Using a between‐subjects experimental design, we tested three scenarios of consumer participation and analyzed the data with one‐way ANOVA and mediation analysis. The findings reveal that although consumer involvement enhances brand attractiveness, it does not significantly increase brand identification. This research provides new insights into the limited effects of consumer participation on deepening brand connections despite its positive influence on brand perception. This study is one of the first to empirically explore the varying impacts of consumer participation on CBI within the gaming sector, offering a nuanced understanding of its role in shaping brand perception. Practical implications suggest that while consumer involvement is beneficial for enhancing brand attractiveness, its effectiveness in fostering brand identification is limited, and marketers should temper expectations when employing this strategy.

Development and Improvement of a Production Company (and their Product) Based on the Value Stream Mapping of Business Processes

Abstract Value stream mapping is one of the basic tools used in the processes improvement or design – in accordance with the Lean concept. This paper presents a model of designing production processes and introducing new products to the market based on the analysis of the value streams flow in the production process. Particular attention was paid to the importance of input data necessary to plan a properly functioning production process, which results in a high-value product (from the customer’s point of view). In the paper also the list of all the most important tools supporting all stages of designing new production processes or improving existing processes has been presented. Also the advantages of big pictures analysis using was highlighted. In this case value stream mapping and big picture analysis were oriented on quality in the product development process and contribute to: creating value (based on customer requirements) while maintaining timely deliveries and constant costs (Value Stream Mapping), sustainable use of tangible and intangible resources (removing waste at the design stage). However, from the company point of view, and particular in the cost level, the product can gain value because a lower input is required for its production. After improvement, the process lead time has been shortened in an area where value was not added, but the consequence of implementing the change is an increase in the production volume while maintaining the process transition time – therefore, unit costs of production will change.

Adaptation of the Automotive Product Development Process for AI Development

Abstract Artificial Intelligence (AI) functionalities are increasingly being used in vehicle applications. While current product development models take the increasing proportion of software into account, the special requirements of artificial intelligence developments are hardly ever explicitly considered. The new requirements result both from increasing standardisation and regulation and from the iterative and explorative approach inherent in AI model development. This paper identifies the key adaptations to the standard automotive product development process that are required to cover the requirements of AI development. The adapted development model was trialled in two vehicle developments, the most important lessons learnt of which are summarised in this paper.

A Study on the Marketing Strategy for a New Product Development and Launch in the Market

In today’s market careful planning and a good product strategy are essential to help you succeeding in the market. Companies everywhere are competing more than ever to develop new and unique products or services and gain a higher position in the market. Companies develop a high number of new products every year. Most of these products fail to secure competitive advantages and end up being just another high cost for the company. The aim of this thesis is to develop a product development and launch process for Company X, Finnish supplier of roll handling equipment for the paper industry. The need for this thesis came during the author´s working experience with the company. Company X is a young company that creates innovative products for the industry. Developing new unique products that offer several benefits to the customers is the company mission and at the same time one of the main strengths. As the new product development is a continuous process and Company X is growing its product portfolio continuously, the commissioner felt the need instructuring the product development and launch process in a well-defined step-by-step process that is easy to follow and communicate internally. The author’s knowledge and experience gained during the studies in international business and working with in the paper industry can be utilized to help Company X in building this process. New products are very essential for the corporate success. Innovation is a must if you want to continue competing in the market. However the new product development is one of the riskiest processes that require focus and high investments. Several studies have been done in the successful product launch cases, and success drivers have been discovered. Corporations are using a structured idea-to- launch processes which help them manage implementing these success drivers and reduce the risk of product launch fail.

