The impact of the sanctions policy of the unfriendly states on the national economic and regional reproduction processes in Russia has been analyzed and the consequences have been summed up. A new concept is introduced – national and regional reproduction under sanctions. It has been found that the certain objective economic laws in the development under sanctions imposed to a certain extent lose their influence on the reproduction of the gross social product (GSP). The changes in the processes of reproduction, distribution, exchange and consumption of national and regional products under sanctions are analyzed. The scheme of withdrawal of added value abroad in the case of sale of labor items is considered. Anti-sanctions measures are proposed at all phases of the GSP reproduction: production, distribution, exchange and consumption. It is emphasized that the sanctions social reproduction as a specific form of socio-economic development should be an independent object of research of regional economic science. There have been revealed the consequences of transformational reproductive processes of creating and using a public product under sanctions. It has been stated that the globalization processes that have recently taken place in the Russian economy have also affected the exclave territory (the Kaliningrad region). Dynamics of the volume of imports and exports in the international trade of the Kaliningrad region for 2014-2021 is illustrated. A scheme of the reproduction of GSP in the country as well as transferring the GSP reproduction abroad are shown. Conclusions are drawn about the need for further studying the sanctions reproduction as a specific form of socio-economic development.