CUSTOMER SATISFACTION REGARDING HONDA BIKES

Customer satisfaction regarding Honda bikes is a critical aspect of assessing market performance and brand loyalty. In recent years, Honda has consistently strived to enhance customer satisfaction through various strategies encompassing product quality, after-sales service, and innovation. Key factors contributing to customer satisfaction include reliability, fuel efficiency, performance, and design aesthetics. Honda's commitment to research and development ensures the incorporation of cutting-edge technology, resulting in bikes that meet or exceed customer expectations. After-sales service plays a pivotal role in enhancing customer satisfaction, with Honda establishing a widespread network of service centers to address maintenance needs promptly. The availability of genuine spare parts further reinforces customer trust and satisfaction.Feedback mechanisms such as customer surveys and online reviews allow Honda to gauge satisfaction levels and identify areas for improvement continually. Incorporating customer feedback into product development processes enables Honda to tailor offerings to meet evolving consumer preferences effectively.Moreover, Honda's emphasis on sustainability and eco-friendliness resonates well with environmentally-conscious consumers, further bolstering satisfaction levels. Through a holistic approach encompassing product quality, service excellence, innovation, and sustainability, Honda consistently strives to foster high levels of customer satisfaction, thereby solidifying its position as a leading brand in the motorcycle industry. Keywords : Honda bikes,customer satisfaction,product quality, performance, reliability, design,affordability,after-sales service

Leveraging data analytics for informed product development from conception to launch

This review paper explores the impact of data analytics on guiding product development processes from conception to launch. It synthesizes findings from existing literature to outline how data-driven strategies can optimize each phase of product development, thereby enhancing efficiency and effectiveness in meeting market demands. The review spans various industries, highlighting the universality of data analytics applications in product innovation. The paper details how data analytics facilitates better decision-making through predictive insights into market trends and consumer preferences, which are crucial for defining product specifications and features. It also examines the role of data in refining production processes, ensuring quality control, and customizing marketing strategies to target potential customer segments effectively. Additionally, the review considers the benefits of continuous data evaluation during the product testing phase, enabling quicker adjustments and improvements. The findings indicate that data analytics significantly shortens the product development timeline and increases the likelihood of market success. Organizations leveraging data-driven insights from the outset of product development gain a competitive edge by creating more aligned and responsive products. The paper recommends broader adoption of robust data analytics tools and practices across industries to maximize product development outcomes.

Crowdsourcing capabilities: fueling new products? How firm size and business type matter

Crowdsourcing has emerged as a valuable tool for organizations seeking to access external knowledge and resources for their innovation processes. This study aims to investigate crowdsourcing capabilities in the context of new product development initiatives, with a focus on exploring the moderating effects of firm size and type. Structural Equation Modeling using Partial Least Squares (SEM-PLS) is used to analyze both the measurement and structural models, with data drawn from 217 owners and managers of diverse businesses in Indonesia. These businesses range from small to medium-scale enterprises across various types, including cafes, restaurants, fashion, culinary, and furniture. The findings reveal a positive and significant impact of crowdsourcing capabilities on new product development initiatives (β = 0.746, p = 0.000). Moreover, the relationship between crowdsourcing and new product development is moderated by firm size (whether small or medium) (β = 0.103, p = 0.045) and the type of business (β = 0.157, p = 0.012). The outcomes of this study are anticipated to enrich the body of knowledge and provide valuable guidance for enterprises seeking to harness crowdsourcing in their new product development processes, with specific factors like firm size and type taken into account. AcknowledgmentThis study was supported by the Indonesian Ministry of Education, Culture, and Technology Research in 2022: Research Grant Scheme “PDUPT”No. 124/LL1/LT/K/2022.

Fostering product development efficiency through cross-functional team leadership: Insights and strategies from industry experts

This study investigates the impact of leadership models on the efficiency and innovation outcomes of cross-functional teams (CFTs) in product development contexts. With the aim of identifying effective leadership practices, the research focuses on how transformational, shared, and situational leadership models influence team dynamics, communication, collaboration, and ultimately, product development efficiency. Employing a systematic literature review combined with content analysis, the study analyzes peer-reviewed articles and scholarly books published from 2013 to 2024. This methodology facilitates a comprehensive examination of current leadership models and their applicability to CFTs. Key findings reveal that transformational leadership inspires and motivates team members, shared leadership enhances ownership and accountability, and situational leadership adapts to the dynamic needs of product development projects. These leadership models significantly contribute to fostering an environment conducive to open communication and collaboration, driving innovation and efficiency in product development processes. Based on these insights, strategic recommendations for industry leaders include adopting flexible leadership styles, promoting open communication, encouraging shared leadership, and investing in leadership development. These strategies are pivotal for leveraging the diverse expertise within CFTs and enhancing product development outcomes. The study underscores the critical role of leadership in maximizing the potential of CFTs for innovation and efficiency. It highlights the need for leaders to adapt their strategies to the unique challenges of managing diverse teams, offering a path forward for effective team leadership in product development. Keywords: Cross-functional teams, Leadership models, Product development efficiency, Innovation outcomes.

Use of Ticketing System in Freelancing Platform to Maintaining Client Trust in Product Development Process

Micro, small, and medium enterprises (MSMEs) are considered to be one of the important components in the economic development of a country, especially Indonesia. However, it has been found that MSMEs are lagging in digitalization, the adoption of information technology, and digital marketing. An information system where MSMEs can have easy access to IT and digital marketing professionals can be a solution to boost and encourage digitalization among local MSMEs. Developing such an information system requires the project to be able to quickly adapt and change based on the user’s needs and current trends. This study proposes an incremental solution to building an accessible information system catered for MSMEs by incorporating the ADDIE model into the development cycle. To understand the feasibility of the system, several group meetings are arranged to demonstrate and try out the system’s capability to the target users. The results indicate that the system is generally able to fit the needs of MSMEs and is quite effective at connecting the MSESs to IT and Digital marketing resources and experts.

Impact of contextual factors on new product development process: evidence from a large company in Thailand

This research investigates the impacts of contextual factors, including organization-, project-, product-, and market-related factors, on New Product Development (NPD) process and explores how these factors shape the NPD process of the company within a specific context—a large-sized company in Thailand. By interviewing 11 managers from a large-sized company in Thailand, the findings reveal different impact of the contextual factors on the company’s NPD process. Based on these findings, we develop a practical NPD model to overcome company-specific challenges and, consequently, offer valuable insights to enhance the NPD process in similar contexts. Importantly, our findings suggest that innovative companies should strategically integrate the route-to-market for radical innovation into their NPD process because it enhances the customer perception of the innovation’s value before commercialization, leading to the success of NPD. Our empirical evidence fills the gaps in the literature regarding the practical configuration of NPD processes in developing countries as well as large-sized companies, acknowledging the variation in the NPD process that depends on contextual factors where innovation occurs. It also provides detailed insights beyond most existing studies that investigate correlation of factors with the NPD process and offers practical implications for management involved in the NPD process, emphasizing the need for contextual awareness in formulating effective NPD strategies.

A Systemic Approach to the Product Life Cycle for the Product Development Process in Agriculture

For a long time, a company’s Product Development Process (PDP) was seen as supporting the operations department, although PDP decisions and mistakes have a considerable impact on market performance. This is critical even in agriculture where bad habits and practices in the PDP can lead rural producers to great losses. Therefore, this research investigates the effect of the PDP on the market performance of rural products (bananas) in the southern region of Brazil, based on two analyses: (i) how sustainability practices support the PDP phases and (ii) how the phases of the Product Life Cycle Assessment (LCA) mediate sustainability practices and PDP phases. This study presents a quantitative analysis using Confirmatory Factor Analysis (CFA) and hierarchical ordinary least squares (OLS) regression of data obtained from a survey of 110 rural producers who directly participate in the banana production and planning process in southern Brazil. Our results show that sustainability practices support the PDP, and we confirm that the product development and post-development phase has an effect on market performance. In addition, we identify that in the pre-development phase of the PDP, dealing with rural products (bananas), the maturity stage of the LCA mediates sustainability. In the PDP development phase, we conclude that rural families who develop economic and environmental practices with their products, which are in the market growth phase may have reduced results. As for the post-development phase of the PDP, we conclude that when companies invest in environmental and social practices, there is a complete mediation of the effect, where these practices lose strength if the product is in the introductory and maturity phases in the market. In an original matter, our study contributes to demonstrating the value of the product life cycle for the Product Development Process in agriculture using sustainability practices through a systemic approach, filling the gap in the literature due to a lack of integrated research on these areas seen.

Development of Efficient and Scalable Production Process of Analytical Grade Sodium Chloride at Laboratory Scale

Development of Efficient and Scalable Production Process of Analytical Grade Sodium Chloride at Laboratory Scale